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Matti Narkia

Overview and perspective in human nutrition. Willett WC. - Asia Pac J Clin Nutr. 2008; - 0 views

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    Overview and perspective in human nutrition.
    Willett WC.
    Asia Pac J Clin Nutr. 2008;17 Suppl 1:1-4. Review.
    PMID: 18296289

    For the last decade, the focus of nutritional advice for prevention of chronic disease has been to limit or reduce
    total fat intake and to consume large amounts of carbohydrate. However, this advice is inconsistent with many
    lines of evidence indicating that unsaturated fats have beneficial metabolic effects and reduce risk of coronary
    heart disease. More recent evidence has also shown that the large majority of carbohydrates in Western diets,
    consisting of refined starches and sugars, have adverse metabolic effects and increase risks of coronary heart
    disease and type 2 diabetes. Unfortunately, a major opportunity for health improvement has been lost by failing
    to distinguish healthy from unhealthy forms of carbohydrates and fats. Recent analyses indicate that moderate
    changes in diet, together with regular physical activity and not smoking, can prevent the large majority of heart
    disease, type 2 diabetes, and some forms of cancer. These findings have substantial relevance for many populations
    in Asia, where incidence of type 2 diabetes is rising rapidly.
Matti Narkia

Reducing the Burden of Disease Through Adequate Intake of Vitamin D3 by William B. Gran... - 0 views

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    Reducing the Burden of Disease Through Adequate Intake of Vitamin D3.
    A presentation at University of California, San Diego,
    April 9, 2008
    by William B. Grant, Ph.D
Matti Narkia

NEJM -- Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reacti... - 0 views

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    Conclusions In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events. \n\nRosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.\nRidker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group.\nN Engl J Med. 2008 Nov 20;359(21):2195-207. Epub 2008 Nov 9.\nPMID: 18997196
Matti Narkia

NEJM -- Expanding the Orbit of Primary Prevention -- Moving beyond JUPITER - 0 views

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    Expanding the orbit of primary prevention--moving beyond JUPITER.
    Hlatky MA.
    N Engl J Med. 2008 Nov 20;359(21):2280-2. Epub 2008 Nov 9.
    PMID: 18997195
Matti Narkia

Statins in the Water? Not So Fast - Well Blog - NYTimes.com - 0 views

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    Last week, Harvard researchers reported how healthy 50-year-old men and 60-year-old women could benefit from taking a statin even if they didn't have high cholesterol. The people they studied had high levels of C-reactive protein, or CRP, which is a marker for inflammation. The study showed that risk for major heart problems was cut by about 50 percent among the statin users.\n\nBut like many industry-sponsored drug studies, the results focused on something called "relative risk," which compares differences between study groups. Relative risk has the effect of exaggerating a drug's benefits. What does a 50 percent reduction in heart risk mean? It means that just one out of 120 statin users was helped by the drug.
Matti Narkia

Well - A Call for Caution in the Rush to Statins - NYTimes.com - 0 views

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    Judging by recent headlines, you might think so. Last week heart researchers reported that millions of healthy people could benefit from taking statins even if they don't have high cholesterol.\n\nAlthough many doctors hailed the study as a major breakthrough, a closer look at the research suggests that statins (like Crestor, from AstraZeneca, and Lipitor, from Pfizer) are far from magic pills. While they clearly save lives in people with a previous heart attack or other serious heart problems, for an otherwise healthy person the potential benefit remains small.
Matti Narkia

Cholesterol-Fighting Drugs Show Wider Benefit - New York Times - 0 views

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    CHART: Statins Reduce Risks: A study of 18,000 people with high levels of C-reactive protein, or CRP, found that the risk of a heart attack or stroke was cut in half among those who took a statin. The study was stopped after two years, but some participants were tracked for up to five years. (Sources: Dr. Paul M. Ridker; New England Journal of Medicine) (pg.A21)
    A large new study suggests that millions more people could benefit from taking the cholesterol-lowering drugs known as statins, even if they have low cholesterol, because the drugs can significantly lower their risk of heart attacks, strokes and death.

    The study, involving nearly 18,000 people worldwide, tested statin treatment in men 50 and older and in women 60 and older who did not have high cholesterol or histories of heart disease. What they did have was high levels of a protein called high-sensitivity C-reactive protein, or CRP, which indicates inflammation in the body.
Matti Narkia

The Bioavailability of Vitamin D from Fortified Cheeses and Supplements Is Equivalent i... - 0 views

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    The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults.
    Wagner D, Sidhom G, Whiting SJ, Rousseau D, Vieth R.
    J Nutr. 2008 Jul;138(7):1365-71.
    PMID: 18567762

    Compared with baseline, serum parathyroid hormone decreased with both fortification (P = 0.003) and supplementation (P = 0.012). These data demonstrate that vitamin D is equally bioavailable from fortified hard cheeses and supplements, making cheese suitable for vitamin D fortification.
Matti Narkia

Where does the gene activity of youth go? New findings may hold the key - 0 views

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    "November 26, 2008

    New evidence may explain why it is that we lose not only our youthful looks, but also our youthful pattern of gene activity with age. A report in the November 26th issue of the journal Cell, a Cell Press publication, reveals that a protein perhaps best known for its role in the life-extending benefits of a low-calorie diet also maintains the stability of the mammalian genome-the complete set of genetic instructions "written" in DNA.

