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Matti Narkia

Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of su... - 0 views

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    SSeason of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D. Porojnicu AC, Robsahm TE, Ree AH, Moan J. Br J Cancer. 2005 Sep 5;93(5):571-4. PMID: 16136030 doi:10.1038/sj.bjc.6602722 Epidemiological data for this period indicate that season of diagnosis is a strong prognostic factor for Hodgkin's lymphoma, with approximately 20% lower case fatality for patients diagnosed during autumn vs winter diagnosis (RR = 0.783, 95% CI,-0.62 to 0.99; P = 0.041). Notably, the improved autumnal survival rate was higher than 60% (RR = 0.364, 95% CI, -0.15 to 0.87; P = 0.025) for patients younger than 30 years. This finding may be related to higher endogenous levels of vitamin D in autumn, with a favourable influence on the conventional therapy. In conclusion, we have found that the prognosis of Hodgkin's lymphoma is significantly correlated with the season of diagnosis, particularly for patients younger than 30 years. This seasonal effect is presumably due to the vitamin D3 synthesis in skin during sun exposure. The present findings should encourage further investigations of the possible adjuvant role of vitamin D derivatives in cancer therapy
Matti Narkia

Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-200... - 0 views

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    Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA. Am J Clin Nutr. 2008 Dec;88(6):1519-27. PMID: 19064511 doi:10.3945/ajcn.2008.26182 Conclusions: Overall, mean serum 25(OH)D was lower in 2000-2004 than 1988-1994. Assay changes unrelated to changes in vitamin D status accounted for much of the difference in most population groups. In an adult subgroup, combined changes in BMI, milk intake, and sun protection appeared to contribute to a real decline in vitamin D status. In summary, age-standardized mean serum 25(OH)D concentrations based on observed values were significantly lower in 2000-2004 than in 1988-1994 in all groups examined. Adjustment for assay changes noticeably reduced the difference between surveys. However, mean serum 25(OH)D concentrations remained significantly lower in males (except Mexican Americans) in NHANES 2000-2004 than in NHANES III, even after adjustment for assay differences. This remaining difference likely represents a real decline in vitamin D status. Changes in BMI, milk intake, and sun protection appeared to contribute to this decline in a subgroup of non-Hispanic white adults. The possibility that trends in overweight, sun protection, and milk intake may continue supports the need to continue monitoring the serum 25(OH)D status of the population
Matti Narkia

Addressing the health benefits and risks, involving vitamin D or skin cancer, of increa... - 0 views

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    Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure.\nMoan J, Porojnicu AC, Dahlback A, Setlow RB.\nProc Natl Acad Sci U S A. 2008 Jan 15;105(2):668-73. Epub 2008 Jan 7.\nPMID: 18180454
Matti Narkia

Despite Sun Exposure, Some Still Vitamin D Deficient - 0 views

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    According to a study conducted by University of Wisconsin researchers, even people who are regularly exposed to sunlight can have low vitamin D levels.\n\nThe study focused on subjects who lived in sunny Hawaii and spent an average of 11.1 hours in the sun each week. (None of the participants in the study used any type of sunscreen.) Despite the exposure, 51 percent of participants were found to be deficient in vitamin D.
Matti Narkia

Effects of Above Average Summer Sun Exposure on Serum 25-Hydroxyvitamin D and Calcium A... - 0 views

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    Barger-Lux MJ, Heaney RP. Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption.J Clin Endocrinol Metab. 2002 Nov;87(11):4952-6.PMID: 12414856 [PubMed - indexed for MEDLINE]
Matti Narkia

Circulating Vitamin D3 and 25-hydroxyvitamin D in Humans: An Important Tool to Define A... - 0 views

