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Nathan Goodyear

Gender and sex hormones in multiple sclerosis pathology and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC2689399

hormones MS multiple Sclerosis Estriol progesterone

shared by Nathan Goodyear on 11 Jan 17 - No Cached
  • It is now well recognized that the disease manifestation is reduced in pregnant women with relapsing-remitting MS
  • This occurs particularly during the third trimester when levels of estrogens (estradiol and estriol) and progesterone (see Table 2) are elevated up to about 20 times
  • This seems well correlated with a decrease in active white matter lesions detected by MRI
  • ...12 more annotations...
  • This clinical improvement is however followed by temporary rebound exacerbations at post-partum, when the hormone levels decline
  • a shift from Th1 to Th2 immune response, expansion of suppressive regulatory T lymphocytes and decrease in the number of circulating CD16+ natural killer (NK)-cells
  • Th1 lymphocytes secrete proinflammatory cytokines (e.g. IL-2, IFNgamma, lymphotoxin) while Th2 cells secrete anti-inflammatory cytokines (e.g. IL-4, IL-5, IL-10), which favor humoral-mediated responses
  • Th2 cytokines are associated with down-regulation of Th1 cytokines and this Th2 shift is believed to provide protection from allograft rejection during pregnancy as well as from Th1-mediated autoimmune disease
  • it is worth noting that the levels of other hormones with anti-inflammatory activity (1,25-dihydroxy-vitamin D3, norepinephrine, cortisol) also increase by 2 to 4 times during late pregnancy
  • 1,25-dihydroxy vitamin D3 induces regulatory T-cell function important for development of self-tolerance
  • breast-feeding does not alter the relapse rate in women with MS
  • Leptin is a pleiotropic hormone produced primarily by adipocytes but also by T lymphocytes and neurons
  • Several lines of evidence indicate that leptin contributes to EAE/MS pathogenesis, influencing its onset and clinical severity, by acting as a proinflammatory cytokine which promotes regulatory T cell (Treg) anergy and hyporesponsiveness, resulting in increased Th1 (TNFalpha, INFgamma) and reduced Th2 (IL-4) cytokine production
  • circulating leptin levels are increased in relapsing-remitting MS patients (men and women analyzed together) while the CD4+CD25+Treg population decreases
  • As the leptin plasma concentrations are proportional to the amount of fat tissue, obese/overweight individuals produce higher levels of leptin
  • Nielsen et al found that estradiol and progesterone exert neuroprotection against glutamate neurotoxicity, while MPA antagonizes the neuroprotective effect of estradiol and exacerbated neuron death induced by glutamate excitotoxicity
  • Nathan Goodyear on 11 Jan 17
     
    very good review of the differences in MS and hormones between the sexes.
Nathan Goodyear

Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3605452

probiotics lactobacillus obesity inflammation gut gut flora gut microbiota

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    probiotics found to reduce body fat in diet-induced obesity study in rats.  Both L. curvets and planetarum found to be the most effective in decreasing dietary fat induction.  Also of not, genetic transcription of inflammatory cytokines was found to be reduced.  The different strains may be of importance here as well.
Nathan Goodyear

Maternal plasma and amniotic fluid coenzyme Q10 levels in preterm and term gestations: ... - 0 views

www.ncbi.nlm.nih.gov/...21547699

CoQ10 pregnancy

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    Pilot study and only abstract available here: Low CoQ10 levels found in amniotic sample in preterm delivered pregnancies; not difference was found in serum levels.
Windows Customer Support Number

Windows tech Support Number 1 800 261 4071 - 0 views

www.postaddz.com/...ort_number_1_800_261_4071.html

Windows technical customer services tech support

shared by Windows Customer Support Number on 18 Jul 16 - No Cached
  • Windows Customer Support Number on 18 Jul 16
     
    An online remote access tech support process is performed remotely to fix different levels of errors.Tech support service is open for windows 7, XP, 8 and 10 for solving various issues remotely. Call us any time on our Windows customers support number 1-800-261-4071 for an instant help,
natgeo127

Have Your Desserts While Losing Weight! - 0 views

changeyourlife.netne.net/?p=86

losing weight Healthy Desserts

shared by natgeo127 on 15 Mar 16 - No Cached
  • natgeo127 on 15 Mar 16
     
    You can definitely lose weight while enjoying desserts! My recipes use all natural sugars, and yes, honey is one of them. Your body processes natural sugars much differently than processed sugars (white sugar, brown sugar, etc.), and in moderate amounts (such as those in my recipes) it is not going to affect your weight loss efforts. Also, you'll notice that my recipes contain fiber and proteins and fats...
Nathan Goodyear

Metabolic characteristics of keto-adapted ultra-endurance runners - Metabolism - Clinic... - 0 views

www.metabolismjournal.com/...abstract

endurance athletes endurance sports exercise carbohydrates ketogenic diet

shared by Nathan Goodyear on 20 Apr 16 - No Cached
  • Nathan Goodyear on 20 Apr 16
     
