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Nathan Goodyear

11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression o... - 0 views

www.ncbi.nlm.nih.gov/...PMC2212859

11-betaHSD1 11-betaHSD metabolic syndrome atherosclerosis

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    inhibition of 11beta-HSD1 improves metabolic syndrome and atherosclerosis.  This suggests that metabolic syndrome is associated with increase 11beta-HSD1 expression/activity.  Animal study
Nathan Goodyear

11β-HSD1 is the major regulator of ... [Proc Natl Acad Sci U S A. 2014] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...24889609

11-betaHSD1 11-betaHSD adipose tissue obesity glucocorticoids cortisol

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    Study proposes that 11beta-HSD type 1 is the key to linking glucocorticoids and metabolic dysfunction.  The key point of this study is that it is the adipose tissue expression of 11beta-HSD type 1 that is the key.
Nathan Goodyear

Cambridge Journals Online - Proceedings of the Nutrition Society - Fulltext -... - 0 views

journals.cambridge.org/...displayFulltext

11-betaHSD1 metabolism obesity energy cortisol nutrition

shared by Nathan Goodyear on 08 Oct 13 - No Cached
  • Nathan Goodyear on 08 Oct 13
     
    Peripheral 11Beta-HSD1 plays critical role in fat metabolism and energy utilization.  Good discussion on the role that extra-adrenal 11Beta-HSD1 plays in metabolism
Nathan Goodyear

Minireview: 11β-Hydroxysteroid Dehydrogenase Type 1- A Tissue-Specific Amplif... - 0 views

press.endocrine.org/...endo.142.4.8114

11beta-HSD 11beta-HSD1 cortisol hormones

shared by Nathan Goodyear on 13 Jul 15 - No Cached
  • Nathan Goodyear on 13 Jul 15
     
    good review of 11beta-HSD type 1 activity.
Nathan Goodyear

Chronic maternal stress inhibits the capacity to up-regulate placental 11beta-hydroxyst... - 0 views

www.ncbi.nlm.nih.gov/...16135661

11beta-HSD2 stress cortisol glucocorticoids

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    acute stress is associated with increased 11beta-HSD2 in pregnant rat model.
Nathan Goodyear

Cortisol Metabolism in Human Obesity: Impaired Cortisone→Cortisol Conversion ... - 0 views

jcem.endojournals.org/...1022.long

cortisone stress cortisol 11beta-HSD obesity overweight metabolism human

shared by Nathan Goodyear on 13 Mar 12 - No Cached
  • Nathan Goodyear on 13 Mar 12
     
    impaired cortisone to cortisol found in obese individuals.  This occurred through a decrease in 11beta-HSD type 1 activity.
Nathan Goodyear

Regulation of 11beta-HSD genes in human adipose tis... [Obes Res. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...14742837

stress cortisol cortisone obesity fat cells adipocytes adipose tissue

shared by Nathan Goodyear on 09 Mar 12 - No Cached
  • Nathan Goodyear on 09 Mar 12
     
    adipocytes increase genetic expression of 11beta-HSD. This increases local cortisol production from cortisone.  This plays a pivotal role in obesity.  Question:  would this play a role in peripheral hypothyroid?  I think so.
Nathan Goodyear

The post-prandial rise in plasma cortisol in men is mediated by macronutrient-specific ... - 0 views

jcem.endojournals.org/...jc.2013-2307.abstract

cortisol post-prandial carbohydrates macronutrients 11beta-HSD1

shared by Nathan Goodyear on 05 Oct 13 - No Cached
  • Nathan Goodyear on 05 Oct 13
     
    Article finds that carbohydrate meals cause increase in extra-adrenal cortisol more than protein and fat.  This is via 11beta-HSD1.
Nathan Goodyear

Increased Visceral Adiposity and Cortisol to Cortisone Ratio in Adults With Congenital ... - 0 views

press.endocrine.org/...jc.2014-2132

fat adipose tissue adiposity visceral 11beta-HSD cortisol cortisone hormones

shared by Nathan Goodyear on 23 Sep 14 - No Cached
  • Nathan Goodyear on 23 Sep 14
     
    Increased visceral adiposity results in increased 11beta-HSD that results in increased cortisone to cortisol production preference.  Cortisol production doesn't just come from the adrenals--it is also produced and metabolized in peripheral and visceral fat.
Nathan Goodyear

11beta-hydroxysteroid dehydrogenase type 1 an... [Front Horm Res. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18230901

