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Nathan Goodyear

Erectile dysfunction and coronary disease: Evaluating the link - 0 views

www.maturitas.org/...abstract

ED erectile dysfunction erectile dysfunction cardiovascular disease CVD heart disease

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    ED in men precedes cardiovascular disease by 3-5 years.
Nathan Goodyear

Heart-brain medicine: Update 2008 - 0 views

www.ccjm.org/...S5.full

neurology inflammation psychiatry psychiatric disease CVD cardiovascular depression PTSD

shared by Nathan Goodyear on 01 Oct 12 - No Cached
  • Nathan Goodyear on 01 Oct 12
     
    It does appear that medicine is moving in the direction of a non-linear approach to disease.  This brief review discusses the early analysis of the relationship of psychiatric conditions, inflammation, and cardiovascular disease.
Nathan Goodyear

http://news.a4m.com/issues/20140211/Testosterone-and-Heart-Disease.pdf?utm_source=web_e... - 0 views

news.a4m.com/...osterone-and-Heart-Disease.pdf

Testosterone low T CVD cardiovascular disease pamela smith therapy treatment men male hormone hormones

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    Excellent review of the current literature on Testosterone and cardiovascular disease as well as a brief discussion of the flaws in the recent published articles pointing to increased CVD with Testosterone therapy.
Nathan Goodyear

Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease... - 0 views

www.telomerescience.com/...-from-the-heart-and-soul-study

Telomere length cardiovascular disease CVD

shared by Nathan Goodyear on 19 Jul 11 - No Cached
  • Nathan Goodyear on 19 Jul 11
     
    telomere length may play a role in cardiovascular disease development
Nathan Goodyear

Nonfasting Apolipoprotein B and Triglyceride Levels as a Useful Predictor of Coronary H... - 0 views

atvb.ahajournals.org/...1918.long

lipoproteins apo B apo A1 apolipoproteins Apolipoprotein B Apolipoprotien A1 cholesterol HDL cardiovascular disease risk heart disease

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    non fasting apo B plus HDL is predictive of cardiovascular disease risk. Apo a1 was not predictive.  
Nathan Goodyear

Beyond the male sex hormone: deciphering the metabolic and vascular actions of testoste... - 0 views

joe.endocrinology-journals.org/...C1.full

AR androgen receptors androgen receptor testosterone androgen receptors Diabetes metabolic syndrome MetS CVD cardiovascular disease men hormone hormones male

shared by Nathan Goodyear on 08 May 13 - No Cached
  • androgen deprivation therapy results in unfavorable changes in body composition, insulin resistance, and dyslipidemia and predisposes men to develop atherosclerosis and an increased risk of cardiovascular mortality
  • The hypogonadal–obesity cycle hypothesis was originally proposed by Cohen in 1999 to explain the relationship between low testosterone levels and metabolic disease. It was based on the finding that obesity impairs testosterone levels by increasing the aromatization of testosterone to estradiol, while low testosterone levels promote increased fat deposition
  • adipocytokines contribute to low testosterone levels as well as to the processes underlying metabolic syndromes and type 2 diabetes
  • ...15 more annotations...
  • hypogonadal–obesity–adipocytokine hypothesis
  • The presence of estradiol and the adipocytokines TNF-α, IL6, and leptin (as a result of leptin resistance in obesity) inhibits the hypothalamic–pituitary–testicular axis response to decreasing androgen levels
  • An increasing number of studies have illustrated the potential for applying metabolomics to the field of androgen research
  • As early as the 1940s, the therapeutic use of testosterone was reported to improve angina pectoris in men with coronary artery disease
  • most of the epidemiological studies reported increased cardiovascular risk and mortality in men with low testosterone levels
  • long-term testosterone replacement appears to be a safe and effective means of treating hypogonadal elderly men
  • a recent interventional trial showed that testosterone treatment was associated with decreased mortality when compared with no testosterone treatment in an observational cohort of men with low testosterone levels
  • a number of short-term studies conducted support the notion that testosterone therapy reduces the cardiovascular risk
  • The majority of animal studies support the hypothesis that the actions of testosterone on vascular relaxation are both endothelium-dependent and -independent vasodilatory effects
  • Endothelial-dependent actions of testosterone increase the expression or activity of endothelial nitric oxide synthase and enhance nitric oxide production, which in turn activates cyclic guanosine monophosphate to induce vasorelaxation in smooth muscle cells
  • Endothelial-independent mechanisms of testosterone are believed to occur primarily via inhibition of voltage-operated Ca2+ channels and/or activation of K+ channels in smooth muscle cells
  • Testosterone may also inhibit intracellular Ca2+ influx via store-operated Ca2+ channels by blocking the response to prostaglandin F2α
  • testosterone has demonstrated anti-inflammatory effects to protect against atherogenesis in animal studies
  • both genomic AR activation to modulate gene transcription and non-genomic activation to modulate the rapid intracellular signaling pathways of ion channels may mediate testosterone effects on vascular function and inflammation.
  • Butenandt & Ruzicka first showed how testosterone is synthesized and responsible for masculine characteristics in the early 1930s
  • Nathan Goodyear on 08 May 13
     