    The researchers found in studies of mammalian stem cells that the protein SIRT1 controls the packaging of DNA into chromatin, thereby setting the youthful pattern of gene activity by keeping select genes switched off. In response to DNA damage, those SIRT1 proteins leave their posts to go off and assist in the necessary repairs. That change in SIRT1's job description leads to shifts in gene activity that parallel those seen in the aging mouse brain, they show. They suspect similar changes would also be found in other body tissues as well."
Matti Narkia

On the Trail of the Elusive X-Factor: A Sixty-Two-Year-Old Mystery Finally Solved - 0 views

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    In 1945, Dr. Weston Price described "a new vitamin-like activator" that played an influential role in the utilization of minerals, protection from tooth decay, growth and development, reproduction, protection against heart disease and the function of the brain.

    Using a chemical test, he determined that this compound-which he called Activator X-occurred in the butterfat, organs and fat of animals consuming rapidly growing green grass, and also in certain sea foods such as fish eggs.

    Vitamin K2 is produced by animal tissues, including the mammary glands, from vitamin K1, which occurs in rapidly growing green plants.

    A growing body of published research confirms Dr. Price's discoveries, namely that vitamin K2 is important for the utilization of minerals, protects against tooth decay, supports growth and development, is involved in normal reproduction, protects against calcification of the arteries leading to heart disease, and is a major component of the brain
Matti Narkia

Vitamin K2 and coronary plaque - Wellsphere - 0 views

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    The vitamin K2 story, though still preliminary, is becoming increasingly interesting from the perspective of CT heart score reduction.
    The origin of this concept came from some unexpected observations. One, the observation that osteoporosis (lack of bone calcium that leads to fractures) arises from deficiency of vitamin K2. Two, deficiency of K2 leads to unrestrained calcium deposition in animal models, leading to heart attack in just weeks.
Matti Narkia

Vitamin D, aging, and cancer. Pentti Tuohimaa. 2008; Nutrition Reviews - Wiley InterSci... - 0 views

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    Vitamin D, aging, and cancer.
    Tuohimaa P.
    Nutr Rev. 2008 Oct;66(10 Suppl 2):S147-52. Review.
    PMID: 18844842
    DOI: 10.1111/j.1753-4887.2008.00095.x

    Deficiency of the prohormone calcidiol (25OH vitamin D3) seems to be associated with several aging-related chronic diseases including cancer. Our results suggest that calcidiol is mainly responsible for differentiation homeostasis, whereas calcitriol might be more involved in calcium homeostasis. Therefore, an imbalance of calcidiol rather than calcitriol is a risk factor for cancer and chronic diseases. Calcidiol insufficiency, as well as insufficient solar exposure, is associated with increased risk of several solid cancers. Both a vitamin D3 deficiency and a high concentration of calcidiol may increase cancer risk. Similarly, aging phenomena show a U-shaped association with vitamin D bioactivity. Therefore, the chronic diseases and cancers related to aging might be prevented by an optimal concentration of serum calcidiol, which remains to be determined.
Matti Narkia

Vitamin D and Cancer - PDFs online - IARC Working Group Reports - 0 views

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    "IARC Publications

    PDFs online - IARC Working Group Reports
    Vitamin D and Cancer "
Matti Narkia

Vitamin D and Cancer - PDFs online - IARC Working Group Reports (full text PDF) - 0 views

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    Vitamin D and Cancer - PDFs online - IARC Working Group Reports

    IARC Publications

    PDFs online - IARC Working Group Reports
    Vitamin D and Cancer "
Matti Narkia

n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects --... - 0 views

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    n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects.
    Jung UJ, Torrejon C, Tighe AP, Deckelbaum RJ.
    Am J Clin Nutr. 2008 Jun;87(6):2003S-9S.
    PMID: 18541602

    Dietary n-3 fatty acids, particularly eicosapentaenoic acid and docosahexaenoic acid, are important nutrients through the life cycle. Evidence from observational, clinical, animal, and in vitro studies indicates a beneficial role of n-3 fatty acids in the prevention and management of cardiovascular disease. Although the precise mechanisms are still unclear, clinical and preclinical studies indicate that the cardioprotective effects of n-3 fatty acids may be attributed to a number of distinct biological effects on lipid and lipoprotein metabolism, blood pressure, platelet function, arterial cholesterol delivery, vascular function, and inflammatory responses.

