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Ravi Kumar

Anti Ageing - 2 views

Everyone comes to get old age and will get ageing of skin (wrinkles). This is not something that you can stop from happening of ageing. Aging is a natural process and in fact, it should even be a...

: Aging Causes How to prevent Ageing Anti food Supplements Happy and Healthy Lifestyle Omega-3 fatty acids Face Creams

started by Ravi Kumar on 16 Oct 13 no follow-up yet
Matti Narkia

Whole Health Source: Eicosanoids and Ischemic Heart Disease, Part II - 0 views

    "Wednesday, May 27, 2009
    Eicosanoids and Ischemic Heart Disease, Part II
    Here's where it gets more complicated and more interesting. The ratio of omega-6 to omega-3 matters, but so does the total amount of each. This is a graph from a 1992 paper by Dr. Lands:

    In sum, this suggests that the single best way to avoid a heart attack is to reduce omega-6 consumption and ensure an adequate source of omega-3. The lower the omega-6, the less the omega-3 matters. This is a nice theory, but where's the direct evidence? In the next post, I'll discuss the controlled trial that proved this concept once and for all: the Lyon diet-heart trial.
Matti Narkia

Omega-3s help stave off age-related vision loss | Reuters - 1 views

    "NEW YORK (Reuters Health) - Want to keep your eyesight sharp as you age? Eating lots of fish packed with healthy omega-3 fatty acids could help, new research suggests.

    Among 1,837 people who had early signs of age-related macular degeneration (AMD), those with the highest consumption of omega-3 fatty acids were 30 percent less likely to progress to the advanced form of the disease over a 12-year period than those with the lowest omega-3 intake, researchers found."
Matti Narkia

NephroPal: Omega 3 Fatty Acid and Adiponectin Levels - 0 views

    "Friday, December 18, 2009
    Omega 3 Fatty Acid and Adiponectin Levels
    Today my wife was watching the Oprah show. A commercial came on and I looked up. It was a Christmas special on liposuction in the local area. Considering that the fat tissue (adipose tissue) is now viewed as an endocrine organ and not just a collection of fat cells, I have always thought that sucking out the fat cells maybe a bad idea. Yet, I have never seen proof of this. But, the science of the adipose tissue as an endocrine organ is relatively new. It seems that in the medical literature adiponectin is receiving the most attention from all of the other adipose hormones - or also referred to as adipokines. This is for good reason. As stated before, adiponectin has the following effects:

    * reduces liver glucose production

    * increases glucose uptake in the muscles and adipose tissues

    * causes oxidation of fats which leads to less lipid production

    * has anti-inflammatory properties

    * protects the heart against ischemia and reduces myocardial infarct size

    * acts as an anti-clotting factor

    * increases nitric oxide production in the vasculature leading to a greater dilation of the vessels"
Matti Narkia

Are omega-3 fatty acids options for prevention and treatment of cognitive decline and d... - 0 views

    Are omega-3 fatty acids options for prevention and treatment of cognitive decline and dementia?
    Cederholm T, Palmblad J.
    Curr Opin Clin Nutr Metab Care. 2009 Dec 16. [Epub ahead of print]
    PMID: 20019606

    PURPOSE OF REVIEW: To report recent data on the potential role of omega-3 fatty acids (n-3 FA) found in oily fish, especially docosahexaenoic acid (DHA), to prevent and treat cognitive decline and Alzheimer's disease. RECENT FINDINGS: Observational studies still provide conflicting results, in which the majority indicate beneficial effects on cognition, both when assessed as a continuous variable or as incident dementia, mainly Alzheimer's disease. Experimental studies have demonstrated potentially ameliorating effects of eicosapentaenoic acid (EPA) and DHA on amyloid fragment formation, signal transduction including upregulation of the apolipoprotein receptor SorLA, as well as on angiogenesis. The role of EPA and DHA metabolites on Alzheimer's disease pathology is under investigation. Recently, three randomized intervention studies, with duration up to 6 months have been reported. In contrast to a small study from Taiwan, no positive overall effects were reported from the Swedish OmegAD Study or from a Dutch study, although post hoc analyses indicate that selected individuals with mild forms of Alzheimer's disease or cognitive decline may respond to treatment. SUMMARY: No firm conclusions can be drawn. Based on epidemiological data, fish including oily fish could be advised as part of a balanced diet for public health purpose, although the evidence for better cognition is only fairly consistent. It is unlikely that n-3 FA will emerge as a treatment option in general for improving cognitive function in patients with Alzheimer's disease. n-3 FA, especially DHA, may turn out as an adjuvant therapy in selected cases. Further long-term intervention studies on individuals with mild cognitive reductions are awaite"
Matti Narkia

New Study Links DHA Type Of Omega-3 To Better Nervous System Function - 0 views

    "The omega-3 essential fatty acids commonly found in fatty fish and algae help animals avoid sensory overload, according to research published by the American Psychological Association. The finding connects low omega-3s to the information-processing problems found in people with schizophrenia; bipolar, obsessive-compulsive, and attention-deficit hyperactivity disorders; Huntington's disease; and other afflictions of the nervous system.

