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Abnormal NK cell activity in the placenta plays a likely role in the development of preeclampsia. This proposes an immunologic role in the development of preeclampsia.  This process is similar to the literatures link between maternal NK and RPL.

preeclampsia associated with oxidative stress.  Low levels of glutathione, vitamin C found in placentas of those with preeclampsia.  Implications for therapy?

This article's conclusion fits the definition of insane. This article found that the flu vaccine in pregnant women found significant increased CRP, TNF-alpha, and IL-6 inflammatory biomarkers.  It is well recognized the impact of inflammation on health and in this case the developing baby.   For example, preeclampsia and preterm birth are inflammatory conditions.  Yet, ACOG has made recommmendations for all pregnant women to get the flu vaccine?!?! Here is their conclusion: "However, further research is needed to confirm that the mild inflammatory response elicited by vaccination is benign in pregnancy".  Take home, you are being studied to see the effects of the flu vaccine on you, if you are pregnant, and your developing child.  And who decides what "mild" is anyways.  If you develop preeclampsia and delivery early, where is the "mild" in that?

same NK link to RPL, linked to preeclampsia.  NK cells play important role in the development of the spiral arteries in the placenta. It has long been thought, that the placenta was the likely culprit in the development of preeclampsia

Preeclampsia associated with lower CoQ10 levels in women.

Women with preeclampsia have lower CoQ10 levels compared to normal pregnant women.

vitamin D deficiency increases preeclampsia risk.  All pregnant women or women considering pregnancy should be evaluated for vitamin D deficiency.

probiotics during pregnancy shown to reduce risk of preeclampsia

preeclampsia should be a history marker that reveals increased cardiovascular disease (CVD).  

only abstract available here, but Coq10 found to decrease incidence of preeclampsia.

200 mg CoQ10 found to decrease the risk of preeclampsia in those women at risk.

As NK over activity has been shown to play in role in recurrent miscarriages, so it appears that loss if immune tolerance (elevated NK activity) may play a role in preeclampsia

women with RPL and preeclampsia carry same immunologic NK abnormalities.  Loss of immune tolerance, elevated maternal NK, shown to play role in both.

Women with elevated androgens, Testosterone and androstenedione, are at higher risk of preeclampsia.  This translates to a higher risk of CVD in women later in life, post pregnancy.  This fits with other literature that CVD is linearly associated with a rising Testosterone.  This has been found in caucasian and black women.

antioxidant support in early pregnancy, including NAC, shown to reduce the incidence in pre-eclampsia

NK cells and their role in pre-eclampsia

CoQ10 at 200 mg shown to significantly reduce the rate of pre-eclampsia in pregnant women.

glutathione low in pregnancies complicated by PIH and HELLP syndrome. Every woman should have her detoxification capacity evaluated prior to pregnancy.