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Matti Narkia

Tissue Phylloquinone and Menaquinones in Rats Are Affected by Age and Gender -- Huber e... - 0 views

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    Tissue phylloquinone and menaquinones in rats are affected by age and gender. Huber AM, Davidson KW, O'Brien-Morse ME, Sadowski JA. J Nutr. 1999 May;129(5):1039-44. PMID: 10222397 The results suggest that in extrahepatic tissues, certain menaquinones may be the predominant form of vitamin K. The specific tissue distribution and the general decline of MK-4 and MK-6 in extrahepatic tissues during aging suggest a vitamin K tissue dynamic that is affected not only by diet, but also by gender, age and the specific roles of phylloquinone, MK-4 and MK-6 in metabolism. All of these factors must be taken into account in establishing the nutrient requirement for vitamin K.
Matti Narkia

Hyperlipid: Vitamin D and UV fluctuations (2) - 0 views

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    "I discussed in my last post how Dr Vieth has a model of tissue 1,25(OH)2D synthesis and degradation in which the level of active substance is pretty well independent of blood vitamin D level, provided the level is either rising or stable. I think it is also worth pointing out that he is talking, hypothetically, about tissue 1,25(OH)2D, not plasma level... As we know, almost nothing is known about tissue 1,25(OH)2D control. By Vieth's hypothesis tissue 1,25(OH)2D is OK so long as there is at least SOME vitamin D present in plasma and the level dose not vary too much. Obviously there is a level below which you can have as much of the enzyme for converting vitamin D to the active form as you like, if there is no vitamin D in your blood you can't make any 1,25(OH)2D in your tissues, or in your kidneys for export to your blood to control calcium levels. At the lower extremes we have rickets and osteomalacia. These are clear cut, unarguable markers of vitamin D deficiency, in the absence of confounding factors (there are a few)."
Matti Narkia

NephroPal: Omega 3 Fatty Acid and Adiponectin Levels - 0 views

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    "Friday, December 18, 2009 Omega 3 Fatty Acid and Adiponectin Levels Today my wife was watching the Oprah show. A commercial came on and I looked up. It was a Christmas special on liposuction in the local area. Considering that the fat tissue (adipose tissue) is now viewed as an endocrine organ and not just a collection of fat cells, I have always thought that sucking out the fat cells maybe a bad idea. Yet, I have never seen proof of this. But, the science of the adipose tissue as an endocrine organ is relatively new. It seems that in the medical literature adiponectin is receiving the most attention from all of the other adipose hormones - or also referred to as adipokines. This is for good reason. As stated before, adiponectin has the following effects: * reduces liver glucose production * increases glucose uptake in the muscles and adipose tissues * causes oxidation of fats which leads to less lipid production * has anti-inflammatory properties * protects the heart against ischemia and reduces myocardial infarct size * acts as an anti-clotting factor * increases nitric oxide production in the vasculature leading to a greater dilation of the vessels"
Matti Narkia

[Vitamin K and Bone Update. In vivo Metabolism of Vitamin K. - In relation to the conve... - 0 views

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    [Vitamin K and Bone Update. In vivo Metabolism of Vitamin K. - In relation to the conversion of vitamin K(1) to MK-4 -] Okano T, Nakagawa K, Kamao M. Clin Calcium. 2009 Dec;19(12):1779-87. Japanese. PMID: 19949269 Phylloquinone is a major form (>90%) of dietary vitamin K, but the form of vitamin K that exists at the highest concentrations in tissues of animals and humans is menaquinone-4 (MK-4) . Despite this great difference, the origin of tissue MK-4 had not been clarified until recently. We demonstrated that deuterium-labeled phylloquinone was converted into deuterium-labeled MK-4 in mice and this conversion occurred following an oral or enteral administration, but not parenteral administration. By the oral route, the phylloquinone with the deuterium-labeled side chain (phytyl side-chain) was clearly converted into menaquinone-4 with a non-deuterium-labeled side chain (geranylgeranyl side-chain) , implying that phylloquinone was converted into menaquinone-4 via integral side-chain removal. Our results suggest that cerebral menaquinone-4 originates from phylloquinone intake and the release of menadione from phylloquinone in the intestine followed by the prenylation of menadione into menaquinone-4 in the intestine or tissues
Matti Narkia

Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on... - 0 views

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    Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria. Davidson RT, Foley AL, Engelke JA, Suttie JW. J Nutr. 1998 Feb;128(2):220-3. PMID: 9446847 These data offer conclusive proof that the tissue-specific formation of MK-4 from K is a metabolic transformation that does not require bacterial transformation to menadione as an intermediate in the process
Matti Narkia

Novel Formulation Of Vitamin E Extract Could Tackle Tumors Without Damaging Healthy Tissue - 0 views

