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Nathan Goodyear

The mineral selenium proves itself as powerful anti-cancer medicine - 0 views

  • In a December 1996 article in the Journal of the American Medical Association, Dr. Larry Clark presented evidence that supplemental selenium could reduce cancer death rates by as much as 50%
  • patients receiving selenium had a 67% decrease in cancer of the prostate, a 58 percent decrease in colon or rectal cancer and a 45% decrease in lung cancer
  • An article in the Journal of the American Medical Association (JAMA) by Clark et al. (1996) showed that 200 mcg of supplemental selenium a day reduced overall cancer mortality by 50% in humans compared to a placebo group not receiving supplemental selenium
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  • In a recent five-year study of nearly 30,000 rural Chinese people, researchers from the NCI found that daily doses of these three nutrients reduced cancer deaths by 13%.
  • In a study in Cancer Letters (Evangelou et al. 1997), animals with malignant tumors given high doses of vitamins C and E and selenium manifested a significant prolongation of the mean survival time. Complete remission of tumors developed in 16.8% of the animals
  • cities and states with high selenium content in the soil also had significantly lower rates of cancer, especially of the digestive and urinary systems.
  • In one study of hundreds of men, a daily intake of 200 micrograms of selenium cut the incidence of prostate cancer by 60 percent.
  • The statistics for breast cancer are particularly striking. "The higher the selenium, the lower the breast cancer
  • In Yugoslavia, scientists studied 33 patients with breast cancer. These women had selenium levels in their bloodstream only half those of healthy volunteers.
  • The overall reduction in cancer incidence was 37% in the selenium-supplemented group; a 50% reduction in cancer mortality was observed over a 10-year period
  • The following are the site-specific reductions in cancer incidence observed in the study: colon-rectal cancers (58%), lung cancer (46%), and prostate cancer (63%)
  • A selenium deficiency appears to increase the risk of prostate cancer fourfold to fivefold
  • It was determined that, as the male population ages, selenium levels decrease, paralleling an increase in prostate cancer
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    exhaustive discussion selenium deficiency and increased cancer risk
Nathan Goodyear

Selenium and human health : The Lancet - 0 views

  • Low selenium status has been associated with increased risk of mortality, poor immune function, and cognitive decline
  • Higher selenium status or selenium supplementation has antiviral effects, is essential for successful male and female reproduction, and reduces the risk of autoimmune thyroid disease.
  • Prospective studies have generally shown some benefit of higher selenium status on the risk of prostate, lung, colorectal, and bladder cancers, but findings from trials have been mixed, which probably emphasises the fact that supplementation will confer benefit only if intake of a nutrient is inadequate
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    Selenium is a "U" shaped curve.  Abstract only available here.
Nathan Goodyear

The antioxidant role of selenium and seleno-compounds. - PubMed - NCBI - 0 views

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    Selenium (Se) deficiency is associated with increased oxidative stress.  Selenium is a cofactor necessary for glutathione perioxidase.  Selenium reduced 8-OHdG, promoted cell growth inhibition and cell death pointing to significant Cancer implications.
Nathan Goodyear

Selenium in reproductive health - 0 views

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    Many studies have been published on Selenium deficiency and decreased reproduction and pregnancy complications.  This study provides a nice review of Selenium and reproduction.  This is a just the abstract and will post the full article when it become available
Nathan Goodyear

Hemolysate Thioredoxin Reductase and Glutathione Peroxidase Activities Correlate with S... - 0 views

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    Study finds selenium supplementation correlates with glutathione peroxidase and thioredoxin reductase activity. The has key implications in cancer as selenium deficiency is a common finding in patients with cancer, here in this study patients at high risk of prostate cancer.
Nathan Goodyear

Uptake, Distribution, and Speciation of Selenoamino Acids by Human Cancer Cells: X-ray ... - 0 views

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    cancer benefits from selenium depend on type of selenium supplemented
Nathan Goodyear

ASSOCIATION BETWEEN SERUM SELENIUM AND THE RISK OF CANCER - 0 views

  • These data support the hypothesis that selenium deficiency increases the rlsk of certain cancers in middle-aged persons.
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    low selenium increases risk of certain cancers
Nathan Goodyear

Selenium and L-carnitine reduce oxidative stress in the heart of rat induced by 2.45-GH... - 0 views

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    animal study finds high dose Carnitine plus selenium protects against oxidative stress of the heart.
Nathan Goodyear

The Role of Selenium in Thyroid Hormone Action -- BERRY and LARSEN 13 (2): 207 -- Endoc... - 0 views

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    selenium deficiency results in low thyroid function: yes a mineral.
Nathan Goodyear

Linus Pauling Institute at Oregon State University - 0 views

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    wonderful review on the benefits of selenium
Nathan Goodyear

ScienceDirect - NeuroToxicology : Selenium from dietary sources and motor functions in ... - 0 views

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    selenium intake shown to improve motor function in those with high methyl Mercury and lead levesl; study of riverside populations with known high mercury levels
Nathan Goodyear

Selenium-vitamin E supplementation in infertile men: effects on - 0 views

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    antioxidants, selenium and Vitamin E, improve infertility rates in men
Nathan Goodyear

The trace element selenium and the thyroid gland. - PubMed - NCBI - 0 views

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    Selenium is very important in thyroid function, not just Iodine.  Low Se levels significantly correlate with thyroid cancer.
Nathan Goodyear

Selenium in soil and endemic diseases in China. - PubMed - NCBI - 0 views

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    Selenium deficiencies, selenosis, lead to disease.
Nathan Goodyear

Dietary intake and urinary excretion of selenium in the Japanese adult population: the ... - 0 views

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    Urinary excretion of selenium proved to be a good marker of dietary Se intake in Japanese study.
Nathan Goodyear

Selenium in Human Health and Disease | Abstract - 0 views

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    Selenium deficiency has important implications in disease: including CVD, GI cancer, prostate cancer, and diabetes.
Nathan Goodyear

Optimal Serum Selenium Concentrations Are Associated with Lower Depressive Symptoms and... - 0 views

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    Optimal Selenium levels associated with lower incidence of depressive moods--link to optimal glutathione pathways?  
Nathan Goodyear

Hypercholesterolemia and apolipoprotein B expression: Regulation by selenium status | L... - 0 views

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    study finds selenium and apoB inversely related.
Nathan Goodyear

The effect of parenteral selenium on outcomes of mechanically ventilated patients follo... - 0 views

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    selenium IV in sepsis patients increased glutathione peroxidase and reduced ventilator associated pneumonia.
Nathan Goodyear

Kolaviron and selenium reduce hydrogen peroxide-induced alterations of the inflammatory... - 0 views

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    selenium reduces inflammatory signaling i.e. IL-1, IL-6...
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