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Nathan Goodyear

UCL Discovery - EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR-gamma-dependent mechanism - 0 views

eprints.ucl.ac.uk/8794

inflammation omega-3 n-3 DHA EPA LPS PPAR-gamma

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Nathan Goodyear on 13 Jun 12
     
    Omega 3, DHA and EPA, reduce LPS stimulated inflammation via PPAR gamma activation.
Nathan Goodyear

PPARγ and human metabolic disease - 0 views

www.ncbi.nlm.nih.gov/...PMC1386124

PPAR-gamma perioxisome proliferator-activated receptor disease PPAR

shared by Nathan Goodyear on 24 Jan 13 - No Cached
  • PPARα and PPARδ appear primarily to stimulate oxidative lipid metabolism
  • PPARγ is principally involved in the cellular assimilation of lipids via anabolic pathways
  • PPARs are members of the nuclear hormone receptor superfamily
  • ...7 more annotations...
  • Expression of PPARγ is highest in adipose tissue,
  • PPARγ also plays a key role in the entraining of adipose tissue lipid metabolism to nutritional state
  • Its expression is highest postprandially
  • its activation leads to upregulation of genes that mediate FA uptake and trapping
  • PPARγ may also promote futile cycling in adipocytes between triglyceride (TG) esterification and de-esterification
  • its high expression in macrophages, which are now known to infiltrate the dysfunctional adipose tissue of obese subjects
    • Nathan Goodyear
      Nathan Goodyear on 28 Aug 14
       
      PPAR gamma is associated with adipocyte differentiation and lipid storage.
  • Nathan Goodyear on 24 Jan 13
     
    review of PPAR gamma
  • Blu Electronic Cigarettes on 03 Sep 14
     
    very informative! Thanks for sharing!
spineneuro

Dr. Sandeep Vaishya: Redefining Neurosurgery Standards - 0 views

spineandneuro.livepositively.com/...new=1

Dr. Sandeep Vaishya Gamma knife surgery Cost top gamma knife radiosurgery neurosurgeon

shared by spineneuro on 07 Nov 23 - No Cached
  • spineneuro on 07 Nov 23
     
    Dr. Sandeep Vaishya is renowned as the leading gamma knife neurosurgeon in India, boasting over two decades of experience in the field. He has collaborated with some of the most prestigious institutions and hospitals across the country.
Nathan Goodyear

Transcriptional regulation of the GL... [Trends Endocrinol Metab. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17317207

inflammation PPAR-gamma GLUT4 insulin resistance obesity weight gain

shared by Nathan Goodyear on 05 May 13 - No Cached
  • Nathan Goodyear on 05 May 13
     
    Inflammation causes dysregulation of GLUT4 receptor.  This leads to insulin resistance and associated weight gain.  PPAR gamma plays a role here.
Nathan Goodyear

PLOS ONE: Overexpression of the Mitochondrial T3 Receptor p43 Induces a Shift in Skeletal Muscle Fiber Types - 0 views

www.plosone.org/...journal.pone.0002501

mitochondria T3 thyroid hormone hormones muscle PPAR-gamma PPAR PGC1-alpha

shared by Nathan Goodyear on 29 Jun 13 - No Cached
  • Nathan Goodyear on 29 Jun 13
     
    T3 induces beneficial oxidative changes in muscles through its interaction with mitochondrial receptors.  PGC-1alpha and PPAR-gamma were involved in this process.  The important point here is that T3 is increasing oxidative function of muscle through interaction with mitochondria.
Nathan Goodyear

Effect of Coenzyme Q10 on Th1/Th2 Paradigm in Females with Idiopathic Recurrent Pregnancy Loss. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25800618

CoQ10 pregnancy inflammation IFN-gamma

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    CoQ10 reduced Th1 inflammatory cytokines in those women with recurrent early pregnancy loss.  CoQ10 specifically, reduced IFN-gamma.
Nathan Goodyear

