Skip to main content

Home/ Dr. Goodyear/ Group items tagged glucocorticoids

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Direct and Indirect Inhibition of Th1 Development by Progesterone and Glucocorticoids - 0 views

www.jimmunol.org/...1087.long

inflammation Th1 progesterone glucocorticoids autoimmune disease

shared by Nathan Goodyear on 09 Nov 12 - No Cached
  • Nathan Goodyear on 09 Nov 12
     
    progesterone and glucocorticoids decrease Th1 activity.
Nathan Goodyear

Pituitary-Adrenal Function After Prolonged Glucocorticoid Therapy for Systemic Inflamma... - 0 views

jcem.endojournals.org/...3199.abstract

glucocorticoid therapy adrenal suppression insufficiency hypoadrenia steroids

shared by Nathan Goodyear on 27 Aug 13 - No Cached
  • Nathan Goodyear on 27 Aug 13
     
    long-term glucocorticoid therapy commonly produces long-term adrenal suppression.
Nathan Goodyear

Direct Inhibitory Effect of Glucocorticoids upon Testicular Luteinizing Hormone Recepto... - 0 views

press.endocrine.org/...endo-108-6-2142

glucocorticoids cortisol Testosterone LH low T low Testosterone men male hormones hormone

shared by Nathan Goodyear on 02 Apr 15 - No Cached
  • Nathan Goodyear on 02 Apr 15
     
    glucocorticoids inhibit Testosterone production via down regulation of LH receptors at the level of the testicles.
Nathan Goodyear

The role of glucocorticoids and progestins in inflammatory, autoimmune, and infectious ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2538604

glucoorticoids progesterone autoimmune disease inflammation immune system

shared by Nathan Goodyear on 09 Nov 12 - No Cached
  • Nathan Goodyear on 09 Nov 12
     
    very nice of how glucocorticoids and progesterone interact with the immune system.   This review article discusses the current understanding of  how hormones can contribute to autoimmune disease states through inflammation.
Nathan Goodyear

Low early morning plasma cortisol in posttraumatic stress disorder is associated with c... - 0 views

www.sciencedirect.com/...S0306453009002509

PTSD low cortisol stress disorder depression

shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    Low cortisol found in those with PTSD.  This study suggest the high ACTH/cortisol ratio is not due to enhanced peripheral sensitization to glucocorticoids.
Nathan Goodyear

Secondary causes of hyperlipidemia. [Med Clin North Am. 1994] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8283927

triglycerides hypertriglyceridemia aromatase activity estrogen glucocorticoids

shared by Nathan Goodyear on 23 Sep 13 - No Cached
  • Nathan Goodyear on 23 Sep 13
     
    Estrogen and Glucocorticoids increase triglyceride levels.
Nathan Goodyear

Progesterone inhibits glucocorticoid-dependent aro... [J Endocrinol. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9846169

progesterone aromatase glucocorticoids bioidentical hormones

shared by Nathan Goodyear on 12 Nov 10 - No Cached
  • Progesterone must be considered a potential physiological inhibitor of glucocorticoid-dependent aromatase induction in adipose tissue. It is proposed that it is a suppressor of aromatase induction in adipose tissue in premenopausal women.
  • Nathan Goodyear on 12 Nov 10
     
    Progesterone inhibits estrogen production from adipose tissue
Nathan Goodyear

11β-HSD1 is the major regulator of ... [Proc Natl Acad Sci U S A. 2014] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...24889609

11-betaHSD1 11-betaHSD adipose tissue obesity glucocorticoids cortisol

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    Study proposes that 11beta-HSD type 1 is the key to linking glucocorticoids and metabolic dysfunction.  The key point of this study is that it is the adipose tissue expression of 11beta-HSD type 1 that is the key.
Nathan Goodyear

Duality of glucocorticoid action in cancer: tumor-suppressor or oncogene? in: Endocrine... - 0 views

erc.bioscientifica.com/...ERC-20-0489.xml

glucocorticoids glucocorticoid receptors cancer

shared by Nathan Goodyear on 12 Sep 23 - No Cached
  • Nathan Goodyear on 12 Sep 23
     
    Very much a mixed bag.
Nathan Goodyear

Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry a... - 0 views

www.ncbi.nlm.nih.gov/...PMC5345989

glucocorticoids cancer glucocorticoid receptors

shared by Nathan Goodyear on 12 Sep 23 - No Cached
  • Nathan Goodyear on 12 Sep 23
     
    Nice article describing solid tumors with high GC receptor expression. The authors point to GC antagonistic activity as an option for adjuvant therapy.
Nathan Goodyear

Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil... - 0 views

www.nature.com/...s12276-022-00784-2

TME NETosis metastasis surgery cancer tumor microenvironment

shared by Nathan Goodyear on 20 Apr 23 - No Cached
  • tumor surgery must be carefully considered because the risk of metastasis could be increased by the surgical procedure.
  • NETosis, which is the process of forming neutrophil extracellular traps (NETs)
  • surgery-induced metastasis
  • ...61 more annotations...
  • surgery per se can promote cancer metastasis through a series of local and systemic events
  • surgery results in a serious wound that disrupts the structural barrier preventing the outspreading of cancer cells, change the properties of the cancer cells and stromal cells remaining in the tumor microenvironment, or impairs the host defense systems against cancers
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Key point; add to presentation on surgery and metastasis
  • After the primary tumor is surgically removed, the metastases can start to grow vigorously via neoangiogenesis because the circulating inhibitors disappear
  • infection and inflammation during the postoperative period have been reported to increase the risk of cancer recurrence in patients
  • Surgeons have long suspected that surgery, even if it is a necessary step in cancer treatment, facilitates cancer metastasis
  • Surgery-induced cancer metastasis has been well established in animal models
  • tumor cell dissemination, tumor-favoring immune responses, and neoangiogenesis
  • the surgical resection of primary tumors is beneficial is controversial
  • CTCs abruptly increase just after surgery
  • Even externally palpitating tumors for diagnosis could increase the numbers of CTCs in skin cancer and breast cancer
  • excessive glucocorticoids negatively modulate immune functions
  • immune surveillance against tumors is considered to be impaired by surgical stress
  • In addition to glucocorticoids, during stimulation of the HPA axis, the catecholamine hormones epinephrine and norepinephrine are released from the adrenal medulla
  • NK cell suppression may be attributed to increased levels of catecholamines as well as glucocorticoids
  • In mice bearing a primary tumor, it was observed that the removal of the primary tumor facilitated the growth of highly vascularized metastases
  • primary tumors may secrete angiogenic inhibitors as well as angiogenic activators
  • second phase of tumor recurrence and metastasis, which are newly acquired events, rather than just outcomes of incomplete treatment.
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Another key point
  • double-edged sword
  • HIF-1 in neutrophils plays a critical role in NETosis and bacteria-killing activity
  • neutrophils play various roles in the initiation and progression of cancer
  • NETosis
  • many inflammatory and neoplastic diseases
  • formation of neutrophil extracellular traps (NETs), which are large extracellular complexes composed of chromatin and cytoplasmic/granular proteins1
  • NETosis has been highlighted as an inflammatory event that promotes cancer metastasis
  • Once activated, neutrophils produce intracellular precursors by using DNA, histones, and granular and cytoplasmic proteins and then spread the mature form of NETs out around themselves
  • A series of these events is called NETosis.
  • neutrophil elastase, myeloperoxidase, cathepsin G, proteinase 3, lactoferrin, gelatinase, lysozyme C, calprotectin, neutrophil defensins, and cathelicidins
  • innate immune response against infection
  • Neutrophils are the most abundant type of granulocytes, comprising 40–70% of all white blood cells
  • two types of NEToses, suicidal (or lytic) NETosis and vital NETosis
  • Suicidal NETosis mainly depends on the production of reactive oxygen species (ROS)
  • Since neutrophils die during this process, it is called suicidal NETosis.
  • vital NETosis
  • vital NETosis occurs independently of ROS production
  • Vital NETosis can be induced by Gram-negative bacteria. LPS
  • NETs are present in a variety of cancers, such as lung cancer, colon cancer, ovarian cancer, and leukemia
  • neutrophils actively undergo NETosis in the tumor microenvironment
  • Hypoxia
  • NETosis plays a pivotal role in noninfectious autoimmune diseases,
  • cytokines
  • tumor-derived proteases
  • tumor exosomes
  • NETosis generally actively progresses in the tumor microenvironment.
  • the proliferative cytokines TGFβ and IL-10 and the angiogenic factor VEGF are representative of neutrophil-derived tissue repair proteins.
  • NETosis is a defense system to protect the body from invading pathogens
  • when neutrophils are excessively stimulated, they produce excess NETs, thereby leading to pathological consequences
  • plasma levels of NETosis markers are elevated after major surgeries
  • local invasion, intravasation into the blood or lymphatic vessels, escape from the immune system, anchoring to capillaries in target organs, extravasation into the organs, transformation from dormant cells to proliferating cells, colonization to micrometastases, and growth to macrometastases
  • NETs promote metastasis at multiple steps
  • NETs loosen the ECM and capillary wall to promote the intravasation of cancer cells
  • NETs and platelets wrap CTCs, which protects them from attack by immune cells and shearing force by blood flow
  • NETs promote the local invasion of cancer cells by degrading the extracellular matrix (ECM)
  • neutrophil elastase, matrix metalloproteinase 9, and cathepsin G
  • NETs also promote the intravasation of cancer cells
  • millions of tumor cells are released into the circulation every day,
  • NETs can wrap up CTCs with platelets
  • β1-integrin plays an important role in the interaction between CTCs and NETs
  • NET-platelet-CTC aggregates.
  • After metastasizing to distant tissues, tumor cells are often found to remain dormant for a period of time and unexpectedly regrow late
  • NETs are believed to participate in the reactivation of dormant cancer cells in metastatic regions
  • NET-associated proteases NE and MMP-9 were found to be responsible for the reactivation of dormant cancer cells
  • Nathan Goodyear on 20 Apr 23
     
    Surgery induced metastasis: it is real and steered by NETosis.
Nathan Goodyear

Immunosuppressive Biological Mechanisms Support Reassessment of Use of the Injectable C... - 0 views

endo.endojournals.org/...985.full

medroxyprogesterone acetate MPA contraception immunosuppression

shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    Injectable medroxyprogesterone acetate for contraception provides immune suppression through glucocorticoid receptors.
Nathan Goodyear

Advantage of salivary cortisol measurements in the... [Clin Biochem. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18280810

hormone testing saliva salivary cortisol

shared by Nathan Goodyear on 03 Nov 10 - No Cached
  • Morning salivary cortisol is as good as serum as screening test for patients with Addison's disease and nighttime salivary cortisol is more adequate than serum in the screening of Cushing's syndrome.
  • Nathan Goodyear on 03 Nov 10
     
    Advantage of salivary cortisol measurements in the diagnosis of glucocorticoid related disorders.
1 - 20 of 50 Next › Last »
Showing 20▼ items per page