Skip to main content

Home/ Dr. Goodyear/ Group items tagged combat

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Low testosterone in a young combat veteran with dual diagnosis and ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25528760

combat low T low Testosterone PTSD

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • Nathan Goodyear on 02 Feb 15
     
    Low T found in young combat veteran with PTSD and SI.  This is no surpass as there is significant HPA dysfunction in these men/women.  The overwhelming cortisol response and resultant PTSD will shut down endogenous Testosterone production.  I have seen this in several combat veterans.
Nathan Goodyear

Journal of Traumatic Stress, Volume 3, Number 3 - SpringerLink - 0 views

www.springerlink.com/...g0423r5415l48147

sleep disorder insomnia PTSD stress combat military

shared by Nathan Goodyear on 03 Jan 12 - No Cached
  • Nathan Goodyear on 03 Jan 12
     
    sleep disruption is a major symptom in those with PTSD.  There is no greater stress than combat.  The majority of research on PTSD is done on combat veterans
Nathan Goodyear

Longitudinal Assessment of Mental Health Problems Among Active and Reserve Component So... - 0 views

jama.ama-assn.org/...2141.long

PTSD combat military soldiers mental health

shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    PTSD in military deployed in combat is very high.  Estimated from between 20.3% to 42.4% of returning soldiers.  
Nathan Goodyear

Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy--A unif... - 0 views

www.surgicalneurologyint.com/...rolInt21107-2574138_070901.pdf

immunoexcitotoxicity excitoxicity TBI traumatic brain injury chronic NFL players football soldiers combat

shared by Nathan Goodyear on 08 Feb 12 - No Cached
  • Nathan Goodyear on 08 Feb 12
     
    Article discusses the immunoexcitotoxic process involved in chronic TBI. This is likely to be the underlying process involved in NFL and other football players delayed neurological effects. A similar process has been see in combat veterans returning from the theatre.
Nathan Goodyear

Biochemical and metabolic mechanisms by which... [J Nutr Biochem. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22995389

whey protein obesity metabolic syndrome type II DM diabetes

shared by Nathan Goodyear on 24 Sep 12 - No Cached
  • Nathan Goodyear on 24 Sep 12
     
    Whey protein should be a tool in every medical provider to combat obesity and type II Diabetes.  The role? through improved insulin function: by interactions with cholecystokinin, peptide YY, incretins...
Nathan Goodyear

Epigenetic changes induced by curcumin and other n... [Genes Nutr. 2011] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...21516481

curcumin cancer natural treatment

shared by Nathan Goodyear on 13 Jun 11 - No Cached
  • Nathan Goodyear on 13 Jun 11
     
    curcumin and other natural compounds combat cancer
healthinfomag

Why New Zealand and Vietnam are more successful against COVID-19 than the United States... - 0 views

healthinfomag.com/-compared-to-the-united-states

coronavirus cases death toll usa covid-19 covid19 u.s.

shared by healthinfomag on 15 May 20 - No Cached
  • healthinfomag on 15 May 20
     
    Every country is trying to combat with COVID-19 according to its resources. Politicians, doctors, scientists and economy experts are trying to find a perfect mix which can work well in this situation. Some countries are acting smartly. Along with these efforts, they are also observing the conditions of other countries to improvise their policies.
harshitatyagi

Penile Yeast Infection in Men, Causes, Symptoms and Treatment - 0 views

vocal.media/...-causes-symptoms-and-treatment

Yeast Infection in Men Penile Yeast Infection in Men Penile Yeast Infection Causes Penile Yeast Infection Symptoms Penile Yeast Infection Treatment

shared by harshitatyagi on 31 Oct 22 - No Cached
  • harshitatyagi on 31 Oct 22
     
    Penile Yeast infections in men are generally not known due to their lack of awareness. This severe illness can cause a range of infections that will affect hygiene and the fertility rate. And due to increasing cases of infertility in men, it becomes significant to acknowledge cautious infections in men to combat the rising infertility cases.
harshitatyagi

