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This article describes how important glutamine is as an alternative energy source in Glioblastoma. Cancer is a substrate-level dependent energy production disease. If one disrupts glycolysis as a source of energy, then many cancers will use glutamine through glutaminolysis. The cancer cells will do this through glutamate dehydrogenase and glutamate production. This will increase alpha-ketoglutarate which will then feed the substrate-level phosphorylation through the TCA cycle. This study mentioned that EGCG is a way to naturally inhibit glutamate dehydrogenase.

low testosterone in boys associated with anxiety/depression and attention problems.  Disruptive behavior found in girls with low testosterone.  All determined by salivary testing.

in this study, children with autism found to have detoxification impairment.  Particularily here, methylation disruption and glutathione depletion.

great read on the current understanding of how obesity and resultant inflammation disrupts hypothalamic function.

The summary statement of this article says it all: "chronic inflammatory state may induce insulin resistance and endothelial dysfunction..."  Inflammation causes insulin dysfunction. And in fact, we know this to be true.  We know that IL-1B and TNF-alpha stimulated by NF-KappaB actually inhibits insulin action via disruption of the GLUT4 receptor.

men with UGT2B17 found to be poor metabolizers of endogenous Testosterone.  Normally, epi-Testosterone and Testosterone exist in a relative 1:1 ratio,  However, in these individuals with this SNP, they will have slightly elevated Testosterone levels due to disrupted phase II testosterone metabolism (glucuronidation).  This is found in 60% of Asian men, 50% of black men, and 1% in white men.

Review finds endocrine disruption from Organocholrides, also called persistent organohalogen pollutants. Common POP, would be DDE, DDT... This is a review of several cohorts, but this follows the rest of the literature that these environmental toxicants are endocrine disruptors.

Fructose is a major player in the obesity epidemic. This article lays out how fructose disrupts physiology

fructose intake, whether in foods or soda, is associated with disrupted metabolism and plays a major role in obesity.

Granted, these are in men seen in an infertility clinic, but Bisphenol A (BPA) found to disrupt thyroid, increase the E2:T ratio, and a decrease in the free androgen index.  Interestingly, 89% of the men seen in this study tested positive for BPA in the urine.

lack of sleep increases inflammation.  This study showed how one night of sleep disruption can stimulate NF-KappaB activation and thus inflammation.

chronic, not acute, inflammation disrupts normal triglyceride metabolism and results in increased FFA

sleep disruption is a major symptom in those with PTSD.  There is no greater stress than combat.  The majority of research on PTSD is done on combat veterans

disruption of gut bacteria balance, dysbiosis, proposed to play role in regression autism. This study treated these children with vancomycin. Short interval improvement was found. The take home from this study is the gut-brain connection in children with regression autism

Dysbiosis is commonly found in children with ASD. Antibiotics disrupt the normal gut microbiota resulting in dysbiosis. This imbalance in gut bacteria is now known to cause systemic inflammatory states such as metabolic endotoxemia. There is no reason to think a similar link may be present between Gut inflammation and ASD

There is growing evidence that some parabens have endocrine disrupting effects.  IN this study, they found that butyl paraben acted as an endocrine disruptor.

parabens effect through mitochondrial disruption in testes?

TBI results in hormone disruption in 25-69% of those effected.  The major cause is a pituitary/neuro-endocrine effect.  This has been described since the early 20th century.

2008 article from diabetes.  This article supports metabolic endotoxemia arising out of the gut.  High fat diet intake results in disrupted gut flora, resulting in increrased LPS release, resulting in inflammation, leads to leaky gut, systemic endotoxemia, inflammation, and thus metabolic dysfunction: see obesity, DM..

intra uterine exposure to BPA disrupts stress response in rat model.