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Matti Narkia

Traditional Chinese Medicine in Treatment of Metabolic Syndrome - 0 views

    Traditional chinese medicine in treatment of metabolic syndrome.
    Yin J, Zhang H, Ye J.
    Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):99-111. Review.
    PMID: 18537696

    Berberine from rhizoma coptidis is an oral hypoglycemic agent. It also has anti-obesity and anti-dyslipidemia activities. The action mechanism is related to inhibition of mitochondrial function, stimulation of glycolysis, activation of AMPK pathway, suppression of adipogenesis and induction of low-density lipoprotein (LDL) receptor expression.
Matti Narkia

Berberine - Altern Med Rev. 2000 Apr;5(2):175-7. - 0 views

    [No authors listed]
    Altern Med Rev. 2000 Apr;5(2):175-7.
    PMID: 10767672

    Berberine is a plant alkaloid with a long history of medicinal use in both Ayurvedic and Chinese medicine. It is present in Hydrastis canadensis (goldenseal), Coptis chinensis (Coptis or goldenthread), Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), and Berberis aristata (tree turmeric). The berberine alkaloid can be found in the roots, rhizomes, and stem bark of the plants. Berberine extracts and decoctions have demonstrated significant antimicrobial activity against a variety of organisms including bacteria, viruses, fungi, protozoans, helminths, and chlamydia. Currently, the predominant clinical uses of berberine include bacterial diarrhea, intestinal parasite infections, and ocular trachoma infection
Matti Narkia

Berberine - a novel approach to cholesterol lowering; Expert Opinion on Investigational... - 0 views

    Berberine--a novel approach to cholesterol lowering.
    Doggrell SA.
    Expert Opin Investig Drugs. 2005 May;14(5):683-5.
    PMID: 15926873
Matti Narkia

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing ... - 0 views

    Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
    Zhang H, Wei J, Xue R, Wu JD, Zhao W, Wang ZZ, Wang SK, Zhou ZX, Song DQ, Wang YM, Pan HN, Kong WJ, Jiang JD.
    Metabolism. 2009 Sep 3

    Liver function was improved greatly in these patients by showing reduction of liver enzymes. Our results confirmed the activity of BBR on InsR in humans and its relationship with the glucose-lowering effect. Together with our previous report, we strongly suggest BBR as an ideal medicine for T2DM with a mechanism different from metformin and rosiglitazone.
Matti Narkia

Efficacy and safety of berberine for congestive heart failure secondary to ischemic or ... - 1 views

    Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
    Zeng XH, Zeng XJ, Li YY.
    Am J Cardiol. 2003 Jul 15;92(2):173-6.
    PMID: 12860219

    Thus, berberine improved quality of life and decreased VPCs and mortality in patients with CHF.
Matti Narkia

Efficacy of Berberine in Patients with Type 2 Diabetes - 0 views

    Efficacy of berberine in patients with type 2 diabetes mellitus.
    Yin J, Xing H, Ye J.
    Metabolism. 2008 May;57(5):712-7.
    PMID: 18442638
    doi: 10.1016/j.metabol.2008.01.013.

    Fasting plasma insulin and homeostasis model assessment of insulin resistance index were reduced by 28.1% and 44.7% (P<.001), respectively. Total cholesterol and low-density lipoprotein cholesterol were decreased significantly as well. During the trial, 20 (34.5%) patients experienced transient gastrointestinal adverse effects. Functional liver or kidney damages were not observed for all patients. In conclusion, this pilot study indicates that berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism

    In summary, that berberine is a potent oral hypoglycemic agent with modest effect on lipid metabolism. It is safe and the cost of treatment by berberine is very low. It may serve as a new drug candidate in the treatment of type 2 diabetes. However, this is a pilot study. The efficacy of berberine needs to be tested in a much larger population and characterized as a function of the known duration of the diabetes. Further studies are needed to evaluate the action of berberine on type 2 diabetes in other ethnic groups.
Matti Narkia

Berberine inhibits adipogenesis in high-fat diet-induced obesity mice - ScienceDirect -... - 0 views

    Berberine inhibits adipogenesis in high-fat diet-induced obesity mice.
    Hu Y, Davies GE.
    Fitoterapia. 2009 Oct 25. [Epub ahead of print]
    PMID: 19861153

    Our previous studies illustrated that berberine inhibited adipogenesis in murine-derived 3T3-L1 preadipocytes and human white preadipocytes. In this study, the effects of berberine on the adipogenesis of high-fat diet-induced obesity (FD) or normal diet (ND) mice and possible transcriptional impact are investigated. The results demonstrated that in FD mice, berberine reduced mouse weight gain and food intake and serum glucose, triglyceride, and total cholesterol levels accompanied with a down-regulation of PPARgamma expression and an up-regulation of GATA-3 expression. Berberine had no adverse effects on ND mice. These encouraging findings suggest that berberine has excellent pharmacological potential to prevent obesity.
Matti Narkia

Neuroprotective effects of berberine on stroke models in vitro and in vivo - ScienceDir... - 0 views

