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acute GC secretion during stress mobilizes peripheral amino acids from muscle as well as fatty acids and glycerol from peripheral fat stores to provide substrates for glucose synthesis by the liver

chronically elevated GC levels alter body fat distribution and increase visceral adiposity as well as metabolic abnormalities in a fashion reminiscent of metabolic syndrome

This local production may play an important role in the onset of obesity and insulin resistance.

The consistent results obtained from the two matrices allow us to consider salivary assays as a useful tool for steroid abuse detection.

Natural flavones were consistently more potent inhibitors

The natural flavone quercetin and isoflavone genistein induced aromatase activity 4- and 2.5-fold induction

To date nearly half of known human tumors show a dysregulation of the WNT signaling pathway

It should be also noted that the WNT pathway is not exclusively employed during development or overactivated in cancer. In adults many healthy tissues rely on it for renewal and homeostasis maintenance, most notably the intestine, haematopoietic system, hair, bones and skin. Therefore one might expect adverse reactions in all these organ systems, which has indeed been observed for many WNT-targeting compounds upon attempts to push them into the clinics

The intestine seems to be the most vulnerable in this regard