Effect of resistance exercise on muscle steroidogenesis | Journal of Applied Physiology - 0 views
jap.physiology.org/...1754
resistance resistance training training exercise Testosterone male female hormone hormones muscle
shared by Nathan Goodyear on 03 Sep 14
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skeletal muscle cell cultures incubated with DHEA produced testosterone in a DHEA dose-dependent manner
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testosterone appears to have a role in the maintenance of muscle mass in women, although the importance of this role has not yet been fully established.
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Circulating testosterone concentrations are generally elevated following a bout of resistance exercise in men (24, 31, 46, 52), whereas findings for the effect of resistance exercise on circulating testosterone in women are equivocal, with increases (10, 42) and no changes observed (22, 31)
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swimming (51) and treadmill running (2) can significantly increase muscle testosterone concentrations in male and female rats
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This upregulation of muscle testosterone in rats appears, at least in part, to be due to an increase in 3β-HSD and 17β-HSD type 1 expression
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The primary finding in this study was that muscle steroidogenesis (i.e., testosterone production) in highly resistance-trained humans was not affected by an acute bout of heavy resistance exercise
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A secondary finding was that the apparent molecular mass of 17β-HSD type 3 was increased following a single bout of heavy resistance exercise.
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No differences were found for muscle testosterone or steroidogenic enzyme (17β-HSD type 3 and 3β-HSD types 1 and 2) concentrations between sexes or in response to resistance exercise
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In conclusion, heavy resistance exercise did not induce changes in muscle steroidogenesis as measured by muscle concentrations of testosterone, 3β-HSD types 1 and 2, and 17β-HSD type 3 in highly resistance-trained young men and women.