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obat sehat

Diabetes - 0 views

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    Insulin is a hormone produced by the pancreas to control blood sugar. Diabetes can be caused by too little insulin, resistance to insulin, or both. To understand diabetes, it is important to first understand the normal process by which food is broken down and used by the body for energy. Several things happen when food is digested: A sugar called glucose enters the bloodstream. Glucose is a source of fuel for the body. An organ called the pancreas makes insulin. The role of insulin is to move glucose from the bloodstream into muscle, fat, and liver cells, where it can be used as fuel. People with diabetes have high blood sugar because their body cannot move sugar into fat, liver, and muscle cells to be stored for energy. This is because either: Their pancreas does not make enough insulin Their cells do not respond to insulin normally Both of the above There are two major types of diabetes. The causes and risk factors are different for each type: Type 1 diabetes can occur at any age, but it is most often diagnosed in children, teens, or young adults. In this disease, the body makes little or no insulin. Daily injections of insulin are needed. The exact cause is unknown. Type 2 diabetes makes up most diabetes cases. It most often occurs in adulthood. However, because of high obesity rates, teens and young adults are now being diagnosed with it. Many people with type 2 diabetes do not know they have it. Gestational diabetes is high blood sugar that develops at any time during pregnancy in a woman who does not have diabetes. Diabetes affects more than 20 million Americans. Over 40 million Americans have pre-diabetes (which often comes before type 2 diabetes).
Nathan Goodyear

The effect of myoinositol supplementation on insulin resistance in patients with gestat... - 0 views

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    Inositol shown to improve insulin resistance in women with gestational diabetes.
Nathan Goodyear

Nutrients | Free Full-Text | Effect of Probiotics on Metabolic Outcomes in Pregnant Wom... - 0 views

  • The gut microbial composition is altered during pregnancy
  • probiotic supplements may contribute to the maintenance of bacterial diversity and glucose homeostasis in individuals with metabolic disturbances
  • Assessment of four randomized controlled trials in this review involving 288 pregnant women with GDM found that a 6–8 week probiotic intervention did not improve FBG or LDL-cholesterol levels
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  • probiotic supplementation in women with GDM was associated with significant reductions in insulin resistance
  • One proposed method is by the production of short chain fatty acids (SCFAs), generated as a by-product of bacterial fermentation of dietary fibers. SCFAs act as an energy source for intestinal cells and have been found to regulate the production of hormones effecting energy intake and expenditure such as leptin and grehlin
  • Another hypothesized mechanism of SCFA action includes reducing gastrointestinal permeability by upregulating transcription of tight junction proteins, enhancing production of Glucagon-like peptide-2 (GLP-2) which promotes crypt cell proliferation, and reducing inflammation in colonic epithelial cells by increasing PPAR-gamma activation
  • Maintenance of the integrity of the gut barrier minimizes the concentration of lipopolysaccharide (LPS) in circulation
  • LPS is a structural component of gram negative bacterial cell walls, which induces an immune-cell response upon absorption into the human bloodstream, stimulating proinflammatory cytokine production and the onset of insulin resistance and hyperglycemia
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    Review (4 studies) found that 6-8 weeks of probiotic therapy of pregnant women with gestational diabetes improved insulin resistance.
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Nathan Goodyear

A randomized clinical trial of exercise during pregnancy to prevent gestation... - 0 views

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    Exercise reduces Gestational Diabetes risk in Obese pregnant women.  The amount of exercise was quite limited: 30 minutes cycling for 3 days/week only. No increased risk of preterm delivery as well.
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Nathan Goodyear

Plasma coenzyme Q10 is increased during gestational diabetes. - PubMed - NCBI - 0 views

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    CoQ10 levels elevated in women with gestational diabetes.  The authors proposed that this was an adaptation to increased oxidative stress.
Nathan Goodyear

Early pregnancy urinary biomarkers of fatty acid and carbohydrate metabolism in pregnan... - 0 views

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    Study finds that fatty acid and carbohydrate metabolism markers can be used to assess gestational diabetes risk in pregnancy.  
Nathan Goodyear

Effects of a Multispecies Probiotic Mixture on Glycemic Control and Inflammatory Status... - 0 views

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    probiotic therapy improves insulin resistance, and reduces inflammation in pregnant women with gestational diabetes.
Nathan Goodyear

Connections between the human gut microbiome and gestational diabetes mellitus | GigaSc... - 0 views

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    Gestational Diabetes risk may just begin in the gut flora.
Nathan Goodyear

Effects of vitamin D supplementation on gluco... [Am J Clin Nutr. 2013] - PubMed - NCBI - 0 views

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    Vitamin D3 replacement was found to decrease fasting glucose, decrease insulin, increase insulin sensitivity, and decrease total cholesterol and LDL in pregnant women with gestational diabetes.  The dosing here was 50,000 IU x 2 doses taken 3 weeks apart. 
Nathan Goodyear

Correlation between inflammatory markers a... [J Obstet Gynaecol. 2014] - PubMed - NCBI - 0 views

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    Interesting, yet not surprising.  TNF-alpha has strong correlation with IR in pregnancy.  This follows metabolic endotoxemia pathophysiology.  I believe this could be used to assess risk for PIH...
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