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Contents contributed and discussions participated by Nathan Goodyear

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Nathan Goodyear

Effects of estrogen on memory funct... [Psychoneuroendocrinology. 1992] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...1484915

estrogen memory women surgical menopause hormones postmenopause

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  • Nathan Goodyear on 10 Mar 14
     
    estrogen therapy in surgical menopause preserves memory.  Rapid decline in estrogen levels post surgical menopause is associated with cognitive/memory decline.  Versus placebo, estrogen therapy preserved memory function.
Nathan Goodyear

ESTROGEN SIGNALING AND NEUROPROTECTION IN CEREBRAL ISCHEMIA - 0 views

www.ncbi.nlm.nih.gov/...PMC3324183

estrogen estradiol cerebral ischemia neuordegeneration brain protection ROS oxidative stress

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  • Nathan Goodyear on 10 Mar 14
     
    estradiol plays an important role in neuropreservation following cerebral ischemia.  The mechanism is through ER alpha stimulation.  The result is a reduction of ROS and oxidative stress.  This occurs through the classic intranuclear and the rapid membrane receptors as well.
Nathan Goodyear

Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-ty... - 0 views

www.ncbi.nlm.nih.gov/...PMC2700344

estrogen estradiol apoptosis neurodegeneration glutamate glutamic acid

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  • Nathan Goodyear on 10 Mar 14
     
    Estradiol inhibits glutamate mediated influx of calcium and thus cell death in cell line.  Glutamate, the principle excitatory neurotransmitter, is involved in neurodegeneration through activation of calcium channels.  This study of cell line cultures found that Estradiol inhibits this process.  I question whether this is applicable to both men and women.  Time will tell.
Nathan Goodyear

Decreased estrogen receptor-alpha expressio... [Acta Neuropathol. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12819990

ER alpha ER-alpha estrogen receptor alzheimer's disease Alzheimers neurodegeneration brain

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  • Nathan Goodyear on 10 Mar 14
     
    Estrogen Receptor alpha expression is decreased in the nucleus of hippocampus in Alzheimer's disease.
Nathan Goodyear

Cognitive dysfunction in postmenopausal breast cancer patients on aromatase inhibitors,... - 0 views

informahealthcare.com/...era.11.112

breast cancer cognitive decline dysfunction women estradiol aromatase

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  • Nathan Goodyear on 10 Mar 14
     
    Just the abstract here.  Declining estradiol production found to be associated with increased cognitive dysfunction or cognitive decline in those using aromatase inhibitor therapy.  Aromatase inhibition therapy is used to block Testosterone to Estradiol production in women with ER+ breast cancer.
Nathan Goodyear

Membrane Estrogen Receptors Stimulate Intracellular Calcium Release and Progesterone Sy... - 0 views

www.jneurosci.org/...12950.full

estradiol estrogen progesterone hypothalamus receptors ER ER-alpha ER alpha hormones CNS astrocytes brain calcium channels

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  • Nathan Goodyear on 10 Mar 14
     
    Estradiol stimulates hypothalamic progesterone synthesis in astrocytes in rat model.  This occurs through activation of calcium channels and influx of calcium.  ER alpha appears to be the prominent ER involved.
Nathan Goodyear

Night work and inflammatory markers - 0 views

www.ncbi.nlm.nih.gov/...PMC3143516

CRP IL-6 TNF-alpha inflammation cytokines sleep deprivation night shift

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  • Nathan Goodyear on 05 Mar 14
     
    Night shift work and sleep deprivation associated with increased inflammatory markers: IL-6, TNF-alpha, and CRP.
Nathan Goodyear

Acellular pertussis vaccines protect against disease but fail to prevent infection and ... - 0 views

www.pnas.org/...1314688110.abstract

whooping cough vaccine vaccines vaccination bordetella pertussis

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  • Nathan Goodyear on 04 Mar 14
     
