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Acute Metabolic Alkalosis Enhances Response of C3H Mouse Mammary Tumors to the Weak Bas... - 0 views

www.ncbi.nlm.nih.gov/...PMC1505597

cancer acid tumor cancer alkaline NaHCO3

shared by Nathan Goodyear on 27 Nov 18 - No Cached

Nathan Goodyear on 27 Nov 18

alkalinization of the tumor microenvironment with NaHCO3 in mouse model improves deliver of chemotherapy to tumor.

<div class="cArrow"> </div><div class="cContentInner">alkalinization of the tumor microenvironment with NaHCO3 in mouse model improves deliver of chemotherapy to tumor.</div>

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The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Ac... - 0 views

cancerres.aacrjournals.org/...2677.long

pH acid tumor cancer alkaline NaHCO3

shared by Nathan Goodyear on 19 Nov 18 - No Cached

Nathan Goodyear on 19 Nov 18

Great diagram of the pH in/around solid tumors. Cancer exists in an obvious hypoxic environment which favors the HIF-1alpha which favors lactate production which drops the pH in the tumor extracellular environment effecting chemoresistance, radioresistance, angiogenesis, invasion, aggressiveness, metastasis, immune evasion...

<div class="cArrow"> </div><div class="cContentInner">Great diagram of the pH in/around solid tumors. Cancer exists in an obvious hypoxic environment which favors the HIF-1alpha which favors lactate production which drops the pH in the tumor extracellular environment effecting chemoresistance, radioresistance, angiogenesis, invasion, aggressiveness, metastasis, immune evasion...</div>

...

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Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases - 0 views

www.ncbi.nlm.nih.gov/...PMC2834485

Cancer "pH and cancer" pH alkaline acid

shared by Nathan Goodyear on 21 May 18 - No Cached

Nathan Goodyear on 21 May 18

NaHCO3 inhibits metastasis of solid tumor.

<div class="cArrow"> </div><div class="cContentInner">NaHCO3 inhibits metastasis of solid tumor.</div>

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Enhancement of chemotherapy by manipulation of tumour pH | British Journal of Cancer - 0 views

www.nature.com/6690455

Cancer pH acid tumor cancer chemotherapy

shared by Nathan Goodyear on 19 Nov 18 - No Cached

Nathan Goodyear on 19 Nov 18

Study from 1999 confirms the extracellular acid pH increases resistance to chemotherapy in in vivo study

<div class="cArrow"> </div><div class="cContentInner">Study from 1999 confirms the extracellular acid pH increases resistance to chemotherapy in in vivo study</div>

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Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many ... - 0 views

NaHCO3 IV vitamin C dihydroascorbate dihydroascorbic acid vitamin C cancer HIF-1

shared by Nathan Goodyear on 03 Jun 19 - No Cached

Nathan Goodyear on 03 Jun 19

To be fully read later.

<div class="cArrow"> </div><div class="cContentInner">To be fully read later.</div>

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