Skip to main content

Home/ Dr. Goodyear/ Group items tagged excitotoxic

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT... - 0 views

www.sciencedirect.com/...S0028390813001238

CBD cannabinoids hemp oil brain excitotoxicity inflammation oxidative stress

shared by Nathan Goodyear on 11 Aug 17 - No Cached
  • Nathan Goodyear on 11 Aug 17
     
    Another animal study finds CBD is neuroprotective.  This study actually found that CBD reduced excitotoxicity, inflammation, and oxidative stress.
Nathan Goodyear

Progesterone exerts neuroprotective effects after brain injury 10.1016/j.brainresrev.20... - 0 views

www.sciencedirect.com/...S0165017307001129

progesterone CNS bioidentical hormone hormones natural

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    progesterone shown to have neuroprotective and  healing properties in the CNS.  This has implications in Stroke, and possibly even excitotoxic disease such as Parkinson's, Alzhemier's...
Nathan Goodyear

Study Suggests Coenzyme Q10 Slows Functional Decline in Parkinson's Disease: National I... - 0 views

www.ninds.nih.gov/...kinsons_coenzymeq10_101402.htm

CoQ10 Parkinson's disease Huntington's ecitotoxic neurotoxic

shared by Nathan Goodyear on 07 Nov 11 - Cached
  • Nathan Goodyear on 07 Nov 11
     
    high dose CoQ10 shown to slow disease progression in Parkinson's disease.  A similar study had shown the same finding in Huntington's disease.  Both are excitotoxic diseases
Nathan Goodyear

Arch Neurol -- Abstract: Mediterranean Diet and White Matter Hyperintensity Volume in t... - 0 views

archneur.ama-assn.org/...251

mediterranean diet white matter brain

shared by Nathan Goodyear on 15 Feb 12 - No Cached
  • Nathan Goodyear on 15 Feb 12
     
    Mediterranean diet is good for your brain.  Could be a preventative strategy for Excitotoxic diseases.
Nathan Goodyear

Antiinflammatory Effects of Estrogen on Microglial Activation - 0 views

endo.endojournals.org/...3646.long

Estradiol E2 neurodegenerative disease Parkinsons's Alzheimer's inflammation microglial glial cells hormones hormone estrogen

shared by Nathan Goodyear on 07 Jun 12 - No Cached
  • Nathan Goodyear on 07 Jun 12
     
    Estradiol (E2) shown to be neuroprotective in those with microglial excitotoxicity diseases, such as Parkinson's and Alzheimer's disease.  this study looked at a rat model.  The effect was not through inhibition of NF-kappaB, but through MAP kinase.
Nathan Goodyear

Brain glutamine and glutamate levels in patients with liver cirrhosis: assessed by 3.0-... - 0 views

www.sciencedirect.com/...S1386634604001330

glutamic acid glutamine glutamate brain liver

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    Brain glutamic acid originates from glutamine.  Glutamine should be avoided in those with excitotoxic diseases.
Nathan Goodyear

NeuroSignals 2005, Vol. 14, No. 1-2 - Neuroprotective Effects of Huperzine A - FullText... - 0 views

www.karger.com/...85387

Huperzine-A Huperzine brain cognition oxidative stress Alzheimer's cognitive decline NMDA

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Huperzine A is a great neuroprotector.  Huperzine A is a acetycholinesterase inhibitor. But, Huperzine A also reduces oxidative stress, reduces beta-Amyloid, protects mitochondria, antagonizes NMDA receptors and thus reduces excitotoxicity, and regulates apoptosis.
Nathan Goodyear

Hyperexcitable brain and refra... [J Neurol Neurosurg Psychiatry. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24109082

brain gluten celiac disease GRD related disorders

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    Study highlights the interaction between the gut and the brain.  In this case, this article describes neuro-excitotoxicity as a result of celiac disease.  They call this syndrome gluten related disorders or GRD.   The point is not the name, but neuro-inflammation that results from the intact of gluten.
Nathan Goodyear

