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spineneuro

Dr. Sandeep Vaishya India Offering Outstanding Care in Neurosurgery Expertise - 0 views

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    The mission of Dr. Sandeep Vaishya India's practice is to provide the best surgical treatment of disorders that impair the spine and brain. He utilizes proven standard techniques and new, minimally invasive techniques for surgical intervention whenever possible. Best neurologists and neurosurgeons in India combine their experience, training, and clinical expertise in providing an environment where surgical intervention is performed to optimize a patient's outcome.
Nathan Goodyear

Effects of estrogen on memory funct... [Psychoneuroendocrinology. 1992] - PubMed - NCBI - 0 views

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    estrogen therapy in surgical menopause preserves memory.  Rapid decline in estrogen levels post surgical menopause is associated with cognitive/memory decline.  Versus placebo, estrogen therapy preserved memory function.
Nathan Goodyear

Surgical oncotaxis--excessive surgical stress and postoperative complications contribut... - 0 views

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    Surgical oncotaxis induced via cytokine storm.
Dr. Jennifer Martinick

Dr Jennifer Martinick offers Non-Surgical Hair Restoration Solutions at her clinics - 0 views

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    Dr Jennifer Martinick is a highly skilled hair transplant surgeon and offers various effective hair restoration solutions. Here you can read a review on Non-Surgical Hair Restoration Solutions provided by Jennifer Martinick and her skilled team of technicians.
Dr. Jennifer Martinick

Dr Jennifer Martinick Follows A Multi-Therapy Approach For Hair Restoration   - 0 views

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    Dr Jennifer Martinick follows a multi-therapy approach to deliver remarkable hair transplant results. The clinic provides various surgical as well as non-surgical hair restoration solutions.
Dr. Jennifer Martinick

Dr Jennifer Martinick shares reviews on Surgical Hair Restoration Solutions - 0 views

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    Dr Jennifer Martinick is a respected hair transplant surgeon who ensures the most appropriate form of treatments based on patient's situation and requirements. Read a quick review on Surgical Hair Restoration Solutions provided.
Dr. Jennifer Martinick

Dr Jennifer Martinick: A Review Of The Surgical Hair Restoration Solutions Provided - 0 views

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    Dr Jennifer Martinick shares her reviews on Surgical Hair Restoration Solutions Provided.
nucosmeticclinic

PRP Therapy - Non Surgical Hair Loss Treatment for Men and Women - 0 views

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    PRP Therapy or Platelet Rich Plasma Therapy is an effective non-surgical hair loss treatment for men and women. PRP Therapy makes efficient utilization of a growth enhancing blood constituent called platelets, which when combined together with plasma, results in an unprecedented increase in the hair follicles across the treated areas.
Nathan Goodyear

Improved wound healing response in surgical patients receiving intravenous nutrition - ... - 0 views

  • These results show that the wound healing response in surgical patients requiring intravenous nutrition is improved by this treatment
  • improved wound healing response is more marked when intravenous nutrition is given before, rather than after the surgical procedure.
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    IV nutrition improves healing after surgery
Nathan Goodyear

ingentaconnect Immunonutrition in Surgical Patients - 0 views

  • Surgery induces an inflammatory response
  • A range of nutrients, including several amino acids, antioxidant vitamins and minerals, ω-3 fatty acids, and nucleotides, are able to modulate inflammation and the associated oxidative stress, and maintain or improve immune function
  • parenteral glutamine is recommended in patients receiving parenteral nutrition
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  • Antioxidants, particularly selenium, should be considered for critically ill patients
  • enteral formulas enriched with fish oils are recommended for patients with acute respiratory distress syndrome.
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    nutrition to improve inflammation in surgical patiens
Nathan Goodyear

Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil... - 0 views

  • tumor surgery must be carefully considered because the risk of metastasis could be increased by the surgical procedure.
  • NETosis, which is the process of forming neutrophil extracellular traps (NETs)
  • surgery-induced metastasis
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  • surgery per se can promote cancer metastasis through a series of local and systemic events
  • surgery results in a serious wound that disrupts the structural barrier preventing the outspreading of cancer cells, change the properties of the cancer cells and stromal cells remaining in the tumor microenvironment, or impairs the host defense systems against cancers
    • Nathan Goodyear
       
      Key point; add to presentation on surgery and metastasis
  • After the primary tumor is surgically removed, the metastases can start to grow vigorously via neoangiogenesis because the circulating inhibitors disappear
  • infection and inflammation during the postoperative period have been reported to increase the risk of cancer recurrence in patients
  • Surgeons have long suspected that surgery, even if it is a necessary step in cancer treatment, facilitates cancer metastasis
  • Surgery-induced cancer metastasis has been well established in animal models
  • tumor cell dissemination, tumor-favoring immune responses, and neoangiogenesis
  • the surgical resection of primary tumors is beneficial is controversial
  • CTCs abruptly increase just after surgery
  • Even externally palpitating tumors for diagnosis could increase the numbers of CTCs in skin cancer and breast cancer
  • excessive glucocorticoids negatively modulate immune functions
  • immune surveillance against tumors is considered to be impaired by surgical stress
  • In addition to glucocorticoids, during stimulation of the HPA axis, the catecholamine hormones epinephrine and norepinephrine are released from the adrenal medulla
  • NK cell suppression may be attributed to increased levels of catecholamines as well as glucocorticoids
  • In mice bearing a primary tumor, it was observed that the removal of the primary tumor facilitated the growth of highly vascularized metastases
  • primary tumors may secrete angiogenic inhibitors as well as angiogenic activators
  • second phase of tumor recurrence and metastasis, which are newly acquired events, rather than just outcomes of incomplete treatment.
    • Nathan Goodyear
       
