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Nathan Goodyear

Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells ... - 0 views

pubmed.ncbi.nlm.nih.gov/26002438

TA-1 peptides PI3K_Akt_mTOR breast cancer thymosin alpha-1 PTEN

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    TA-1 induces apoptosis through PTEN mediated PI3k/Akt/mTOR pathway inhibition. Sorry, only abstract available here. Significant in that TA-1 works beyond just immune stimulation.
Nathan Goodyear

Thymosin alpha 1: A comprehensive review of the literature - 0 views

www.ncbi.nlm.nih.gov/...PMC7747025

peptides cancer thymosin alpha-1 TA-1

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    Awesome review article on TA-1 and its broad immunomodulatory effects, i.e. increase IL-1, IFN-gamma, increase dendritic cell activity, inhibition of tumor growth…
Nathan Goodyear

Zadaxin (Thymalfasin): Uses, Dosage, Side Effects, Interactions, Warning - 0 views

www.rxlist.com/zadaxin-drug.htm

peptide cancer TA-1 thymosin alpha-1

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    Not an article, but a drug review of the medication Zadaxin, which is a commercial synthetic form of TA-1; Thymosin alpha 1 improved immunological parameters increased tumor response rates, and improved survival and quality of life
Nathan Goodyear

Thymosin alpha-1 blocks the accumulation of myeloid suppressor cells in NSCLC by inhibi... - 0 views

pubmed.ncbi.nlm.nih.gov/32942159

MDSC TME TA-1 VEGF tumor microenvironment myeloid-derived suppressor cells thymosin alpha-1

shared by Nathan Goodyear on 16 Aug 21 - No Cached
  • Nathan Goodyear on 16 Aug 21
     
    TA-1 alters tumor microenvironment via VEGF induced decrease in MDSC.
Nathan Goodyear

Cells | Free Full-Text | Functional Assessment of Pharmacological Telomerase Activators... - 0 views

www.mdpi.com/htm

TA-65 telomere Telomerase telomerase activator natural aging wellness health

shared by Nathan Goodyear on 16 May 16 - No Cached
  • Nathan Goodyear on 16 May 16
     
    Full study of previously posted abstract of TA-65 increase of telomere length in cell culture.
Nathan Goodyear

Cells | Free Full-Text | Functional Assessment of Pharmacological Telomerase Activators... - 0 views

www.mdpi.com/57

TA-65 telomere telomerase activator Telomerase aging natural wellness health

shared by Nathan Goodyear on 16 May 16 - No Cached
  • Nathan Goodyear on 16 May 16
     
    TA-65 found to significantly increase telomerase activity in cell culture.
Nathan Goodyear

Immune responses to malignancies - 0 views

www.ncbi.nlm.nih.gov/...PMC3721350

cancer immune system

shared by Nathan Goodyear on 18 Apr 18 - No Cached
  • increased densities of T-cell infiltrates with a high proportion of CD8+ T cells within primary colorectal carcinomas were associated with a significant protection against tumor recurrence
  • coexpression of genes mediating cytotoxicity and TH1 adaptive immune responses accurately predicted survival in patients with colorectal carcinoma independently of the metastatic status.
  • tumor-specific cytolytic T lymphocytes (CTLs)
  • ...10 more annotations...
  • tumor-associated antigens (TAs)
  • Proinflammatory cytokines secreted by inflammatory cells can contribute to tumor progression, and soluble factors produced by the tumor in response to nonspecific or tumor-specific signals, such as prostaglandin E2 (PGE2), adenosine, or TGF-β, downregulate functions of immune cells
  • they are largely ineffective in arresting tumor growth, although they can proliferate and mediate antitumor cytotoxicity on their removal from the tumor bed and ex vivo IL-2 activation.42
  • DCs (HLA-DR+CD86+CD80+CD14−) are nature’s best APCs
  • They are a common component of tumor immune infiltrates and are responsible for the uptake, processing, and cross-presentation of TAs to naive or memory T cells, thus playing a crucial role in the generation of tumor-specific effector T cells
  • DCs control the induction of Treg cells. In patients with cancer, cellular interactions between antigen-presenting DCs and T cells lead to expansion and accumulation of Treg cells at the tumor site and in the periphery
  • NK cells (CD3−CD56+CD16+), which mediate innate immunity and contain both perforin-rich and granzyme-rich granules, are well equipped to mediate lysis of tumor cells
  • B cells (CD19+, CD20+) are also rare in most human tumors, with the exception of breast cancer and melanoma
  • The initial acute inflammation involving the recruitment and influx of antitumor effector cells is replaced by chronic inflammation in later stages of tumor progression
  • Tissue hypoxia plays a major role in shaping the nature of immune infiltrates in tumors
  • Nathan Goodyear on 18 Apr 18
     
    Another great review of the immune system during different stages of carcinogenesis; how the cancer manipulates the immue system to cloak itself from the immune system.
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