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Nathan Goodyear

Delayed-Onset Hemolytic Anemia in Patients with Travel-Associated Severe Malaria Treate... - 0 views

  • delayed hemolytic events occur in ≈20% of patients with severe imported malaria, and 60% of these patients require blood transfusion
  • Delayed-onset anemia (herein referred to as postartesunate delayed-onset hemolysis [PADH] pattern of anemia) has been observed to occur 2–3 weeks after initiation of IV artesunate
  • The mechanism of this anemia is hemolytic, as demonstrated by high serum lactate dehydrogenase (LDH) and low plasma haptoglobin levels
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  • this side effect is associated with artesunate
  • PADH occurred in 27% of patients in this study, but it was rarely associated with severe anemia and was never fatal
  • median delayed drop in hemoglobin levels was 1.3 g/dL
  • This transfusion rate (<5%) is markedly lower than that previously reported for patients with severe imported malaria and delayed-onset anemia (≈60%)
  • Side effects of artesunate frequently include gastrointestinal disturbances, neutropenia (1.3%), reticulocytopenia (0.6%), and elevated liver enzymes (1.1%)
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    artesunate
Nathan Goodyear

PsychiatryOnline | American Journal of Psychiatry | Delayed-Onset Posttraumatic Stress ... - 0 views

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    delayed PTSD
Nathan Goodyear

Cortisol Exerts Bi-Phasic Regulation of Inflammation in Humans - 0 views

  • GCs induce increased cellular expression of receptors for several pro-inflammatory cytokines including interleukin (IL)-1 (Spriggs et al. 1990), IL-2 (Wiegers et al. 1995), IL-4 (Paterson et al. 1994), IL-6 (Snyers et al. 1990), and IFN-g (Strickland et al. 1986), as well as GM-CSF
  • GCs have also been shown to stimulate effector cell functions including phagocytosis by monocytes (van der Goes et al. 2000), effector cell proliferative responses (Spriggs et al. 1990), macrophage activation (Sorrells and Sapolsky 2010), and a delay of neutrophil apoptosis
  • a concentration- and time-dependent range of GC effects that are both pro- and anti-inflammatory
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  • basal (diurnal) concentrations of cortisol do not exert an anti-inflammatory effect on several pro-and anti-inflammatory mediators of the human immune inflammatory response
  • withdrawal of cortisol activity in vivo did not lead to increased inflammatory responsiveness of immune effector cells
  • maximal suppression of inflammation was achieved by a stress-associated, but still physiologic, cortisol concentration. There was no greater anti-inflammatory effect at higher cortisol concentrations (Yeager et al. 2005) although IL-10 concentrations continued to increase with increasing cortisol concentrations as we and others have shown
  • acutely, physiological cortisol concentrations are anti-inflammatory and, as proposed, act to limit over expression of an inflammatory response that could lead to tissue damage
  • Acutely, cortisol has anti-inflammatory effects following a systemic inflammatory stimulus (Figure 4). However, a cortisol concentration that acts acutely to suppress systemic inflammation also has a delayed effect of augmenting the inflammatory response to subsequent, delayed stimulu
  • 1) GCs can exert pro-inflammatory effects on key inflammatory processes and, 2) GC regulation of inflammation can vary from anti- to a pro-inflammatory in a time-dependent manner
  • The immediate in vivo effect of both stress-induced and pharmacological GC concentrations is to suppress concurrent inflammation and protect the organism from an excessive or prolonged inflammatory response
  • GCs alone, in the absence of an inflammatory stimulus, up-regulate monocyte mRNA and/or receptors for several molecules that participate in pro-inflammatory signaling, as noted above and in the studies presented here.
  • In humans, as shown here, if in vivo GC concentrations are elevated concurrent with an inflammatory stimulus, anti-inflammatory effects are observed
  • In sharp contrast, with a time delay of 12 or more hours between an increased GC concentration and the onset of an inflammatory stimulus, enhancing effects on inflammation are observed. These effects have been shown to persist in humans for up to 6 days
  • GC-induced enhancement of inflammatory responses is maximal at an intermediate concentration, in our studies at a concentration that approximates that observed in vivo following a major systemic inflammatory stimulus
  • In addition to enhanced responses to LPS, recently identified pro-inflammatory effects of GCs also show enhanced localization of effector cells at inflammatory sites
  • we hypothesize that pre-exposure to stress-associated cortisol concentrations “prime” effector cells of the monocyte/macrophage lineage for an augmented pro-inflammatory response by; a) inducing preparative changes in key regulators of LPS signal transduction, and b) enhancing localization of inflammatory effector cells at potential sites of injury
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    very interesting read on the effects of inflammation on cortisol and visa versa.
Nathan Goodyear