    The study, reported in the journal Behavioral Neuroscience, provides more evidence that fish is brain food. The key finding was that two omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) appear to be most useful in the nervous system, maybe by maintaining nerve-cell membranes.

    "It is an uphill battle now to reverse the message that 'fats are bad,' and to increase omega-3 fats in our diet," said Norman Salem Jr., PhD, who led this study at the Laboratory of Membrane Biochemistry and Biophysics at the National Institute on Alcohol Abuse and Alcoholism.
Matti Narkia

Could Omega-3s Boost Blood Fat Levels?: MedlinePlus - 0 views

    "THURSDAY, Dec. 17 (HealthDay News) -- In a surprise finding, Canadian researchers report that the immediate effect of the fish oil fatty acids that are good for the heart is a short-term increase in blood fats and the molecules that help them form clots.

    "We were surprised to find that the acute response has some potentially negative effects in comparison to what you might expect from chronic, long-term intake," said Lindsay E. Robinson, an associate professor of nutrition at the University of Guelph, and leader of the group reporting the finding in the January issue of the Journal of Nutrition.

    However, the study results shouldn't affect the current recommendation for eating more oily fish to get the omega-3 polyunsaturated acids that reduce the risk of blood clots that can cause heart attacks and stroke, Robinson said.

    "The recommendation to increase intake is very well-studied, and this doesn't change it," she said.

    And the effects were seen in a selected group of middle-aged men with metabolic syndrome, a combination of high blood pressure, obesity and elevated blood fat levels, Robinson noted.

    In the study, eight men had controlled intake of three regimens: high doses of omega-3 fatty acids, low doses of them and just plain water. Robinson and her colleagues measured several blood components involved in clotting, including fats and clotting factors such as plasminogen-activator inhibitor-1 (PAI-1) for the following eight hours.

    PAI-1 inhibits the destruction of blood clots, so high levels of it in the blood increase the risk of artery-blocking clots.

    The researchers found that both omega-3 fatty acid regimens increased blood fat and clotting factor activity. But the increase in clotting factor was greater for the higher doses of omega-3 fatty acids than for the lower intakes.

    Robinson said her group hopes to do further studies of the immediate effects of omega-3 fatty acid intake. "We need to look at the mechanisms, why blood lipid levels go up," she
Matti Narkia

Acute Ingestion of Long-Chain (n-3) Polyunsaturated Fatty Acids Decreases Fibrinolysis ... - 0 views

    Acute Ingestion of Long-Chain (n-3) Polyunsaturated Fatty Acids Decreases Fibrinolysis in Men with Metabolic Syndrome.
    Montegaard C, Tulk HM, Lauritzen L, Tholstrup T, Robinson LE.
    J Nutr. 2009 Nov 4. [Epub ahead of print]
    PMID: 19889809

    Individuals with metabolic syndrome (MetS) often have elevated plasma plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA), contributing to an increased risk of cardiovascular disease. PAI-1 and t-PA may be affected by chronic (n-3) long-chain PUFA [(n-3)LCPUFA] supplementation; however, the acute impact of fat ingestion on these risk factors has not been established. Our objective was to investigate the acute effect of (n-3)LCPUFA on plasma PAI-1, t-PA, and platelet aggregation. We conducted a randomized crossover study in which men (n = 8, ≥45 y) with MetS consumed water or a high-saturated fat beverage (1 g fat/kg body weight) with either a high or low content of (n-3)LCPUFA. Blood samples were collected over 8 h to measure triacylglycerol (TAG), PAI-1, t-PA, and platelet aggregation. Both fat loads resulted in a significant increase in whole blood TAG concentration, plasma PAI-1 and t-PA concentrations, and PAI-1 activity, as well as a significant decrease in t-PA activity during the postprandial period. Interestingly, PAI-1 concentration and activity increased more following the high (n-3)LCPUFA compared with the low (n-3)LCPUFA beverage (P < 0.05). Furthermore, the high (n-3)LCPUFA beverage resulted in a lower t-PA activity (P < 0.05), whereas the effects of the 2 fat loads on the plasma t-PA concentration and platelet aggregation did not differ. Overall, acute intake of a high (n-3)LCPUFA beverage shifted the balance between plasma PAI-1 and t-PA, which might indicate a lower capacity for fibrinolysis
Matti Narkia