    Neuroprotective effects of berberine on stroke models in vitro and in vivo.
    Zhou XQ, Zeng XN, Kong H, Sun XL.
    Neurosci Lett. 2008 Dec 5;447(1):31-6. Epub 2008 Sep 30.
    PMID: 18838103

    Findings of this study suggest that berberine protects against ischemic brain injury by decreasing the intracellular ROS level and subsequently inhibiting mitochondrial apoptotic pathway.
Matti Narkia

Berberine: a plant alkaloid with therapeutic potential for central nervous system disor... - 0 views

    Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders.
    Kulkami SK et al.
    Phytotherapy Research, Published Online: 8 Dec 2009

    This review attempts to discuss the pharmacological basis of the use of berberine in various central nervous system
    and related disorders. Its protective effect in Alzheimer's, cerebral ischemia, mental depression, schizophrenia
    and anxiety are highlighted. However, more detailed clinical trials along with a safety assessment of berberine
    are warranted for positioning the alkaloid in the treatment of neurological disorders.
Matti Narkia

A systematic review of the anticancer properties of berberine, a natural product from C... - 0 views

    A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs.
    Sun Y, Xun K, Wang Y, Chen X.
    Anticancer Drugs. 2009 Oct;20(9):757-69.
    PMID: 19704371
Matti Narkia

Goldenseal - - 0 views

    "Today, goldenseal is marketed as a tonic to aid digestion, sooth upset stomach, and as an antibacterial and antiviral agent. It is considered a natural antibiotic and is most often combined with echinacea in preparations designed to strengthen the immune system. Many professional herbalists recommend goldenseal in herbal remedies for hay fever (also called allergic rhinitis), colds, and the flu. Goldenseal is considered a useful antiseptic (which is why some herbalists use it topically to disinfect cuts and scrapes) and astringent. It is commonly used to treat severak skin, eye, and mucous membrane inflammatory and infectious conditions (such as sinusitis, conjunctivitis, and urinary tract infections). It is also available in mouthwashes for sore throats and canker sores.

    Goldenseal has not been thoroughly investigated in scientific studies, but some trials have looked at berberine, one of the active compounds in goldenseal. Berberine is a substance widely used in Traditional Chinese Medicine to treat dysentery and infectious diarrhea. Berberine may be effective in humans for malaria, heart failure, and various types of infections, including upper respiratory problems."
Matti Narkia

BERBERINE: Uses, Side Effects, Interactions and Warnings - WebMD - 0 views

    Some medications are changed and broken down by the liver.
    Berberine might decrease how quickly the liver breaks down some medications. Taking berberine along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking berberine, talk to your healthcare provider if you are taking any medications that are changed by the liver.
    Some medications changed by the liver include cyclosporin (Neoral, Sandimmune), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others."
Matti Narkia

Goldenseal, Berberine : Safety - 0 views

    "Possible effects of berberine, a chemical found in small amounts in goldenseal, include headache, slow heart rate, nausea, vomiting, abdominal bloating, and low white blood cell count. It is not clear if the amount of berberine in goldenseal products is enough to cause these reactions. Toxic doses of berberine may cause seizures or irritation of the esophagus and stomach when taken by mouth. Berberine used intravenously (through the veins) may cause abnormal heart rhythms. Based on laboratory and animal studies, berberine may increase blood concentrations of bilirubin. Berberine theoretically may cause low blood pressure, although a different chemical in goldenseal, hydrastine, may actually cause increased blood pressure. There is limited study of the blood pressure effects of these agents in humans.

    Based on laboratory and animal studies, the use of goldenseal or berberine could increase the risk of bleeding. However, there are no reliable published reports of bleeding in humans. Caution is advised in patients with bleeding disorders or taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary.

    Based on an initial report, goldenseal or berberine may cause increased sun sensitivity, although this is not a commonly reported symptom.

    Based on laboratory studies, berberine may lower blood sugar. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Serum glucose levels may need to be monitored by a healthcare provider, and medication adjustments may be necessary. "
Matti Narkia

Huanglian - Sloan-Kettering - 0 views

    "Derived from the root of the plant. This supplement is used in traditional Chinese medicine primarily for gastrointestinal complaints, diarrhea, hypertension, bacterial and viral infections. Berberine and berberine-like alkaloids are thought responsible for its activity (1). Laboratory studies indicate that berberine induces morphological changes and internucleosomal DNA fragmentation in hepatoma cancer cells (3). Preliminary data support the hypothesis that huanglian suppresses cyclin B1 protein and causes cell cycle arrest at G2 (5). Huanglian has potent antiangiogenesis activity (6). It also interacts with acetylcholine and muscarinic receptors and inhibits cholinesterase. Possible adverse effects include nausea and vomiting (1). Theoretically huanglian may have additive hypotensive effects with antihypertensive agents. A phase I dose escalation study of huanglian in solid tumors is currently underway at Memorial Sloan-Kettering Cancer Center based on"
Matti Narkia