Success chances with IVF after failed IUI` - 0 views

sco.lt/6GOKnI

IVF IVF Treatment IUI Treatment Infertility Treatment Best IVF Centre in Delhi NCR IVF Centre in Noida

shared by harshitatyagi on 05 Sep 22 - No Cached
  • harshitatyagi on 05 Sep 22
     
    Being the popular form of ART, In-vitro fertilization is a treatment that stands out to combat the infertility challenges when all other treatments fail.
Teresa conrad

Common Breast Cancer Treatments - 1 views

www.placidway.com/...Breast-Cancer-Treatment-Abroad

cancer

shared by Teresa conrad on 11 Mar 14 - No Cached
Teresa conrad liked it
  • Teresa conrad on 11 Mar 14
     
    A diagnosis of breast cancer can be a devastating bit of news to anyone. However, recent developments in treatments and medical advances that combat breast cancer offer today's women more choices, less discomfort and improved prognosis.
Nathan Goodyear

Hypothalamic IKKbeta/NF-kappaB and ER stress link ... [Cell. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18854155

hypothalamus NF-KappaB inflammation ikkbeta

shared by Nathan Goodyear on 22 Mar 11 - No Cached
  • Our results show that the hypothalamic IKKbeta/NF-kappaB program is a general neural mechanism for energy imbalance underlying obesity and suggest that suppressing hypothalamic IKKbeta/NF-kappaB may represent a strategy to combat obesity and related diseases
  • Nathan Goodyear on 22 Mar 11
     
    INflammation of hypothalamus through NF-KappaB leads to obesity and related diseases
Nathan Goodyear

Vitamin D and cardiovascular risk. [Int Urol Nephrol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20039126

D vitamin cardiovascular disease hypertension atherogenesis

shared by Nathan Goodyear on 06 Oct 11 - No Cached
  • vitamin D supplementation in adults may be regarded as simple means with few potential side effects to prevent atherogenesis or halt its progression and combat arterial hypertension
  • Nathan Goodyear on 06 Oct 11
     
    Vitamin D proves to be powerful benefit in those at risk for cardiovascular disease.
regeneration1

Organic Supplements - 0 views

www.regenerationusa.net/company.html

hormones food supplements organic health

shared by regeneration1 on 01 Apr 15 - No Cached
  • regeneration1 on 01 Apr 15
     
    It all started in 2008. Our Anti-Aging Whole Food Bar evolved from the collision of two competing forces - the desire to eat foods that can combat aging with the need to do so easily, conveniently, and affordably.
Nathan Goodyear

Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Tr... - 0 views

ajp.amjpathol.org/...fulltext

Lyme Lyme disease borrelia burgdorferi

shared by Nathan Goodyear on 14 Dec 17 - No Cached
  • In this study, we have demonstrated microscopic pathology ranging from minimal to moderate in multiple different tissues previously reported to be involved with LD, including the nervous system (central and peripheral), heart, skeletal muscle, joint-associated tissues, and urinary bladder 12 to 13 months following tick-inoculation of rhesus macaques by Bb strain B31
  • Based on histomorphology, inflammation consisted predominantly of lymphocytes and plasma cells, with rare scattered histiocytes
  • in rare instances, morphologically intact spirochetes were observed in inflamed brain and heart tissue sections from doxycycline-treated animals
  • ...41 more annotations...
  • colocalization of the Bb 23S rRNA probe was not observed in any of the sections of experimental inoculated animals shown to harbor rare persistent spirochetes (Supplemental Figure S1). Previous in vitro work has shown large decreases in Bb rRNA levels when in a stationary phase of growth despite the majority of spirochetes remaining viable
  • The possibility that the spirochetes were intact but dead also exists, though this may be unlikely given the precedence for viable but non-cultivable B. burgdorferi post-treatment
  • The doxycycline dose utilized in this study (5mg/kg) was based on a previous pharmacokinetic analysis of oral doxycycline in rhesus macaques proven to be comparable to levels achieved in humans and was meant to mimic treatment of disseminated LD
  • In addition to the brain of two treated animals, rare morphologically intact spirochetes immunoreactive to OspA were observed in the heart of one treated animal
  • Although we did not measure the doxycycline levels in the cerebrospinal fluid, they have been found to be 12% to 15% of the amount measured in serum
  • We and others have demonstrated the development of a drug-tolerant persister population when B. burgdorferi are treated with antibiotics in vitro
  • The adoption of a dormant or slow-growing phenotype likely allows the spirochetes to survive and re-grow following removal of antibiotic
  • The basic premise that antibiotic tolerance may be an adaptation of the sophisticated stringent response required for the enzootic cycle by the spirochetes is described in a recent review as well
  • Although current IDSA guidelines recommend intravenous ceftriaxone (2g daily for 30 days) over oral doxycycline for treatment of neuroborreliosis, a randomized clinical trial failed to show any enhanced efficacy of I.V. penicillin G to oral doxycycline for treatment of Lyme neuroborreliosis (no treatment failures were reported in this study of 54 patients).
  • we can speculate that the minimal to moderate inflammation that was observed, especially within the CNS and PNS can, in part, explain the breadth of symptoms experienced by late stage Lyme disease patients, such as cognitive impairment and neuralgia.
  • Erythema migrans, the clinical hallmark of early localized Lyme disease, was observed in one of the rhesus macaques from this study.
  • In 2014, a trailblazing study in mice demonstrated a dramatic decline in B. burgdorferi DNA in the tissues for up to eight months after antibiotic treatment followed by the resurgence of B. burgdorferi growth 12 months after treatment
  • This study provides evidence that the slow-growing spirochetes which persist after treatment, but are not cultivable in standard growth media may remain viable.
  • The first well-documented indication of Lyme disease (LD) in the United States occurred in the early 1970s
  • Lyme, Connecticut.
  • Lyme disease is now known to be caused by multiple closely related genospecies classified within the Bb sensu lato complex, representing the most common tick-borne human disease in the Northern Hemisphere
  • approximately 30,000 physician-reported cases occur annually in the United States, the annual incidence has been estimated to be 10-fold higher by the Centers for Disease Control and Prevention.6
  • Current antibiotic therapy guidelines outlined by the Infectious Disease Society of America (IDSA) are successful in the treatment of LD for the majority of LD patients, especially when administered early in disease immediately following identification of erythema migrans (EM)
  • ‘post-treatment Lyme disease syndrome’ (PTLDS)
  • host-adapted spirochetes that persist in the tissues, probably in small numbers, inaccessible or impervious to antibiotic
  • inflammatory responses to residual antigens from dead organisms
  • residual tissue damage following pathogen clearance;
  • autoimmune responses, possibly elicited by antigenic mimicry
  • Experimental studies on immunocompetent mice, dogs, and rhesus macaques have provided evidence for the persistence of Bb spirochetes subsequent to antibiotic treatment in the form of residual spirochetes detected within tissue by IFA and PCR, and recovered by xenodiagnoses
  • Ten male rhesus macaques
  • half (five) of the NHP received antibiotic treatment, consisting of 5 mg/kg oral doxycycline twice per day.
  • Minimal and focal lymphoplasmacytic inflammation
  • inflammation was observed in the leptomeninges overlying a section of temporal cerebral cortex
  • Minimal localized lymphoplasmacytic choroiditis
  • Peripheral nerves contained minimal to moderate lymphoplasmacytic inflammation with a predilection for collagen-rich epineurium and perivascular spaces
  • Inflammation was observed in 56% (5/9) of the NHPs irrespective of treatment group
  • For all animals, inflammation was reserved to perineural tissue
  • The treatment lasted 28 days
  • Minimal to mild lymphoplasmacytic inflammation of either the myocardial interstitium (Figure 2Figure 2A), pericardium (Figure 2Figure 2B), or combination therein was observed in 60% of NHPs
  • A single morphologically intact spirochete, as indicated by positive red immunofluorescence (Figure 2Figure 2C), was observed in the myocardium of one treated animal
  • mild, multifocal lymphoplasmacytic inflammation was observed in one doxycycline-treated animal
  • three animals exhibited minimal to mild lymphoplasmacytic inflammation affecting joint-associated structures
  • 10% to -20% of human patients treated
  • Multiple randomized placebo-controlled studies which evaluated sustained antimicrobial therapy concluded that there is no benefit in alleviating patients’ symptoms and indicated that long-term antibiotic therapy may even be detrimental to patients due to potential associated complications (ie, catheter infection and/or clostridial colitis)
  • and the rapid clearance of dead spirochetes in a murine model
  • higher doses may be needed to combat neuroborreliosis
  • Nathan Goodyear on 14 Dec 17
     
