Group items tagged

inhibition of 11beta-HSD1 improves metabolic syndrome and atherosclerosis.  This suggests that metabolic syndrome is associated with increase 11beta-HSD1 expression/activity.  Animal study

Peripheral 11Beta-HSD1 plays critical role in fat metabolism and energy utilization.  Good discussion on the role that extra-adrenal 11Beta-HSD1 plays in metabolism

Article finds that carbohydrate meals cause increase in extra-adrenal cortisol more than protein and fat.  This is via 11beta-HSD1.

11-betaHSD1 expression and effect is site specific.

good review of 11beta-HSD type 1 activity.

Study proposes that 11beta-HSD type 1 is the key to linking glucocorticoids and metabolic dysfunction.  The key point of this study is that it is the adipose tissue expression of 11beta-HSD type 1 that is the key.

hyperactive HPA axis associated with depression. This is becoming evident in the literature.  This study looked at SNPS in the etiology of elevated cortisol and/or androstenedione.  They followed the results with saliva and found that 3 SNPS were associated with increased 11Beta-HSD1 activity and associated increased depression.

PPAR alpha and/or PPAR gamma does not down regulate 11Beta-HSD1.

Adipose 11Beta-HSD1 activity is increased in obese individuals with type II DM.  

Animal study, finds that DHEA inhibited 11beta-HSD type I and thus improved glucose uptake and adipocyte proliferation.  This effect occurred peripherally.