11-betaHSD1 fat adipose tissue adipoxytes liver metabolic syndrome insulin resistance dyslipidemia hypertension fatty

shared by Nathan Goodyear on 14 Mar 12 - No Cached
  • Adipose-selective 11beta -HSD1 transgenic mice exhibited elevated intra-adipose and portal, but not systemic corticosterone levels, abdominal obesity, hyperglycaemia, insulin resistance, dyslipidaemia and hypertension
  • transgenic overexpression of 11beta -HSD1 in liver yielded an attenuated metabolic syndrome with mild insulin resistance, dyslipidaemia, hypertension and fatty liver, but not obesity or glucose intolerance
  • Nathan Goodyear on 14 Mar 12
     
    11-betaHSD1 expression and effect is site specific.
Nathan Goodyear

11Beta hydroxysteroid dehydrogenase ty... [Clin Endocrinol (Oxf). 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17121533

11-betaHSD 11-betaHSD1 muscle hormone hormones

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I dominantly expressed in muscle.
Nathan Goodyear

Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte prolifera... - 0 views

ajpendo.physiology.org/...E1134

DHEA 11-betaHSD1 11beta-HSD1 adipocyte glucose hormone hormones

shared by Nathan Goodyear on 14 Nov 13 - No Cached
  • Nathan Goodyear on 14 Nov 13
     
    Animal study, finds that DHEA inhibited 11beta-HSD type I and thus improved glucose uptake and adipocyte proliferation.  This effect occurred peripherally.
Nathan Goodyear

Inhibitory effects of some possible endocrine-di... [Environ Sci. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16184081

endocrine disrupting chemicals hormone hormones cortisol cortisone endocrine disruptors EDC 11-betaHSD 11-betaHSD1 11beta-HSD2

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I and type II are no equally expressed across all tissues.  Endocrine disrupting chemicals (EDC) inhibit both.
Nathan Goodyear

The effect of common genetic variati... [J Clin Endocrinol Metab. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22112815

saliva salivary hormone hormones depression 11-betaHSD1 HPA SNPs

shared by Nathan Goodyear on 10 Oct 12 - No Cached
  • Nathan Goodyear on 10 Oct 12
     
    hyperactive HPA axis associated with depression. This is becoming evident in the literature.  This study looked at SNPS in the etiology of elevated cortisol and/or androstenedione.  They followed the results with saliva and found that 3 SNPS were associated with increased 11Beta-HSD1 activity and associated increased depression.
Nathan Goodyear

Effects of Peroxisome Proliferator-Activated Receptor-α and -γ Agonists on 11... - 0 views

jcem.endojournals.org/...1848.long

11-betaHSD1 PPAR agonist PPAR-alpha PPAR-gamma PPARs cortisol

shared by Nathan Goodyear on 08 Oct 13 - No Cached
  • Nathan Goodyear on 08 Oct 13
     
    PPAR alpha and/or PPAR gamma does not down regulate 11Beta-HSD1.
Nathan Goodyear

Increased whole-body and sustained liver cortisol r... [Diabetes. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21266326

11-betaHSD1 adipose tissue obesity diabetes cortisol

shared by Nathan Goodyear on 08 Oct 13 - No Cached
  • Nathan Goodyear on 08 Oct 13
     
    Adipose 11Beta-HSD1 activity is increased in obese individuals with type II DM.  
Nathan Goodyear

Liver X Receptors Downregulate 11β-Hydroxysteroid Dehydrogenase Type 1 Expres... - 0 views

diabetes.diabetesjournals.org/...2426.long

11-betaHSD 11-betaHSD1 cortisol hormone hormones liver fat adipose tissue adipose tissue

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type 1 is predominantly expressed in liver and adipose tissue.
Nathan Goodyear

Immunohistochemical localization of ... [J Clin Endocrinol Metab. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9543163

11-betaHSD 11-betaHSD1 cortisol hormone hormones ovary liver fat adipose tissue adrenal glands

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I is highly expressed in liver, adrenal glands, ovaries, and adipose tissue in human immunohistochemical analysis.
Nathan Goodyear

JCI - Reduced activity of 11β-hydroxysteroid dehydrogenase in patients with c... - 0 views

www.jci.org/12745

11-betaHSD cortisol hormone hormones

shared by Nathan Goodyear on 23 May 14 - No Cached
  • Nathan Goodyear on 23 May 14
     
    good discussion of 11beta-HSD in cortisol metabolism
Nathan Goodyear

Hypertension and the cortisol-cortis... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12788832

cortisol: cortisone shuttle cortisol:cortisone cortisol:cortisone shunt cortisol cortisone 11-betaHSD 11beta-HSD2 hypertension blood pressure

shared by Nathan Goodyear on 03 Jun 14 - No Cached
  • Nathan Goodyear on 03 Jun 14
     
    Abstract only available.  Cortisol-cortisone shuttle play a role in hypertension.  Those with 11betaHSD type II defects will have elevated blood pressure due to increase in mineralcorticoids.
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