    For endurance athletes, low carb and high fat diet utilizes the high fat oxidation in these athletes compared to a high carb diet.  Glycogen stores did not differ between the two groups.  
Nathan Goodyear

Posttraumatic Stress Disorder: Does the Gut Microbiome Hold the Key? - 0 views

cpa.sagepub.com/...204.abstract

stress PTSD post traumatic stress disorder gut health gut flora gut gut microbiome gut microbiota

shared by Nathan Goodyear on 04 May 16 - No Cached
  • Nathan Goodyear on 04 May 16
     
    Gut microbiome diversity is different in stressed mice and calm mice in animal study.  Authors propose intricate connection between gut:brain and possible evaluation and therapy in PTSD.
Nathan Goodyear

Activation of the hypothalamic-pituitary... [Growth Horm IGF Res. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11527096

cortisol cortisone obesity obese adipose tissue 11-betaHSD1 5-alpha reductase

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • Nathan Goodyear on 24 Apr 12
     
    obesity is associated with increased cortisol metabolism.  This would be found in increased urinary metabolites, especially via the 5-allpha reductase pathway.  Increased cortisone to cortisol production occurs via 11 beta-HSD1.  This occurs predominately in adipose tissue.  The thought here is cortisol metabolism is tissue specific and functionally different.
Nathan Goodyear

Oral testosterone supplementation and chronic low-grade inflammation in elderly men: A ... - 0 views

www.ahjonline.com/...abstract

oral testosterone CRP inflammation elderly men

shared by Nathan Goodyear on 26 Apr 12 - No Cached
  • Nathan Goodyear on 26 Apr 12
     
    this study showed that oral testosterone did not increase CRP.  This is a different finding than other studies.  I question the use of the oral testosterone due to first pass metabolism.  This would result in less testosterone reaching the peripheral sites of aromatase activity.  
Nathan Goodyear

The Dual, Opposing Roles of Estrogen in the Prostate - Ellem - 2009 - Annals of the New... - 0 views

onlinelibrary.wiley.com/...30E32040B060F42071BE703.d02t04

estrogen prostate ER-alpha ER-beta androgens men

shared by Nathan Goodyear on 02 May 12 - No Cached
  • Nathan Goodyear on 02 May 12
     
    As it relates to the prostate, there is more than just androgens and estrogen levels.  There is balance.  Then there is estrogen receptors.  This article discusses the different action the ER-alph and ER-beta have on the prostate.
Nathan Goodyear

Testosterone Concentrations in Women and Men With NIDDM - 1 views

care.diabetesjournals.org/...405.short

testosterone T men women insulin resistance IR type II DM diabetes

shared by Nathan Goodyear on 11 Feb 12 - No Cached
  • Nathan Goodyear on 11 Feb 12
     
    insulin resistance has different effects in men versus women.  In men, insulin resistance is associated with low T in men, but in elevate T in women.
Nathan Goodyear

Urinary Cortisol and Cortisol Metabolite Excretion in Chronic Fatigue Syndrome - 0 views

www.psychosomaticmedicine.org/...578.full.pdf

CFS chronic fatigue syndrome salivary saliva cortisol metabolism metabolization

shared by Nathan Goodyear on 13 Mar 12 - No Cached
  • Nathan Goodyear on 13 Mar 12
     
    It has been suggested in the literature that low salivary cortisol is a common finding in those with chronic fatigue. This study found no difference in the cortisol metabolite excretion. This would suggest that an increase metabolization of cortisol exists in those with CFS.
Nathan Goodyear

Obesity and cortisol - 0 views

www.nutritionjrnl.com/...abstract

obesity cortisol

shared by Nathan Goodyear on 13 Mar 12 - No Cached
  • Nathan Goodyear on 13 Mar 12
     
    central and peripheral cortisol are 2 different things as it relates to obesity.  
Nathan Goodyear

Fish Oil Triglycerides vs. Ethyl Esters: A comparative review of absorption, stability ... - 0 views

www.ascentahealth.com/...thyl-esters-as-nature-intended

omega-3 n-3 triacylglycerols ethyl esters fish oil health fish oil

shared by Nathan Goodyear on 14 Jul 12 - No Cached
  • Nathan Goodyear on 14 Jul 12
     
    Nice review of the difference, and the science, behind triacylglycerols and ethyl esters.
Nathan Goodyear

SpringerLink - Journal of Behavioral Medicine, Volume 30, Number 1 - 0 views

www.springerlink.com/...a1j7606452726mhg

saliva cortisol salivary melatonin catecholamines breast cancer hormone hormones test testing evaluation

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    no difference in salivary cortisol, melatonin, catecholamines seen in women with breast cancer versus healthy people in control group
Nathan Goodyear

