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Contents contributed and discussions participated by Nathan Goodyear

Nathan Goodyear

Sex differences in the gut microbiome drive hormone-dependent regul... - PubMed - NCBI - 0 views

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    mouse study finds but flora effects Testosterone levels.  This study, available only in abstract form, found that commensal transplant from male to female mice resulted in an increase in Testosterone levels in the female mice.
Nathan Goodyear

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syn... - 0 views

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    Great article--only abstract available here.  Animal study finds that emulsifiers in process foods alters gut flora resulting in gut inflammation and obesity/metabolic syndrome.  Need an indictment against process foods--here you go.
Nathan Goodyear

PLOS ONE: Microbial Dysbiosis Is Associated with Human Breast Cancer - 0 views

  • it is tempting to speculate that a decrease in bacterial load in a healthy individual may be a signal of heightened breast cancer risk
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    Study finds a decrease in gut bacterial load in women with breast cancer versus those without.  The authors propose that a decrease in bacterial load in healthy individuals might be a means to estimate breast cancer risk.  Could it all start in the gut?
Nathan Goodyear

PLOS ONE: Microbial Dysbiosis in Colorectal Cancer (CRC) Patients - 0 views

  • differences in the colon microbiota in individuals with colon cancer versus those with a normal colonoscopy
  • qPCR revealed significant elevation of the Bacteroides/Prevotella population in cancer patients that appeared to be linked with elevated IL17 producing cells in the mucosa of individuals with cancer.
  • Bacteroides genus populations and more specifically those of Bacteroides fragilis, have recently been shown to produce a metalloprotease in colon cancer patients, but not in controls [12] suggesting this species sub population might favor carcinogenesis
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  • It is noteworthy that among the many mechanisms that may mediate associations between microbiota and human health [21]–[22], pro-inflammatory and immune cell activation in colon mucosa are of great importance in relation to malignancy
  • B. fragilis has been shown to induce mucosal regulatory T-cell responses in the intestine involving TH17 cell recruitment in experimental models
  • the elevations of Bacteroides in the stool and/or IL17 immunoreactive cells in the normal mucosa appear to be promising sensitive markers
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    A relationship between dysbiosis and colon cancer appears to be present.  Particularly an increase in Bacteroidetes and Prevotella species were found in those with colon cancer versus those without.  An inflammatory up regulation of IL-17 appears to be involved.  Whether this is a cause or effect is yet to be determined, but the presence of elevated Bacteroidetes species with increased IL17 could be used as sensitive biomarkers.
Nathan Goodyear

The Relation of Childhood BMI to Adult Adiposity: The Bogalusa Heart Study - 0 views

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    Childhood obesity continues to adulthood for a significant percentage of people.
Nathan Goodyear

N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis o... - 0 views

  • compared effects of NAC with placebo or metformin in women with PCOS
  • NAC significantly improved rates of live births and spontaneous ovulation compared to placebo in women with PCOS
  • we found no evidence of effects of NAC on improving menstrual regularity, acne, hirsutism, BMI, fasting insulin, fasting glucose, or HOMA-IR
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  • NAC was not associated with greater benefits to metformin for improving pregnancy rate, spontaneous ovulations, and menstrual regularity
  • Metformin also improved the BMI, total testosterone, insulin level, and lipid levels compared to NAC
  • All the studies were of short duration (three months)
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    Data review finds NAC improves pregnancy rates and ovulation rates in women with PCOS against placebo.  Meta-analysis revealed limited studies on the topic.  When compared to metformin, there was no difference found.  Though, one wonders if attacking insulin resistance through proper diet and additional neutraceutical approach would negate that.  The reason?  NAC and metformin are working in different biochemical pathways.  The authors here seem to not realize this. It appears that they think NAC and metormin are both working in the same manner, but they don't.  The fact that there is still benefit found compared to placebo, despited the authors lack of understanding of what NAC is and does is a positive.
Nathan Goodyear

The effect of marjoram (Origanum majorana) tea on the hormonal prof... - PubMed - NCBI - 0 views

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    small study finds marjoram daily intake reduced DHEA and insulin and improved insulin sensitivity (when compared to placebo group) in women with PCOS.  This study too is ahead of print and only abstract is available.
Nathan Goodyear

Risk of Breast Cancer in Relation to Combined Effects of Hormone Th... - PubMed - NCBI - 0 views

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    Study finds increases serum Estradiol and Testosterone levels associated with increased risk of breast cancer.  Increased risk was also found associated with being overweight/obese, increased alcohol intake, alcohol combined with HT.  This was found in estrogen receptor + cases of breast cancer.
Nathan Goodyear

Lowered testosterone in male obesity: mechanisms, morbidity and management - 0 views

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    great review of obesity, low Testosterone, and implications in therapy.  The relationship between obesity and low T is bi-modal and this has implications in T therapy.
Nathan Goodyear

Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation - 0 views

  • Thymidine kinase 1 (TK1), a proliferation marker involved in DNA repair
  • prognostic potential
  • TK1 upregulation is an early event in tumor tissue formation
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    Upregulation of TK-1 found to be an early event in breast tumor development. This has implications in precancerous tissue and elevations correlate to stage of cancer. TK-1 has also been found to correlate with Cancer recurrence.
Nathan Goodyear

http://www.centromedicoathenas.com.br/Content/Uploads/Info/158.pdf - 0 views

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    to be read.
Nathan Goodyear

PLOS ONE: Caramel Color in Soft Drinks and Exposure to 4-Methylimidazole: A Quantitativ... - 0 views

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    Study finds 4-MEI, a known carcinogen, is found in variable levels in soft drinks.  4-MEI is found in caramel flavoring.
Nathan Goodyear

Coconut oil supplementation and physical exercise improves baroreflex sensitivity and o... - 0 views

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    Animal study finds the combination of coconut oil and exercise training reduced oxidative stress and lowered blood pressure.
Nathan Goodyear

Controversies in testosterone replacement therapy: testosterone and cardiovascular dise... - 0 views

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    to be read.
Nathan Goodyear

Testosterone therapy in men with prostate cancer: literature review, clinical experienc... - 0 views

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    To be read
Nathan Goodyear

Testosterone and metabolic syndrome Cunningham GR, - Asian J Androl - 0 views

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    to be read
Nathan Goodyear

Exercise-Induced Responses in Salivary Testosterone, Cortisol, and ... - PubMed - NCBI - 0 views

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    Meta analysis of salivary Testosterone and cortisol finds mixed results.  The results are by no means uniform, but resistance training appears to trend to an increased salivary Testosterone and salivary Testosterone to salivary cortisol ratio.  Cardio trends the opposite.  This fits with prior literature on the types of exercise and hormone results.
Nathan Goodyear

Higher serum testosterone and dihydrotestosterone, but not estradio... - PubMed - NCBI - 0 views

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    Higher Testosterone and DHT levels in men was found to be positively associated with FEV1 and FVC; Estradiol was not.  The question here is cause or effect.   Also interesting is the fact that smokers had higher Testosterone levels compared to non-smokers.
Nathan Goodyear

Low testosterone levels are associated with poor peripheral bone mi... - PubMed - NCBI - 0 views

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    low Testosterone as defined by levels < 300 was found to be associated with bone loss in aging men.
Nathan Goodyear

Adverse effects of reverse triiodothyronine on cellular metabolism as assessed by 1H an... - 0 views

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    Only abstract available here.  In vitro study finds that rT3 decreased the metabolic effect of T3.  This gives the impression that rT3 has an antagonist effect to T3 on the receptor.
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