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Women with metabolic syndrome have increased recurrence of breast cancer after initial therapy.  Likewise, Increasing Testosterone was associated with increasing risk of metabolic syndrome.  This is the opposite of men.  One wonders what this massive doping of Testosterone that is underway is doing to women?  Are we merely feeding disease?

Testosterone therapy followed over 5 years in hypogonadal men found physiologic replacement of Testosterone decreased Total cholesterol, decreased LDL, increased HDL, decreased blood pressure, decreased blood glucose, decreased HgbA1c, decreased CRP, ALT, and AST. All men with metabolic syndrome  should have appropriate hormone evaluation done.

retrospective study found low Testosterone levels associated with increased mortality in male veterans.

Study finds little link to Testosterone replacement therapy to elevation in PSA in "healthy" men.  All the members of this study had negative prostate biopsies prior to therapy.

Good article.  This article (case series) found that 40% of the men included had no increase in PSA with Testosterone.  One point on the Testosterone dosage is that they used androgen, which is an overdose of Testosterone.  That gives 60% that the PSA did increase.  These men had higher PSA to begin with which leads to the suggestion that the prostate cells were abnormal.  Those men that had a prostatectomy were more likely to have little if any increase in PSA.  This study did use a the 5 alpha reductase inhibitor dutasteride.

IL-6 suppresses TSH.

Viagra associated with a 84% increased risk of melanoma.  The key word here is associated.  No cause and effect relationship is seen.  Anytime use was also associated with increased risk.  This study did not look at the other phopsphodiesterase 5 inhibitors, though the logic is there risk may be higher as they are longer acting.

Startling statistic--25% of men started on Testosterone therapy have had not diagnostic evaluation of Testosterone levels.

Study links peripheral neuropathy and ED in men.  Though, both are likely a reflection of low Testosterone as elevated aromatase activity.

New study finds no cardiovascular benefits from resveratrol.  It has long been claimed that reserveratrol is the polyphenol from red wine and chocolate that is the source of cardiovascular benefits such as found in the "french paradox".  However, this new study finds that resveratrol provides no benefit.  Studies still point to dark chocolate and red wine as means to reduce inflammation and reduce CVD risk, this study just points away from resveratrol as the source of the benefit.

Study finds that HRT is associated with a 35% reduction in relative risk of colorectal cancer in postmenopausal women.  Even use within the previous 5 years was associated with reduced risk.  This benefit is lost at 5 years..

Lead exposure associated with increased cardiovascular disease and mortality.

Great article from 2008 that discusses glycemic index and glycemic load.  What is great about this article is the supplementary appendix listing the above for > 1000 items.

Ultra endurance athletic events associated with significant increase in systemic inflammation due to damaged gut.

Gut effects on metabolism are widespread.

A study to evaluate serum and urinary hormone levels following short and long term administration of two regimens of progesterone cream in postmenopausal women

DHA/EPA (omega-3)  inhibit cancer growth; have been shown to improve chemotherapy

Treatment in subclinical hypothyroidism provides statistical benefits to patient symptoms

up to 1.55 x increase risk of death with antipsychotic use

Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer's disease