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    Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status. Hollis BW, Wagner CL, Drezner MK, Binkley NC. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):631-4. Epub 2007 Jan 10. PMID: 17218096 In the present study, we sought to investigate what circulating 25(OH)D levels would result in populations exhibiting no substrate limitations to the vitamin D-25-hydroxylase. To perform this, we chose two distinct populations. The first were individuals from a year-found sunny environment who spent a good deal of time outdoors. The second were a group of lactating women receiving a substantial daily oral dose of vitamin D3. Surprisingly, a study such as this previously had not been undertaken. There are several reasons for this. First, finding a group of sun-exposed individuals is not an easy task; in fact, we had to go to Hawaii to find them. Secondly, very few studies have been performed where subjects actually received adequate vitamin D3 supplementation to make them replete. Finally, it is very difficult and costly to measure circulating vitamin D3 and relate it to circulating 25(OH)D. The results of our study are far-reaching. This study also demonstrates that individuals can be vitamin D deficient with significant sun exposure if the skin area exposed is limited as was suggested several years ago (19). Finally, whether one receives their vitamin D3 orally or through UV exposure, the vitamin D-25-hydroxylase appears to handle it in an equivalent fashion with respect to maintaining circulating 25(OH)D levels. Thus, we believe that the relationship between circulating vitamin D and 25(OH)D may define adequate nutritional vitamin D status.
Matti Narkia

Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D d... - 0 views

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    Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D deficiency epidemic. Cannell JJ, Vieth R, Willett W, Zasloff M, Hathcock JN, White JH, Tanumihardjo SA, Larson-Meyer DE, Bischoff-Ferrari HA, Lamberg-Allardt CJ, Lappe JM, Norman AW, Zittermann A, Whiting SJ, Grant WB, Hollis BW, Giovannucci E. Ann Otol Rhinol Laryngol. 2008 Nov;117(11):864-70. Review. PMID: 19102134 Until we have better information on doses of vitamin D that will reliably provide adequate blood levels of 25(OH)D without toxicity, treatment of vitamin D deficiency in otherwise healthy children should be individualized according to the numerous factors that affect 25(OH)D levels, such as body weight, percent body fat, skin melanin, latitude, season of the year, and sun exposure.2 The doses of sunshine or oral vitamin D3 used in healthy children should be designed to maintain 25(OH)D levels above 50 ng/mL. As a rule, in the absence of significant sun exposure, we believe that most healthy children need about 1,000 IU of vitamin D3 daily per 11 kg (25 lb) of body weight to obtain levels greater than 50 ng/mL. Some will need more, and others less. In our opinion, children with chronic illnesses such as autism, diabetes, and/or frequent infections should be supplemented with higher doses of sunshine or vitamin D3, doses adequate to maintain their 25(OH)D levels in the mid-normal of the reference range (65 ng/mL) - and should be so supplemented year round. Otolaryngologists treating children are in a good position to both diagnose and treat vitamin D deficiency.
Matti Narkia

Investigating the links between muscle strength, sun exposure, dietary vitamin D intake... - 0 views

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    Investigating the links between muscle strength, sun exposure, dietary vitamin D intake and the vitamin D status of ambulatory older adults in South East Queensland Borradale, David (2008) QUT Thesis]
Matti Narkia

High prevalence of vitamin D deficiency in Chilean healthy postmenopausal women with no... - 0 views

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    Gonzalez G, Alvarado JN, Rojas A, Navarrete C, Velasquez CG, Arteaga E. High prevalence of vitamin D deficiency in Chilean healthy postmenopausal women with normal sun exposure: additional evidence for a worldwide concern. Menopause. 2007 May-Jun;14(3
Matti Narkia

Benefits of Vitamin D Supplementation - Journal of American Physicians and Surgeons Vol... - 0 views