Neuroprotective and disease-modifying effects of the ketogenic diet - 0 views

www.ncbi.nlm.nih.gov/...PMC2367001

ketogenic diet nutrition diet CNS brain Epilepsy alzheimer's disease Parkinson's disease

shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • Nathan Goodyear on 20 Feb 16
     
    great review of the ketogenic diet in neuroprotective and treatment of excitotoxic disease.
Nathan Goodyear

Targeting Dopamine in Acute Traumatic Brain Injury - 0 views

www.ncbi.nlm.nih.gov/...PMC3269831

TBI traumatic brain injury dopamine brain brain injury concussion PCS post concussion syndrome

shared by Nathan Goodyear on 21 Feb 16 - No Cached
  • Nathan Goodyear on 21 Feb 16
     
    great read on the current understanding of dopamine in TBI--essentially an excitotoxic story.
Nathan Goodyear

Differential neuroprotective and antiinflammatory effects of estrogen recepto... - 0 views

www.ncbi.nlm.nih.gov/...PMC1976208

Estrogen receptor estrogen receptor beta ER-beta inflammation anti-inflammatory alzheimer's Parkinson's ALS MSanti-inflammation neuroprotection excitotoxicity

shared by Nathan Goodyear on 23 Nov 12 - No Cached
  • Nathan Goodyear on 23 Nov 12
     
    ER-beta as anti-inflammatory and neuroprotective?  According to this review, yes.
Nathan Goodyear

JAMA Network | JAMA Neurology | Refractory Nonmotor Symptoms in Male Patients With Park... - 0 views

archneur.jamanetwork.com/article.aspx

testosterone Parkinson's Parkinson's disease therapy low T treatment inflammation neurodegenerative disease excitotoxicity neurology male

shared by Nathan Goodyear on 21 May 13 - No Cached
  • Nathan Goodyear on 21 May 13
     
    Testosterone therapy aids symptoms of Parkinson's disease.  Whether low T is an associated finding or plays a role has yet to be determined.  However, we do know that androgens play an anti-inflammatory role in men and we know that inflammation plays a role in the neurodegenerative disease that is Parkinson's disease.
Nathan Goodyear

The Danger of Excessive Vaccination During Brain Development - 0 views

articles.mercola.com/...-during-brain-development.aspx

Dr. Dr. Blaylock vaccinations excitotoxicity brain development

shared by Nathan Goodyear on 07 Nov 12 - Cached
  • Nathan Goodyear on 07 Nov 12
     
    Dr. Blaylock, neurosurgeon, on the detrimental effects of excessive vaccinations in our children.  This is heavily referenced.
Nathan Goodyear

Gender and sex hormones in multiple sclerosis pathology and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC2689399

hormones MS multiple Sclerosis Estriol progesterone

shared by Nathan Goodyear on 11 Jan 17 - No Cached
  • It is now well recognized that the disease manifestation is reduced in pregnant women with relapsing-remitting MS
  • This occurs particularly during the third trimester when levels of estrogens (estradiol and estriol) and progesterone (see Table 2) are elevated up to about 20 times
  • This seems well correlated with a decrease in active white matter lesions detected by MRI
  • ...12 more annotations...
  • This clinical improvement is however followed by temporary rebound exacerbations at post-partum, when the hormone levels decline
  • a shift from Th1 to Th2 immune response, expansion of suppressive regulatory T lymphocytes and decrease in the number of circulating CD16+ natural killer (NK)-cells
  • Th1 lymphocytes secrete proinflammatory cytokines (e.g. IL-2, IFNgamma, lymphotoxin) while Th2 cells secrete anti-inflammatory cytokines (e.g. IL-4, IL-5, IL-10), which favor humoral-mediated responses
  • Th2 cytokines are associated with down-regulation of Th1 cytokines and this Th2 shift is believed to provide protection from allograft rejection during pregnancy as well as from Th1-mediated autoimmune disease
  • it is worth noting that the levels of other hormones with anti-inflammatory activity (1,25-dihydroxy-vitamin D3, norepinephrine, cortisol) also increase by 2 to 4 times during late pregnancy
  • 1,25-dihydroxy vitamin D3 induces regulatory T-cell function important for development of self-tolerance
  • breast-feeding does not alter the relapse rate in women with MS
  • Leptin is a pleiotropic hormone produced primarily by adipocytes but also by T lymphocytes and neurons
  • Several lines of evidence indicate that leptin contributes to EAE/MS pathogenesis, influencing its onset and clinical severity, by acting as a proinflammatory cytokine which promotes regulatory T cell (Treg) anergy and hyporesponsiveness, resulting in increased Th1 (TNFalpha, INFgamma) and reduced Th2 (IL-4) cytokine production
  • circulating leptin levels are increased in relapsing-remitting MS patients (men and women analyzed together) while the CD4+CD25+Treg population decreases
  • As the leptin plasma concentrations are proportional to the amount of fat tissue, obese/overweight individuals produce higher levels of leptin
  • Nielsen et al found that estradiol and progesterone exert neuroprotection against glutamate neurotoxicity, while MPA antagonizes the neuroprotective effect of estradiol and exacerbated neuron death induced by glutamate excitotoxicity
  • Nathan Goodyear on 11 Jan 17
     
