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Nathan Goodyear

PLOS ONE: Healthy Lifestyles Reduce the Incidence of Chronic Diseases and Dementia: Evi... - 0 views

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    Despite evidence that non-smoking, normal BMI, regular exercise, high fruit/vegetable intake and low/moderate alcohol intake, less than 1% of men change lifestyle.  Translation:  many don't want health even when presented with evidence of its benefits and the means to achieve it.   This study found a decrease in cognitive decline in individuals undergoing these lifestyle changes.
Nathan Goodyear

Alcohol intake and risk of dementia. [J Am Geriatr Soc. 2004] - PubMed - NCBI - 0 views

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    Moderate wine intake daily associated with a lower risk of Alzheimer's disease in the elderly.  But, only in those without the APOE epsilon-4 allele.
Nathan Goodyear

Mediterranean diet, cognitive function, and dementia: a systematic review. - PubMed - NCBI - 0 views

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    review finds Mediterranean diet may slow cognitive decline and decrease risk of Alzheimer's disease.
Nathan Goodyear

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence - 0 views

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    review finds Mediterranean diet associated with improved cognitive function and possible delay in cognitive decline.
Nathan Goodyear

Age-Related White Matter Changes - 0 views

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    Good review of White matter changes associated with aging and associated risks and treatments.
Nathan Goodyear

Sex hormones and cognitive decline ... [Psychoneuroendocrinology. 2009] - PubMed - NCBI - 0 views

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    increased estradiol and estrone levels in men associated with cognitive decline.  This was distinct from age, CVD, and APOE genotype.  This points to a clear association between increased aromatase activity and inflammation that contributes to cognitive decline in men.
Nathan Goodyear

Neuroprotective lifestyles and the aging brain - 0 views

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    exercise limits brain atrophy in the elderly.  Exercise provides neuroprotection.
Nathan Goodyear

Frontiers | Adherence to a Mediterranean-Style Diet and Effects on Cognition in Adults:... - 0 views

  • adherence to a MedDiet pattern is associated with less cognitive decline, dementia, or AD
  • higher adherence to a MedDiet was related to either slowing the rate of cognitive decline, minimizing the conversion to AD or improving the cognitive function
  • The more specific cognitive domains that improved with MedDietS were memory, delayed recognition, executive function, long-term working memory, and visual constructs
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    Mediterranean diet found to improve cognition and slow progression and/or risk of Alzheimer's disease.
Nathan Goodyear

Omega-3 polyunsaturated fatty acid suppl... [J Nutr Health Aging. 2011] - PubMed - NCBI - 0 views

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    omega-3 supplementation shown to slow cognitive decline in study of elderly Chinese women and men
Nathan Goodyear

Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 trans... - 0 views

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    IV vitamin C improves cognitive function in mice model.  
Nathan Goodyear

JAMA Network | Archives of Neurology | Insulin Resistance in Cognitive ImpairmentThe In... - 0 views

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    insulin resistance shown to play a role in cognitive impairment.  Rising Insulin resistance is not just associated with obesity, but also brain dysfunction similar to that in strokes.  This indicates a vascular component in the cognitive function.  The same rise in obesity will likely result in a rise in neurodegenerative disorders.
Nathan Goodyear

Lifelong Estrogen Exposure and Memory in Older Postmenopausal Women - Journal of Alzhei... - 0 views

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    Study finds suggestion of cognitive protection by enduring estrogen exposure.  Interesting, that estrogen seems to protect against cognitive decline in women, yet increases cognitive decline in men.
Nathan Goodyear

Lower-But-Normal Serum TSH level Is Associated With the Development or Progression of C... - 0 views

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    This study points to an association between a low-normal TSH and cognitive decline in the elderly.  An association is not causative, but functional hypothyroidism does result in cognitive impairment, so the association would logically fit.  The results of this study do as well.
Nathan Goodyear

Decreased Accumulation of Subcellular Amyloid-β with Improved Mitochondrial F... - 0 views

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    Huperzine A, a natural acetylcholinesterase inhibitor, provides neuroprotection through increase mitochondrial function and decrease in accumulated amyloid Beta protein.
Nathan Goodyear

http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.po... - 0 views

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    Another meta-analysis, this time of 20 studies, finds benefit of huperzine A in the treatment of Alzheimer's disease.
Nathan Goodyear

Antipsychotic drug use and mortality in older adul... [Ann Intern Med. 2007] - PubMed r... - 0 views

  • Atypical antipsychotic use is associated with an increased risk for death compared with nonuse among older adults with dementia
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    up to 1.55 x increase risk of death with antipsychotic use
Nathan Goodyear

Coenzyme Q10 in neuromuscular and neurodegenerativ... [Curr Drug Targets. 2010] - PubMe... - 0 views

  • a deficit in CoQ10 status has been determined in a number of neuromuscular and neurodegenerative disorders
  • A secondary loss of CoQ10 status following HMG-Coa reductase inhibitor (statins) treatment has be implicated in the pathophysiology of the myotoxicity associated with this pharmacotherapy
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    CoQ10 contributes to neurodegenerative disease, Parkinson's, Alzheimer's, ALS..., in some
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