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    A new formulation of the vitamin E extract tocotrienol could play a key role in treating cancerous tumors without harming healthy tissue. Tocotrienol has anti-cancer properties, but when given intravenously it has secondary effects on healthy tissue; now researchers in the UK have found that delivering the compound encapsulated in transferrin-bearing vesicles can shrink tumors without causing visible toxic effects.
Matti Narkia

Ergothioneine - Wikipedia, the free encyclopedia - 0 views

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    Ergothioneine is a naturally-occurring amino acid and is a thiourea derivative of histidine, containing a sulfur atom in the imidazole ring. This compound is made in rather few organisms, notably Actinobacteria and filamentous fungi.[1] Ergothioneine was discovered in 1909 and named after the ergot fungus from which it was first purified, with its structure being determined later, in 1911.[2] This amino acid has antioxidant properties, but its chemistry differs from conventional sulfur-containing antioxidants such as glutathione or lipoic acid. Although ergothioneine cannot be made in human cells, it is present in some tissues at high levels as it is absorbed from the diet.[3] In humans ergothioneine is taken up from the gut and concentrated in the tissues by a specific transporter called the novel organic cation transporter. However, even today, one hundred years after its discovery, precisely what ergothioneine does in the human body remains a mystery
Matti Narkia

Vitamin D in preventive medicine: are we ignoring the evidence? - 0 views

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    Vitamin D in preventive medicine: are we ignoring the evidence? Zittermann A. Br J Nutr. 2003 May;89(5):552-72. Review. PMID: 12720576 Vitamin D is metabolised by a hepatic 25-hydroxylase into 25-hydroxyvitamin D (25(OH)D) and by a renal 1alpha-hydroxylase into the vitamin D hormone calcitriol. Calcitriol receptors are present in more than thirty different tissues. Apart from the kidney, several tissues also possess the enzyme 1alpha-hydroxylase, which is able to use circulating 25(OH)D as a substrate. Serum levels of 25(OH)D are the best indicator to assess vitamin D deficiency, insufficiency, hypovitaminosis, adequacy, and toxicity. European children and young adults often have circulating 25(OH)D levels in the insufficiency range during wintertime. Elderly subjects have mean 25(OH)D levels in the insufficiency range throughout the year. In institutionalized subjects 25(OH)D levels are often in the deficiency range. There is now general agreement that a low vitamin D status is involved in the pathogenesis of osteoporosis. Moreover, vitamin D insufficiency can lead to a disturbed muscle function. Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer. Some intervention trials have demonstrated that supplementation with vitamin D or its metabolites is able: (i) to reduce blood pressure in hypertensive patients; (ii) to improve blood glucose levels in diabetics; (iii) to improve symptoms of rheumatoid arthritis and multiple sclerosis. The oral dose necessary to achieve adequate serum 25(OH)D levels is probably much higher than the current recommendations of 5-15 microg/d.
Matti Narkia

Whole Health Source: Vitamin K2 in Marrow - 0 views

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    I'm always on the lookout for foods rich in vitamin K2 MK-4, because it's so important and so rare in the modern food system. I heard some internet rumors that marrow might be rich in fat-soluble vitamins. Google let me down, so I decided to look through the rat studies on K2 MK-4 in which they looked at its tissue distribution. I found one that looked at the K2 MK-4 content in different tissues of rats fed vitamin K1. Marrow was rich in K2, along with testes. It contains 10-20 times more MK-4 than liver by weight, and more than any of the other organs they tested (serum, liver, spleen, kidney, heart, testes, marrow, brain) except testes. They didn't include values for salivary gland and pancreas, the two richest sources.
Matti Narkia

Whole Health Source: Are the MK-4 and MK-7 Forms of Vitamin K2 Equivalent? - 0 views

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    "As far as I can tell, MK-4 is capable of performing all the functions of vitamin K. MK-4 can even activate blood clotting factors, which is a role traditionally ascribed to vitamin K1. Babies are often born clotting deficient, which is why we give newborns vitamin K1 injections in the U.S. to prevent hemorrhaging. In Japan, they give children MK-4 to prevent hemorrhage, an intervention that is very effective. Could that have to do with the fact that Japan has half the infant mortality rate of the U.S.? Today, I found another difference between MK-4 and MK-7. I was reading a paper about SXR-independent effects of vitamin K2 on gene expression. The investigators found that MK-4 strongly activates transcription of two specific genes in osteoblast cells. Osteoblasts are cells that create bone tissue. The genes are GDF15 and STC2 and they're involved in bone and cartilage formation. They tested K1 and MK-7, and in contrast to MK-4, they did not activate transcription of the genes in the slightest. This shows that MK-4 has effects on gene expression in bone tissue that MK-7 doesn't have. That being said, MK-7 may still have a place in a healthy diet. Just because it can't do everything MK-4 can, doesn't mean it has no role. It may be able to fill in for MK-4 in some functions, or reduce the dietary need for MK-4. But no one really knows at this point. Hunter-gatherers would have had a source of longer menaquinones, including MK-7, from livers. So it's possible that we're adapted to a modest MK-7 intake on top of MK-4. "
Matti Narkia

