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Nathan Goodyear

Singapore Medical Association (SMA) - Formed in 1959, the Singapore Medical Association... - 0 views

sma.org.sg/...articles.aspx

type II diabetes Diabetes DM omega 3 EPA HbA1C HgbA1C insulin sensitivity insulin resistance insulin

shared by Nathan Goodyear on 06 Aug 13 - No Cached
  • Nathan Goodyear on 06 Aug 13
     
    Omega 3 associated with improved insulin sensitivity, reduced HbA1C, reduced fasting glucose.  This study looked at the specific effect of EPA in those with type II diabetes
Nathan Goodyear

Arch Intern Med -- Cardiovascular Risk Prediction in Diabetic Men and Women Using Hemog... - 0 views

archinte.ama-assn.org/...archinternmed.2011.351

cardiovascular diabetic HbA1C

shared by Nathan Goodyear on 22 Aug 11 - No Cached
  • Nathan Goodyear on 22 Aug 11
     
    HbA1C predictive of cardiovascular disease risk
Nathan Goodyear

Medical News: HbA1c More Predictive than Glucose - in Cardiovascular, Diabetes from Med... - 0 views

www.medpagetoday.com/...18815

HbA1C glucose diabetes cardiovascular disease risk

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    HgbA1C more predictive than fasting glucose in predicting cardiovascular disease risk in non-diabetics
Nathan Goodyear

Effect of vitamin C on blood glucose, serum lipids... [Indian J Med Res. 2007] - PubMed... - 0 views

www.ncbi.nlm.nih.gov/...18160753

vitamin C blood glucose lipids cholesterol

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • Nathan Goodyear on 09 Jul 11
     
    1,000 mg Vitamin C improves Blood glucose and lipid levels in Type II DM. Also, known to improve HbA1c levels as well
Nathan Goodyear

Nutrients | Free Full-Text | Vitamin C Status Correlates with Markers of Metabolic and ... - 0 views

www.mdpi.com/...htm

vitamin C health cognition

shared by Nathan Goodyear on 28 Feb 18 - No Cached
  • vitamin C deficiency is the fourth most prevalent nutrient deficiency reported in the United States
  • Hypovitaminosis C (defined as a plasma concentration ≤23 µmol/L)
  • The CHALICE (Canterbury Health, Ageing and Lifecourse) study is a unique New Zealand study comprising a comprehensive database of determinants of health
  • ...17 more annotations...
  • The CHALICE cohort of 404 individuals aged 50 years had an average vitamin C intake of ~110 mg/day, which should provide adequate plasma concentrations [14]. Despite this, a significant proportion of the participants had inadequate plasma vitamin C status
  • inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
  • adequate plasma levels (i.e., >50 µmol/L)
  • Higher plasma vitamin C status was associated with lower weight, BMI and waist circumference
  • plasma vitamin C was negatively associated with blood triglycerides, HbA1c and insulin, and positively associated with HDL levels.
  • No correlation was found between plasma vitamin C and the two indicators of heart health; blood pressure and cardiovascular risk score.
  • 2.4% of 50-year-olds were deficient in vitamin C (i.e., <11 µmol/L)
  • hypovitaminosis C (i.e., <23 µmol/L)
  • A high proportion (63%) of our participants had inadequate plasma vitamin C concentrations (i.e., <50 µmol/L)
  • The association of low vitamin C with obesity in this study replicates results in the literature [35,40,41,42,43,44], and it is apparent that individuals with higher weight require higher intakes of vitamin C to reach adequate vitamin C status
  • higher plasma vitamin C status is associated with lower circulating levels of blood triglycerides, insulin and HbA1c
  • A role for vitamin C in the prevention or management of diabetes and/or metabolic syndrome has been suggested
  • In this study, we also demonstrate lower levels of mild cognitive impairment in those with high vitamin C status
  • The odds of mild cognitive impairment were twice as high for those below 23 μmol/L plasma vitamin C concentration.
  • Vitamin C is present at very high concentrations in the brain
  • animal models have shown that the brain is the last organ to be depleted of the vitamin during prolonged deficiency
  • A recent animal study has shown that moderate vitamin C deficiency may play a role in accelerating amyloid plaque accumulation in Alzheimer’s disease
  • Nathan Goodyear on 28 Feb 18
     
