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Nathan Goodyear

Vagal Regulation, Cortisol, and Sleep Disruption in Women with Metastatic Breast Cancer - 0 views

  • an association between disrupted nocturnal sleep and flattened diurnal cortisol rhythm in women with metastatic breast cancer
  • They suggest that the stress-buffering effects of sleep may be associated with improved parasympathetic tone and normalized cortisol patterns during the day.
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    women with metastatic breast cancer shown to have more disruption in cortisol pattern and thus dysfunctional sleep.  This has implications on survival.
Nathan Goodyear

Arch Neurol -- Abstract: Prefrontal Cortex and Executive Function Impairments in Primar... - 0 views

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    Chemotherapy patients often complain of "chemo brain".  This article confirms significant reduction in prefrontal cortical activity, thus supporting brain dysfunction, "brain fog", as a result of chemotherapy.
Nathan Goodyear

CNS Spectrums: Inflammation, Glutamate, and Glia in Depression: A Literature Review - 0 views

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    inflammation, glutamate excitotoxicity and depression.  A very nice review of how inflammation can remotely contribute to other arenas of dysfunction, ie. depression.
Nathan Goodyear

Obesity is associated with macrophage accumulation in adipose tissue - 0 views

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    obesity is associated with dysfunctional immune response to adipose tissue.  The cause is inflammation from White adipose tissue resultant in increased recruitment of macrophages and resultant further inflammation.  M1 macrophages are the predominate culprit.
Nathan Goodyear

Multiple Sclerosis is not a Disease of the Immune System - 0 views

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    good read on an alternate hypothesis of the pathophysiology of MS. THe author proposes that MS is an inflammatory induced dysfunction of lipid metabolism. This is in contrast to the current held dogma that MS is an autoimmune disease.
Nathan Goodyear

Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with... - 0 views

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    Study shows that gastrointestinal epithelial dysfunction is found in autism. This would play a critical role in systemic inflammation and would contribute to ASD symptoms through the gut-brain connection.
Nathan Goodyear

Effect of Exogenous Thyroid Hormone Intake on the Interpretation of Serum TSH Test Results - 0 views

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    TSH is promoted as the test of choice to diagnosis and monitor thyroid dysfunction. However, Warmingham hypothesis, would suggest otherwise.
Nathan Goodyear

Hypothalamopituitary Dysfunction Following Traumatic Brain Injury and Aneurysmal Subara... - 0 views

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    TBI results in altered pituitary function.  This study reviewed research articles published over a 7 year time (2000-2007).
Nathan Goodyear

Thyroid function and thyroid hormone metabol... [Klin Wochenschr. 1981] - PubMed - NCBI - 0 views

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    This study doesn't find evidence of low t3-syndrome, but suggests the impairment of TSH secretion (low TSH)is the first potential sign of thyroid dysfunction.
Nathan Goodyear

Gastrointestinal abnormalities in children with autistic disorder - 0 views

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    study shows that gastrointestinal dysfunction, reflux esophagitis and disaccharide malabsorption, found in children with autism. This confirms the gut-brain link component of autism
Nathan Goodyear

Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in ... - 0 views

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    immune dysfunction found in children with autism. This again, suggests a gut-brain link in autism.
Nathan Goodyear

Colonic CD8 and γδ T-cell infiltration with epithelial damage in children wit... - 0 views

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    Gut dysfunction, lymphocytic colitis, found in children with autism.
Nathan Goodyear

Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: ... - 0 views

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    Dysfunctions of the innate immune system, in the gastrointestinal system, in children with autism found. LPS found to be involved. Again, revealing a gut-brain connection in autism.
Nathan Goodyear

Autistic enterocolitis: Fact or fiction? - 0 views

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    report of 2 cases studies that find link between autism and gastrointestinal inflammation. Again, suggestion some immune system dysfunction in the gastrointestinal system in some children with autism
Nathan Goodyear

Brazilian Journal of Medical and Biological Research - Is the infertility in hypothyroi... - 0 views

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    functional hypothyroidism associated with elevated prolactin levels and thus gonadotropin dysfunction and infertility
Nathan Goodyear

Nutrition Journal | Full text | Homocysteine and reactive oxygen species in metabolic s... - 0 views

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    homocysteine contributes to atherogenesis and CVD via: increased ROS, induces endothelial dysfunction, increases platelete adhesion and thrombosis, increases smooth muscle cell proliferation, endothelial cell cytotoxicity, increases LDL oxidation, vasoconstriction, increased MCP-1 and IL-8, and induces endothelial HMG CoA reductase.
Nathan Goodyear

Testosterone and the aging male: to treat or not to treat? - 0 views

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    nice review of low Testosterone, the metabolic dysfunction as a result of low T, Testosterone therapy, and things to consider when supporting Testosterone.
Nathan Goodyear

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fa... - 0 views

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    2008 article from diabetes.  This article supports metabolic endotoxemia arising out of the gut.  High fat diet intake results in disrupted gut flora, resulting in increrased LPS release, resulting in inflammation, leads to leaky gut, systemic endotoxemia, inflammation, and thus metabolic dysfunction: see obesity, DM..
Nathan Goodyear

JAMA Network | Archives of Neurology | Insulin Resistance in Cognitive ImpairmentThe In... - 0 views

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    insulin resistance shown to play a role in cognitive impairment.  Rising Insulin resistance is not just associated with obesity, but also brain dysfunction similar to that in strokes.  This indicates a vascular component in the cognitive function.  The same rise in obesity will likely result in a rise in neurodegenerative disorders.
Nathan Goodyear

Effects of selective serotonin reuptake inhibitors o... [Thyroid. 2009] - PubMed - NCBI - 0 views

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    Interesting study.  They found a "significant reduction of T(3) after 15 and 30 days" with SSRI use, yet their conclusion is SSRI is safe in hypothyroid.   The take is that part of the weight gain associated with SSRI use is through dysfunction of thyroid hormone production as the effects were also found with T4.
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