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Nathan Goodyear

PLOS ONE: Microbial Dysbiosis Is Associated with Human Breast Cancer - 0 views

  • it is tempting to speculate that a decrease in bacterial load in a healthy individual may be a signal of heightened breast cancer risk
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    Study finds a decrease in gut bacterial load in women with breast cancer versus those without.  The authors propose that a decrease in bacterial load in healthy individuals might be a means to estimate breast cancer risk.  Could it all start in the gut?
Nathan Goodyear

JISSN | Full text | International Society of Sports Nutrition position stand: creatine ... - 0 views

  • the energy supplied to rephosphorylate adenosine diphosphate (ADP) to adenosine triphosphate (ATP) during and following intense exercise is largely dependent on the amount of phosphocreatine (PCr) stored in the muscle
  • Creatine is chemically known as a non-protein nitrogen
  • It is synthesized in the liver and pancreas from the amino acids arginine, glycine, and methionine
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  • Approximately 95% of the body's creatine is stored in skeletal muscle
  • About two thirds of the creatine found in skeletal muscle is stored as phosphocreatine (PCr) while the remaining amount of creatine is stored as free creatine
  • The body breaks down about 1 – 2% of the creatine pool per day (about 1–2 grams/day) into creatinine in the skeletal muscle
  • The magnitude of the increase in skeletal muscle creatine content is important because studies have reported performance changes to be correlated to this increase
  • "loading" protocol. This protocol is characterized by ingesting approximately 0.3 grams/kg/day of CM for 5 – 7 days (e.g., ≃5 grams taken four times per day) and 3–5 grams/day thereafter [18,22]. Research has shown a 10–40% increase in muscle creatine and PCr stores using this protocol
  • Additional research has reported that the loading protocol may only need to be 2–3 days in length to be beneficial, particularly if the ingestion coincides with protein and/or carbohydrate
  • A few studies have reported protocols with no loading period to be sufficient for increasing muscle creatine (3 g/d for 28 days)
  • Cycling protocols involve the consumption of "loading" doses for 3–5 days every 3 to 4 weeks
  • Most of these forms of creatine have been reported to be no better than traditional CM in terms of increasing strength or performance
  • Recent studies do suggest, however, that adding β-alanine to CM may produce greater effects than CM alone
  • These investigations indicate that the combination may have greater effects on strength, lean mass, and body fat percentage; in addition to delaying neuromuscular fatigue
  • creatine phosphate has been reported to be as effective as CM at improving LBM and strength
  • Green et al. [24] reported that adding 93 g of carbohydrate to 5 g of CM increased total muscle creatine by 60%
  • Steenge et al. [23] reported that adding 47 g of carbohydrate and 50 g of protein to CM was as effective at promoting muscle retention of creatine as adding 96 g of carbohydrate.
  • It appears that combining CM with carbohydrate or carbohydrate and protein produces optimal results
  • Studies suggest that increasing skeletal muscle creatine uptake may enhance the benefits of training
  • Nearly 70% of these studies have reported a significant improvement in exercise capacity,
  • Long-term CM supplementation appears to enhance the overall quality of training, leading to 5 to 15% greater gains in strength and performance
  • Nearly all studies indicate that "proper" CM supplementation increases body mass by about 1 to 2 kg in the first week of loading
  • short-term adaptations reported from CM supplementation include increased cycling power, total work performed on the bench press and jump squat, as well as improved sport performance in sprinting, swimming, and soccer
  • Long-term adaptations when combining CM supplementation with training include increased muscle creatine and PCr content, lean body mass, strength, sprint performance, power, rate of force development, and muscle diameter
  • subjects taking CM typically gain about twice as much body mass and/or fat free mass (i.e., an extra 2 to 4 pounds of muscle mass during 4 to 12 weeks of training) than subjects taking a placebo
  • The gains in muscle mass appear to be a result of an improved ability to perform high-intensity exercise via increased PCr availability and enhanced ATP synthesis, thereby enabling an athlete to train harder
  • there is no evidence to support the notion that normal creatine intakes (< 25 g/d) in healthy adults cause renal dysfunction
  • no long-term side effects have been observed in athletes (up to 5 years),
  • One cohort of patients taking 1.5 – 3 grams/day of CM has been monitored since 1981 with no significant side effects
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    Nice review of the data, up to the publication date, on creatine.
Nathan Goodyear

Dietary glycemic load and atherothrombo... [Curr Atheroscler Rep. 2002] - PubMed - NCBI - 0 views

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    glycemic load
Nathan Goodyear

International Tables of Glycemic Index and Glycemic Load Values: 2008 - 1 views

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    Great article from 2008 that discusses glycemic index and glycemic load.  What is great about this article is the supplementary appendix listing the above for > 1000 items.
wheelchairindia9