    New study: vitamin C levels correlate with cognitive and metabolic health. What is your vitamin C level? Despite the adequate levels of vitamin C intake, a large % of the individuals had inadequate vitamin C levels which points to a demand issue.  Higher oxidative stress, chronic inflammation... would drive demand for vitamin C higher. Lower vitamin C levels were associated with more metabolic disease, ie. DM, and more cognitive decline.
Nathan Goodyear

Type 2 diabetes mellitus and testosterone: a meta-... [Int J Androl. 2010] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...20969599

testosterone diabetes Type II hormone

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • Combining the results of RCTs, TRT was associated with a significant reduction in fasting plasma glucose, HbA1c, fat mass and triglycerides
  • TRT seems to improve glycometabolic control as well as fat mass in T2DM subjects.
  • Nathan Goodyear on 19 Nov 10
     
    Testosterone therapy improved Type II diabetes control
Nathan Goodyear

Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Typ... - 0 views

onlinelibrary.wiley.com/...full

Cinnamon HgbA1c diabetes glucose control blood pressure

shared by Nathan Goodyear on 05 Apr 11 - No Cached
  • Intake of 2g of cinnamon for 12 weeks significantly reduces the HbA1c, SBP and DBP among poorly controlled type 2 diabetes patients. Cinnamon supplementation could be considered as an additional dietary supplement option to regulate blood glucose and blood pressure levels
  • Nathan Goodyear on 05 Apr 11
     
    Cinnamon lowers HgbA1C over 12 weeks of treatment
Nathan Goodyear

Testosterone and benign prostatic hyperplasia Jarvis TR, Chughtai B, Kaplan SA, - Asian... - 0 views

www.ajandrology.com/preprintarticle.asp

Testosterone BPH low T low Testosterone prostate cancer men male hormone hormones

shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • The prevalence of hypogonadism (often defined as serum testosterone < 300 ng dl−1 ) ranges from 6% [10] to as high as 38%
  • The process of BPH, however, continues as men age and despite the fact their serum testosterone decreases
  • Liu et al. [12] demonstrated that in a group of older males (mean age 59.8 years) that there was not a significant correlation of serum testosterone levels (total, free or bioavailable) with either prostate volume or International Prostate Symptom Score (IPSS)
  • ...11 more annotations...
  • in eugonadal men, studies have demonstrated that the prostate can increase in volume by approximately 12%
  • There seems to be little doubt that the treatment with testosterone of a young hypogonadal male leads to significant growth of the prostate
  • Behre et al. [22] demonstrated increased prostate volume and prostate-specific antigen (PSA) levels in hypogonadal men
  • Most studies, however, have shown no effect of exogenous androgens on PSA or prostate volume for older hypogonadal males
  • They argue that the prostate is relatively insensitive to changes in androgen concentration at normal levels or in mild hypogonadism because the AR is saturated by androgens and therefore maximal androgen-AR binding is achieved. Conversely, the prostate is very sensitive to changes in androgen levels when testosterone is low
  • saturation model
  • visceral obesity (one of the most significant components of metabolic syndrome) is associated with prostate volume and influences prostate growth during TRT.
  • This hypothesis of inflammation induced LUTS is also argued to be a mechanism for improvement of LUTS with PDE5I
  • The concept, therefore, that treatment with TRT of hypogonadal males with metabolic syndrome might lead to improvement/stabilization of their LUTS, appears to be confirmed in recent work by Francomano et al.
  • There was also an improvement in components of the patient's metabolic syndrome (such as BMI, waist circumference, hemoglobin A1c [HbA1c], insulin sensitivity, and lipid profile) as well as inflammatory markers and C-reactive protein.
  • They concluded that TRT was safe in this group of men, and hypothesize that TRT mitigates the pro-inflammatory factors associated with metabolic syndrome.
  • Nathan Goodyear on 01 Dec 14
     
    Authors review the literature behind Testosterone and BPH.  The authors highlight the 4 proposed theories behind BPH: Testosterone, Estrogen, inflammation, and metabolic.   The conclusion is mixed: pointing out that no high level of evidence exists on either side of the debate of Testosterone and BPH.
Nathan Goodyear

Correlation between elevated serum ferritin and HbA1c in type 2 diabetes mellitus - Int... - 0 views

www.scopemed.org/?mno=33486

ferritin diabetes glucose

shared by Nathan Goodyear on 04 Nov 15 - No Cached
  • Nathan Goodyear on 04 Nov 15
     
    positive correlation between ferritin and HgbA1c and fasting blood glucose.
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