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Nathan Goodyear

Diurnal variation of adrenocortical activ... [Neuropsychobiology. 1998] - PubMed - NCBI - 0 views

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    adrenocortical dysfunction found to play a role in CFS
Nathan Goodyear

Effects of Cortisol on Carbohydrate, Lipid, and Protein Metabolism: Studies of Acute Co... - 0 views

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    This study they looked at the withdrawal of cortisol on glucose homeostasis.  The point is that cortisol has profound effects on glucose homeostasis.  Elevated cortisol or exogenous intake reduces T3 and increases insulin resistance.
Nathan Goodyear

Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity - 0 views

  • acute GC secretion during stress mobilizes peripheral amino acids from muscle as well as fatty acids and glycerol from peripheral fat stores to provide substrates for glucose synthesis by the liver
  • chronically elevated GC levels alter body fat distribution and increase visceral adiposity as well as metabolic abnormalities in a fashion reminiscent of metabolic syndrome
  • This local production may play an important role in the onset of obesity and insulin resistance.
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  • In adipocytes, cortisol inhibits lipid mobilization in the presence of insulin, thus leading to triglyceride accumulation and retention.
  • Since the density of GC receptors is higher in intra-abdominal (visceral) fat than in other fat depots, the activity of cortisol leading to accumulation of fat is accentuated in visceral adipose tissue (24, 158), providing a mechanism by which excessive endogenous or exogenous GC lead to abdominal obesity and IR
  • obese patients generally have normal or subnormal plasma cortisol concentrations
  • This may be explained by an increased intratissular/cellular concentration of cortisol in adipose tissues
  • Intracellular GC may be produced from recycling of GC metabolites such as cortisone in adipose tissues
  • Local GC recycling metabolism is mediated by 11β-hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 11β-HSD2
  • Cortisol also increases 11β-HSD1 expression in human adipocytes
  • In humans, elevated 11β-HSD1 expression in visceral adipose tissue is also associated with obesity
  • even if obese patients generally have normal or subnormal plasma cortisol concentrations (131, 158), triglyceride accumulation in visceral adipose tissue may be due, at least in part, to the local production of GC in insulin- and GC-responsive organs such as adipose tissue, liver, and skeletal muscle
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    another nice article on the dysregulation of cortisol and its role in insulin resistance, metabolic syndrome, and obesity.
Nathan Goodyear

Increased 5α-Reductase Activity and Adrenocortical Drive in Women with Polycy... - 0 views

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    increased 5-alpha reductase activity found in women with PCOS. Weight showed no variance.  Additionally, no change in 11-betaHSD activity was found.
Nathan Goodyear

Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones - J... - 0 views

  • The consistent results obtained from the two matrices allow us to consider salivary assays as a useful tool for steroid abuse detection.
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    saliva testing for cortisol, DHEA, androstenedione
Nathan Goodyear

Induction and Inhibition of Aromatase (CYP19) Activity by Natural and Synthetic Flavono... - 0 views

  • Natural flavones were consistently more potent inhibitors
  • The natural flavone quercetin and isoflavone genistein induced aromatase activity 4- and 2.5-fold induction
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    Quercetin shown to be a good natural aromatase inhibitor
Nathan Goodyear

Pituitary-adrenocortical function in abdominal obesity of males: ev... - PubMed - NCBI - 0 views

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    Obesity associated with decreased adrenal 21alpha-hydroxylase activity.  The result is decreased cortisol production in obese individuals.  
Nathan Goodyear

Cancers | Free Full-Text | A Second WNT for Old Drugs: Drug Repositioning against WNT-D... - 0 views

  • To date nearly half of known human tumors show a dysregulation of the WNT signaling pathway
  • It should be also noted that the WNT pathway is not exclusively employed during development or overactivated in cancer. In adults many healthy tissues rely on it for renewal and homeostasis maintenance, most notably the intestine, haematopoietic system, hair, bones and skin. Therefore one might expect adverse reactions in all these organ systems, which has indeed been observed for many WNT-targeting compounds upon attempts to push them into the clinics
  • The intestine seems to be the most vulnerable in this regard
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  • Ivermectin inhibits proliferation of human colon cancer and lung cancer cells both in vitro and in vivo
  • The anti-proliferative action, affecting both the bulk tumor cells and CSCs, was linked in this study to inhibition of WNT signaling
  • the anti-WNT IC50 of ivermectin is 5–10 times (~1–2 µM vs. 10 µM) lower than that of its toxic effect against chloride channels
  • oral bioavailability of the drug, as for other antiparasitic drugs discussed in this section, is very low
  • Toxicity studies in vivo have also demonstrated a wide therapeutic index for ivermectin
  • Its anti-proliferative activity has been demonstrated in a wide array of cancer cell lines representative of WNT-dependent cancers: non-small lung carcinoma [96], multiple myeloma [97], hepatoma [98], adrenocortical carcinoma [99], ovarian cancer [100] and glioblastoma
  • Niclosamide inhibits the canonical WNT pathway
  • In addition to inhibiting the canonical WNT pathway, niclosamide may mediate its anticancer activities through several other signaling pathways such as NOTCH [107], MTOR [108], NF-κB [97] and STAT3 [96]
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    review article highlights older medications that have anti-Wnt pathway effects in cancer.  Roughly, 50% of cancer involve upregulated Wnt pathway activity. Other drugs of note: metformin
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