Golden Motor Electric Wheelchair - 0 views

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    Powerchairs are generally four-wheeled or six-wheeled and non-folding, however some folding designs exist and other designs may have some ability to partially dismantle for transit. Four general styles of powerchair drive systems exist: front, centre or rear wheel drive and all-wheel drive. Powered wheels are typically somewhat larger than the trailing/castoring wheels, while castoring wheels are typically larger than the castors on a manual chair. Centre wheel drive powerchairs have castors at both front and rear for a six-wheel layout. Angel Wheelchair Electric standing wheelchair Standing up, driving function by power. Head and signal light (controlled by joystick). Adjustable headrest. Adjustable footplate. Detachable backrest Rigid steel framework W/liquid coating Flip-backward armrest Max speed: 9.15KM/H Front castor: 2.80/2.50-4 pneumatic castor (9") Rear wheels: 3.00-8 pneumatic tire (14") Available seat width: A (46 cm), D (42 cm) Max loading: A size: 135 kg Net weight w/o battery: 62.7 kg A powerchairs is a wheelchair that is propelled by means of an electric motor rather than manual power. Power wheelchairs are useful for those unable to propel a manual wheelchair or who may need to use a wheelchair for distances or over terrain which would be fatiguing in a manual wheelchair. They may also be used not just by people with 'traditional' mobility impairments, but also by people with cardiovascular and fatigue based condition. An powerwheelchair powers more than just chair. It gives the power to safely travel long distances on own. It empowers to navigate through home, backyard, school, workplace or local park. It gives power to do the things,want to do. It gives power. When accidents occur that leave permanent leg injuries, or as age sets in and joint pain becomes unbearable, the power chair acts as a gateway to continue living life to the fullest. The powerwheelchairs in our lineup are all battery powered, yet each device fills
Nathan Goodyear

Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian pros... - 0 views

  • GI is a measure of carbohydrate quality in relation to glucose availability and is independent of quantity, whereas GL is a measure of the total glycemic effect and hence is anindicator of the insulin demand of the diet. High-glycemic diets are in fact generally associated with greater insulin secretion
  • the consumption of large quantities of high-GI foods rather than the consumption of high quantities of carbohydrates is linked to the development of breast cancer.
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    High glycemic load and glycemic index associated with increased breast cancer risk in premenopausal women.
Nathan Goodyear

Dietary glycemic index, glycemic load, and cancer risk: results from the EPIC-Italy stu... - 0 views

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    High glycemic index diet was found to be associated with increased risk of colon and bladder cancer where as a high glycemic load was associated with increased risk of colon cancer and other diabetes-related cancers.
Nathan Goodyear

Taylor & Francis Online :: The effect of longer-term creatine supplementation on elite ... - 0 views

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    4 days of creatine loading with 25 grams improved times in elite swimmers in 19/22 individuals.  Two months provided no significant benefit.
wheelchairindia9

Golden Motor Wheelchair - 0 views

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    GM LITE POWER WHEELCHAIR GM Lite Brushless Power Wheelchair with Batteries is a revolutionary light weight power wheelchair using brushless motor. It is the most economic power wheelchair without sacrificing safety & durability. The wheelchair promotes pressure redistribution, reduces downward sliding and helps maintain good posture. Specifications: 10 times longer life Lightest - 23 kg 5 year long life, safe LiFePO4 battery (10ah) High efficiency brushless hub motor 5 seconds folding and unfolding Easy to carry Load : 120 kg Speed : 8km/hr Range: 15 km Slope : 12% 24V180W brushless 8-inch gear hub motor
Nathan Goodyear

Exercise-induced right ventricular dysfunction and structural remodelling in endurance ... - 0 views