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    Benefits of Vitamin D Supplementation Joel M. Kauffman, Ph.D. Journal of American Physicians and Surgeons Volume 14 Number 2 - Summer 2009 Clinical trials show that vitamin D supplementation at higher levels than previously recommended is beneficial for many conditions. It decreases the frequency of falls and fractures, helps prevent cardiovascular disease, and reduces symptoms of colds or influenza. Benefits are also seen in diabetes mellitus, multiple sclerosis, Crohn disease, pain, depression, and possibly autism. Sunlight does not cause an overdose of vitamin D production, and toxicity from supplementation is rare. Dose recommendations are increasing, but appear to be lagging the favorable trial results. A number of common drugs deplete vitamin D levels, and others may limit its biosynthesis from sunlight. People with adequate levels from sun exposure will not benefit from supplementation. While dietary intake is helpful, supplementation is better able to raise serum 25-hydroxyvitamin D , the major circulating metabolite, to the level now thought adequate, 30-50 ng/mL. Where there is inadequate daily sun exposure, oral doses of 1,000-2,000 IU/d are now considered routine, with much higher doses (up to 50,000 IU) for rapid repletion now considered safe.
Mango Dash india

Health And Fitness Benefits of Mango Fruit Juice - 0 views

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    Mangoes are the richest source of most important vitamins (A, C, B, E, K), minerals, dietary fibbers, electrolytes and iron which are mostly required by the for better growth and development as well as being healthy and live life without any diseases and infections. It is liked by all people due to its nice color, taste, flavor and quality health aspects. I have mentioned below the few beneficial aspects of the mangoes which you must know to enhance your interest while eating mangoes: Benefits of Mango juice for Cancer Prevention Mango fruit has antioxidant compounds (such as quercetin, fisetin, astragalin, gallic acid, isoquercitrin, methyl gallate and etc) and lots of enzymes which help in protecting against various body organs cancers like colon, leukemia, breast, stomach, prostate, lungs, cervical, oral cavity cancers and etc. These compounds include, as well as the abundant. Polyphenols found in it acts as an anti inflammatory agent and restricts the growth of cancerous cells. The soluble dietary fibers, pectin found in it has property of decreasing the action of protein (galectin) found in the cancerous cells. Benefits of Mango juice for Heart health It contains highest level of soluble dietary fibers (pectin) and vitamin C which involves in lowering the bad serum cholesterol levels means Low-Density Lipoproteins as well as enhancing the good serum cholesterol levels means High-Density Lipoproteins thus keeps the heart healthy by keeping all the heart problems away. It is the rich source of potassium which involves in controlling the blood pressure thus heart rate. Benefits of Mango juice for Skin It is beneficial for the skin in both ways whether it is eaten or applied externally on the skin. It India juice has antioxidants which make the skin healthy, smooth, glowing and wrinkles free. It clear out the blocked pores and provides solution to get free from the pimples if applied on the face. It makes the skin glowing by reducing the dark spot
Mango Dash india

Mango Dash: Mango Juice Uses Cures Acne And Skin Health - 0 views

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    Mango Juice Perhaps you are surprised to know that mangoes are closely related to skin health. Other than bringing a healthy glow to your face, mango Juice also help to lighten skin color. You can easily enhance your beauty by including this tasty fruit in your diet on a regular basis.



    Mangoes effectively treat acne by opening the clogged pores of the skin. Once these pores are opened, acne formation will eventually stop. Unclogging the pores of the skin is the most effective way to eliminate acne. To enjoy this benefit, there is no need to eat mangoes every day you need to remove the mango pulp and apply it on the skin for around 10 minutes, then rinse it off.



    Consuming this Mango Juice regularly will help keep your body healthy and slow down premature skin aging caused by environmentally stresses such as pollution and sun damage.



    THE ROLE OF JUICE IN SKIN HEALTH

    Mango Juices are anti-inflammatory, antioxidant, astringent, loaded with phytonutrients and they help build and repair skin collagen and connective tissue, thus reducing acne scars and acne scarring.

    Some juices may also help to balance hormones, whereas others may have antibacterial and antibiotic properties.

    Furthermore, these juices can help reduce stress, improve circulation, and speed healing.



