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Estradiol in mice predisposed to Lupus have increased inflammation and characteristics of Lupus.  In contrast, Estradiol in those without predisposition, do not.  Clearly this is an inflammatory signaling problem.  Studies have shown an Interferon gamma signaling deficit in those with Lupus.  Testosterone decreases the above inflammation signaling.

GLA, omega-6 found in plant based oils,  kills 42% of leukemia cells; with dexamethasone, the kill rate increases to 86%

Saccharomyces boulardii decreased TNF-alpha and INF-gamma as well as decreased candida colonization.

Study found that viral oncolytic therapy improved efficacy of PD-1 check point inhibitors by 62%. Increased CD8 expression, interferon-gamma...Interesting, starting CD8 levels played no role in predicting outcome.

elevated GGTP helpful in identifying liver metastasis.

only abstract available here.  Great review and discussion of the research behind Germanium Sesquioxide and its immune effects in the fight against cancer.  Primary effects are via increase in Interferon gamma and increase in NK cell activity; but it also inhibits tumor growth and metastatic potential. The germanium compound is specific to the sesquioxide compound.

Awesome review article on TA-1 and its broad immunomodulatory effects, i.e. increase IL-1, IFN-gamma, increase dendritic cell activity, inhibition of tumor growth…

M-Lorax is a veterinary cream which generally used to treat various type of wounds eg. cut wound, Lacerated wound, surgical wound & Maggot wound with Fly repellent Properties. M-Lorax cream has Gamma Benzene Hexachloride which is also helpful in treatment of scabies and lice infestations, Proflavin Hemisulphate & cetrimide which is widely used for antiseptic purposes. Uses of M-Lorax cream: Used to treat various types of wounds. Also useful in treatment of scabies and lice infestations. It is widely used as antiseptic. It heals wounds and cuts with excellent efficacy. Benefits: It is an antiseptic for pets. It prevents pets from lice and mites. Improves scalps from insects. Reduces rashes caused by bacterias. Effective in treatment of scabies. Prevent pets from itching & burning sensation.

PPARs are key regulators in inflammation control. PPARs are nuclear transcription factors that decrease NF-KappaB transcription.

fascinating read on gut inflammation and glucose metabolism.  The gut bacteria implicated her is Akkermansia muciniphila.

Women with preeclampsia have lower CoQ10 levels compared to normal pregnant women.

ATMs and obesity induced inflammation initiates insulin resistance and thus type II diabetes. The bodies reaction to a fat cell is no different than a bacterial, viral, or parasitic infection.  The body recognizes something (fat) that shouldn't be there and it attempts to destroy it and remove it.

Study shows that gastrointestinal epithelial dysfunction is found in autism. This would play a critical role in systemic inflammation and would contribute to ASD symptoms through the gut-brain connection.

patients given 6 grams of Evening primrose oil had improvement in Raynaud's symptoms in 8 weeks.

Vitamin C, in oral route, prevents elevations in liver enzymes after liver insult from Paraquat.

anti-depressants inhibit inflammatory IL-6 production from microglial cells in brain, suggesting anti-inflammatory effects of antidepressants as role in improving depression symptoms

GLA found to inhibit 5 alpha reductase activity in prostate cancer cells.

Review (4 studies) found that 6-8 weeks of probiotic therapy of pregnant women with gestational diabetes improved insulin resistance.

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