Group items tagged

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.\nChen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M.\nProc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. Epub 2007 May 14.\nPMID: 17502596 \n doi: 10.1073/pnas.0702854104\n

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9. Epub 2008 Aug 4. PMID: 18678913 doi: 10.1073/pnas.0804226105

Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 mice. Wu D, Pae M, Ren Z, Guo Z, Smith D, Meydani SN. J Nutr. 2007 Jun;137(6):1472-7. PMID: 17513409

White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice. Adams LS, Phung S, Wu X, Ki L, Chen S. Nutr Cancer. 2008;60(6):744-56. PMID: 19005974

White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in mice.\nRen Z, Guo Z, Meydani SN, Wu D.\nJ Nutr. 2008 Mar;138(3):544-50.\nPMID: 18287364

Tumours with PI3K activation are resistant to dietary restriction. Nada Y. Kalaany & David M. Sabatini Nature. Published online 11 March 2009 doi:10.1038/nature07782

Mechanisms underlying the biphasic effect of vitamin K1 (phylloquinone) on arterial blood pressure.\nTirapelli CR, Resstel LB, de Oliveira AM, Corrêa FM.\nJ Pharm Pharmacol. 2008 Jul;60(7):889-93.\nPMID: 18549675 \nDOI: 10.1211/jpp.60.7.0010\n

ScienceDaily (Feb. 12, 2009) - A Texas AgriLife Research scientist and fellow researchers have discovered that arginine, an amino acid, reduces fat mass in diet-induced obese rats and could help fight human obesity.

DURHAM, N.C. -- Restricting carbohydrates, regardless of weight loss, appears to slow the growth of prostate tumors, according to an animal study being published this week by researchers in the Duke Prostate Center. "Previous work here and elsewhere has shown that a diet light in carbohydrates could slow tumor growth, but the animals in those studies also lost weight, and because we know that weight loss can restrict the amount of energy feeding tumors, we weren't able to tell just how big an impact the pure carbohydrate restriction was having, until now," said Stephen Freedland, M.D., a urologist in the Duke Prostate Center and lead investigator on this study. The researchers believe that insulin and insulin-like growth factor contribute to the growth and proliferation of prostate cancer, and that a diet devoid of carbohydrates lowers serum insulin levels in the bodies of the mice, thereby slowing tumor growth, Freedland said.

[Action of soluble carbohydrates from avocado (Persea gratissima Gaertner) fruit on utilization of calcium in the rat] Raonimalala AF, Digaud A, Fournier P. Ann Nutr Aliment. 1980;34(4):735-44. French. PMID: 7224495

Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancer. Chapkin RS, Davidson LA, Ly L, Weeks BR, Lupton JR, McMurray DN. J Nutr. 2007 Jan;137(1 Suppl):200S-204S. PMID: 17182826

Dietary omega-3 polyunsaturated fatty acids promote colon carcinoma metastasis in rat liver. Griffini P, Fehres O, Klieverik L, Vogels IM, Tigchelaar W, Smorenburg SM, Van Noorden CJ. Cancer Res. 1998 Aug 1;58(15):3312-9. PMID: 9699661

Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Xia S, Lu Y, Wang J, He C, Hong S, Serhan CN, Kang JX. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12499-504. Epub 2006 Aug 3. PMID: 16888035 doi: 10.1073/pnas.0605394103 In vitro experiments showed that addition of the n-3 fatty acid eicosapentaenoic acid or PGE(3) inhibited the growth of B16 cell line and increased the expression of PTEN, which could be partially attenuated by inhibition of PGE(3) production, suggesting that PGE(3) may act as an antitumor mediator. These data demonstrate an anticancer (antimelanoma) effect of n-3 fatty acids through, at least in part, activation of PTEN pathway mediated by PGE(3).

15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation. Paul-Clark MJ, Van Cao T, Moradi-Bidhendi N, Cooper D, Gilroy DW. J Exp Med. 2004 Jul 5;200(1):69-78. PMID: 15238606

Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Schambach F, Schupp M, Lazar MA, Reiner SL. Eur J Immunol. 2007 Sep;37(9):2396-9. PMID: 17694576 DOI: 10.1002/eji.200737621

White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice. Adams LS, Phung S, Wu X, Ki L, Chen S. Nutr Cancer. 2008;60(6):744-56. n PMID: 19005974

Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse. Bommareddy A, Zhang X, Schrader D, Kaushik RS, Zeman D, Matthees DP, Dwivedi C. Nutr Cancer. 2009;61(2):276-83. PMID: 19235044 DOI: 10.1080/01635580802419764

These results suggest that combination chemotherapy (FO+Cur or Lim) may favorably modulate CD4+ T-cell-mediated inflammation.D ietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice. Kim W, Fan YY, Smith R, Patil B, Jayaprakasha GK, McMurray DN, Chapkin RS. J Nutr. 2009 May;139(5):1042-8. Epub 2009 Mar 25. PMID: 19321585 doi:10.3945/jn.108.102772

Mice fed fish oil and curcumin showed a significantly reduced tumor volume, 25% (P < 0.04) and 43% (P < 0.005), respectively, and importantly, a combination of curcumin and fish oil diet showed > 72% (P < 0.0001) tumor volume reduction. Expression and activity of iNOS, COX-2, and 5-LOX are downregulated, and p21 is upregulated in tumor xenograft fed curcumin combined with fish oil diet when compared to individual diets. The preceding results evidence for the first time that curcumin combined with omega-3 fatty acids provide synergistic pancreatic tumor inhibitory properties. Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids. Swamy MV, Citineni B, Patlolla JM, Mohammed A, Zhang Y, Rao CV. Nutr Cancer. 2008;60 Suppl 1:81-9. PMID: 19003584