    Five Best Skin Health Benefits of Mango Juice:

    Besides being extremely pleasing to your taste buds, mango is amazing for your skin as it is a great source of antioxidants, particularly vitamin C, which keep your skin healthy and glowing. It is often used in various face masks and scrubs. Its various skin benefits are as follows:



    1. Mango juice for Glowing Skin:



    Mango Juice are great for your skin as they have the ability to reduce dark spots, blemishes and acne, thus imparting a natural glow to
Matti Narkia

Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz... - 0 views

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    Sun Z, Sood S, Li N, Ramji D, Yang P, Newman RA, Yang CS, Chen X. Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinoge
Matti Narkia

The Association of Solar Ultraviolet B (UVB) with Reducing Risk of Cancer: Multifactori... - 0 views

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    The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Grant WB, Garland CF. Anticancer Res. 2006 Jul-Aug;26(4A):2687-99. PMID: 16886679 CONCLUSION: These results provide additional support for the hypothesis that solar UVB, through photosynthesis of vitamin D, is inversely-associated with cancer mortality rates, and that various other cancer risk-modifying factors do not detract from this link. It is thought that sun avoidance practices after 1980, along with improved cancer treatment, led to reduced associations in the latter period. The results regarding solar UVB should be studied further with additional observational and intervention studies of vitamin D indices and cancer incidence, mortality and survival rates.
Matti Narkia

Vitamin D status in apparently healthy adults in Kashmir Valley of Indian subcontinent ... - 0 views

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    Vitamin D status in apparently healthy adults in Kashmir Valley of Indian subcontinent. Zargar AH, Ahmad S, Masoodi SR, Wani AI, Bashir MI, Laway BA, Shah ZA. Postgrad Med J. 2007 Nov;83(985):713-6. PMID: 17989271 doi:10.1136/pgmj.2007.059113 Conclusions: In spite of abundant sunlight, healthy individuals in Kashmir valley are vitamin D deficient, particularly women. Serum 25 (OH) D concentrations are significantly related to sun exposure
Matti Narkia

How this horrible weather could give you heart disease | Mail Online - 1 views

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    "We are fond of grumbling about Britain's grey skies, but there may be a good medical reason for doing so. It seems the dreary weather is bad for our hearts - worse, even, than raised cholesterol and an unhealthy diet. That's the controversial claim being made by Dr David Grimes, a gastroenterologist from Blackburn. He's been gazing at the sky for 20 years for clues about why his patients get more sick than those in the south of the country. And what he's found turns key assumptions about heart disease on their head. 'It's not diet or cholesterol levels that raise your risk of heart disease,' he claims. 'It's where you live. People in the north are more likely to be ill because they get less sunshine Basically they are suffering from 'latitude' sickness. The link is vitamin D. While we get some from our diet, the main source is the sun - sunlight converts a compound in the skin into vitamin D, so the amount you make is directly related to the amount of sunshine you get. In a new book Dr Grimes argues the higher the level of vitamin D in your blood, the lower your risk of heart disease and a range of other illnesses. If he's right, what we need is not diet and lifestyle advice, but food fortified with vitamin D. For years the vitamin was thought to be useful only for preventing rickets. So how does he treat them? 'You can do it with diet,' he says 'One Bangladeshi woman eats oily fish every day and now has a vitamin D blood level of 40. 'We give supplements of 1,000 international units (IU) a day or we can give an injection of 300,000 IU that lasts for a year. 'The patients respond well,' says Grimes 'but what's needed is a proper controlled, long-term trial and who is going to fund that? Not a drug company.'"
Fitness Dada

Your one-stop egg recipes for Dinner with the Spinach, Feta, and Sun-dried Tomato Omele... - 0 views

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    Foods that are capable of offering a number of treats are admired by all which is why eggs have been one of the favourite delights. These not only offer a mouth-watering treat but also a number of health benefits.
Matti Narkia

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and h... - 0 views

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    Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.\nChen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M.\nProc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. Epub 2007 May 14.\nPMID: 17502596 \n doi: 10.1073/pnas.0702854104\n
Matti Narkia

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive ... - 0 views

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    Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9. Epub 2008 Aug 4. PMID: 18678913 doi: 10.1073/pnas.0804226105
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