Group items tagged

Gout is a result of Insulin resistance?  It makes perfect biologic sense.  IR causes inflammation and what is Gout?  Nothing but an inflammatory condition.  So is Gout merely a join representation of metabolic dysfunction?  I say yes.

Vitamin C shown to be inversely associated with uric acid. This has implications in those with gout, which is caused from xanthine oxidase production of uric acid.  Vitamin C can be used in those at risk for elevated uric acid levels and gout.

new animal study finds that high fiber diet intake increases gut flora SCFA production that reduces inflammation in gout

sex hormones play a role in the gout.  It appears that testosterone therapy increases uric acid levels and estradiol decreases uric acid levels.  Though, I question this based on the use of serum levels and thus inadequate assessment of aromatase activity.  Aromatase activity does not occur in the serum, it occurs in the tissue, thus saliva would be the best tool.

vitamin C shown to decrease gout in men

This population study finds increased risk, significantly more for women vs men, of type II Diabetes with gout.  This should come as no surprise as the underlying pathophysiology is the same.  Fructose increases Uric acid.  Uric acid is a biomarker of MetS.  Fructose increases abdominal adiposity and eventually inflammation which leads to diabetes.  

review of gout and purine metabolism

Vitamin C therapy, at low doses, shown to reduce uric acid

occupational lead poisoning