Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
1More
Lifestyle and nutritional imbalances associated with Western diseases: causes and conse... - 0 views
-
This study finds most "western" diseases are the result of environment and only <5% genetic. Evidence is growing that the environment is the largest contributor to disease. The greatest environment contributor is diet. This is great, because we can change diet...if one wants too. This article also shows are current understanding on how dietary inflammation results in insulin/glucose disruption.
1More
Wheelchair Pediatric - 0 views
www.wheelchairindia.com/...CP-PEDIATRIC-WHEELCHAIR
Electric Wheelchair For Increased Independence foot rests and four wheels large wheels at the back strengths and environment propelled by a motor comfortable and functional stretching abdominal muscle
shared by wheelchairindia9 on 14 May 15
- No Cached
-
When it comes to wheelchairs, young children have a different set of needs than adults. Aesthetically, devices designed for kids are often sleek and colorful, and functionally, they are typically lightweight and adjustable. As any parent knows, young people don't stay the same size for long and since a wheelchair is a major purchase don't want a simple growth spurt to render it useless. That's why kids wheelchair category offers models that feature seat width and depth adjustability, elevating legrests, and other versatile features. Pediatric walkers differ from adult walkers in several ways. For one, walking aids for children are usually adjustable, taking growth patterns into account; but many models also provide gait training and postural correction. Those caring for kids in their formative years must be concerned about more than just the young person's mobility, they must also consider their development. Cerebral Palsy Wheelchair: Cerebral Palsy Wheelchair Description: The model designed for cerebral palsy child only. Ultra light weight aluminium alloy frame Seat Width 38 cms (15") Net Weight: 18.5 kgs Epoxy powder coated frame Detachable arm rest & foot rest provided Elevated and swinging foot rest Elevated foot rest provided to elevate leg angle Height adjustable and detachable head rest Hydraulic reclining high back for a comfortable posture Hydraulic adjustable seat angle Detachable back and seat pad Extra cushion upholstery provided to under arm, head & calg Foldable Lever and paddle brakes provided Safety belt provided Maintenance free rear solid wheels Cloth look like water proof upholstery Anti wheels for better safety and stability Extra cushion upholstery provided to under arm, head & leg Folding action Lever and paddle brakes provided Safety belt provided Maintenance free rear solid wheels Cerebral Palsy Wheelchair Recline system: Recline system provides kids with the most comfortable resting environme
1More
Evidence of estrogenic endocrine disruption in smallmouth and largemouth bass inhabitin... - 0 views
www.sciencedirect.com/...S0147651315301093
low T low Testosterone hormones environment EDC endocrine disruptor endocrine disruptors fish estrogen
shared by Nathan Goodyear on 05 Jan 16
- No Cached
-
Is our effect on the environment and the environments, in turn, effect on us politics or science? It is science that is manipulated by politicians for political gain/power. In this study of male small/large mouth bass in NE America are found to have significant female characteristics i.e. eggs where testes should exist...where none should exist. The numbers were as high as 85% in the small mouth base compared to 27% for the large mouth bass. Is there any wonder we have a low T epidemic in men? The most likely cause are endocrine disruptors. It is a concern that the authors did not look for endocrine disruptors in the water at the time of this study of the fish.
41More
Metabolic management of brain cancer - 0 views
-
the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
-
Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
- ...37 more annotations...
-
most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
-
We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
-
complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
-
As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
-
New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
-
The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
-
Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
-
Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
-
Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
-
Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
-
the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
-
The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
-
We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
-
In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
-
mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
-
targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
-
The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
-
Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
-
TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
-
Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
-
DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
-
We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
-
Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
-
More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
-
The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
-
targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
-
Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
1More
Environmental Erectile Dysfunction: Can the Environment Really Be Hazardous to Your Ere... - 0 views
2More
Toxic environment and obesity pandemia: is there a... [Ital J Pediatr. 2010] - PubMed r... - 0 views
-
Recent cumulating evidence suggests that obesity may represent an adverse health consequence of exposure during the critical developmental windows to environmental chemicals disrupting endocrine function. Moreover, exposure to these chemicals seems to play a key role in the development of obesity-related metabolic and cardiovascular diseases.
1More
Paradoxical effects of antioxidants on cancer. [Rejuvenation Res. 2014] - PubMed - NCBI - 0 views
-
Just the abstract available here. Cancer is proving to be very complex--no surprise here. Antioxidant therapy can actually promote cancer progression as can tumor suppressor genes. The issue is context of the environment and the tumor in that environment. Vitamin C is antioxidant in serum, but pro oxidant in the cancer cell. The result is a production of H2O2 and lysis of the cell.