    persistent borrelia burgdorferia were found in the brain (2) and the heart (1) up to 13 months post standard antibiotic treatment suggesting borrelia burdorferia, the cause of Lyme, can persist in a chronic, persistant state poste acute treatment.
Nathan Goodyear

The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A... - 0 views

www.ncbi.nlm.nih.gov/...PMC9925039

COVID-19 SARS-CoV-2 COVID WBC ascorbic acid vitamin C

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • vitamins A, B, C, E, B6, B12, folate, zinc, iron, copper, and selenium
  • White blood cells, including neutrophils and monocytes, accumulate concentrations of vitamin C up to 100 times greater than that of plasma
  • Vitamin C is a crucial component of both the innate (nonspecific) and adaptive (specific) portions of the immune system
  • ...52 more annotations...
  • play a role during the initial chemotactic response of neutrophils shortly after infection
  • following vitamin C supplementation, a 20% increase in neutrophil chemotactic activity was observed
  • also contributes to the phagocytosis and killing of microbes by neutrophils
  • low levels of vitamin C occurring in high-stress situations
  • maturation, proliferation, and viability of T cells have all been shown to be upregulated by the presence of normal physiologic concentrations of vitamin C
  • Vitamin C has been shown to directly affect the number of Igs released from B cells
  • vitamin C among healthy young adult males showed a significant increase in serum levels of IgA, IgG, and IgM
  • effects of high-dose vitamin C on cytokine levels in cancer patients, finding decreased amounts of the cytokines Interleukin-1 alpha (IL-1 alpha), IL-2, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after high-dose vitamin C infusion
  • when vitamin C was supplemented with vitamin E in healthy adults, it increased the production of cytokines IL-1 beta and TNF-alpha
  • vitamin C acts to modulate the levels of cytokines to prevent them from fluctuating in either direction
  • vitamin C also acts as an important antioxidant to the cells of the immune system.
  • human leukocytes, neutrophils, in particular, possess the ability to transport the oxidized form of vitamin C across its membrane to use as a defense mechanism against ROS produced during an immune response
  • Vitamin C also can recover other endogenous antioxidants in the body such as vitamin E and glutathione, returning them to their active state
  • vitamin C can decrease the activation of NF-kB
  • can reduce harmful nitrogen-based compounds such as N-nitrosamines and nitrosamides, both of which are carcinogenic 
  • subjects taking oral vitamin C supplementation saw a 60% to 90% reduction in oxidative stress compared to a placebo control
  • subjects infused with vitamin C alone had a 516% increase in glutathione levels compared to subjects not provided the 500 mg daily supplementation
  • hydroxylating proline and lysine
  • mature and stabilize the tissue of a healing wound
  • healing
  • oral surgery
  • improved soft tissue regeneration
  • vitamin C increases the mRNA levels of type I and type III collagen in the human dermis
  • Studies have demonstrated that those with low levels of vitamin C are at a significantly higher risk of respiratory infection compared to those with normal levels
  • viral cold duration was reduced by about 8% in adults and 13.5% in children using prophylactic daily doses of 200 mg of oral vitamin C
  • prophylactically supplementing vitamin C decreases the risk of infection with respiratory viruses such as the common cold
  • combined with probiotics, oral vitamin C supplementation showed a 33% decrease in the incidence of respiratory tract infections in preschool-age children [
  • high-dose oral supplementation of vitamin C managed to prevent or reduce symptoms if taken before or just after the onset of cold- or flu-like symptoms
