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Nathan Goodyear

High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fat... - 0 views

www.thelancet.com/...fulltext

lipoproteins apolipoproteins apo B apo A1 Apo B:Apo A1 Apolipoprotein B Apolipoprotien A1 cholesterol heart health cardiovascular disease risk

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Study finds strong correlation between Apo B and Apo B:apo A1 in fatal MI risk in men and women.  Apo B was a stronger than LDL in predicting risk in men and women.  Apo A1 was noted to be protective, but the stats were less strong.
Nathan Goodyear

Associations between apolipoprotein B, apolipop... [J Intern Med. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16629854

Apo B:Apo A1 apo B apo A1 Apolipoprotein B Apolipoprotien A1 lipoproteins cardiovascular disease risk

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  • Nathan Goodyear on 26 Aug 14
     
    Meta-analysis finds "strong association" between Apo A1, Apo B and the ratio Apo B:A1 and cardiovascular risk.
Nathan Goodyear

Apo B/Apo A-I Ratio is Statistically A Better Predictor of Cardiovascular Disease (CVD)... - 0 views

www.ncbi.nlm.nih.gov/...PMC3972591

cardiovascular disease Apo B:Apo A1 cholesterol apo A1 apo B apolipoprotein lipoprotein Apolipoprotein B Apolipoprotien A1 risk

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Apo B:apo A1 is a better predictor of cardiovascular risk than a traditional cholesterol panel is.
Nathan Goodyear

http://www.aacc.org/members/nacb/LMPG/OnlineGuide/PublishedGuidelines/risk/Documents/Ch... - 0 views

www.aacc.org/...Chapter6.pdf

Apolipoprotein B Apolipoprotien A1 Apo B:Apo A1 lipoproteins cardiovascular disease risk CVD cholesterol

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    chapter points to the evidence on Apolipoprotien B and Apolipoprotein A1.  The evidence is strongest for Apo B and the Apo B:Apo A1 ratio.  
Nathan Goodyear

Nonfasting Apolipoprotein B and Triglyceride Levels as a Useful Predictor of Coronary H... - 0 views

atvb.ahajournals.org/...1918.long

lipoproteins apo B apo A1 apolipoproteins Apolipoprotein B Apolipoprotien A1 cholesterol HDL cardiovascular disease risk heart disease

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    non fasting apo B plus HDL is predictive of cardiovascular disease risk. Apo a1 was not predictive.  
Nathan Goodyear

Effect of potentially modifiable risk facto... [Lancet. 2004 Sep 11-17] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15364185

heart health cardiovascular disease risk Apo B:Apo A1 apo B apo A1 lipoproteins apolipoproteins cholesterol

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Stronger association found with apo B:apo A1 and cardiovascular disease risk than compared to cholesterol panel.
Nathan Goodyear

Plasma lipoproteins: composition, structure and biochemistry - 0 views

lipidlibrary.aocs.org/...index.htm

apolipoproteins cholesterol VLDL chylomicrons LDL HDL lipoproteins biochemistry

shared by Nathan Goodyear on 21 May 13 - No Cached
  • triacylglycerols
  • The most abundant lipid constituents are triacylglycerols, free cholesterol, cholesterol esters and phospholipids (phosphatidylcholine and sphingomyelin especially ), though fat-soluble vitamins and anti-oxidants are also transported in this way
  • the lipoprotein aggregates should be described in terms of the different protein components or apoproteins (or 'apolipoproteins'
  • ...8 more annotations...
  • these classes can be further refined by improved separation procedures, and intermediate-density lipoproteins (IDL) and subdivisions of the HDL (e.g. HDL1, HDL2, HDL3 and so forth
  • Density is determined largely by the relative concentrations of triacylglycerols and proteins and by the diameters of the broadly spherical particles
  • Lipoproteins are spherical (VLDL, LDL, HDL) to discoidal (nascent HDL) in shape with a core of non-polar lipids, triacylglycerols and cholesterol esters, and a surface monolayer, ~20Å thick, consisting of apoproteins, phospholipids and non-esterified cholesterol, which serves to present a hydrophobic face to the aqueous phase
  • the various lipid components should not be considered as absolute, as they are in a state of constant flux
  • Apo A1 is the main protein component of HDL
  • Apo A2 is the second most important HDL apolipoprotein
  • the main groups are classified as chylomicrons (CM), very-low-density lipoproteins (VLDL), low-density lipoproteins (LDL) and high-density lipoproteins (HDL), based on the relative densities of the aggregates on ultracentrifugation
  • The lipoproteins can be categorised simplistically according to their two main metabolic functions. The principal role of the chylomicrons and VLDL is to transport triacylglycerols ‘forward’ as a source of fatty acids from the intestines or liver to the peripheral tissues. In contrast, the HDL remove excess cholesterol from peripheral tissues and deliver it to the liver for excretion in bile in the form of bile acids (‘reverse cholesterol transport’). While these functions are considered separately here for convenience, it should be recognised that the processes are highly complex and inter-related, and they involve transfer of apoproteins, enzymes and lipid constituents among the heterogeneous mix of all the lipoprotein fractions.
  • Nathan Goodyear on 21 May 13
     
    Awesome review of apolipoproteins, their function, and their metabolism.
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