    Substantial evidence supports n-3 fatty acids as a practical, therapeutic adjuvant for promoting cardiovascular health and preventing and treating disease. n-3 Fatty acids modulate a number of important physiologic responses that can contribute to their cardioprotective effects. The multiple and complex mechanisms through which DHA and EPA exert their action appear to be distinct but also complementary. However, more studies are needed to quantify their protective effects and to define exact mechanisms of action.
Matti Narkia

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults - 0 views

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    Fish consumption and risk of subclinical brain abnormalities on MRI in older adults.
    Virtanen JK, Siscovick DS, Longstreth WT Jr, Kuller LH, Mozaffarian D.
    Neurology. 2008 Aug 5;71(6):439-46.
    PMID: 18678827
    doi: 10.1212/01.wnl.0000324414.12665.b0

    Conclusions:
    Among older adults, modest consumption of tuna/other fish, but not fried fish, was associated with lower prevalence of subclinical infarcts and white matter abnormalities on MRI examinations. Our results add to prior evidence that suggest that dietary intake of fish with higher eicosapentaenoic acid and docosahexaenoic acid content, and not fried fish intake, may have clinically important health benefits
Matti Narkia

Fish consumption and risk of major chronic disease in men -- Virtanen et al. 88 (6): 16... - 0 views

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    Fish consumption and risk of major chronic disease in men.
    Virtanen JK, Mozaffarian D, Chiuve SE, Rimm EB.
    Am J Clin Nutr. 2008 Dec;88(6):1618-25.
    PMID: 19064523
    doi:10.3945/ajcn.2007.25816

    Conclusions: Modest fish consumption was associated with a lower risk of total cardiovascular disease, consistent with cardiac mortality benefits but not with total cancer or overall major chronic disease; n-6 fatty acid consumption did not influence these relations.
Matti Narkia

Traditional Chinese Medicine in Treatment of Metabolic Syndrome - 0 views

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    Traditional chinese medicine in treatment of metabolic syndrome.
    Yin J, Zhang H, Ye J.
    Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):99-111. Review.
    PMID: 18537696

    Berberine from rhizoma coptidis is an oral hypoglycemic agent. It also has anti-obesity and anti-dyslipidemia activities. The action mechanism is related to inhibition of mitochondrial function, stimulation of glycolysis, activation of AMPK pathway, suppression of adipogenesis and induction of low-density lipoprotein (LDL) receptor expression.
Matti Narkia

Long-term consumption of a carbohydrate-restricted diet does not induce deleterious met... - 0 views

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    Long-term consumption of a carbohydrate-restricted diet does not induce deleterious metabolic effects.
    Grieb P, K?apcin'ska B, Smol E, Pilis T, Pilis W, Sadowska-Krepa E, Sobczak A, Bartoszewicz Z, Nauman J, Stan'czak K, Langfort J.
    Nutr Res. 2008 Dec;28(12):825-33.
    PMID: 19083495
    doi:10.1016/j.nutres.2008.09.011

    These results indicate that long-term (>1 year) compliance with a low-CHO high-fat "optimal diet" does not induce deleterious metabolic effects and does not increase the risk for cardiovascular disease, as evidenced by maintenance of adequate glycemic control and relatively low values for conventional cardiovascular risk factors.
Matti Narkia

Serum Vitamin D Concentration and Prostate Cancer Risk: A Nested Case-Control Study -- ... - 0 views

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    Serum vitamin D concentration and prostate cancer risk: a nested case-control study.
    Ahn J, Peters U, Albanes D, Purdue MP, Abnet CC, Chatterjee N, Horst RL, Hollis BW, Huang WY, Shikany JM, Hayes RB; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Project Team.
    J Natl Cancer Inst. 2008 Jun 4;100(11):796-804. Epub 2008 May 27.
    PMID: 18505967
    doi:10.1093/jnci/djn152

    CONCLUSION: The findings of this large prospective study do not support the hypothesis that vitamin D is associated with decreased risk of prostate cancer; indeed, higher circulating 25(OH)D concentrations may be associated with increased risk of aggressive disease.

    In summary, results from this large prospective study of men who underwent standardized prostate cancer screening in the context of a screening trial do not support the hypothesis that higher serum vitamin D status is associated with decreased risk of prostate cancer. The study showed no association of vitamin D level with nonaggressive disease; however, it raises the possibility that higher vitamin D level may be associated with increased risks for aggressive disease, although a clear monotonic dose-response relationship was lacking. Along with recent reports of adverse associations for higher vitamin D status and risk of pancreatic (32) and esophageal (33,34) cancer, caution should be taken in recommending high doses of vitamin D or sunlight exposure to the general public for prostate cancer prevention. Future analyses are warranted to confirm these results and to further clarify the effects of vitamin D on aggressive prostate cancer.
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