Age and Dietary Form of Vitamin K Affect Menaquinone-4 Concentrations in Male Fischer 3... - 0 views

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    Age and dietary form of vitamin K affect menaquinone-4 concentrations in male Fischer 344 rats. Booth SL, Peterson JW, Smith D, Shea MK, Chamberland J, Crivello N. J Nutr. 2008 Mar;138(3):492-6. PMID: 18287355 These data suggest that dihydrophylloquinone, which differs from phylloquinone in its side phytyl chain, is absorbed but its intake results in less MK-4 in certain tissues. Dihydrophylloquinone may be used in models for the study of tissue-specific vitamin K deficiency
Matti Narkia

Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pa... - 0 views

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    Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. Peterlik M, Cross HS. Eur J Clin Nutr. 2009 Dec;63(12):1377-86. Epub 2009 Sep 2. PMID: 19724293 doi:10.1038/ejcn.2009.105 A compromised vitamin D status, characterized by low 25-hydroxyvitamin D (25-(OH)D) serum levels, and a nutritional calcium deficit are widely encountered in European and North American countries, independent of age or gender. Both conditions are linked to the pathogenesis of many degenerative, malignant, inflammatory and metabolic diseases. Studies on tissue-specific expression and activity of vitamin D metabolizing enzymes, 25-(OH)D-1alpha-hydroxylase and 25-(OH)D-24-hydroxylase, and of the extracellular calcium-sensing receptor (CaR) have led to the understanding of how, in non-renal tissues and cellular systems, locally produced 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and extracellular Ca2+ act jointly as key regulators of cellular proliferation, differentiation and function. Impairment of cooperative signalling from the 1,25-(OH)2D3-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency causes cellular dysfunction in many organs and biological systems, and, therefore, increases the risk of diseases, particularly of osteoporosis, colorectal and breast cancer, inflammatory bowel disease, insulin-dependent diabetes mellitus type I, metabolic syndrome, diabetes mellitus type II, hypertension and cardiovascular disease. Understanding the underlying molecular and cellular processes provides a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases worldwide.
Mango Dash india

Mango Dash: Mango Juice Uses Cures Acne And Skin Health - 0 views

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    Mango Juice Perhaps you are surprised to know that mangoes are closely related to skin health. Other than bringing a healthy glow to your face, mango Juice also help to lighten skin color. You can easily enhance your beauty by including this tasty fruit in your diet on a regular basis.



    Mangoes effectively treat acne by opening the clogged pores of the skin. Once these pores are opened, acne formation will eventually stop. Unclogging the pores of the skin is the most effective way to eliminate acne. To enjoy this benefit, there is no need to eat mangoes every day you need to remove the mango pulp and apply it on the skin for around 10 minutes, then rinse it off.



    Consuming this Mango Juice regularly will help keep your body healthy and slow down premature skin aging caused by environmentally stresses such as pollution and sun damage.



    THE ROLE OF JUICE IN SKIN HEALTH

    Mango Juices are anti-inflammatory, antioxidant, astringent, loaded with phytonutrients and they help build and repair skin collagen and connective tissue, thus reducing acne scars and acne scarring.

    Some juices may also help to balance hormones, whereas others may have antibacterial and antibiotic properties.

    Furthermore, these juices can help reduce stress, improve circulation, and speed healing.



    Five Best Skin Health Benefits of Mango Juice:

    Besides being extremely pleasing to your taste buds, mango is amazing for your skin as it is a great source of antioxidants, particularly vitamin C, which keep your skin healthy and glowing. It is often used in various face masks and scrubs. Its various skin benefits are as follows:



    1. Mango juice for Glowing Skin:



    Mango Juice are great for your skin as they have the ability to reduce dark spots, blemishes and acne, thus imparting a natural glow to
silver line

Cost Effective Treatment for Hormone Growth Deficiency India - 0 views

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    Silver Line offer treatment for growth abnormalities, abnormal growth of cells, hormone growth deficiency, adult growth hormone deficiency, growth hormone deficiency in children, abnormal bone and tissue growth, endocrine disorders.
nirvana-india

