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Nathan Goodyear

Testosterone: a metabolic hormone in health and disease - 0 views

joe.endocrinology-journals.org/...JOE-12-0455.full.pdf

low T low testosterone testosterone metabolic syndrome MetS hormone hormones men male health disease

shared by Nathan Goodyear on 26 Feb 13 - No Cached
  • Nathan Goodyear on 26 Feb 13
     
    Great, great read and review on the current understanding of testosterone and metabolic dysfunction. Very well referenced.
Nathan Goodyear

Erectile dysfunction and depression in patients with chronic lead poisoning - Gonulalan... - 0 views

onlinelibrary.wiley.com/...abstract

erectile dysfunction ED lead Pb

shared by Nathan Goodyear on 10 Jun 13 - No Cached
  • Nathan Goodyear on 10 Jun 13
     
    chronic lead toxicity linked with increased ED in men.
Nathan Goodyear

A Case of Galactorrhea Associated with Excitalopram - 0 views

www.ncbi.nlm.nih.gov/...PMC2796073

Lexapro excitalopram SSRI Prolactin low libido galactorrhea

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Nathan Goodyear on 17 Jun 13
     
    Lexapro can increase Prolactin levels which can cause libido dysfunction and galactorrhea as in this case.
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Nathan Goodyear

Chylomicron formation and glucagon-like peptide 1 receptor are involved in activation o... - 0 views

www.jnutbio.com/...abstract

chylomicron inflammation atherosclerosis CAD arteriosclerosis plaque vascular disease

shared by Nathan Goodyear on 01 May 13 - No Cached
  • Nathan Goodyear on 01 May 13
     
    Inflammatory foods coupled with elevated glucose levels and hypertriglyceridemia induces endotoxemia, oxidative damage and immune,inflammatory dysfunction; thus activated chylomicrons
Nathan Goodyear

PLOS Medicine: Erectile Dysfunction Severity as a Risk Marker for Cardiovascular Diseas... - 0 views

www.plosmedicine.org/...journal.pmed.1001372

erectile dysfunction ED CVD cardiovascular disease

shared by Nathan Goodyear on 02 Feb 13 - No Cached
  • Nathan Goodyear on 02 Feb 13
     
    As ED is a cardiovascular problem, it is no surprise that those with ED have an increase in CVD.
Nathan Goodyear

Residual adverse changes in arterial endothelial fun... [Ann Med. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/pubmed

flu vaccine LDL oxidation CRP fibrinogen inflammation

shared by Nathan Goodyear on 07 Nov 12 - No Cached
  • Nathan Goodyear on 07 Nov 12
     
    could the flu vaccine cause a short-term increase in cardiovascular event risk?  According to this study yes.  So, with a recent study showing no benefit in children and adults, then with this finding of increased arterial dysfunction, increased CRP and fibrinogen, and increased LDL oxidation...why would an adult get the flu vaccine??? The focus should be on what the science shows, not an individuals bias!
Nathan Goodyear

Physical activity and exercise for erectile dysfunction: systematic review and meta-ana... - 0 views

bjsm.bmj.com/...bjsports-2016-096418

exercise ED erectile dysfunction men men's health care

shared by Nathan Goodyear on 26 Oct 16 - No Cached
  • Nathan Goodyear on 26 Oct 16
     
    review study points out that exercise, predominantly cardio, improved ED in men.
Nathan Goodyear

New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-relate... - 0 views

www.ncbi.nlm.nih.gov/...21442412

curcumin polyphenols obesity diabetes lipids inflammation leptin resistance adiponectin

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    Review article of Curcumin, a polyphenol, reduces insulin resistance, leptin resistance,  elevated glucose levels, elevated lipids, and inflammation in obesity and metabolic dysfunction.  Adiponectin levels were increased.
Nathan Goodyear

Testosterone Treatment and Sexual Function in Older Men with Low Testosterone Levels: T... - 0 views

press.endocrine.org/...jc.2016-1645

low T low Testosterone Testosterone male hormones libido ED estradiol hormones

shared by Nathan Goodyear on 13 Jul 16 - No Cached
  • Nathan Goodyear on 13 Jul 16
     
    new study finds that men >65 with low libido and Testosterone levels < 275 increase sexual function with Testosterone therapy.  Only libido was improved; no benefit to erectile function was noted--note that is likely due to depleted NO.  Given time that should improve with he increase in NO synthase and thus NO.  I have a fault with on elf the comments on this study: they point out that increased free Testosterone and estradiol levels were associated with improved sexual activity.  This lacks an understanding of the physiology.  In men with low T > 65, the majority are dealing with inflammation and excess weight; all of which increase aromatase activity and thus estradiol activity.  This does not indicate that an increase in estradiol activity is associated with improved libido in men.  How can elevated estrogen levels lead to low T and then increase levels are associated with improved libido?  This is merely a reflection of the body's dysfunctional physiology.  This observation of increased estradiol by no means shows cause and effect.  Scientists need to due a better job in vetting what they write!
Nathan Goodyear

Obesity and Gender influence cortisol secretion and metabolism in man - 0 views

jcem.endojournals.org/...1806.full.pdf

obesity obese overweight cortisol cortisone HPA

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • Nathan Goodyear on 24 Apr 12
     