Delayed Neuroendocrine Sexual Maturation in Female Rats After a Very Low Dose of Bisphe... - 0 views

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    low dose of BPA in rat model finds delayed sexual maturation.
Nathan Goodyear

Increased frequency of delayed type hypersensitivity to metals in patients with connect... - 0 views

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    increased delayed type hypersensitivity reactions in individuals with certain autoimmune diseases.
Nathan Goodyear

Lead-Chelation Therapy -- A Treatment for Chronic Renal Disease? - General Medicine - 1 views

  • Therapy with EDTA delayed the progression of chronic renal insufficiency in patients with high-normal body lead burdens
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    Therapy with EDTA delayed the progression of chronic renal insufficiency in patients with high-normal body lead burdens
Nathan Goodyear

Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome - 0 views

  • beta glucan (β-glucan), which is a dietary fiber readily found in oat and barley bran
  • Among cereals, the highest content (g per 100 g dry weight) of β-glucan has been reported for barley: 2–20 g (65% is water-soluble fraction) and for oats: 3–8 g (82% is water-soluble fraction). Other cereals also contain β-glucan but in much lower amounts: sorghum 1.1–6.2 g, rye 1.3–2.7 g, maize 0.8–1.7 g, triticale 0.3–1.2 g, wheat 0.5–1.0 g, durum wheat 0.5-0.6 g, and rice 0.13 g
  • Other sources of β-glucan include some types of seaweed [17] and various species of mushrooms such as Reishi, Shiitake, and Maitake [18].
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  • Distinction between soluble and insoluble dietary fibers is based on the solubility characteristics of dietary fiber in hot aqueous buffer solutions
  • Insoluble fibers primarily consist of cellulose and some hemicelluloses, resistant starch, and chitin while soluble fibers include pectins, β-glucans, galactomannan gums, mucilages, and some hemicelluloses
  • insoluble fibers increase fecal bulk and the excretion of bile acids and decrease intestinal transit time
  • Soluble fibers increase total transit time by delaying gastric emptying and also slow glucose absorption
  • only soluble viscous fibers delay gastric emptying time and slow glucose absorption while nonviscous soluble fibers primarily act as a substrate for microbial fermentation in the colon
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    good review on Beta glucan.
hadiyasafdar

Cosmetic Surgeons on United Arab Emirates: Things you should know about tummy tuck surgery - 0 views

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    If you are suffering from any serious medical condition, you may not qualify for a tummy tuck treatment. You should delay the surgery if you are pregnant. If you have excessive fat deposits but minimal skin, you are not an ideal candidate for a tummy tuck surgery. You can opt for liposuction in Dubai for fat removal.
hadiyasafdar

How Does fillers and Facelift Surgery Work? - Cosmetic Surgeon - Medium - 0 views

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    Who wouldn't love to look young and beautiful? Minor signs of ageing can make us panic because such signs start appearing one after the other making you look older and less pretty as would look without them. Wrinkles and lines appear because your skin loses its elasticity and volume over time. We know that ageing is an inevitable process but we wish to delay it and look youthful for more and more time.
Nathan Goodyear