Arch Gen Psychiatry -- Abstract: Trajectories of Depression Severity in Clinical Trials... - 0 views

archpsyc.ama-assn.org/...1227

depression psychiatry SSRI therapy treatment cymbalta duloxetine non-resonders

shared by Nathan Goodyear on 10 Dec 11 - No Cached
  • Nathan Goodyear on 10 Dec 11
     
    amazingly, up to 20% of patents with depression do worse on anti-depressant therapy (SSRI).  These are labeled non-responders, but when compared to placebo, the difference was significant.  Maybe, we should check their neurotransmitters first? 
Nathan Goodyear

Associations of Salivary Cortisol Levels with Metabolic Syndrome and Its Components: Th... - 0 views

www.medaus.com/index.php

metabolic syndrome salivary saliva cortisol testing hormone hormones

shared by Nathan Goodyear on 08 Dec 11 - No Cached
  • Nathan Goodyear on 08 Dec 11
     
    Salivary cortisol testing used to evaluate cortisol pattern in those with metabolic syndrome.  In this study, they found no difference in cortisol pattern in people with metabolic syndrome.
Nathan Goodyear

Adipose Tissue as an Endocrine Organ - 0 views

jcem.endojournals.org/...2548.abstract

fat overweight obesity weight-loss adipose tissue endocrine hormones

shared by Nathan Goodyear on 20 Dec 11 - No Cached
  • Nathan Goodyear on 20 Dec 11
     
    You need to think of your fat differently.
Nathan Goodyear

PPARs, Obesity, and Inflammation - 0 views

www.ncbi.nlm.nih.gov/...PMC1783744

obesity inflammation PPARs perioxisome proliferator-activated receptor

shared by Nathan Goodyear on 16 Jan 12 - No Cached
  • increase of 61% within 10 years
  • Many of the inflammatory markers found in plasma of obese individuals appear to originate from adipose tissue
  • obesity is a state of chronic low-grade inflammation that is initiated by morphological changes in the adipose tissue.
  • ...19 more annotations...
  • secretion of MCP-1, resistin, and other proinflammatory cytokines is increased by obesity, the adipose secretion of the anti-inflammatory protein adiponectin is decreased
  • the peroxisome proliferators- activated receptor (PPAR) family are involved in the regulation of inflammation and energy homestasis
  • natural agonists, including unsaturated fatty acids and eicosanoids
  • PPARα also regulates inflammatory processes, mainly by inhibiting inflammatory gene expression
  • upregulation of COX-2 is seen in alcoholic steatohepatitis and nonalcoholic steatohepatitis and has been directly linked to the progression of steatosis to steatohepatitis, the inhibitory effect of PPARα on COX-2 may reduce steatohepatitis
  • PPARα agonists have a clear anorexic effect resulting in decreased food intake, evidence is accumulating that PPARα may also directly influence adipose tissue function, including its inflammatory status.
  • PPARα may govern adipose tissue inflammation in three different ways: (1) by decreasing adipocyte hypertrophy, which is known to be connected with a higher inflammatory status of the tissue [3, 11, 59], (2) by direct regulation of inflammatory gene expression via locally expressed PPARα, or (3) by systemic events likely originating from liver
  • PPARγ is considered the master regulator of adipogenesis
  • Unsaturated fatty acids and several eicosanoids serve as endogenous agonists of PPARγ
  • PPARγ2, which is adipose-tissue specific
  • two different molecular mechanisms have been proposed by which anti-inflammatory actions of PPARγ are effectuated: (1) via interference with proinflammatory transcription factors including STAT, NF-κB, and AP-1
  • and (2) by preventing removal of corepressor complexes from gene promoter regions resulting in suppression of inflammatory gene transcription
  • diet-induced obesity is associated with increased inflammatory gene expression in adipose tissue via adipocyte hypertrophy and macrophage infiltration
  • PPARγ is able to reverse macrophage infiltration, and subsequently reduces inflammatory gene expression
  • Inflammatory adipokines mainly originate from macrophages which are part of the stromal vascular fraction of adipose tissue [18, 19], and accordingly, the downregulation of inflammatory adipokines in WAT by PPARγ probably occurs via effects on macrophages
  • By interfering with NF-κB signaling pathways, PPARγ is known to decrease inflammation in activated macrophages
  • Recent data suggest that activation of PPARγ in fatty liver may protect against inflammation
  • PPARs may influence the inflammatory response either by direct transcriptional downregulation of proinflammatory genes
  • anti-inflammatory properties of PPARs in human obesity
  • Nathan Goodyear on 16 Jan 12
     
    PPARs play pivotal in obesity.  PPARs appear to reduce the inflammatory cascade associated with obesity.  Downregulation of PPARs are associated with increased inflammation.  Natural PPARs include unsaturated fats and eicosanoids.
Nathan Goodyear

Pathway Central: PPAR Pathway - 0 views

www.sabiosciences.com/pathway.php

PPAR lipid metabolism

shared by Nathan Goodyear on 05 Jan 12 - No Cached
  • Nathan Goodyear on 05 Jan 12
     
    good description of the different types of PPAR's.  PPAR's are nuclear transcription factors that regulate lipid metabolism and mitochondrial function.
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