    This study reveals the degree of metabolism dysfunction in obesity. This study suggests that cortisol metabolism is increased in obesity, which results in increased HPA activity resulting in increased peripheral cortisol production. The question to be asked: is serum, salivary, and urinary cortisol results revealing the same function of cortisol. The answer is no.
Nathan Goodyear

Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. - 0 views

www.ncbi.nlm.nih.gov/...PMC303514

cortisol mineralcorticoid low potassium hypokalemia hypertension 11-betaHSD

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • These results suggest that cortisol acts as a potent mineralocorticoid in 11 beta-OHSD deficiency
  • major site for the oxidation of cortisol to cortisone is the kidney
  • congenital deficiency of 11 beta-OHSD results in high intrarenal cortisol levels which then act on renal type I mineralocorticoid receptors
  • ...1 more annotation...
  • deficiency of 11 beta-OHSD results in high intrarenal cortisol concentrations that then bind to the type I receptor.
  • Nathan Goodyear on 24 Apr 12
     
    mechanism of how cortisol acts as a mineralcorticoid in those with dysfunctional 11-beta HSD activity.
Nathan Goodyear

Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic w... - 0 views

www.ncbi.nlm.nih.gov/...PMC1257426

stress HPA adrenal adrenals cortisol saliva salivary pain

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    Those with chronic pain shown to have HPA dysfunction.  Elevated cortisol was found via saliva evaluation.  This with pain had the higher cortisol levels.
Nathan Goodyear

Salivary Cortisol Measurement: A Practical Approach to Assess Pituitary-Adrenal Function - 0 views

jcem.endojournals.org/...343.abstract

cortisol saliva salivary testing hormone hormones evaluation Cushing's syndrome adrenal insufficiency

shared by Nathan Goodyear on 30 Apr 12 - No Cached
  • We conclude that salivary cortisol measurements are an excellent index of plasma free cortisol concentrations
  • Nathan Goodyear on 30 Apr 12
     
    this study showed salivary cortisol to be an "excellent" means to evaluate both those with adrenal disease and adrenal dysfunction.  Salivary test is a good tool to evaluate the free active cortisol.
Nathan Goodyear

Diurnal variation of adrenocortical activ... [Neuropsychobiology. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9813459

CFS chronic fatigue syndrome adrenal adrenals adrenocortical activity fatigue

shared by Nathan Goodyear on 02 May 12 - No Cached
  • Nathan Goodyear on 02 May 12
     
    adrenocortical dysfunction found to play a role in CFS
Nathan Goodyear

a possible central mechanism in autism spectrum disorder, part 1 - 0 views

www.mpwhi.com/autism_part_1.pdf

autism ASD Blaylock excitoxicity immunoexcitotoxicity

shared by Nathan Goodyear on 20 Mar 12 - No Cached
  • Nathan Goodyear on 20 Mar 12
     
    Autism and biochemistry dysfunction. Must read from Dr. Blaylock.
Nathan Goodyear

Gout, diet, and the insulin resistance syndrome. - 1 views

www.jrheum.org/...1350.full.pdf+html

gout insulin resistance IR inflammation uric acid metabolic metabolism

shared by Nathan Goodyear on 19 Mar 12 - No Cached
  • Nathan Goodyear on 19 Mar 12
     
    Gout is a result of Insulin resistance?  It makes perfect biologic sense.  IR causes inflammation and what is Gout?  Nothing but an inflammatory condition.  So is Gout merely a join representation of metabolic dysfunction?  I say yes.
Nathan Goodyear

effects of beta-hydroxybutyrate on cognition in memory-impaired adults - 0 views

w.numedica.net/...Reger%202004.pdf

ketogenic diet ketone bodies ketosis Alzheimer's disease neurodegenerative disease MCT medium chain fatty acids

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Those with Alzheimer's disease have associated dysfunction of glucose metabolism in the brain, particularly in the hippocampus. It has been reported that a ketogenic diet can improve cognitive function in these individuals. In this study, the ketone bodies were initiated through a diet high in medium chain fatty acids. The ketone bodies served as an alternative fuel source for the brain.
Nathan Goodyear

Bentham Science Publishers - 0 views

www.benthamdirect.org/...content.php

brain sex ED erectile dysfunction endothelial dysfunction hormone hormones inflammation

shared by Nathan Goodyear on 11 Jul 12 - No Cached
  • Gonadal, adrenal and neurosteroids
  • Nathan Goodyear on 11 Jul 12
     
    hormones are the link between the brain and sex for men?  Yes, but a little more complex than that: interaction between the immune system (inflammation) and the endocrine system (hormones).
Nathan Goodyear

Diagnosis of secondary adrenal insufficiency in patients with hypothalamic-pituitary di... - 0 views

www.eje-online.org/...9.full

saliva salivary cortisol hormone hormones HPA

shared by Nathan Goodyear on 22 Aug 12 - No Cached
  • Nathan Goodyear on 22 Aug 12
     
    European journal of endocrinology article compared serum to salivary cortisol and found them to be equal, but due to ease of collection, salivary cortisol to be preferable.  This article was using cortisol to assess HPA axis dysfunction.
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