DHA revisions offer hope to health claim rejections - 0 views

    "The affirmation that the omega-3 DHA can benefit cognitive and eye health offers hope to previously rejected claims. And it's business as usual regarding the overall health claims process, despite ratification of the Lisbon Treaty, said a European Commission representative.

    At the NutraIngredients Health Claims 2010 conference in Brussels, the EC's Lars Korsholm explained the regulatory state-of-play for DHA claims.

    "I think it will offer some hope to previously rejected claims in the sense that these claims that are now subject for discussion are generic in the sense that if other food business operators than those who actually submitted the application can claim to fulfill the conditions of use then they are equally entitled to use the claim," explains Korsholm.

    The statements come in relation to an October decision whereby the European Food Safety Authority (EFSA) affirmed that the omega-3 fatty acids, DHA and ALA, can benefit eye and cognitive development in babies.

    Responding to the public comment period for Merck Selbstmedikation GmbH's article 14 cognitive development claim that was rejected in March, EFSA affirmed its original stance that there was no need for additional supplementation of DHA (docosahexaenoic acid) and ALA (alpha-linolenic acid) because it already existed at adequate levels in the diet.

    It supported their role in foetal and newborn eye and brain development but said there was an adequate supply in breast milk. "
Matti Narkia

Arch Ophthalmol -- Cigarette Smoking, Fish Consumption, Omega-3 Fatty Acid Intake, and ... - 0 views

    Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration.
    Seddon JM, George S, Rosner B.
    Arch Ophthalmol. 2006 Jul;124(7):995-1001.
    PMID: 16832023

    Conclusions This study of twins provides further evidence that cigarette smoking increases risk while fish consumption and omega-3 fatty acid intake reduce risk of AMD
Matti Narkia

New study links DHA type of omega-3 to better nervous-system function - 0 views

    "ScienceDaily (Dec. 16, 2009) - The omega-3 essential fatty acids commonly found in fatty fish and algae help animals avoid sensory overload, according to research published by the American Psychological Association. The finding connects low omega-3s to the information-processing problems found in people with schizophrenia; bipolar, obsessive-compulsive, and attention-deficit hyperactivity disorders; Huntington's disease; and other afflictions of the nervous system

    The study, reported in the journal Behavioral Neuroscience, provides more evidence that fish is brain food. The key finding was that two omega-3 fatty acids -- docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) -- appear to be most useful in the nervous system, maybe by maintaining nerve-cell membranes"
Matti Narkia

Intake of Fish and n3 Fatty Acids and Risk of Coronary Heart Disease Among Japanese: Th... - 0 views

    Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I.
    Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, Kokubo Y, Tsugane S; JPHC Study Group.
    Circulation. 2006 Jan 17;113(2):195-202. Epub 2006 Jan 9.
    PMID: 16401768
    doi: 10.1161/CIRCULATIONAHA.105.581355

    Conclusions- Compared with a modest fish intake of once a week or &20 g/d, a higher intake was associated with substantially reduced risk of coronary heart disease, primarily nonfatal cardiac events, among middle-aged persons
Matti Narkia

Fish Oil-Derived Fatty Acids, Docosahexaenoic Acid and Docosapentaenoic Acid, and the R... - 0 views

    Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study.
    Rissanen T, Voutilainen S, Nyyssönen K, Lakka TA, Salonen JT.
    Circulation. 2000 Nov 28;102(22):2677-9.
    PMID: 11094031

    Methods and Results-We studied this association in the Kuopio Ischaemic Heart Disease Risk Factor Study, a prospective population study in Eastern Finland. Subjects were randomly selected and included 1871 men aged 42 to 60 years who had no clinical coronary heart disease at baseline examination. A total of 194 men had a fatal or nonfatal acute coronary event during follow-up. In a Cox proportional hazards' model adjusting for other risk factors, men in the highest fifth of the proportion of serum DHA+DPA in all fatty acids had a 44% reduced risk (P=0.014) of acute coronary events compared with men in the lowest fifth. Men in the highest fifth of DHA+DPA who had a low hair content of mercury (<=2.0 µg />2.0 µg/g). There was no association between proportion of eicosapentaenoic acid and the risk of acute coronary events.

