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Matti Narkia

Whole Health Source: Eicosanoids and Ischemic Heart Disease, Part II - 0 views

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    "Wednesday, May 27, 2009
    Eicosanoids and Ischemic Heart Disease, Part II
    Here's where it gets more complicated and more interesting. The ratio of omega-6 to omega-3 matters, but so does the total amount of each. This is a graph from a 1992 paper by Dr. Lands:

    In sum, this suggests that the single best way to avoid a heart attack is to reduce omega-6 consumption and ensure an adequate source of omega-3. The lower the omega-6, the less the omega-3 matters. This is a nice theory, but where's the direct evidence? In the next post, I'll discuss the controlled trial that proved this concept once and for all: the Lyon diet-heart trial.
Matti Narkia

Are Omega-3 Fatty Acids Effective in Enhancing Tumoricidal Cell Activity? - Are Omega-3... - 0 views

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    K. L. Fritsche
    Are Omega-3 Fatty Acids Effective in Enhancing Tumoricidal Cell Activity?
    J. Nutr., December 1, 2005; 135(12): 2916S - 2917S.
Matti Narkia

Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and prefe... - 0 views

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    Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer.
    Cerchietti LC, Navigante AH, Castro MA.
    Nutr Cancer. 2007;59(1):14-20.
    PMID: 17927497
Matti Narkia

Modulation of inflammation in brain: a matter of fat. - J Neurochem. 2007 May - 0 views

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    Modulation of inflammation in brain: a matter of fat.
    Farooqui AA, Horrocks LA, Farooqui T.
    J Neurochem. 2007 May;101(3):577-99. Epub 2007 Jan 25. Review.
    PMID: 17257165
    DOI: 10.1111/j.1471-4159.2006.04371.x
Matti Narkia

Immunomodulation by omega-3 fatty acids - Prostaglandins Leukot Essent Fatty Acids. 200... - 0 views

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    Immunomodulation by omega-3 fatty acids.
    Calder PC.
    Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):327-35. Epub 2007 Nov 26. Review.
    PMID: 18032006
    doi:10.1016/j.plefa.2007.10.015
Matti Narkia

Comparison of biochemical effects of statins and fish oil in brain: the battle of the t... - 0 views

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    Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans.
    Farooqui AA, Ong WY, Horrocks LA, Chen P, Farooqui T.
    Brain Res Rev. 2007 Dec;56(2):443-71. Epub 2007 Oct 23. Review.
    PMID: 17959252
    doi:10.1016/j.brainresrev.2007.09.004    
Matti Narkia

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators : Abs... - 0 views

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    Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators.
    Serhan CN, Chiang N, Van Dyke TE.
    Nat Rev Immunol. 2008 May;8(5):349-61. Review.
    PMID: 18437155
    doi:10.1038/nri2294
Matti Narkia

Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic gen... - 0 views

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    Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus.
    Serhan CN, Chiang N.
    Br J Pharmacol. 2008 Mar;153 Suppl 1:S200-15. Epub 2007 Oct 29. Review.
    PMID: 17965751
    DOI: 10.1038/sj.bjp.0707489
Matti Narkia

The relationship between the fatty acid composition of immune cells and their function ... - 0 views

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    The relationship between the fatty acid composition of immune cells and their function.
    Calder PC.
    Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):101-8. Epub 2008 Oct 23. Review.
    PMID: 18951005
    doi:10.1016/j.plefa.2008.09.016
Matti Narkia

Novel omega -- 3-derived local mediators in anti-inflammation and resolution. - Science... - 0 views

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    Novel omega -- 3-derived local mediators in anti-inflammation and resolution.
    Serhan CN.
    Pharmacol Ther. 2005 Jan;105(1):7-21. Review.
    PMID: 15626453
    doi:10.1016/j.pharmthera.2004.09.002
Matti Narkia

Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic gen... - 0 views

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    Endogenous pro-resolving and anti-inflammatory lipid mediators: a new
    pharmacologic genus.
    Serhan CN, Chiang N.
    Br J Pharmacol. 2008 Mar;153 Suppl 1:S200-15. Epub 2007 Oct 29. Review.
    PMID: 17965751
    doi:10.1038/sj.bjp.0707489
Matti Narkia

Prostacyclin - Wikipedia, the free encyclopedia - 0 views

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    Prostacyclin (or PGI2) is a member of the family of lipid molecules known as eicosanoids.\nAs a drug, it is also known as "epoprostenol".[1] The terms are sometimes used interchangeably

    Prostacyclin (PGI2) chiefly prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation). It is also an effective vasodilator. Prostacyclin's interactions in contrast to thromboxane (TXA2), another eicosanoid, strongly suggest a mechanism of cardiovascular homeostasis between the two hormones in relation to vascular damage.


Matti Narkia

Thromboxane - Wikipedia, the free encyclopedia - 0 views

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    Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2.
    Thromboxane is named for its role in clot formation (thrombosis).
Matti Narkia

Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins. - Bentham Science Publi... - 0 views

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    Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins.
    Romano M.
    Inflamm Allergy Drug Targets. 2006 Apr;5(2):81-90. Review.
    PMID: 16613567
Matti Narkia

Lipoxin - Wikipedia, the free encyclopedia - 0 views

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    Lipoxins are a series of anti-inflammatory mediators. Lipoxins are short lived endogenously produced nonclassic eicosanoids whose appearance in inflammation signals the resolution of inflammation. They are abbreviated as LX, an acronym for lipoxygenase (LO) interaction products. At present two lipoxins have been identified; lipoxin A4 (LXA4) and lipoxin B4 (LXB4)
Matti Narkia

The role of eicosanoids in the brain. [Asia Pac J Clin Nutr. 2008] - PubMed Result - 0 views

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    The role of eicosanoids in the brain.
    Tassoni D, Kaur G, Weisinger RS, Sinclair AJ.
    Asia Pac J Clin Nutr. 2008;17 Suppl 1:220-8. Review.
    PMID: 18296342

    Liberation of these PUFA from the phosphoglycerides occurs via the action of specific phospholipases (PLA2).
Matti Narkia

Essential fatty acid - Wikipedia, the free encyclopedia - 0 views

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    Essential fatty acids, or EFAs, are fatty acids that cannot be constructed within an organism from other components (generally all references are to humans) by any known chemical pathways; and therefore must be obtained from the diet. The term refers to t
Matti Narkia

Eicosanoid - Wikipedia, the free encyclopedia - 0 views

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    In biochemistry, eicosanoids are signaling molecules derived from omega-3 (ω-3) or omega-6 (ω-6) fats. They exert complex control over many bodily systems, especially in inflammation, immunity and as messengers in the central nervous system. The network
Matti Narkia

Cyclooxygenase - Wikipedia, the free encyclopedia - 0 views

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    Cyclooxygenase (COX) is an enzyme (EC 1.14.99.1) that is responsible for formation of important biological mediators called prostanoids (including prostaglandins, prostacyclin and thromboxane). Pharmacological inhibition of COX can provide relief from the
Matti Narkia

Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential ... - 0 views

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    Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms.
    Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A.
    Am J Clin Nutr. 2004 Jun;79(6):935-45. Review.
    PMID: 15159222
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