    Whooping cough vaccine (acellular) proves to be useless.
Nathan Goodyear

Press Announcements > FDA study helps provide an understanding of rising rates of whoop... - 0 views

www.fda.gov/...ucm376937.htm

Whooping cough vaccine vaccination Bordetella pertussis

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  • Nathan Goodyear on 04 Mar 14
     
    FDA statement on Whooping cough vaccine: poor in prevention and spread.
Nathan Goodyear

PLOS ONE: Mode of Delivery and Offspring Body Mass Index, Overweight and Obesity in Adu... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0087896

caesarean section delivery obesity BMI overweight

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  • Nathan Goodyear on 04 Mar 14
     
    Caesarean Section appears to be associated with increased obesity rates, according to meta-analysis.
Nathan Goodyear

Oestradiol levels in diabetic men with and without a... [Q J Med. 1987] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3671665

aromatase Estradiol E2 Testosterone men male Diabetes hormone hormones MI myocardial infarction

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  • Nathan Goodyear on 04 Mar 14
     
    High Estradiol is reproducible finding in men with Diabetes.  Link to MI not able to be determined.
Nathan Goodyear

Salivary estradiol and testosterone in filipin... [Am J Hum Biol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24573919

saliva salivary hormone hormones male men Testosterone Estradiol E2 obesity aromatase

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  • Nathan Goodyear on 04 Mar 14
     
    Study finds association between elevated Estradiol in young men and obesity.  No correlation was found with Testosterone.  This fits other research that points to early increased Estradiol production and late decrease in low T.  The men in this study were "young".  Testing was done in saliva.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Trends in Androgen Prescribing in the United St... - 0 views

archinte.jamanetwork.com/article.aspx

androgens low T Testosterone men male hormones hormone prescribing US

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  • Nathan Goodyear on 04 Mar 14
     
    A review of the prescribing patterns of androgens in the US.  Up to 25% of men are prescribed Testosterone without a test evaluation--scarry!
Nathan Goodyear

Increased heart attacks in men using testosterone: the UK importantly lags far behind t... - 0 views

www.bmj.com/...bmj.g1789

Testosterone therapy treatment UK US low T men male hormone hormones

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  • Nathan Goodyear on 04 Mar 14
     
    Prescribing levels of Testosterone is lower in the UK versus US.
Nathan Goodyear

Associations between serum phthalates and biomar... [Environ Int. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24583187

phthalates androgen receptors AR toxins hormones men male

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  • Nathan Goodyear on 04 Mar 14
     
    Phthalates have both central inhibition and peripheral effects. This article highlights the peripheral anti-androgen effects of phthalates and phthalate metabolites. 
Nathan Goodyear

Endogenous sex hormones, metabolic syndrome... [Curr Cardiol Rep. 2014] - PubMed - NCBI - 1 views

www.ncbi.nlm.nih.gov/...24585109

sex hormones men women Testosterone metabolic syndrome metabolic syndrome MetS diabetes SHBG

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  • Nathan Goodyear on 04 Mar 14
     
    Abstract ahead of print.  Low Testosterone in men is associated with increased risk of metabolic syndrome and type II Diabetes.  Just the opposite is the case in women: elevated Testosterone in women is associated with increasing metabolic syndrome and diabetes risk. Low  SHBG is associated with increased risk in both.
Nathan Goodyear

Discrepancy between Exercise Performance, Body Comp... [PLoS One. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24586293

sex hormones exercise performance

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  • Nathan Goodyear on 04 Mar 14
     
    Short 6 week study finds no correlation between sex hormones and soccer performance.
Nathan Goodyear

A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism - 0 views

www.biologicalpsychiatryjournal.com/...fulltext

autism ASD glutathione NAC N-acetylcysteine children

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  • Nathan Goodyear on 04 Mar 14
     
    900 mg of NAC over short 4 week course provided significant improvement in behavior of children with autism.  No pre treatment evaluation was performed.  One wonders if therapeutic therapy was actually undertaken if the results would have been better.  NAC is a precursor to Glutathione production and detoxification compromise is common place in autism.
Nathan Goodyear