14More
Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibrobla... - 0 views
www.ncbi.nlm.nih.gov/...PMC3478457
warburg effect Cancer cancer associated fibroblasts CAFs reverse warburg effect lactate aerobic glycolysis mitochondria oxidative stress ROS H2O2
shared by Nathan Goodyear on 11 Nov 14
- No Cached
-
L-lactate functions as an onco-metabolite, stimulating mitochondrial biogenesis and OXPHOS in adjacent cancer cells, directly providing energy for tumor growth
-
Oxidative stress in stromal fibroblasts then induces their metabolic conversion into cancer-associated fibroblasts. Such oxidative stress drives the onset of autophagy, mitophagy, and aerobic glycolysis in fibroblasts, resulting in the local production of high-energy mitochondrial fuels (such as L-lactate, ketone bodies, and glutamine). These recycled nutrients are then transferred to cancer cells, where they are efficiently burned via oxidative mitochondrial metabolism (OXPHOS)
-
stromal L-lactate serves as a high-energy mitochondrial “fuel” for cancer cells. We have termed this new model of cancer metabolism “Two-Compartment Tumor Metabolism”, where two opposing metabolic compartments co-exist, side-by-side, with stromal glycolysis fueling OXPHOS in cancer cells
- ...10 more annotations...
-
Reverse Warburg Effect”, is that catabolic fibroblasts should promote tumor growth, without any increases in angiogenesis
-
when cancer cells use L-lactate as a mitochondrial fuel source, this metabolic phenotype is a predictor of lethal cancer metabolism
-
mitochondrial dysregulation is likely the “root cause” of several human disease(s), and especially epithelial cancers
-
Both in vitro and in vivo studies have now provided convincing evidence that “activated” stromal fibroblasts, a.k.a., myofibroblasts, may play a critical role in initiating tumor recurrence, via paracrine interactions with adjacent tumor epithelial cells
-
A new hypothesis is that cancer is not a cell autonomous disease, but rather a disease of the tumor microenvironment
-
cancer cells behave as metabolic parasites, by inducing oxidative stress in adjacent normal fibroblasts
-
recent experimental evidence indicates that cancer-associated fibroblasts have a catabolic phenotype, and undergo autophagy and mitophagy, resulting in the onset of glycolytic metabolism, driving L-lactate production, and its release into the tumor microenvironment
-
oncogenic mutations in cancer cells lead to ROS production and the “secretion” of hydrogen peroxide species
-
A good discussion of what is proposed the Reverse Warburg effect. A process by which the local environment dictates tumor progression. The cancer cells release ROS primarily in the form of H2O2 and this leads to Cancer Associated Fibroblasts (CAFs) in the stroma. The altered stromal environment increases ROS further and promotes ocogenic metabolites through the classic Warburg effect. This high lactate production from the CAFs then is used by the cancer cells via classic oxidative phosphorylation. Complex, beautiful and still an the understanding is a work in progress. This study/article points to the importance of oxidative stress in some cancer development through CAFs.
1More
The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Ac... - 0 views
-
Great diagram of the pH in/around solid tumors. Cancer exists in an obvious hypoxic environment which favors the HIF-1alpha which favors lactate production which drops the pH in the tumor extracellular environment effecting chemoresistance, radioresistance, angiogenesis, invasion, aggressiveness, metastasis, immune evasion...
1More
Theoretical causes of autism - 0 views
www.rescuepost.com/...-autism-causes-a-review1-1.pdf
autism ASD immunoexcitotoxicity immunology toxin toxic environment
shared by Nathan Goodyear on 17 Apr 12
- No Cached
95More
Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeu... - 0 views
www.sciencedirect.com/...S0891584923005014
COVID19 COVID-19 cancer inflammation SARS-CoV-2 spike proteins COVID spikeopathy
shared by Nathan Goodyear on 01 Sep 23
- No Cached
- ...88 more annotations...