Figure 2 : Targeting gut microbiota in obesity: effects of prebiotics and probiotics : Nature Reviews Endocrinology - 0 views

www.nature.com/...nrendo.2011.126_F2.html

gut obesity probiotics metabolic endotoxemia LPS inflammation PPAR-gamma microbiota endocannabinoid system

shared by Nathan Goodyear on 18 Jan 12 - No Cached
  • Nathan Goodyear on 18 Jan 12
     
    nice diagram of proposed mechanism of how diet and gut microbiota can influence the production of PPAR-gamma inducing growth of adipose tissue.  Also proposes how LPS and the endocannabinoid system contributed to a leaky gut and thus the proposed "metabolic endotoxemia"
Nathan Goodyear

IOS Press - Journal Article - 0 views

iospress.metapress.com/...vux3g01201610607

neuroinflammation excitotoxicity inflammation air pollution air pollution Alzheimer's disease IL-6 IL-1 TNF-alpha IFN-gamma

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    neuroinflammaiton, also described as excitotoxicity, found in the brains of children/young adults that lived in high air pollution areas.  Neuroinflammation (IL-6, IL-1, TNF-alpha, IFN-gamma...) found in the brains of these children and young adults.  This is the same process found in Alzheimers and other excitotoxicity disease states.  Addtionally, it is also involved in most chronic diseases of aging.
Nathan Goodyear

Access : Sulforaphane Inhibits Mitotic Clonal Expansion During Adipogenesis Through Cell Cycle Arrest : Obesity - 0 views

www.nature.com/...oby2011388a.html

sulphoraphane obesity overweight weight-loss PPAR-gamma C_EBP-alpha

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    sulphoraphane shown to arrest fat cell growth.  Sulphoraphane decreased PPAR-gamma and C/EBP-alpha expression as well as suppressing the cell growth cycle.  Obvious implications in weight loss
Nathan Goodyear

Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimulated Proinflammatory Responses and Neurotoxicity by PPARγ Agonists - 0 views

www.jneurosci.org/...558.long

inflammation AD alzheimer's neurodegenerative disease PPAR-gamma PPAR microglial alzheimer

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • PPARγ agonists were shown to inhibit the β-amyloid-stimulated expression of the cytokine genes interleukin-6 and tumor necrosis factor α. Furthermore, PPARγ agonists inhibited the expression of cyclooxygenase-2.
  • Nathan Goodyear on 11 Jun 12
     
    Not that we are recommending NSAIDS to reduce inflammation: but the learned biochemical pathways of inflammation involved with AD, allows a natural approach to reduce microglial associated inflammation through PPAR-gamma activation.
Nathan Goodyear

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice - 0 views

www.jimmunol.org/...7094.long

MS multiple Sclerosis DHEA dehydroepiandrosterone inflammation TNF-alpha IFN-gamma

shared by Nathan Goodyear on 30 Jul 13 - No Cached
  • Nathan Goodyear on 30 Jul 13
     
    DHEA found to decrease IFN-gamma, IL-12, and TNF-alpha through inhibition of NF-kappaB in animal model of MS.
Nathan Goodyear

Effects of Peroxisome Proliferator-Activated Receptor-α and -γ Agonists on 11β-Hydroxysteroid Dehydrogenase Type 1 in Subcutaneous Adipose Tissue in Men - 0 views

jcem.endojournals.org/...1848.long

11-betaHSD1 PPAR agonist PPAR-alpha PPAR-gamma PPARs cortisol

shared by Nathan Goodyear on 08 Oct 13 - No Cached
  • Nathan Goodyear on 08 Oct 13
     
    PPAR alpha and/or PPAR gamma does not down regulate 11Beta-HSD1.
Nathan Goodyear

1a,25-Dihydroxyvitamin D3 as New Immunotherapy in Treatment of Recurrent Spontaneous Abortion-Ori - 0 views

www.scribd.com/...urrent-Spontaneous-AbortionOri

vitamind D inflammation INF-gamma TNF-alpha IL-2

shared by Nathan Goodyear on 24 Sep 11 - No Cached
  • Nathan Goodyear on 24 Sep 11
     