Inhibitory effect of breast milk on inf... [Pediatr Infect Dis J. 2010] - PubMed - NCBI - 0 views

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    absolutely crazy recommendation from authors of study from CDC: delay breast-feeding to improve effectiveness of rotavirus vaccine.  This was because the study proposed that the IgA from the mother's breast milk reduced the potency of the vaccine.  
Nathan Goodyear

Access : The role of exercise and PGC1|[alpha]| in inflammation and chronic disease : N... - 0 views

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    study shows increased activity and exercise delays onset of chronic disease.   Inactivity and obesity decreased the age of 
Nathan Goodyear

Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy--A unif... - 0 views

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    Article discusses the immunoexcitotoxic process involved in chronic TBI. This is likely to be the underlying process involved in NFL and other football players delayed neurological effects. A similar process has been see in combat veterans returning from the theatre.
Nathan Goodyear

JAMA Network | Archives of Neurology | Damage to Lipids, Proteins, DNA, and RNA in Mild... - 0 views

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    oxidative damage found to be present in early Alzheimer's disease.  This early mild cognitive impairment is the time for treatment to delay disease progression.  As this study points out, most studies up to this point have been done on individuals with late Alzheimer's disease.  This show that oxidative damage plays a prominent role in disease development.  This study found oxidative damage through several markers: lipid peroxides,isoprostanes, 8-hydroxy-2-deoxyguanosine...
Nathan Goodyear

Prophylactic and therapeutic effects of n-3 polyunsaturated fatty acids, capsaicin, and... - 0 views

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    Rat study, but it finds that n-3, capsaicin, and curcumin can not only decrease the inflammation associatied with arthritis, but it can delay it all together.
Nathan Goodyear

Association between Lead and Cadmium and Reproductive Hormones in Peripubertal U.S. Girls - 0 views

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    Study finds higher Pb levels in young girls is associated with delayed puberty onset.  This occurs through an inverse relationship with inhibin B and follicular development.  This relationship was also found with Cadmium.  Both of these heavy metals are toxic to the ovaries.
Nathan Goodyear

Coenzyme Q10 as a possible treatment for neurodege... [Free Radic Res. 2002] - PubMed r... - 0 views

  • CoQ10 can significantly extend survival, delay motor deficits and delay weight loss and attenuate the development of striatal atrophy in a transgenic mouse model of HD
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    CoQ10 shown to shown to slow progression of the neurodegenerative disease: Huntington's disease
Nathan Goodyear

Carbohydrate feeding during prolonged strenuous ex... [J Appl Physiol. 1983] - PubMed r... - 1 views

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    carbohydrates during exercise delay fatigue development
Nathan Goodyear

Letrozole Significantly Improves Growth Potential in a Pubertal Boy With Growth Hormone... - 0 views

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    Letrazole improves growth potential in boys with HGH deficiency through aromatase inhibition and delayed closure of the growth plates
Nathan Goodyear

Review of high-dose intravenous vitami... [Asia Pac J Clin Oncol. 2014] - PubMed - NCBI - 0 views

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    Study reviews the studies of IV vitamin C and cancer.  The authors discuss the mechanism of action of the high dose vitamin C.  The authors are correct in their conclusion that a large body of evidence is lacking and that the majority are case study.  However, to even discount these in the face of the safety and the reduction in side effects associated with chemotherapy by IV vitamin C would be unacceptable. To delay recommendation due to a full lack of understanding would be unacceptable as well.   No deaths have been reported due to IV vitamin C.  Contrast this with chemotherapy.  However, case studies have pointed to IV vitamin C as a positive tool to attach cancer.  
Nathan Goodyear

Endocrine actions of pesticides m... [Environ Sci Pollut Res Int. 2014] - PubMed - NCBI - 0 views

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    low dose pesticide (organophosphates) exposure associated with delayed sexual development in boys and girls.  In addition, there was an inverse correlation with free T4 and a positive correlation with TSH.  
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