      Another key point
  • double-edged sword
  • HIF-1 in neutrophils plays a critical role in NETosis and bacteria-killing activity
  • neutrophils play various roles in the initiation and progression of cancer
  • NETosis
  • many inflammatory and neoplastic diseases
  • formation of neutrophil extracellular traps (NETs), which are large extracellular complexes composed of chromatin and cytoplasmic/granular proteins1
  • NETosis has been highlighted as an inflammatory event that promotes cancer metastasis
  • Once activated, neutrophils produce intracellular precursors by using DNA, histones, and granular and cytoplasmic proteins and then spread the mature form of NETs out around themselves
  • A series of these events is called NETosis.
  • neutrophil elastase, myeloperoxidase, cathepsin G, proteinase 3, lactoferrin, gelatinase, lysozyme C, calprotectin, neutrophil defensins, and cathelicidins
  • innate immune response against infection
  • Neutrophils are the most abundant type of granulocytes, comprising 40–70% of all white blood cells
  • two types of NEToses, suicidal (or lytic) NETosis and vital NETosis
  • Suicidal NETosis mainly depends on the production of reactive oxygen species (ROS)
  • Since neutrophils die during this process, it is called suicidal NETosis.
  • vital NETosis
  • vital NETosis occurs independently of ROS production
  • Vital NETosis can be induced by Gram-negative bacteria. LPS
  • NETs are present in a variety of cancers, such as lung cancer, colon cancer, ovarian cancer, and leukemia
  • neutrophils actively undergo NETosis in the tumor microenvironment
  • Hypoxia
  • NETosis plays a pivotal role in noninfectious autoimmune diseases,
  • cytokines
  • tumor-derived proteases
  • tumor exosomes
  • NETosis generally actively progresses in the tumor microenvironment.
  • the proliferative cytokines TGFβ and IL-10 and the angiogenic factor VEGF are representative of neutrophil-derived tissue repair proteins.
  • NETosis is a defense system to protect the body from invading pathogens
  • when neutrophils are excessively stimulated, they produce excess NETs, thereby leading to pathological consequences
  • plasma levels of NETosis markers are elevated after major surgeries
  • local invasion, intravasation into the blood or lymphatic vessels, escape from the immune system, anchoring to capillaries in target organs, extravasation into the organs, transformation from dormant cells to proliferating cells, colonization to micrometastases, and growth to macrometastases
  • NETs promote metastasis at multiple steps
  • NETs loosen the ECM and capillary wall to promote the intravasation of cancer cells
  • NETs and platelets wrap CTCs, which protects them from attack by immune cells and shearing force by blood flow
  • NETs promote the local invasion of cancer cells by degrading the extracellular matrix (ECM)
  • neutrophil elastase, matrix metalloproteinase 9, and cathepsin G
  • NETs also promote the intravasation of cancer cells
  • millions of tumor cells are released into the circulation every day,
  • NETs can wrap up CTCs with platelets
  • β1-integrin plays an important role in the interaction between CTCs and NETs
  • NET-platelet-CTC aggregates.
  • After metastasizing to distant tissues, tumor cells are often found to remain dormant for a period of time and unexpectedly regrow late
  • NETs are believed to participate in the reactivation of dormant cancer cells in metastatic regions
  • NET-associated proteases NE and MMP-9 were found to be responsible for the reactivation of dormant cancer cells
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    Surgery induced metastasis: it is real and steered by NETosis.
spineneuro

Dr. Vidyadhara S India Introduces ClarifEye Augmented Reality Spine Surgical Navigation - 0 views

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    "Augmented reality surgical navigation facilitates us to place pedicle screws in positions wherein we simply couldn't or would not do in any other case," said Dr. Vidyadhara S India. Contact Details Dr. Vidyadhara S. Best Spine Surgeon Manipal Bangalore
teremoso

Non Surgical Face Lift Hamilton Facial Rejuvenation - 4 views

This is actually an innovative beauty support that is actually distinctive throughout the market and has the prospective to improve your general wellness and help you look fresh. Microcurrent i...

Non Surgical Face Lift Hamilton

started by teremoso on 21 May 12 no follow-up yet
Nathan Goodyear

LOW SERUM TESTOSTERONE LEVELS ARE ASSOCIATED WITH POSITIVE SURGICAL MARGINS IN RADICAL ... - 0 views

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    Low T is bad prognostic sign in prostate cancer: correlates with positive surgical margins.
nucosmeticclinic

Relevant Details about Liquid Facelift or Non-Surgical Facelift in London UK - 0 views

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    Liquid Facelift represent the class of cosmetic therapies that doesn't require surgical interventions which itself is a great advantage of this treatment meant to revive your facial appearance by replacing the lost volume of your cheeks.
Nathan Goodyear

Preoperative parenteral nutrition of malnourished surgical patients. - PubMed - NCBI - 0 views

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    malnutrition is associated with increased surgical complication and mortality risk; IV decreased complications and mortality
Nathan Goodyear

Immunonutrition in Surgical Patients: Ingenta Connect - 0 views

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    Malnutrition is associated with increased surgical risk and poor outcomes. The authors support IV preoperative nutrition at least 10 days prior to surgery and for 7 days post surgery.  This therapy reduced inflammation and oxidative stress.
Nathan Goodyear

Perioperative Nutrition and Nutritional Supplements : Plastic Surgical Nursing - 0 views

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    Optimize nutrition to decrease complications and optimize surgical outcomes in plastic surgery or any surgery for that matter as poor nutrition will negatively effect both.
Nathan Goodyear

Surgically induced accelerated local and distant tumor growth is significantly attenuat... - 0 views

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    Cox II inhibition helps to slow surgical induced metastatic and local recurrence of cancer. Surgery does cause metastasis and local recurrence and cox II inhibition stops spread.
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