-
Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
-
Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
-
Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
-
Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
-
Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
-
Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
-
Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
-
Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
-
Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
-
Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
-
direct consequence of redox iMeBalance, itself a consequence of decreased energy yield by the mitochondria
-
direct consequence of redox iMeBalance, itself a consequence of decreased energy yield by the mitochondria
-
mitochondrial dysfunction and increased levels of lactate, which are important characteristics of metabolic shift and Warburg effect in many diseases
-
mitochondrial dysfunction and increased levels of lactate, which are important characteristics of metabolic shift and Warburg effect in many diseases
-
cell division is the most sophisticated way to release entropy
-
redox signaling plays an important role in regulating immune function and inflammation, and disruptions in this signaling can lead to excessive cytokine production and immune system activation
-
reduced extracellular environment in the elderly and the increased susceptibility to Covid-19 infection
-
reduced extracellular environment in the elderly and the increased susceptibility to Covid-19 infection
-
Redox signaling tightly modulates the inflammatory response and oxidative stress has been reported in acute Covid-19
-
People at high risk are the elderly, patients suffering from metabolic syndrome such as obesity, or those suffering from chronic diseases such as cancer or inflammation
-
COVID-19 patients with severe disease have higher levels of oxidative stress markers and lower antioxidant levels
-
oxidative stress can activate the NLRP3 inflammasome, which is a protein complex that plays a key role in the cytokine storm
-
inflammation leads to the formation of ROS and RNS, while redox iMeBalance results in cellular damage, which in turn triggers an inflammatory response
-
persistently elevated mtROS triggers endothelial dysfunction and inflammation, which results in a vicious loop involving ROS, inflammation, and mitochondrial dysfunction
-
IL-2 is highly up-regulated in Covid-19 patients [37], and IL-2 is known to significantly stimulate the generation of NO in patients
-
Elevated levels of lactate, a characteristic of the Warburg effect, were also reported in the high-risk Covid-19
-
vaccinated with RNA or DNA vaccines triggering the synthesis of the viral spike protein in human cells
-
viral reactivation in varicella-zoster virus [55] or hepatitis [56], coagulopathy and resulting stroke and myocarditis following both DNA-based vaccines [57] and RNA-based vaccines
-
characteristic of the Warburg effect is present in almost every disease and appears to be a central feature in most of the hallmarks of cancer
-
inflammation, mitochondrial dysfunction and increased lactate concentrations in the extracellular fluid
-
As the mitochondria are impaired, the infected cell cannot catabolize efficiently. It will release lactic acid in the blood stream
-
Striking similarities are seen between cancer, Alzheimer's disease and Covid-19, all related to the Warburg effect
-
Cancer, inflammation, Alzheimer's, and Parkinson's diseases share a common peculiarity, the inability of the cell to export entropy outside the body in the harmless form of heat
-
MEB relieves the Warburg effect [87], improves memory [77], is active in the treatment of depressive episodes [79,80] and reduces the importance of ischemic strokes
-
MEB relieves the Warburg effect [87], improves memory [77], is active in the treatment of depressive episodes [79,80] and reduces the importance of ischemic strokes
-
It has been shown that Covid-19-patients treated with MEB, have a significant reduction in hospital stay duration and mortality
-
MeB + can take a pair of electrons (of H atoms) and MeBH can release this pair easily, so that MeB is partially recycled like a catalyst
-
MeB acts as an electron bridge between a donor (FADH2, FMNH, NADH) and an acceptor (complex IV of ETC or oxygen itself)
-
As a coenzyme of pyruvate dehydrogenase (PDH), alpha-lipoic acid (ALA) initiates the formation of acetyl-CoA to feed the TCA cycle
-
ALA enhances the catabolism of carbon. cycle and therefore may reduce the Warburg effect and consequently, lactate production
-
Methylene Blue plays a similar role after the TCA cycle, by carrying electrons to complex IV of the electron transport chain
-
Drugs such as lipoic acid and MeB, which target the metabolism, decrease the redox shift by increasing catabolism
1More
The monounsaturated fatty acid intake modulates the effect of ADIPOQ polymorphisms on o... - 0 views
2More
Interaction between a peroxisome proliferator-activated receptor γ gene polym... - 0 views
hmg.oxfordjournals.org/...2923.long
peroxisome proliferator activated receptor gamma PPAR PPAR-gamma epigenetics obesity fat dietary diet intake gene genetics
shared by Nathan Goodyear on 21 Jan 13
- No Cached
-
Peroxisome proliferator-activated receptor gamma plays an important role in obesity and fat generation. In this study, they showed how the genetic expression of different PPAR gamma genotypes results in altered physiologic response to fat intake in humans. The interaction between genetics and the environment.
1More
Glyphosate induces human breast cancer cel... [Food Chem Toxicol. 2013] - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...23756170
glyphosate xenoestrogen breast cancer cancer ER alpha ER beta food human
shared by Nathan Goodyear on 17 Jun 13
- No Cached
1More
Access : The neurobiology of appetite: hunger as addiction : International Journal of O... - 0 views
1More
Vitamin D and autism: Clinical review. [Res Dev Disabil. 2012] - PubMed - NCBI - 1 views
-
Vitamin D deficiency may play a role in autism. Though this may seem logical, through NF-KappaB inhibition, the mode of protection may be more in pregnancy. I believe that the in-utero environment is setting up our children for increased ASD rates. Then add in the manner in which we treat our children as infants with massive vaccinations.
1More
A Healthy Body in a Healthy Mind-and Vice Versa-The Damaging Power of "Uncontrollable" ... - 0 views
1More
The role of glutathione in cancer - Balendiran - 2004 - Cell Biochemistry and Function ... - 0 views
1More
PLoS ONE: Influence of Milk-Feeding Type and Genetic Risk of Developing Coeliac Disease... - 0 views
www.plosone.org/...journal.pone.0030791
celiac disease PROFICEL study dysbiosis intestinal microbiota breast milk
shared by Nathan Goodyear on 29 Feb 12
- No Cached