    Awesome review on the current understanding of Testosterone and Diabetes, metabolic syndrome, and CVD.  This article even goes into the literature on androgen receptors.
Nathan Goodyear

Clinical Importance of Obesity Versus the Metabolic Syndrome in Cardiovascular Risk in ... - 0 views

circ.ahajournals.org/...706.full

metabolic syndrome MetS weight-loss overweight obesity CVD cardiovascular disease

shared by Nathan Goodyear on 30 Mar 12 - No Cached
  • Nathan Goodyear on 30 Mar 12
     
    weight loss improves metabolic syndrome, which results in reduced cardiovascular disease
Nathan Goodyear

Medical News: HbA1c More Predictive than Glucose - in Cardiovascular, Diabetes from Med... - 0 views

www.medpagetoday.com/...18815

HbA1C glucose diabetes cardiovascular disease risk

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    HgbA1C more predictive than fasting glucose in predicting cardiovascular disease risk in non-diabetics
Nathan Goodyear

Androgen Deprivation Therapy, Insulin Resistance, and Cardiovascular Mortality: An Inco... - 0 views

onlinelibrary.wiley.com/...full

androgen deprivation therapy androgen male men hormone hormones deprivation therapy prostate cancer cardiovascular disease insulin resistance diabetes metabolic syndrome mortality CVD

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    Androgen deprivation therapy is associated with increased diabetes, metabolic syndrome, insulin resistance, and cardiovascular mortality.  The longer the duration of therapy, the more the progression of metabolic dysfunction.  This process seems similar to chemotherapy i.e. secondary cancer due to chemotherapy.  The treatment of one disease, prostate cancer in this case, leads to an increase in the risk of the #1 killer in men--logic seems severely flawed there.
Nathan Goodyear

Blood Lead Is a Predictor of Homocysteine Levels: Abstract and Introduction - 0 views

www.medscape.com/...497373

lead homocysteine cardiovascular disease

shared by Nathan Goodyear on 14 Feb 11 - No Cached
  • These results suggest that homocysteine could be a mechanism that underlies the effects of lead on the cardiovascular and central nervous systems, possibly offering new targets for intervention to prevent the long-term consequences of lead exposure
  • Nathan Goodyear on 14 Feb 11
     
    Lead, homocysteine, and cardiovascular disease, oh my
Nathan Goodyear

More about plasma renin and cardiovascular mortality - 0 views

eurheartj.oxfordjournals.org/...eurheartj.ehr187.extract

plasma renin cardiovascular disease mortality hypertension

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    plasma renin and cardiovascular disease and mortality.
Nathan Goodyear

Vitamin D and cardiovascular risk. [Int Urol Nephrol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20039126

D vitamin cardiovascular disease hypertension atherogenesis

shared by Nathan Goodyear on 06 Oct 11 - No Cached
  • vitamin D supplementation in adults may be regarded as simple means with few potential side effects to prevent atherogenesis or halt its progression and combat arterial hypertension
  • Nathan Goodyear on 06 Oct 11
     
    Vitamin D proves to be powerful benefit in those at risk for cardiovascular disease.
Nathan Goodyear

