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An increased plasma homocysteine level is a strong, independent risk factor for the development of dementia and Alzheimer's disease.

dementia and depression associated with vascular disease

COX-2 expression associated with increasing dementia in AD.

lower HDL and total cholesterol associated with higher incidence of depression and dementia.

alpha-GPC provides improvement in mild to moderate dementia found in Alzheimer's disease.

Alpha lipoic acid at relatively low oral dosing found to slow progression of moderate dementia as compared to cholinesterase inhibitors.

pre-diabetes increases risk of neurodegenerative diseases ie. dementia, Alzheimers...

alpha-GPC and to a lesser degree acetyl-l-carnitine improved dementia in multi-center trial.

Alzheimer's is a mental illness that mostly affects the elderly. It is characterized by dementia, cognitive impairment, and mood swings. The patient gradually fades into a state of perpetual darkness and lack of self-awareness. Here are some steps we can take to reduce our own risk.

Scientists are trying to find ways to prevent Alzheimer's before it comes knocking at your doorstep. Extensive research is taking place even as you read this. Everyone hopes to put together the answer before it becomes a global issue. Here are a few risk factors that you can and can't avoid:

white matter dimentia

good review of treatment for Alzheimer's, both prescription and natural.

study finds that HRT given as women transition through menopause has benefiical effect in people with Alzheimer's.  However, when given years later, after menopause, no benefit is found.  In fact, rates increased.  Several flaws with this study.  First, they used synthetic hormones, particularily progestins.  Second, there seems to be no thought that the interpretation of the signal  has changed.  For example, we know that when men have low T, their estrogen receptor status changes from ER beta to ER alpha, which is more proinflammatory.  Third, use bioidentical hormones and compare these to synthetic hormones.

Tynor Restrainer Applications To manage combative or disoriented patient. Manage post anesthesia delirium. Patients with head injuries or recovering from seizures. Schizophrenia, mental illness, dementia, or side effects from their treatment. To limit the body movement. Maintain a particular position. Tynor Restrainer Features Cushiony & comfortable. Easy to tie and open. Strong and durable. Fits left, right, wrist & ankle. Tynor Restrainer Measurements Size Chart - Size Inches CM Universal 5-9.5 12.5-23.8

SAMe helps to correct disordered homocysteine metabolism due to B- vitamin deficiency found in Alzheimer's disease.  SAMe show to reduce amyloid production, improve memory, decrease Tau, and reduced plaque formation.  Now, this was in a mice model, but SAMe as a methyl donor can benefit clients with dementia with minimal side effects.

Small case study of 3 finds significant improvement in Alzheimer's with Turmeric.

Estrogen with progestin worsens cognitive decline in women >65.  Little can be taken from this study other than, medroxyprogesterone acetate is a bad drug and should not be given to women for any purpose, especially in those >65.  One wonders if bioidentical, physiologic hormone replacement would have the same effect?  I doubt it.  The likely negative impact of hormones on the brain in women >65 is due to the negative effects of MPA, the change in inflammatory cytokines, and the change in receptors.

Early estrogen therapy in perimenopause and early menopause, with Estradiol, provides more health benefits than later therapy.  This article looked at Estrogen's effects on a woman's brain.  This likely has its origins in the change in estrogen receptors. The signal is not changing, but the reception of that signal is.  How else can one explain a different response to the same hormone dosage?

Estradiol appears to have an age dependent effect on the transcription of mRNA and brain neuroplasticity.  This has a future impact on the risk of cognitive decline and dementia in elderly women.  This is only the abstract, but points to one effect of early Estradiol effect on improved brain health versus late therapy.  

Even in the non-diabetic, an elevated glucose level is association with an increase risk of Alzheimer's.

Folic acid inversely associated with brain atrophy.  Also, homocysteine is associated directly with brain atrophy in the cortical, subcortical, and hippocampus regions.