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Melanoma is a known estrogen sensitive cancer.  This study finds ER Beta loss correlates with thickness of lesion.  The authors propose ERalpha/ERbeta ratio be assessed.  ERbeta has been shown to decrease proliferation, promotes differentiation, and decrease inflammation in breast studies.  In contrast, ERalpha promotes proliferation, decreases differentiation, and promotes inflammation.  Here, the same effects seem to apply to melanoma. Of interesting note, men have lower skin ERbeta than women and ERbeta declines with age and menopause in women.  Essentially, the loss of the ability to differentiate, decrease proliferation and inflammation  occurs with increase estrogen stimulus--set up for estrogen promoting cancers.

RIGVIR shown to improve survival against standard therapy in stage IB, IIA, IIB, and IIC in malignant melanoma patients in retrospective study. Side effects are minimal. Neutralizing antibodies are an area to watch that likely effects individual outcome beyond that of the type of cancer

High dose IV vitamin C effective against melanoma review finds. Low dose appears to promote melanoma.

Elevated prolactin found statistically elevated in melanoma versus dysplastice nevi.

Elevated prolactin clearly directly associated with malignant melanoma.

Ketogenic diet (low carb/high fats) slows malignant melanoma proliferation no matter the genomic mutations present. It matches with most BRAF+ as this points to increased GLUT1 expression.

Viagra associated with a 84% increased risk of melanoma.  The key word here is associated.  No cause and effect relationship is seen.  Anytime use was also associated with increased risk.  This study did not look at the other phopsphodiesterase 5 inhibitors, though the logic is there risk may be higher as they are longer acting.

Progesterone decreased melanoma cell growth in cell line study.  This inhibition occurred through non-progesterone receptor pathways.

TIL immunotherapy in the treatment of melanoma

BRAF V600 mutations present in appx 50% of melanomas.

Intralesional dye to treat melanoma.

IV vitamin C suppresses growth of melanoma cancer.

ERbeta found to be associated with benign nevi and malignant melanomas.  No association was found with ERalpha.

Low dose cisplatin, low dose IL-2 and high dose melatonin as effective as first line therapy in the treatment of melanoma

It is important to realize that birth control pills are associated with increased risk.  This review found and increase in cardiovascular disease, melanoma, lupus, and breast cancer; however, a lower risk of colon and ovarian cancer was found.

In vitro studies confirm reduced viability of melanoma, rhabdomyoscarcoma, gastric adenocarcinoma, lun carcinoma, and pancreas adenocarcinoma cells with the use of the oncolytic RIGVIR virus

Quercetin and tamoxifen were shown to reduce HSP27 expression when used in conjunction with severe hyperthermia (42.5 C)

vitamin C at low concentrations promoted cell growth, migration and cell cycle progression, and protected against mitochondrial stress; but vitamin C at high concentrations inhibited cell growth, promoted apoptosis, inhibited metastasis and was adjunctive with vemurafenib.

Really great read.  Cancer is a majority lifestyle disease.