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Nathan Goodyear

Ubiquinone (Coenzyme Q10) - 0 views

faculty.washington.edu/...JOM5.html

coenzyme ubiquinone q10 mitochondria

shared by Nathan Goodyear on 14 Jan 11 - Cached
  • Nathan Goodyear on 14 Jan 11
     
    A Brief Update on Ubiquinone (Coenzyme Q10)
Nathan Goodyear

Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeu... - 0 views

www.sciencedirect.com/...S0891584923005014

COVID19 COVID-19 cancer inflammation SARS-CoV-2 spike proteins COVID spikeopathy

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • Redox shift is due to Warburg effect and mitochondrial impairment.
  • Redox shift is due to Warburg effect and mitochondrial impairment.
  • Redox shift is due to Warburg effect and mitochondrial impairment.
  • ...88 more annotations...
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • most diseases display a form of anabolism due to mitochondrial impairment
  • most diseases display a form of anabolism due to mitochondrial impairment
  • most diseases display a form of anabolism due to mitochondrial impairment
  • infection by Covid-19 follows a similar pattern
  • chronic inflammation
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • infection by Covid-19 follows a similar pattern
  • unrelenting anabolism leads to the cytokine storm,
  • unrelenting anabolism leads to the cytokine storm,
  • unrelenting anabolism leads to the cytokine storm,
  • chronic inflammation
  • chronic inflammation
  • infection by Covid-19 follows a similar pattern
  • Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
  • Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
  • Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
  • Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
  • Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
  • Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
  • direct consequence of redox iMeBalance, itself a consequence of decreased energy yield by the mitochondria
  • direct consequence of redox iMeBalance, itself a consequence of decreased energy yield by the mitochondria
  • mitochondrial dysfunction and increased levels of lactate, which are important characteristics of metabolic shift and Warburg effect in many diseases
  • mitochondrial dysfunction and increased levels of lactate, which are important characteristics of metabolic shift and Warburg effect in many diseases
  • increased lactate dehydrogenase activity (LDH) was observed in COVID-19 patients
  • increased lactate dehydrogenase activity (LDH) was observed in COVID-19 patients
  • almost every disease presents an increased anabolism
  • almost every disease presents an increased anabolism
  • cell division is the most sophisticated way to release entropy
  • cell division is the most sophisticated way to release entropy
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Wow
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Wow
  • transition from catabolism to anabolism is driven by a redox shift
  • transition from catabolism to anabolism is driven by a redox shift
  • viral spike protein binds to ACE2 receptor of the host cell [22,23].
  • redox signaling plays an important role in regulating immune function and inflammation, and disruptions in this signaling can lead to excessive cytokine production and immune system activation
  • Aging is associated with a poor control of the redox balance
  • thiol/disulfide homeostasis
  • reduced extracellular environment in the elderly and the increased susceptibility to Covid-19 infection
  • reduced extracellular environment in the elderly and the increased susceptibility to Covid-19 infection
  • Redox signaling tightly modulates the inflammatory response and oxidative stress has been reported in acute Covid-19
  • People at high risk are the elderly, patients suffering from metabolic syndrome such as obesity, or those suffering from chronic diseases such as cancer or inflammation
  • COVID-19 patients with severe disease have higher levels of oxidative stress markers and lower antioxidant levels
  • oxidative stress can activate the NLRP3 inflammasome, which is a protein complex that plays a key role in the cytokine storm
  • inflammation leads to the formation of ROS and RNS, while redox iMeBalance results in cellular damage, which in turn triggers an inflammatory response
  • persistently elevated mtROS triggers endothelial dysfunction and inflammation, which results in a vicious loop involving ROS, inflammation, and mitochondrial dysfunction
  • Damaged mitochondria releasing ROS induce inflammation via the NLRP3 inflammasome
  • Damaged mitochondria releasing ROS induce inflammation via the NLRP3 inflammasome
  • reduced environment during the cytokine storm
  • IL-2 is highly up-regulated in Covid-19 patients [37], and IL-2 is known to significantly stimulate the generation of NO in patients
  • Nitric acid is also the key mediator of IL-2-induced hypotension and vascular leak syndrome
  • mitochondrial dysfunction has been linked to the pathogenesis of Covid-19
  • mitochondrial dysfunction triggered by SARS-CoV-2 leads to damage to the mitochondria
  • mitochondrial dysfunction triggered by SARS-CoV-2 leads to damage to the mitochondria
  • As catabolism is decreased, entropy is released through anabolism
  • Elevated levels of lactate, a characteristic of the Warburg effect, were also reported in the high-risk Covid-19
  • elevated levels of ventricular lactic acid consistent with oxidative stress
  • A decrease of ΔΨm is implicated in several inflammation-related diseases
  • decrease in ΔΨm in leucocytes from Covid-19 patients
  • vaccinated with RNA or DNA vaccines triggering the synthesis of the viral spike protein in human cells
  • viral reactivation in varicella-zoster virus [55] or hepatitis [56], coagulopathy and resulting stroke and myocarditis following both DNA-based vaccines [57] and RNA-based vaccines
  • Covid-19, mitochondrial impairment
  • characteristic of the Warburg effect is present in almost every disease and appears to be a central feature in most of the hallmarks of cancer
  • inflammation, mitochondrial dysfunction and increased lactate concentrations in the extracellular fluid
  • In Covid-19, like any inflammation, there is a metabolic rewiring where cells rely on glycolysis
  • As the mitochondria are impaired, the infected cell cannot catabolize efficiently. It will release lactic acid in the blood stream
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Mitochondrial impairment
  • Striking similarities are seen between cancer, Alzheimer's disease and Covid-19, all related to the Warburg effect
  • Cancer, inflammation, Alzheimer's, and Parkinson's diseases share a common peculiarity, the inability of the cell to export entropy outside the body in the harmless form of heat
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Entropy: lack of order or predictability; gradual decline into disorder.
  • MEB relieves the Warburg effect [87], improves memory [77], is active in the treatment of depressive episodes [79,80] and reduces the importance of ischemic strokes
  • MEB relieves the Warburg effect [87], improves memory [77], is active in the treatment of depressive episodes [79,80] and reduces the importance of ischemic strokes
  • MEB has been shown to inhibit SARS-Cov-2 replication in vitro
  • MEB has been shown to inhibit SARS-Cov-2 replication in vitro
  • It has been shown that Covid-19-patients treated with MEB, have a significant reduction in hospital stay duration and mortality
  • MeB is an acceptor-donor molecule
  • MeB + can take a pair of electrons (of H atoms) and MeBH can release this pair easily, so that MeB is partially recycled like a catalyst
  • MeB acts as an electron bridge between a donor (FADH2, FMNH, NADH) and an acceptor (complex IV of ETC or oxygen itself)
  • As a coenzyme of pyruvate dehydrogenase (PDH), alpha-lipoic acid (ALA) initiates the formation of acetyl-CoA to feed the TCA cycle
  • ALA enhances the catabolism of carbon. cycle and therefore may reduce the Warburg effect and consequently, lactate production
  • Methylene Blue plays a similar role after the TCA cycle, by carrying electrons to complex IV of the electron transport chain
  • Drugs such as lipoic acid and MeB, which target the metabolism, decrease the redox shift by increasing catabolism
Nathan Goodyear

Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation ... - 0 views

onlinelibrary.wiley.com/...abstract

CoQ10 coenzyme Q10

shared by Nathan Goodyear on 07 Mar 13 - No Cached
  • Nathan Goodyear on 07 Mar 13
     
    good review on CoQ10.  The abstract is the only format available on line to the general public.
Nathan Goodyear

Coenzyme Q10 in the central nervous system and its... [Mol Aspects Med. 1997] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...9266519

CoQ10 neurodegenerative disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • These findings suggest that coenzyme Q10 might be useful in treating neurodegenerative diseases.
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 useful in treating neurodegenerative diseases
Nathan Goodyear

Coenzyme Q10 in neurodegenerative diseases. [Curr Med Chem. 2003] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...12871093

CoQ10 Parkinson's disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • supplemental coenzyme Q(10) can slow the functional decline in these disorders, particularly Parkinson's disease.
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 may slow some aspects of Parkinson's disease
Nathan Goodyear

Coenzyme Q10 effects in neurodegenerative disease. [Neuropsychiatr Dis Treat. 2009] - P... - 0 views

www.ncbi.nlm.nih.gov/...19966907

coenzyme q10 neurodegenerative Parkinson's Alzheimer's Huntington's ALS

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 shown to be beneficial in treatment of neurodegenerative diseases, Parkinson's, Alzheimer's, ALS, Huntington's, in animal models
Nathan Goodyear

Coenzyme Q10 as a possible treatment for neurodege... [Free Radic Res. 2002] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...12069110

coenzyme q10 CoQ10 Huntington's disease neurodegenerative

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • CoQ10 can significantly extend survival, delay motor deficits and delay weight loss and attenuate the development of striatal atrophy in a transgenic mouse model of HD
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 shown to shown to slow progression of the neurodegenerative disease: Huntington's disease
Nathan Goodyear

Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis - 0 views

ajcn.nutrition.org/...268.abstract

CHF congestive heart failure CoQ10 heart failure

shared by Nathan Goodyear on 25 Jan 13 - No Cached
  • Nathan Goodyear on 25 Jan 13
     
    Meta-analysis shows that coQ10 "may" improve heart function in those with CHF.
Nathan Goodyear

Positive correlation between maternal serum coenzyme Q10 levels and infant birth weight... - 0 views

www.ncbi.nlm.nih.gov/...20641057

CoQ10 pregnancy

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    low serum CoQ10 maternal levels associated with low birth weight.
Nathan Goodyear

Maternal plasma and amniotic fluid coenzyme Q10 levels in preterm and term gestations: ... - 0 views

www.ncbi.nlm.nih.gov/...21547699

CoQ10 pregnancy

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    Pilot study and only abstract available here: Low CoQ10 levels found in amniotic sample in preterm delivered pregnancies; not difference was found in serum levels.
Nathan Goodyear

Clinical aspects of coenzyme Q10: an update. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19932599

CoQ10 pregnancy preeclampsia

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    only abstract available here, but Coq10 found to decrease incidence of preeclampsia.
Nathan Goodyear

Preeclampsia is associated with a decrease in plasma coenzyme Q10 levels. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...14642393

preeclampsia CoQ10 pregnancy

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    Preeclampsia associated with lower CoQ10 levels in women.
Nathan Goodyear

Lipid-soluble antioxidants and pregnancy: maternal serum levels of coenzyme Q10, alpha-... - 0 views

www.ncbi.nlm.nih.gov/...14988604

CoQ10 preeclampsia pregnancy

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    Women with preeclampsia have lower CoQ10 levels compared to normal pregnant women.
Nathan Goodyear

Coenzyme Q10 in pregnancy. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8823607

CoQ10 pregnancy

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    low CoQ10 associated with spontaneous miscarriage in abstract.  The authors of this paper found CoQ10 levels increased throughout "normal pregnancy".  Only abstract available here.
Nathan Goodyear

Plasma coenzyme Q10 is increased during gestational diabetes. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21816499

CoQ10 pregnancy oxidative stress gestational diabetes

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    CoQ10 levels elevated in women with gestational diabetes.  The authors proposed that this was an adaptation to increased oxidative stress.
Nathan Goodyear

Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. - PubM... - 0 views

www.ncbi.nlm.nih.gov/...19154996

CoQ10 pregnancy preeclampsia

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    200 mg CoQ10 found to decrease the risk of preeclampsia in those women at risk.
Nathan Goodyear

Effect of Coenzyme Q10 on Th1/Th2 Paradigm in Females with Idiopathic Recurrent Pregnan... - 0 views

www.ncbi.nlm.nih.gov/...25800618

CoQ10 pregnancy inflammation IFN-gamma

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    CoQ10 reduced Th1 inflammatory cytokines in those women with recurrent early pregnancy loss.  CoQ10 specifically, reduced IFN-gamma.
Nathan Goodyear

Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme ... - 0 views

www.ncbi.nlm.nih.gov/...21996047

CoQ10 cardiovascular disease catalase SOD super oxide dismutase MDA CAD coronary artery disease heart health

shared by Nathan Goodyear on 11 Apr 17 - No Cached
  • Nathan Goodyear on 11 Apr 17
     
    CoQ10 supplementation of 150 mg in individuals with CAD found to have increased catalase activity, increased SOD activity, an increased MDA levels.  This reduced oxidative stress, TC, and LDL levels.
Nathan Goodyear

Study Suggests Coenzyme Q10 Slows Functional Decline in Parkinson's Disease: National I... - 0 views

www.ninds.nih.gov/...kinsons_coenzymeq10_101402.htm

CoQ10 Parkinson's disease Huntington's ecitotoxic neurotoxic

shared by Nathan Goodyear on 07 Nov 11 - Cached
  • Nathan Goodyear on 07 Nov 11
     
    high dose CoQ10 shown to slow disease progression in Parkinson's disease.  A similar study had shown the same finding in Huntington's disease.  Both are excitotoxic diseases
Nathan Goodyear

Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia - 0 views

www.ijgo.org/...abstract

CoQ10 antioxidant antioxidants pregnancy pre-eclampsia preeclampsia detoxification

shared by Nathan Goodyear on 02 Mar 12 - No Cached
  • Nathan Goodyear on 02 Mar 12
     
    CoQ10 at 200 mg shown to significantly reduce the rate of pre-eclampsia in pregnant women.
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