Group items tagged

Only abstract available.  Meta-analysis of Testosterone therapy in post-menopausal women finds significant bias, some improvement in sexual function and cholesterol levels, yet safety and long-term data is significantly lacking.  Take this with studies on endogenous Testosterone in women, significant caution needs to be followed with Testosterone in women. Only abstract available here.

increased inflammatory markers associated with increased hot flash severity in menopausal women.  This is also associated with increased cardiovascular disease. Interesting that progesterone has anti-inflammatory properties.  So, therapy to reduce hot flashes should include inflammation reduction.

"...in the subgroup of women starting HRT between ages 50 and 59 or less than 10 years after menopause...reduction of overall mortality and coronary artery disease."

Women with SLE enter menopause earlier.  This study comments on the need for hormone testing in women with SLE and appropriate therapy as indicated.  This study recommended against estrogen therapy due to studies revealing increased flares.  The problem with those studies is that they looked at OCPs and synthetic HRT.

alcohol increases estrogen production in pre-menopausal women;  implications that alcohol intake increases risk of estrogen sensitive cancers

The early post menopause phase is critical for women. This is the phase that requires intensify strategy for exercise. The ER alpha signaling is actually increased and the ability to build muscle is intensified if exercise, particularly resistance training, is employed.

Early estrogen therapy in perimenopause and early menopause, with Estradiol, provides more health benefits than later therapy.  This article looked at Estrogen's effects on a woman's brain.  This likely has its origins in the change in estrogen receptors. The signal is not changing, but the reception of that signal is.  How else can one explain a different response to the same hormone dosage?

Menopause transition is associated with increasing Testosterone levels in women.  This is associated with an increase in MetS.

study finds hormone evaluations in post menopause women aids in breast cancer risk assessment.

Birth control pills were found to reduce IGF-1 levels in the short term and long term.  Those that had used birth control pills had lower IGF-1 levels compared to those that had never used birth control pills.  This fits with the current knowledge that oral estrogen reduces HGH and IGF-1.  Those were in post-menopausal women, but this is in pre-menopaus women.  This has implications on health, weight, disease...

Post menopause women with PCOS have high CVD.  PCOS is essentially metabolic syndrome separated by age.  Both PCOS and MetS in women is associated with an increase in Testosterone levels.

study finds that HRT given as women transition through menopause has benefiical effect in people with Alzheimer's.  However, when given years later, after menopause, no benefit is found.  In fact, rates increased.  Several flaws with this study.  First, they used synthetic hormones, particularily progestins.  Second, there seems to be no thought that the interpretation of the signal  has changed.  For example, we know that when men have low T, their estrogen receptor status changes from ER beta to ER alpha, which is more proinflammatory.  Third, use bioidentical hormones and compare these to synthetic hormones.

study identifies 15 Endocrine Disrupting Chemicals that lead to earlier Menopause.  Maybe we should change it to Chemopause.

Study looked at hormone levels via serum analysis at the time of sudden cardiac arrest in both men and women.  Low Testosterone and elevated Estrogen levels in  men were associated with increased odds (OR) versus women only had increased odds with elevated Estrogen.   ManBoob nation, my first book, discusses the mechanism behind this for men.  The finding in women really calls into question the Estrogen only model currently employed by physicians for post menopausal women.

testosterone associated with elevated CRP, increase BMI, and increased waist circumference in early, post-menopausal women.

A decrease in the SHBG in post menopause women is associated with increase in free Testosterone, which is associated with increase in MetS and CVD

Review of data of Testosterone in post-menopausal women is seriously lacking--especially long-term safety data and this is worrisome as other data points to increased CVD and cancer with increasing Testosterone levels in women.

Melanoma is a known estrogen sensitive cancer.  This study finds ER Beta loss correlates with thickness of lesion.  The authors propose ERalpha/ERbeta ratio be assessed.  ERbeta has been shown to decrease proliferation, promotes differentiation, and decrease inflammation in breast studies.  In contrast, ERalpha promotes proliferation, decreases differentiation, and promotes inflammation.  Here, the same effects seem to apply to melanoma. Of interesting note, men have lower skin ERbeta than women and ERbeta declines with age and menopause in women.  Essentially, the loss of the ability to differentiate, decrease proliferation and inflammation  occurs with increase estrogen stimulus--set up for estrogen promoting cancers.

ERr 731 extract from Siberian Rhubarb found to be effective against anxiety related to menopause.

Menopause transition can become a Testosterone dominant phase associated with increased CVD and increased metabolic syndrome.