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Nathan Goodyear

Pattern recognition receptors (PRRs): toll-like receptors | British Society for Immunology - 0 views

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    Not an article, but a good review of TLRs and their immunologic role
Nathan Goodyear

Uterine and circulating natural killer cell... [J Reprod Immunol. 2011] - PubMed - NCBI - 0 views

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    women with RPL and preeclampsia carry same immunologic NK abnormalities.  Loss of immune tolerance, elevated maternal NK, shown to play role in both.
Nathan Goodyear

Assessment of Autoantibodies to Meningioma in a Population-based Study - 0 views

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    This study finds an immunologic component to meningioma in men.
Nathan Goodyear

Angiogenic Factors and Natural Killer (NK) Cells in the Pathogenesis of Preeclampsia - 0 views

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    Abnormal NK cell activity in the placenta plays a likely role in the development of preeclampsia. This proposes an immunologic role in the development of preeclampsia.  This process is similar to the literatures link between maternal NK and RPL.
Nathan Goodyear

NK Cells Expressing a Progesterone Receptor Are Susceptible to Progesterone-Induced Apo... - 0 views

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    NK cells have progesterone receptors.  This has important immunologic and reproductive impact.
Nathan Goodyear

Plasma lipoproteins are important components of the immune system - Han - 2010 - Microb... - 0 views

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    Is all cholesterol bad?  Of course not.  We have got to get away from the linear thinking that plagues medicine.  This article proposes and supports  a protective claim of lipoproteins: VLDL, LDL, Lp(a), and HDL.  Even shown to protect against bacterial, viral, LPS, and parasitic infectious damage.
Nathan Goodyear

Complement Split Products C3a and C4a in Chronic Lyme Disease - Stricker - 2008 - Scand... - 0 views

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    C4a a useful marker in those with symptoms of chronic lyme disease.
Nathan Goodyear

ScienceDirect - Molecular Immunology : Mechanisms of heavy metal-induced autoimmunity - 0 views

  • Mechanisms of heavy metal-induced autoimmunity
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    Heavy metals and autoimmune disease
Nathan Goodyear

PosterSessionOnline - 0 views

  • Poster number: 552 No. visits: 16 Title: ALCAT test results in the treatment of gastrointestinal symptoms Authors : Mara De Amici , Centre: Foundation IRCCS Hospital San Matteo
  • Poster number: 553 No. visits: 12 Title: Evaluation of ALCAT test results in the non IgE-mediated pathology of the skin Authors : Mara De Amici , Centre: Foundation IRCCS Hospital San Matteo
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    Recent Poster presentation at European Academy of Allergy and Clinical Immunology reveals 66 % improvement in skin conditions with ALCAT diet.  Read poster #552
Nathan Goodyear

Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin - Journa... - 0 views

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    atopic dermatitis in children is different than in adults.  In children, Th2 and Th17 are involved in the initiation; in contrast the adults shows Th2, but some Th1 and not Th17.
Nathan Goodyear

IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in L... - 0 views

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    New study finds link between Lyme and chronic arthritis. The cause was upregulated TLR2 and resultant Tcell activation.  This points to a likely autoimmune threat from Lyme.
Nathan Goodyear

IL-2: The First Effective Immunotherapy for Human Cancer | The Journal of Immunology - 0 views

  • IL-2 is a 15.5-kDa cytokine secreted predominately by Ag-simulated CD4+ T cells, but it can also be produced by CD8+ cells, NK cells, and activated dendritic cells
  • IL-2 is the predominant factor responsible for the maintenance of CD4+ regulatory T cells
  • A generalized capillary leak syndrome was induced by IL-2 in vivo that resulted in interstitial pulmonary infiltrates and substantial weight gain in patients
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  • The side effects were transient and returned to baseline following treatment
  • Tumors do not express IL-2 receptors and thus the antitumor activity was the result of IL-2 stimulation of immune cell
  • Patients with metastatic melanoma or metastatic renal cell cancer were uniquely responsive to high-dose IL-2 administration, and except for patients with advanced non-Hodgkin’s lymphomas (35) only rare responses were seen in patients with other tumor types
  • The underlying toxicity of IL-2 results from a capillary leak that leads to fluid extravasation into visceral organs that can compromise their function
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    Great review of the history of IL-2 in the treatment of cancer.  IL-2 stimulates the immune system to attack cancer.  Don't reinvent the wheel; use what is already present and available.
Nathan Goodyear

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immun... - 0 views

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    Acidic pH in TME favors cancer growth and spread immunologically.
Nathan Goodyear

The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epi... - 0 views

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    "The tissue niche imprints macrophage identity, phenotype and function". This quote says it all.
Nathan Goodyear

Spontaneous tumor regression - ScienceDirect - 0 views

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    Immunologic spontaneous tumor regressions. Great read and historical reference.
Nathan Goodyear

Human CD56bright NK Cells: An Update | The Journal of Immunology - 0 views

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    Awesome review on CD16/56 NK cells in disease, particularly cancer.
Nathan Goodyear

Manipulating the Immunological Tumor Microenvironment | Frontiers Research Topic - 0 views

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    Additional studies on TME to read
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