Therapeutic hyperthermia: The old, the new, and the upcoming - Critical Reviews in Onco... - 1 views
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not well understood, but it is felt to be a combination of both heat-induced necrosis and of protein inactivation (e.g., repair enzymes) as opposed to DNA damage
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alterations in tumor cytoskeletal and membrane structures, which disrupt cell motility and intracellular signal transduction
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A common explanation for HT-enhancement of RT and CT involves inhibition of homologous recombination repair of double-strand DNA breaks, preventing cells from repairing sub-lethal damage
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