Search Blog 2014 - Nirvana Naturopathy & Retreat - 0 views

shared by nirvana-india on 20 Sep 15 - No Cached
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    It is one of the most useful and well-known forms of naturopathy in India. It is a passive form of exercise that stimulates the soft tissues of the body through pressure, tension, motion and vibration provided both mechanically and manually. It helps in toning up the body, increasing the metabolism rates of the body and also curing some of the worst diseases like cervical spondylosis, arthritis, etc. For free discussion please fill up the contact us form. Website:http://www.nirvananaturopathy.com/archive/search-blog-2014
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    It is one of the most useful and well-known forms of naturopathy in India. It is a passive form of exercise that stimulates the soft tissues of the body through pressure, tension, motion and vibration provided both mechanically and manually. It helps in toning up the body, increasing the metabolism rates of the body and also curing some of the worst diseases like cervical spondylosis, arthritis, etc. For free discussion please fill up the contact us form. Website:http://www.nirvananaturopathy.com/archive/search-blog-2014
Matti Narkia

Polyunsaturated (n-3) Fatty Acids Susceptible to Peroxidation Are Increased in Plasma a... - 0 views

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    Song JH, Fujimoto K, Miyazawa T. Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. J Nutr. 2000 Dec;130(12):3028-33. PMID: 11110863 [PubMed - index
Matti Narkia

Serum vitamin D level after an annual intramuscular injection of ergocalciferol. - [Cal... - 0 views

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    Serum vitamin D level after an annual intramuscular injection of ergocalciferol. Heikinheimo RJ, Haavisto MV, Harju EJ, Inkovaara JA, Kaarela RH, Kolho LA, Rajala SA. Calcif Tissue Int. 1991;49 Suppl:S87. PMID: 1933611 An annual intramuscular injection of ergocalciferol (150,000 IU) normalized low serum (25(OH)D concentrations in elderly people for 1 year. The treatment had a slight effect on serum 24,25(OH)2D levels but no effect on 1,25(OH)2D levels.
Matti Narkia

Annual injection of vitamin D and fractures of aged bones. - [Calcif Tissue Int. 1992] ... - 0 views

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    Annual injection of vitamin D and fractures of aged bones. Heikinheimo RJ, Inkovaara JA, Harju EJ, Haavisto MV, Kaarela RH, Kataja JM, Kokko AM, Kolho LA, Rajala SA. Calcif Tissue Int. 1992 Aug;51(2):105-10. PMID: 1422948
Matti Narkia

NEJM -- Mercury, Fish Oils, and the Risk of Myocardial Infarction - 0 views

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    Mercury, fish oils, and the risk of myocardial infarction. Guallar E, Sanz-Gallardo MI, van't Veer P, Bode P, Aro A, Gómez-Aracena J, Kark JD, Riemersma RA, Martín-Moreno JM, Kok FJ; Heavy Metals and Myocardial Infarction Study Group. N Engl J Med. 2002 Nov 28;347(22):1747-54. PMID: 12456850 Conclusions The toenail mercury level was directly associated with the risk of myocardial infarction, and the adipose-tissue DHA level was inversely associated with the risk. High mercury content may diminish the cardioprotective effect of fish intake.
Matti Narkia

A Diet Rich in Coconut Oil Reduces Diurnal Postprandial Variations in Circula... - 0 views

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    A diet rich in coconut oil reduces diurnal postprandial variations in circulating tissue plasminogen activator antigen and fasting lipoprotein (a) compared with a diet rich in unsaturated fat in women. Müller H, Lindman AS, Blomfeldt A, Seljeflot I, Pedersen JI. J Nutr. 2003 Nov;133(11):3422-7. PMID: 14608053 In conclusion, our results indicate that a coconut oil-based diet (HSAFA-diet) lowers postprandial t-PA antigen concentration, and this may favorably affect the fibrinolytic system and the Lp(a) concentration compared with the HUFA-diet. The proportions of dietary saturated fatty acids more than the percentage of saturated fat energy seem to have a beneficial influence on Lp(a) levels. The connection between Lp(a) and atherosclerosis is not entirely understood. Different studies have provided strong evidence that Lp(a) level is an independent risk factor for developing coronary artery disease in men (47,48), but the question of causality continues to be debated. Recent data suggest that Lp(a) might be atherogenic (49), in particular when combined with other risk factors. High levels of Lp(a) combined with other risk factors such as the ratio of plasma total/HDL cholesterol have been shown to increase the risk for coronary heart diseases (50). It has also been reported that when substantial LDL cholesterol reductions were obtained in men with coronary heart disease, persistent elevations of Lp(a) were no longer atherogenic or clinically threatening (51). In conclusion, the present results show that the HSAFA-diet lowered postprandial t-PA antigen and thus potentially improved fibrinolysis compared with the HUFA-diet. Diets with either high or low levels of saturated fatty acids from coconut oil beneficially decrease Lp(a) compared with a HUFA-diet. The proportions of dietary saturated fatty acids more than the percentage of saturated fat energy may be of importance if the goal is to decrease Lp(a).
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