Group items tagged

Exercise is not just for calories out.  Exercise increases growth hormone, IGF-1, glucagon-like peptide 1, IL-6, and IL-1ra.  The effect is to GH increases beta islet cell mass and protects beta cell lines against IL-1beta, Interferon-gamma and TNF-alhpa induced apoptosis.  IL-6 increased production increases GLP-1 and IL-1ra which counters IL-1beta.  Interleukin-1beta induces islet cell apoptosis and thus IL-1ra counters this pro-inflammatory signal.

Tamoxifen and more importantly, flaxseed increases endogenous IL-1Ra that is a known inhibitor of the pro-inflammatory cytokines IL-1alpha and IL-1beta. These pro-inflammatory cytokines are associated with breast cancer.  Conclusion: diet modification can effect inflammatory cytokines associated with breast cancer.  This should be explored as true preventative therapies for women. This study also found a positive association with estradiol and IL-1Beta in breast tissue and SC fat; inversely associated with IL-Ra in the breast.

ibuprofen provided no reduction in muscle damage/soreness in 29 ultra marathoners.  However, LPS, CRP, IL-6, IL-10, IL-8, IL-1ra, GSF, MCP-1, and MIP-1beta were increased in the ibuprofen group.  TNF-alpha was unaffected.