    Conclusions-Our data provide further confirmation for the concept that fish oil-derived fatty acids reduce the risk of acute coronary events. However, a high mercury content in fish could attenuate this protective effect.
Matti Narkia

Fish Consumption Shifts Lipoprotein Subfractions to a Less Atherogenic Pattern in Human... - 0 views

    Fish consumption shifts lipoprotein subfractions to a less atherogenic pattern in humans.
    Li Z, Lamon-Fava S, Otvos J, Lichtenstein AH, Velez-Carrasco W, McNamara JR, Ordovas JM, Schaefer EJ.
    J Nutr. 2004 Jul;134(7):1724-8.
    PMID: 15226460

    The effect of fish consumption on plasma lipoprotein subfraction concentrations was studied in 22 men and women (age > 40 y). Subjects were provided an average American diet (AAD, 35% of energy as fat, 14% as saturated fat, and 35 mg cholesterol/MJ) for 6 wk before being assigned to a National Cholesterol Education Program (NCEP) Step 2 high-fish diet (n = 11, 26% of energy as fat, 4.5% as saturated fat, and 15 mg cholesterol/MJ) or a NCEP Step 2 low-fish diet (n = 11, 26% of energy as fat, 4.0% as saturated fat, and 11 mg cholesterol/MJ) for 24 wk. All food and drink were provided to study participants. Consumption of the high-fish NCEP Step 2 diet was associated with a significant reduction in medium and small VLDL, compared with the AAD diet, whereas the low-fish diet did not affect VLDL subfractions. Both diets significantly reduced LDL cholesterol concentrations, without modifying LDL subfractions. Both diets also lowered HDL cholesterol concentrations. However, the high-fish diet significantly lowered only the HDL fraction containing both apolipoprotein (apo) AI and AII (LpAI:AII) and did not change HDL subfractions assessed by NMR, whereas the low-fish diet significantly lowered the HDL fraction containing only apo AI (LpAI) and the large NMR HDL fractions, resulting in a significant reduction in HDL particle size. Neither diet affected VLDL and LDL particle size. Our data indicate that within the context of a diet restricted in fat and cholesterol, a higher fish content favorably affects VLDL and HDL subspecies
Matti Narkia

Clinical Prevention of Sudden Cardiac Death by n-3 Polyunsaturated Fatty Acids and Mech... - 0 views

    Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils.
    Leaf A, Kang JX, Xiao YF, Billman GE.
    Circulation. 2003 Jun 3;107(21):2646-52. Review.
    PMID: 12782616
    doi: 10.1161/01.CIR.0000069566.78305.33

    This review will be limited specifically to the beneficial prevention by the n-3 polyunsaturated fatty acids (PUFAs) of arrhythmic deaths, including sudden cardiac death, which annually causes some 300 000 deaths in the United States and millions more worldwide. We will also show that the growing body of positive clinical studies is supported by what has been learned in animal and laboratory studies regarding the mechanism by which n-3 PUFAs prevent cardiac arrhythmias.
Matti Narkia

n-3 Fatty acids and cardiovascular disease -- Breslow 83 (6): S1477 -- American Journal... - 0 views

    n-3 fatty acids and cardiovascular disease.
    Breslow JL.
    Am J Clin Nutr. 2006 Jun;83(6 Suppl):1477S-1482S. Review.
    PMID: 16841857

    The results of prospective cohort studies indicate that consuming fish or fish oil containing the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is associated with decreased cardiovascular death, whereas consumption of the vegetable oil-derived n-3 fatty acid {alpha}-linolenic acid is not as effective. Randomized control trials (RCTs) in the context of secondary prevention also indicate that the consumption of EPA plus DHA is protective at doses <1 g />3 g/d, EPA plus DHA can improve cardiovascular disease risk factors, including decreasing plasma triacylglycerols, blood pressure, platelet aggregation, and inflammation, while improving vascular reactivity. Mainly on the basis of the results of RCTs, the American Heart Association recommends that everyone eat oily fish twice per week and that those with coronary heart disease eat 1 g/d of EPA plus DHA from oily fish or supplements. Directions for future research include 1) RCTs to confirm the initial trials showing that EPA plus DHA decreases cardiovascular death and additional studies to determine whether this effect is due to EPA, DHA, or the combination; the dosage of the effective components; and whether the mechanism of action in humans is prevention of fatal arrhythmias. 2) Clinical studies to determine whether the reduction in cardiovascular disease risk factors is due to EPA, DHA, or the combination and the dosage of the effective components. 3) Clinical studies to determine whether vegetable oil-derived {alpha}-linolenic acid added to a diet enriched in n-6 fatty acids can effectively substitute for fish oil-derived EPA plus DHA.
Matti Narkia