Nature Clinical Practice Endocrinology & Metabolism | Testosterone and ill-health in ag... - 0 views

www.nature.com/...ncpendmet1050.html

low T Testosterone health men male hormone hormones metabolic syndrome metabolic syndrome MetS insulin resistance diabetes aging

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Levels of total and bioavailable testosterone and SHBG were reported to be inversely correlated with the prevalence of the metabolic syndrome in men aged 40–80 years
  • as were total testosterone and SHBG in men aged 65–96 years
  • and in a cross-sectional analysis of a large cohort of non-diabetic men aged 70–89 years
  • ...18 more annotations...
  • In longitudinal studies, decreased levels of total testosterone and SHBG predicted an increased incidence of metabolic syndrome in nonobese men
  • Free testosterone level is not associated with the prevalence of metabolic syndrome in middle-aged and older men
  • Levels of free, bioavailable and total testosterone are lower in men with T2DM than in age-matched controls,34, 35 and decreased total testosterone level predicts incident T2DM in middle-aged men.
  • men with T2DM commonly have low total or free testosterone levels
  • Total, bioavailable and free testosterone levels are inversely correlated with fasting insulin level and insulin resistance in middle-aged men without T2DM
  • total testosterone is positively correlated with insulin sensitivity in men with normal or impaired glucose tolerance or T2DM
  • low SHBG level is more strongly associated with metabolic syndrome than low total testosterone in aging men
  • the recognized association between low SHBG level and insulin resistance
  • Low levels of SHBG are also associated with smaller, denser LDL-cholesterol molecules in nondiabetic men,58 and were found to predict increased cardiovascular disease mortality in one study of older men
  • Low levels of SHBG might reflect obesity, insulin resistance and overall poor health
  • Compared with those who have normal testosterone levels, men aged 40 years or more with total testosterone levels <9.8 nmol/l or elevated LH level have greater CIMT
  • In men aged 73–94 years, total testosterone was inversely correlated with CIMT
  • a prospective analysis of men aged 73–91 years, progression of CIMT was not related to total testosterone level, but it was inversely related to free testosterone level
  • A study of men aged 55 years or more found that those with total and bioavailable testosterone levels in the highest tertile had a lower risk of severe aortic atherosclerosis (detected by radiography as abdominal aortic calcification) than those with the lowest testosterone levels.
  • a large study of men aged 69–80 years, those with total or free testosterone in the lowest quartile had increased odds of lower-extremity peripheral arterial disease
  • the possibility of reverse causation has to be considered, as systemic illness can result in decreased testosterone levels
  • previous case–control studies and longitudinal studies have failed to identify low testosterone levels as strong predictors of clinically significant coronary disease
  • Reviews of trials on testosterone therapy in men with either low or low-to-normal testosterone levels have not shown consistent beneficial effects either on lipid profiles or on actual cardiovascular events.24, 54, 55 These trials, however, have not been designed or powered to detect treatment-related differences in cardiovascular outcome
  • Nathan Goodyear on 03 Mar 14
     
    Declining Testosterone or low Testosterone is clearly associated with poor health in men.   Very nice review of the association between low Testosterone and metabolic dysfunction.  Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...
Nathan Goodyear

Androgen Deprivation Therapy, Insulin Resistance, and Cardiovascular Mortality: An Inco... - 0 views

onlinelibrary.wiley.com/...full

androgen deprivation therapy androgen male men hormone hormones deprivation therapy prostate cancer cardiovascular disease insulin resistance diabetes metabolic syndrome mortality CVD

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  • Nathan Goodyear on 03 Mar 14
     
    Androgen deprivation therapy is associated with increased diabetes, metabolic syndrome, insulin resistance, and cardiovascular mortality.  The longer the duration of therapy, the more the progression of metabolic dysfunction.  This process seems similar to chemotherapy i.e. secondary cancer due to chemotherapy.  The treatment of one disease, prostate cancer in this case, leads to an increase in the risk of the #1 killer in men--logic seems severely flawed there.
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