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xeno... - 0 views

    Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model.
    Ho YT, Yang JS, Lu CC, Chiang JH, Li TC, Lin JJ, Lai KC, Liao CL, Lin JG, Chung JG.
    Phytomedicine. 2009 Sep;16(9):887-90. Epub 2009 Mar 20.
    PMID: 19303753

    Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10mg/kg of body weight) and doxorubicin (4mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4mg/kg of doxorubicin or with 10mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic.
Matti Narkia

Berberine is a novel cholesterol-lowering drug working through a unique mechanism disti... - 0 views

    Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.
    Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, Wang Y, Wang Z, Si S, Pan H, Wang S, Wu J, Wang Y, Li Z, Liu J, Jiang JD.
    Nat Med. 2004 Dec;10(12):1344-51. Epub 2004 Nov 7.
    PMID: 15531889

    We identify berberine (BBR), a compound isolated from a Chinese herb, as a new cholesterol-lowering drug. Oral administration of BBR in 32 hypercholesterolemic patients for 3 months reduced serum cholesterol by 29%, triglycerides by 35% and LDL-cholesterol by 25%. Treatment of hyperlipidemic hamsters with BBR reduced serum cholesterol by 40% and LDL-cholesterol by 42%, with a 3.5-fold increase in hepatic LDLR mRNA and a 2.6-fold increase in hepatic LDLR protein. Using human hepatoma cells, we show that BBR upregulates LDLR expression independent of sterol regulatory element binding proteins, but dependent on ERK activation. BBR elevates LDLR expression through a post-transcriptional mechanism that stabilizes the mRNA. Using a heterologous system with luciferase as a reporter, we further identify the 5' proximal section of the LDLR mRNA 3' untranslated region responsible for the regulatory effect of BBR. These findings show BBR as a new hypolipidemic drug with a mechanism of action different from that of statin drugs.
Matti Narkia

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine... - 0 views

    Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.
    Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning G.
    J Clin Endocrinol Metab. 2008 Jul;93(7):2559-65. Epub 2008 Apr 8.
    PMID: 18397984

    Conclusions: Berberine is effective and safe in the treatment of type 2 diabetes and dyslipidemia.
Matti Narkia

Berberine - - 0 views

    "Berberine is a bitter-tasting, yellow, plant alkaloid with a long history of medicinal use in Chinese and Ayurvedic medicine. Berberine is present in the roots, rhizomes and stem bark of various plants including Hydrastis canadensis (goldenseal), Coptis chinensis (coptis or goldenthread), Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), and Berberis aristata (tree turmeric). Berberine has also been used historically as a dye, due to its yellow color.
    Clinical trials have been conducted using berberine. There is some evidence to support its use in the treatment of trachomas (eye infections), bacterial diarrhea, and leishmaniasis (parasitic disease). Berberine has also shown antimicrobial activity against bacteria, viruses, fungi, protozoans, helminths (worms), and chlamydia (STD). Future clinical research is warranted in these areas, as well as cardiovascular disease, skin disorders, and liver disorders.
    Berberine has been shown to be safe in the majority of clinical trials. However, there is a potential for interaction between berberine and many prescription medications, and berberine should not be used by pregnant or breastfeeding women, due to potential for adverse effects in the newborn."
Matti Narkia

Berberine, dosing and safety - - 0 views

    Side Effects and Warnings
    Berberine has been reported to cause nausea, vomiting, hypertension (high blood pressure), respiratory failure and paresthesias (abnormal sensations such as numbness or tingling); however, clinical evidence of such adverse effects is not prominent in the literature. Rare adverse effects including headache, skin irritation, facial flushing, headache, bradycardia (slowed heart rate) have also been reported with the use of berberine. Use cautiously when taking berberine for longer than eight weeks due to theoretical changes in bacterial gut flora.
    Use cautiously in individuals with diabetes, as both human and animal studies indicate that berberine may decrease blood sugar levels. Also use cautiously in individuals with hypotension (low blood pressure), as berberine may have antihypertensive effects.
    Patients with cardiovascular disease should also use caution as berberine has been associated with the development of ventricular arrhythmias in subjects with congestive heart failure.
    Although not well studied in humans, berberine may also theoretically cause delays in small intestinal transit time or increase the risk of bleeding.
    Berberine may cause abortion, eye or kidney irritation, nephritis (inflamed kidneys), dyspnea (difficulty breathing), flu-like symptoms, giddiness, lethargy, or liver toxicity.
    Patients with leukopenia (abnormally low white blood cell count) should use cautiously due to the potential for development of leukopenia symptoms.
    When injected under the skin, berberine may cause hyperpigmentation in the arm. Use berberine cautiously in individuals with high exposure to sunlight or artificial light due to potential for adverse phototoxic reactions.
    Avoid in newborns due to potential for increase in free bilirubin, jaundice, and development of kernicterus (brain damage caused by severe newborn jaundice). Use berberine cautiously in children due to a lack of safety information.
    Pregnancy and Breastfeeding
    Berberine is not recomme
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