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Nathan Goodyear

The Candida albicans INT1 gene facilitates cecal colonization in endotoxin-treated mice. - 0 views

www.uniprot.org/...10847632

candida albicans candidiasis endotoxin endotoxins

shared by Nathan Goodyear on 22 Jul 13 - No Cached
  • Nathan Goodyear on 22 Jul 13
     
    Antibiotics lead to Candida intestinal colonization which results in increased risk of systemic candidiasis.
Nathan Goodyear

http://medind.nic.in/jac/t05/i2/jact05i2p155.pdf - 0 views

medind.nic.in/...jact05i2p155.pdf

polyglandular autoimmune syndrome type 1 diabetes endocrinopathies hormones hypoparathyroidism candidiasis hypogonadism low T low Testosterone low T Testosterone

shared by Nathan Goodyear on 11 Aug 14 - No Cached
  • Nathan Goodyear on 11 Aug 14
     
    Case presentation of a young man with Polyglandular autoimmune syndrome type I.
Nathan Goodyear

Evaluation of candidal colonization and specific humoral responses against Candida albi... - 0 views

onlinelibrary.wiley.com/...abstract

candida candida albicans candidiasis yeast psoriasis dermatology

shared by Nathan Goodyear on 03 Dec 15 - No Cached
  • Nathan Goodyear on 03 Dec 15
     
    higher colonization of candida albicans found in people with psoriasis vs controls.  Higher in oral cultures vs skin.
Nathan Goodyear

Incidence of Candida in psoriasis--a study on the fungal flora of psoriatic patients. -... - 0 views

www.ncbi.nlm.nih.gov/...11413927

candida candida albicans candidiasis psoriasis dermatology yeast

shared by Nathan Goodyear on 03 Dec 15 - No Cached
  • Nathan Goodyear on 03 Dec 15
     
    statistically higher candida detected in those with psoriasis vs controls.
Nathan Goodyear

Saccharomyces boulardii decreases inflammation and intestinal colonization by Candida a... - 0 views

www.ncbi.nlm.nih.gov/...17885943

saccharomyces boulardii inflammation TNF-alpha candida candida albicans candidiasis

shared by Nathan Goodyear on 03 Dec 15 - No Cached
  • Nathan Goodyear on 03 Dec 15
     
    Saccharomyces boulardii decreased TNF-alpha and INF-gamma as well as decreased candida colonization.
Nathan Goodyear

Rare Occurrence of 3 "H": Hypercalcemia, Hemolytic Anemia and Hodgkin's Lymphoma - 0 views

www.ncbi.nlm.nih.gov/...PMC4925562

Hodgkin's lymphoma Hodgkin's disease hypercalcemia lymphoma

shared by Nathan Goodyear on 21 Aug 18 - No Cached
  • administered zoledronic acid (4 mg). Prednisolone (1 mg/kg/day) was started and simultaneously, she was administered first cycle of ABVD (Adriamycin: 25 mg/m2, Bleomycin: 10 U/m2, Vinblastine: 6 mg/m2 and Dacarbazine: 375 mg/m2), which led to normalisation of serum calcium levels over 4 days and improvement in her hemoglobin levels
  • Etiology of anemia in Hodgkin’s lymphoma is multifactorial. Anemia of chronic disease, decreased red cell survival, infiltration of bone marrow by tumor and marrow suppression by chemotherapy/radiotherapy are the common mechanisms
  • Our case had only a transient response to steroids and chemotherapy. Therefore, she was treated with Rituximab which brought hemolysis under control
  • ...7 more annotations...
  • Mechanism of hypercalcemia in HL has long been suggested to involve extra-renal activation of 1α-hydroxylase leading to production of 1, 25(OD)2 Vitamin D3 or Calcitriol, an active metabolite of Vitamin D, which leads to increased re-absorption of calcium and phosphate from intestine, increased osteoclast activation and bone resorption as well as increased phosphate re-absorption in renal tubules
  • Hypercalcemia of malignancy involves three mechanisms: 1. Humoral hypercalcemia mediated by PTHrP—seen in solid tumors like breast cancer and adult T cell leukemia/lymphoma (ATLL), 2. Direct osteoclast mediated bone resorption due to bony metastasis—seen in solid tumors and multiple myeloma, 3. Calcitriol mediated hypercalcemia—seen in Hodgkin’s and non-Hodgkin’s lymphoma as well as granulomatous disorders like tuberculosis, sarcoidosis, leprosy and disseminated Candidiasis
  • Hypercalcemia in HL is rare and its incidence has been reported as 0.9, 1.6 and 5.4 % in different series
  • The source of 1α-hydroxylase in HL has been postulated as monocytes and macrophages infiltrating the tumor akin to tuberculosis or sarcoidosis and is stimulated by IFN-γ secreted by T-lymphocytes
  • Like sarcoidosis, patients with HL exhibit increased sensitivity to Vitamin D supplements and sunlight, which have been found to precipitate hypercalcemia in these patients
  • Classical biochemical profile in Calcitriol mediated hypercalcemia include: an elevated calcium, normal/slightly elevated phosphate, normal 25(OH) Vitamin D, suppressed PTHrP and PTH, elevated Calcitriol and a normal/increased tubular reabsorption of phosphate
  • not been associated with a poorer prognosis and tends to subside after treatment of the underlying disease
  • Nathan Goodyear on 21 Aug 18
     
    great read on hypercalcemia in hodgkin's lymphoma.
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