  • In a cohort of well-trained athletes, we demonstrated that intense endurance exercise causes an acute reduction in RV function that increases with race duration and correlates with increases in biomarkers of myocardial injury
  • no relationship between LV function and biomarker levels
  • focal gadolinium enhancement and increased RV remodelling were more prevalent in those athletes with a longer history of competitive sport, suggesting that repetitive ultra-endurance exercise may lead to more extensive RV change and possible myocardial fibrosis
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  • he cardiac impact of both acute and cumulative exercise is greatest on the RV.
  • Greater reductions in RV function occurred in those athletes competing for a longer duration, suggesting that the heart has a finite capacity to maintain the increased work demands of exercise
  • We enrolled elite and subelite athletes and found a significant association between fitness (VO2max) and the reduction in post-race RVEF
  • Previous investigators have documented reductions in RV function in less trained subjects over the marathon distance
  • cardiac injury is greatest in the least trained
  • Even after many years of detraining, cardiac dilation may not completely regress in elite athletes
  • The focus on well-trained athletes may be of particular relevance, given that they perform exercise of highest intensity and duration most frequently, and, thus, may be at a greater risk of cumulative injury.
  • The lack of correlation between increases in troponin and changes in LV function seen in this study has been previously interpreted as evidence that post-exercise elevations in cardiac biomarkers are benign.
  • a significant correlation between changes in RVEF and post-race biomarker levels and this relationship was even stronger in the athletes who completed the race of longest duration, the ultra-triathlon
  • It has been demonstrated that ventricular load increases with exercise intensity and is greater for the RV than the LV,29 thus potentially explaining why the RV is more susceptible to fatigue after prolonged exercise.
  • BNP release during intense exercise is associated with greater relative increases in RV systolic pressures, but not LV pressures
  • BNP may provide a measure of both acute RV load and the resultant fatigue which occurs when this load is sustained
  • The correlations with RVEF, but not LVEF, provide further evidence of the differential effects of intense exercise on RV and LV function
  • This study demonstrates, for the first time, an association between endurance exercise of increasing duration and structural, functional, and biochemical markers of cardiac dysfunction in highly trained athletes
  • Functional abnormalities were confined to the RV and were largely reversible 1 week following the event
  • there remained a significant minority of athletes in whom there was evidence of myocardial fibrosis in the interventricular septum
  • RV abnormalities may be acquired through cumulative bouts of intense exercise and provides direction for prospective investigations aimed at elucidating whether extreme exercise may promote arrhythmias in some athletes.
  • the acute injury and chronic remodelling of the myocardium both disproportionately affect the RV and it remains possible that the two are linked.
  • focal DGE was confined to the interventricular septum and commonly at the site of RV attachment
  • emerging evidence that intense endurance exercise may be associated with an excess in arrhythmic disorders, the mechanisms for which remain unexplained
  • RVEF (and not LVEF) was reduced in athletes with complex ventricular arrhythmias when compared with healthy athletes and non-athletes without arrhythmias
  • it is premature to conclude that these changes may represent a proarrhythmic substrate
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    Study finds endurance racing results in reduce Right ventricle ejection fraction even in elite athletes.  This post-race RVEF reduction is associated with VO2max.
Nathan Goodyear

http://annonc.oxfordjournals.org/content/12/11/1533.full.pdf#page=1&view=FitH - 0 views

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    Study finds link between higher glycemic index and glycemic load with increased breast cancer risk.   The proposed mechanisms are: hyperinsulinemia and its affinity for IGF-1 receptor resulting in a + growth signal.  Increased IGF-1 via the same mechanism. Insulin and IGF-1 have negative regulation effects on SHBG. This all makes sense as insulin receptors are highly expressed on cancer cells.
Nathan Goodyear

Dietary glycine and blood pressure: the International Study on Macro/Micronutrients and... - 0 views

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    This study links glycine to increased blood pressure.  However, meat is the primary source of glycine. So, if the meat is loaded with omega-6, hormones...these will be the source of the inflammation and resultant increase in blood pressure, not the glycine.  One must read these studies closely.  No conclusion can be made from this study.
babypips

How to Make Blue Cheese Turkey Meatloaf - 0 views

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    This recipe is loaded with flavor, but the blue cheese gives it a little something extra. Try serving it with classic mashed potatoes for a complete meal. http://myvigour.com/make-blue-cheese-turkey-meatloaf-recipe/
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Windows technical support number 1-800-261-4071 - 0 views

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Nathan Goodyear

CDC Fourth Report - 0 views

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    CDC's report on the toxic load of Americans.
Nathan Goodyear

The nutritional biochemistry of creatine - 0 views

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    Loading dose of creatine, 20 grams/day, over 5-6 days increases total muscle creatine levels.  This has been shown to improve athletic performance.  The phosphocreatine  in Type II muscle fibers are particularly increased.  This can be maintained at 2 grams/day.
Nathan Goodyear

Creatine supplementation improves the anae... [Acta Physiol Hung. 2009] - PubMed - NCBI - 0 views

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    Four day loading dose with 20 grams of creatine significantly improved swimming time in elite swimmers.
Nathan Goodyear

Creatine monohydrate supplement... [Int J Sport Nutr Exerc Metab. 2000] - PubMed - NCBI - 0 views

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    Creatine loading dose of 25 grams over 4 days shown to increase high-intensity exercise performance in both males/females.
Nathan Goodyear

Combined creatine and sodium bicarbonate... [J Strength Cond Res. 2004] - PubMed - NCBI - 0 views

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    In this study, creatine + sodium bicarbonate improved time in interval swimming.  All were loaded for 6 days prior to randomization.
Nathan Goodyear

JISSN | Full text | Creatine supplementation enhances muscle force recovery after eccen... - 0 views

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    Creatine supplementation shown to improve muscle recovery in injury.  The dosing included the standard loading dose at 0.3 g/kg of body weight divided in multiple doses.  Maintenance was at 0.1 g/kg of body weight.
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