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Nathan Goodyear

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model - 0 views

www.ncbi.nlm.nih.gov/...PMC6983418

check point inhibitors CTL lymphoma cytotoxic T cells PD-1 vitamin C immune check point inhibitors IV vitamin C NK cells NK

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    high dose vitamin C shown to augment PD-1 immune check point inhibitors in Lymphoma mouse model.
Nathan Goodyear

Immune checkpoint inhibitors: recent progress and potential biomarkers | Experimental &... - 0 views

www.nature.com/...s12276-018-0191-1

cancer immunotherapy check point inhibitors immune check point inhibitors

shared by Nathan Goodyear on 28 Feb 21 - No Cached
  • Nathan Goodyear on 28 Feb 21
     
    Evidence points to their lacking benefits
Nathan Goodyear

[Enhancing Antitumor Effects Using Hyperthermia(Including Immune Checkpoint Inhibitor)]... - 0 views

pubmed.ncbi.nlm.nih.gov/30382051

hyperthermia check point inhibitors immunotherapy chemotherapy radiation

shared by Nathan Goodyear on 18 Feb 21 - No Cached
  • Nathan Goodyear on 18 Feb 21
     
    Only abstract available here. Hyperthermia augments radiation, chemotherapy, and checkpoint inhibitors.
Nathan Goodyear

Oncolytic virotherapy promotes intratumoral T cell infiltration and improves Anti-PD-1... - 0 views

www.cell.com/...S0092-8674(17)30952-2

immunotherapy cancer RIGVIR oncolytic therapy PD-1 check point inhibitors

shared by Nathan Goodyear on 23 Oct 18 - No Cached
  • Nathan Goodyear on 23 Oct 18
     
    Study found that viral oncolytic therapy improved efficacy of PD-1 check point inhibitors by 62%. Increased CD8 expression, interferon-gamma...Interesting, starting CD8 levels played no role in predicting outcome.
Nathan Goodyear

Development of PD-1/PD-L1 Pathway in Tumor Immune Microenvironment and Treatment for No... - 0 views

www.nature.com/...srep13110

PD-1 cancer check point inhibitors PD-L1 CLTA-4 immunotherapy

shared by Nathan Goodyear on 20 Apr 18 - No Cached
  • the lack of immunologic control is recognized as a hallmark of cancer currently
  • Programmed death-1 (PD-1) and its ligand PD-L1 play a key role in tumor immune escape and the formation of tumor microenvironment, closely related with tumor generation and development
  • Blockading the PD-1/PD-L1 pathway could reverse the tumor microenvironment and enhance the endogenous antitumor immune responses.
  • ...4 more annotations...
  • environmental factors, living habits, genetic mutations, dysfunction of the immune system and so on
  • special tumor immune microenvironment
  • cytotoxic T lymphocyte-associated antigen 4 (CLTA-4), Programmed death-1 (PD-1) and its ligands PD-L1 (B7H1) and PD-L2 (B7-DC)
  • CTLA-4 regulates T cell activity in the early stage predominantly, and PD-1 mainly limits the activity of T-cell in the tumor microenvironment at later stage of tumor growth
  • Nathan Goodyear on 20 Apr 18
     
    PD-1 to read.
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