  • improvements in oxygen saturation and decreased IL-6 levels (a marker of inflammation) in the treatment group compared to the control group
  • 8 g doses of oral vitamin C
  • there is a negative correlation between age and serum levels of vitamin C
  • Patients with COVID-19 will likely also experience depletion in serum levels of vitamin C as a direct result of the upregulation of the immune system to combat the infection
  • Colunga et al. suggested that oral vitamin C can be combined with oral Quercetin, an antiviral flavonoid, to improve Quercetin’s ability to block viral membrane fusion of SARS-CoV-2
  • high doses of 1-2 g/day of oral vitamin C could prevent other upper respiratory infections
  • It appears vitamin C supplementation by itself does not provide a striking benefit in preventing COVID-19 infection for those without a deficiency
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Flawed statement. What is normal? Vitamin D. Many variables effect levels and dose, including the two compartment kinetics and absorption.
  • Hiedra et al. were able to show decreases in inflammatory biomarkers, such as D-dimer and ferritin
  • some evidence to support that prophylactic use of vitamin C helps reduce the severity of respiratory infection symptoms once a subject has already been infected
  • oral vitamin C in combination with zinc provided the largest amount of antibody titers 42 days
  • linear relationship between days of vitamin C therapy and survival duration
  • other studies were unable to find any definitive improvement concerning therapy with vitamin C
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Either these studies are designed to fail or the authors are lacking some basic understanding of pharmacokinetics and pharmacodynamics with vitamin C.
  • Fowler et al. aimed to see if a high-dose vitamin C infusion would benefit patients affected by ARDS, but they were unable to conclude that vitamin C infusion, compared to a placebo, could decrease vascular inflammation and damage in ARDS
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      At what dose, duration, frequency???
  • in a sample of 67 COVID-19-positive ICU patients, 82% of them displayed plasma vitamin C levels below 0.4 mg/dL
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      They are kind of make the point from my earlier note.
  • continuous vitamin C infusion at a rate of 60 mg/kg/day for four days decreased the need for mechanical ventilation and vasopressor use but had no significant effect on overall mortality
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Again, designed to fail or ignorance designed the study which failed
  • Carr et al. suggested that high-dose IV vitamin C is most effective when treating sepsis as septic patients receiving the normal daily recommendations through diet still showed decreased vitamin C levels
  • High-dose IV vitamin C treatment has also been shown by Kakodkar et al. to decrease syndecan-1, an endothelial glycocalyx that contributes to mortality in septic patients
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • reduced overall mortality
  • reduced overall mortality
  • propose the use for high-dose vitamin C to aid in the treatment of septic shock-induced hypotension
  • treatment of severe sepsis using a high dose (up to 200 mg/kg/day) of IV vitamin C was explored in phase I, a double-blind, randomized, placebo-controlled trial by Fowler et al. [75]. Their findings included a reduction in SOFA scores and decreased vascular injury compared to a placebo control group, all while showing minimal adverse side effects
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      High dose here is laughable. Again, duration and frequency also.
  • Maintaining a daily intake of 75 and 100 mg for men and women, respectively, as recommended by the U.S. Institute of Medicine
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      This recommendation is FRANK IGNORANCE
1 - 18 of 18
Showing 20▼ items per page