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Nathan Goodyear

Approach To A Patient With Elevated Serum Alkaline Phosphatase - 0 views

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    case review of patient with elevated alkaline phosphatase. This case study includes a nice review of bile formation/function.
Nathan Goodyear

Serum Leptin, Parathyroid Hormone, 1,25-Dihydroxyvitamin D, Fibroblast Growth Factor 23... - 0 views

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    high leptin, high PTH, fibroblastic growth factor, and bone alkaline phosphatase associated with obesity.
Nathan Goodyear

DISTURBED MINERAL METABOLISM IN HYPERTHYROIDISM: GOOD CORRELATION WITH TRMODOTHYRONINE ... - 0 views

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    hyperthyroidism, whether medication induced or iatrogenic, results in elevated calcium, phosphorus, and alkaline phosphates.  The T3 levels show the best correlation
Nathan Goodyear

Hepatoprotective Effect of Vitamin C (Ascorbic Acid) - 0 views

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    Vitamin C is hepatoprotective.  This review highlights the proposed methods by which vitamin C reduces ALT, AST, alkaline phosphatase, LDH, malondialdegyde...
Nathan Goodyear

Cellular pH Gradient in Tumor versus Normal Tissue: Potential Exploitation for the Trea... - 0 views

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    Cancer has an acid bed compared to alkaline in health cell environment.
Nathan Goodyear

Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for ... - 0 views

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    Tumor Microenvironment is hypoxia and acid which negates effects of therapies such as DCA. Alkalinization of the tumor micronenvironment is a means to open the tumor to the effects of therapies such as DCA.
Nathan Goodyear

Acute Metabolic Alkalosis Enhances Response of C3H Mouse Mammary Tumors to the Weak Bas... - 0 views

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    alkalinization of the tumor microenvironment with NaHCO3 in mouse model improves deliver of chemotherapy to tumor.
Nathan Goodyear

Procaine and Procaine-Base-Infusion: A Review of the Safety and Fields of Application a... - 0 views

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    Procaine helpful in the alkalinization of the tumor Microenvironmenta.
Nathan Goodyear

Alkaline phosphatase isoenzyme activities in rheumatoid arthritis: hepatobiliary enzyme... - 0 views

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    ALP fractionation isoenzyme study can provide deeper understanding of disease involvement.
Nathan Goodyear

Changes in the rate of PSA progression and the level of alkaline phosphatase during hig... - 0 views

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    Brief read...will re-read, but IV vitamin C (albeit relatively low doses) correlate with decline in psa and alkP.
Nathan Goodyear

The antioxidant effects of vitamin C on liver enzymes: aspartate aminotransferase, alan... - 0 views

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    Vitamin C, in oral route, prevents elevations in liver enzymes after liver insult from Paraquat.
Nathan Goodyear

ScienceDirect - 0 views

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    Awesome read on the immune system and cancer. Specifically, the acid/base environment in the local cancer bed and its effects on the immune system and therapies.
Nathan Goodyear

Manipulating tumor acidification as a cancer treatment strategy. - 0 views

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    Manipulation of the tumor pH bed is possible.
Nathan Goodyear

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases - 0 views

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    NaHCO3 inhibits metastasis of solid tumor.
Nathan Goodyear

The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Ac... - 0 views

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    Great diagram of the pH in/around solid tumors. Cancer exists in an obvious hypoxic environment which favors the HIF-1alpha which favors lactate production which drops the pH in the tumor extracellular environment effecting chemoresistance, radioresistance, angiogenesis, invasion, aggressiveness, metastasis, immune evasion...
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