Cardiovascular Risk in Adult Patients With Growth Hormone (GH) Deficiency and Following... - 0 views

press.endocrine.org/...jc.2013-2394

Growth hormone growth hormone GH hormones cardiovascular disease metabolism

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    low Growth hormone levels in adults shown to be associated with increased cardiovascular disease.  Increased inflammatory cytokines, CRP, glucose, and abnormal lipid profile are all found to be associated with low GH in adults.
Nathan Goodyear

Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the ... - 0 views

www.nejm.org/...NEJMoa021993

CRP c-reactive protein LDL cholesterol cardiovascular disease cardiovascular events

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    CRP is more predictive than LDL in predicting cardiovascular events.
Nathan Goodyear

Effect of selenium and Q10 on the cardiac biomarker NT-proBNP: Scandinavian Cardiovascu... - 0 views

www.tandfonline.com/...14017431.2013.820838

CoQ10 Selenium cardiovascular disease mortality NT-proBNP cardiovascular heart health

shared by Nathan Goodyear on 11 Apr 17 - No Cached
  • Nathan Goodyear on 11 Apr 17
     
    4 year study finds that 200 mg CoQ10 and 200 mg Se reduced NT-proBNP and cardiovascular mortality.  
Nathan Goodyear

Blood Lead Below 0.48 μmol/L (10 μg/dL) and Mortality Among US Adults - 0 views

circ.ahajournals.org/...1388.full

Pb lead cardiovascular disease mortality

shared by Nathan Goodyear on 18 Sep 14 - No Cached
  • Nathan Goodyear on 18 Sep 14
     
    Lead levels lead to increased risk of cardiovascular events at lower than previous thought levels.  Levels as low as 2mcg/dl found to be associated with increased cardiovascular mortality.  This equates to 38% of Americans.  The author concludes with this statement, "Although a 10-fold decline in blood lead levels has occurred in the United States in recent decades, current levels remain orders of magnitude higher than in pre industrialized times".
Nathan Goodyear

Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Am... - 0 views

circ.ahajournals.org/...731

CRP cardiovascular risk women

shared by Nathan Goodyear on 04 Feb 11 - No Cached
  • CRP is a strong independent risk factor for cardiovascular disease that adds to the predictive value of risk models based on usual factors alone.
  • Nathan Goodyear on 04 Feb 11
     
    CRP is marker for cardiovascular risk in women
Nathan Goodyear

Abstract 21277: Homocysteine and Cardiovascular Risk in Low Risk Healthy Adults - An An... - 0 views

circ.ahajournals.org/...A21277

homocysteine cardiovascular CAD disease

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • Homocysteine significantlyimproves risk prediction of cardiovascular events in healthyadults
  • Nathan Goodyear on 03 Aug 11
     
    homocysteine found to be helpful in predicting cardiovascular events in healthy adults
Nathan Goodyear

Menopausal Complaints Are Associated With Cardiovascular Risk Factors - 0 views

hyper.ahajournals.org/...1492.full

cardiovascular disease CVD heart health hot flashes night sweats vasomotor symptoms women female menopausal symptoms

shared by Nathan Goodyear on 11 Mar 15 - No Cached
  • women with complaints of flushing or night sweats have an unfavorable cardiovascular risk profile compared with women without vasomotor complaints and with increased cholesterol levels, systolic and diastolic blood pressures, and BMI.
  • Nathan Goodyear on 11 Mar 15
     
    Women with hot flashes and night sweats have increased cardiovascular risk compared to women that do not.
Nathan Goodyear

In vivo transcriptomic profile after a Mediterranean diet in high-cardiovascular risk p... - 0 views

ajcn.nutrition.org/...845.short

Mediterranean diet nutrition heart failure heart heart health cardiovascular disease hypertension extra virgin olive oil cardiovascular

shared by Nathan Goodyear on 01 Jun 17 - No Cached
  • Nathan Goodyear on 01 Jun 17
     
    Diet is a language that interacts with out DNA.  Study finds that Mediterranean diet + extra virgin olive oil alters genetic expression to reduce cardiovascular risk.
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