    very good review of the differences in MS and hormones between the sexes.
Nathan Goodyear

Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy-A unify... - 0 views

www.surgicalneurologyint.com/article.asp

CTE chronic traumatic encephalopathy immunoexcitotoxicity excitotoxicity

shared by Nathan Goodyear on 07 Apr 12 - No Cached
  • Nathan Goodyear on 07 Apr 12
     
    great analysis of immunoexcitoxicity and it's pathophysiologic role in CTE.
Nathan Goodyear

Calcium: A target in the war on Alzheimer's disease - 0 views

dl-web.dropbox.com/...heimers_Disease_WhitePaper.pdf

Alzheimer's disease excitotoxicity neurotoxicity calcium

shared by Nathan Goodyear on 17 Feb 12 - No Cached
  • Nathan Goodyear on 17 Feb 12
     
    good discussion on Alzheimer's disease and the role of calcium
Nathan Goodyear

A possible central mechanism in autism spectrum disorders, Part 2: Immunoexcitotoxicity - 0 views

www.mpwhi.com/autism_part_2.pdf

immunoexcitotoxicity excitotoxicity Blaylock ASD autism

shared by Nathan Goodyear on 20 Mar 12 - No Cached
  • Nathan Goodyear on 20 Mar 12
     
    Must read on immunoexcitotoxicity by Dr. Blaylock. Discuss on the biochemical changes found in ASD and the associated precipitants
Nathan Goodyear

THE NEUROPROTECTIVE PROPERTIES OF CALORIE RESTRICTION, THE KETOGENIC DIET, AND KETONE B... - 0 views

www.ncbi.nlm.nih.gov/...PMC2649682

calorie restriction ketogenic diet NF-KappaB BDNF neuroprotection SIRT1 mitochondria glutamate excitotoxicity inflammation antioxidants

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Fantastic read on the biochemical benefits of calorie restriction and a ketogenic diet.
Nathan Goodyear

Regenerative potential for allopregnanolone - 0 views

pharmweb.usc.edu/...WangJ_BrainResRev57_2008.pdf

progesterone allopregnanolone hormone hormones BDNF neurodegeneration excitotoxicity Alzheimer's disease

shared by Nathan Goodyear on 10 Jul 12 - No Cached
  • Nathan Goodyear on 10 Jul 12
     
    Progesterone and allopregnanolone shown to have neuroprotective and neurogenesis properties in the brain. BDNF was positively correlated with progesterone. So as women age, progesterone falls, as progesterone falls, then BDNF falls and neuroplasticity declines and thus we see neurodegenerative disorders. And hormones are not needed? Who are these scientists that don't read research?!
Nathan Goodyear

Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy-A unify... - 0 views

www.ncbi.nlm.nih.gov/...PMC3157093

immunoexcitotoxicity TBI traumatic brain injury excitotoxicity neurodegeneration glutamic acid quinolinate glial glia cells

shared by Nathan Goodyear on 09 Feb 12 - No Cached
  • Nathan Goodyear on 09 Feb 12
     
    immunoexcitotoxicity and traumatic brain injury
‹ Previous 21 - 40 of 48 Next ›
Showing 20▼ items per page