    Vitamin D lowers INF-gamma, TNF-alpha, and IL-2 cytokines.  Vitamin D reduces inflammation.
Nathan Goodyear

Interferon-[alpha] reduces the density of monoaminergic axon... : NeuroReport - 0 views

journals.lww.com/..._reduces_the_density_of.7.aspx

depression inflammation IFN-gamma 5-HT serotnin noradrenergic neurotransmitter

shared by Nathan Goodyear on 14 Sep 11 - No Cached
  • Nathan Goodyear on 14 Sep 11
     
    inflammation, IFN-gamma, shown to lead to 5-HT and noradrenergic axon degeneration.  This reveals another inflammatory contribution to depression
Nathan Goodyear

http://www.diabetologia-journal.org/files/Narendran.pdf - 0 views

www.diabetologia-journal.org/...Narendran.pdf

exercise inflammation growth hormone GH IGF-1 TNF-alpha IL-6 IL-1beta IL-1Ra interferon-gamma diabetes islet cells

shared by Nathan Goodyear on 28 Oct 14 - No Cached
  • Nathan Goodyear on 28 Oct 14
     
    Exercise is not just for calories out.  Exercise increases growth hormone, IGF-1, glucagon-like peptide 1, IL-6, and IL-1ra.  The effect is to GH increases beta islet cell mass and protects beta cell lines against IL-1beta, Interferon-gamma and TNF-alhpa induced apoptosis.  IL-6 increased production increases GLP-1 and IL-1ra which counters IL-1beta.  Interleukin-1beta induces islet cell apoptosis and thus IL-1ra counters this pro-inflammatory signal.
Nathan Goodyear

EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR-γ-dependent mechanism - ScienceDirect - 0 views

www.sciencedirect.com/...S0085253815505322

inflammation omega 3 omega-3 EPA DHA LPS lipopolysaccharides NF-kappaB PPAR-gamma

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Omega 3 essential fatty acids, specifically EPA and DHA, decrease LPS activation of NF-kappaB via PPAR-gamma activation.
forestgood

Ce Uzum: A Perfect Cleansing of Blood Vessels Find out how Ce Uzum can help clear bloc... - 0 views

UZUM est un produit tres efficace ; Uzum, le complément alimentaire révolutionnaire qui nettoie efficacement les vaisseaux sanguins Les problèmes de santé cardiovasculaire sont devenus de plus en...

heart disease men inflammation obesity

started by forestgood on 05 Aug 23 no follow-up yet
Nathan Goodyear

4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ - 0 views

www.ncbi.nlm.nih.gov/...PMC37529

estrogen related receptors estrogen receptors estrogen receptor receptors estrogen related elements

shared by Nathan Goodyear on 08 Jan 13 - No Cached
  • Nathan Goodyear on 08 Jan 13
     
    estrogen-related receptors.  There are 3 types: alpha, beta, and gamma.  These don't respond to estrogens, but to estrogen related elements
Nathan Goodyear

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review - 0 views

www.ncbi.nlm.nih.gov/...PMC4212005

PPAR-gamma PPAR inflammation natural

shared by Nathan Goodyear on 26 Apr 16 - No Cached
  • Nathan Goodyear on 26 Apr 16
     
    to read.
Nathan Goodyear

Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimulated Proinflammatory Responses and Neurotoxicity by PPARγ Agonists - 0 views

www.jneurosci.org/...558.full

microglia microglial cells inflammation Alzheimer's disease neurodegenerative

shared by Nathan Goodyear on 06 Jan 12 - No Cached
  • The activated microglia mount a complex local proinflammatory response
  • PPARγ plays a critical role in regulating the inflammatory responses of microglia and monocytes to β-amyloid
  • Nathan Goodyear on 06 Jan 12
     
    microglial and inflammatory response in Alzheimer's disease.  Agonists of PPAR-gamma inhibit this action.  This has important implications in reducing the local inflammatory response found in the brains of those with Alzheimers and other neuordegenerative disease.
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