Cardiac Benefits of Fish Consumption May Depend on the Type of Fish Meal Consumed: The ... - 0 views

    Cardiac benefits of fish consumption may depend on the type of fish meal consumed: the Cardiovascular Health Study.
    Mozaffarian D, Lemaitre RN, Kuller LH, Burke GL, Tracy RP, Siscovick DS; Cardiovascular Health Study.
    Circulation. 2003 Mar 18;107(10):1372-7.
    PMID: 12642356
    doi: 10.1161/01.CIR.0000055315.79177.16

    Conclusions- Among adults aged >=65 years, modest consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower risk of IHD death, especially arrhythmic IHD death. Cardiac benefits of fish consumption may vary depending on the type of fish meal consumed.
Matti Narkia

Effect of Fish Oil on Heart Rate in Humans: A Meta-Analysis of Randomized Controlled Tr... - 0 views

    Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials.
    Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB.
    Circulation. 2005 Sep 27;112(13):1945-52. Epub 2005 Sep 19.
    PMID: 16172267
    doi: 10.1161/CIRCULATIONAHA.105.556886

    Conclusions- In randomized controlled trials in humans, fish oil reduces HR, particularly in those with higher baseline HR or longer treatment duration. These findings provide firm evidence that fish oil consumption directly or indirectly affects cardiac electrophysiology in humans. Potential mechanisms such as effects on the sinus node, ventricular efficiency, or autonomic function deserve further investigation.
Matti Narkia

n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects --... - 0 views

    n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects.
    Jung UJ, Torrejon C, Tighe AP, Deckelbaum RJ.
    Am J Clin Nutr. 2008 Jun;87(6):2003S-9S.
    PMID: 18541602

    Dietary n-3 fatty acids, particularly eicosapentaenoic acid and docosahexaenoic acid, are important nutrients through the life cycle. Evidence from observational, clinical, animal, and in vitro studies indicates a beneficial role of n-3 fatty acids in the prevention and management of cardiovascular disease. Although the precise mechanisms are still unclear, clinical and preclinical studies indicate that the cardioprotective effects of n-3 fatty acids may be attributed to a number of distinct biological effects on lipid and lipoprotein metabolism, blood pressure, platelet function, arterial cholesterol delivery, vascular function, and inflammatory responses.

    Substantial evidence supports n-3 fatty acids as a practical, therapeutic adjuvant for promoting cardiovascular health and preventing and treating disease. n-3 Fatty acids modulate a number of important physiologic responses that can contribute to their cardioprotective effects. The multiple and complex mechanisms through which DHA and EPA exert their action appear to be distinct but also complementary. However, more studies are needed to quantify their protective effects and to define exact mechanisms of action.
Matti Narkia

n-3 Fatty acids and gene expression -- Deckelbaum et al. 83 (6): S1520 -- American Jour... - 0 views

    n-3 fatty acids and gene expression.
    Deckelbaum RJ, Worgall TS, Seo T.
    Am J Clin Nutr. 2006 Jun;83(6 Suppl):1520S-1525S. Review. Erratum in: Am J Clin Nutr. 2006 Oct;84(4):949.
    PMID: 16841862

    Accumulating evidence in both humans and animal models clearly indicates that a group of very-long-chain polyunsaturated fatty acids, the n-3 fatty acids (or omega-3), have distinct and important bioactive properties compared with other groups of fatty acids. n-3 Fatty acids are known to reduce many risk factors associated with several diseases, such as cardiovascular diseases, diabetes, and cancer. The mechanisms whereby n-3 fatty acids affect gene expression are complex and involve multiple processes. As examples, n-3 fatty acids regulate 2 groups of transcription factors, such as sterol-regulatory-element binding proteins and peroxisome proliferator-activated receptors, that are critical for modulating the expression of genes controlling both systemic and tissue-specific lipid homeostasis. Modulation of specific genes by n-3 fatty acids and cross-talk between these genes are responsible for many effects of n-3 fatty acids.
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