The gut microbiota participates in the body’s metabolism by affecting energy balance, glucose metabolism, and low-grade inflammation associated with obesity and related metabolic disorders
1More
shared by wheelchairindia9 on 11 May 15
- No Cached
Folding Wheelchair - 0 views
www.wheelchairindia.com/...Folding-Wheelchair
Lightweight Folding Recline Wheelchairs portable and compact shape folding wheelchair lighter and easier to lift maximum comfort and health reclining wheelchair
![](/images/link.gif)
-
Lightweight, compact-folding wheelchairs for children, teenagers, and young adults let go anywhere, while still ensuring proper positioning and support. Going to school, appointments and even on vacation is possible with the convenient, lightweight design. Just fold it up and put it in trunk. Foldable Wheelchair by features a powder coat steel frame with durable nylon upholstery and padded armrests. Composite mag wheels with maintenance-free bearings and composite handrims make for a smooth ride. As with anything with moveable parts, the folding wheelchair is not as durable as the rigid frame wheelchair. Therefore maintenance is required more frequently to keep all parts in good working order. Before purchasing a wheelchair, consider all activity level. If traveling often, and need a highly-portable option, a folding lightweight wheelchair may be. Lightweight wheelchairs provide convenience and comfort to the user and caregiver alike and are often built using materials like aluminum and titanium alloy, while foldable wheelchairs allow for easy storage and transport. Merge the two styles, and got a great mobility aid that isn't a pain to lug around. Folding wheelchairs also have removable foot rests which allow for easy folding. Most frames are made from aluminum or titanium and are heavier than the rigid frame. wheelchair is designed to fit the body of the user, while the primary design of the folding wheelchair is to fold. Folding wheelchairs are generally more "boxy" while rigid wheelchairs conform to the shape of the body. This means it can hold the users body in place by tapering the frame and seat. The folding wheelchair cannot be tapered or it would not close completely. Features: Powder coat steel frame. Durable nylon upholstery. Composite mag wheels with maintenance-free bearings. Composite footplates. Padded armrests. Composite handrims. Maximum weight capacity.
1More
shared by Nathan Goodyear on 03 Mar 14
- No Cached
Changes in body composition during a... [J Clin Endocrinol Metab. 2002] - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...11836291
body composition lean muscle mass obesity weight gain adipose tissue androgen deprivation therapy prostate cancer male men hormone hormones
![](/images/link.gif)
1More
shared by Nathan Goodyear on 01 Oct 13
- No Cached
Effect of increasing glutathione with cysteine and glycine supplementation on mitochond... - 0 views
jcem.endojournals.org/...jc.2013-2376.abstract
mitochondria detoxification gluathione insulin sensitivity muscle cysteine glycine
![](/images/link.gif)
25More
shared by Nathan Goodyear on 27 Jul 14
- No Cached
Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Dis... - 0 views
www.ncbi.nlm.nih.gov/...PMC3448089
dysbiosis diet nutrition metabolic endotoxemia disease inflammation gut
![](/images/link.gif)
-
Firmicutes and Bacteroidetes represent the two largest phyla in the human and mouse microbiota and a shift in the ratio of these phyla has been associated with many disease conditions, including obesity
- ...21 more annotations...
-
there is conflicting evidence on the composition of the obese microbiota phenotype with regards to Bacteroidetes and Firmicutes ratios
-
Bifidobacteria spp. from the phyla Actinobacteria, has been shown to be depleted in both obese mice and human subjects
-
While it is not yet clear which specific microbes are inducing or preventing obesity, evidence suggests that the microbiota is a factor.
-
targeted manipulation of the microbiota results in divergent metabolic outcomes depending on the composition of the diet
-
The microbiota has been linked to insulin resistance or type 2 diabetes (T2D) via metabolic syndrome and indeed the microbiota of individuals with T2D is also characterized by an increased Bacteroidetes/Firmicutes ratio, as well as an increase in Bacillus and Lactobacillus spp
-
It was also observed that the ratio of Bacteriodes-Prevotella to C. coccoides-E. rectale positively correlated with glucose levels but did not correlate with body mass index [80]. This suggests that the microbiota may influence T2D in conjunction with or independently of obesity
-
In humans, high-fat Western-style diets fed to individuals over one month can induce a 71% increase in plasma levels of endotoxins, suggesting that endotoxemia may develop in individuals with GI barrier dyfunction connected to dysbiosis
-
LPS increases macrophage infiltration essential for systemic inflammation preceding insulin resistance, LPS alone does not impair glucose metabolism
-
early treatment of dysbiosis may slow down or prevent the epidemic of metabolic diseases and hence the corresponding lethal cardiovascular consequences
-
increased Firmicutes and decreased Bacteroidetes, which is the microbial profile found in lean phenotypes, along with an increase in Bifidobacteria spp. and Lactobacillus spp
-
mouse and rat models of T1D have been shown to have microbiota marked by decreased diversity and decreased Lactobacillus spp., as well as a decrease in the Firmicutes/Bacteroidetes ratio
-
The microbiota appears to be essential in maintaining the Th17/Treg cell balance in intestinal tissues, mesenteric and pancreatic lymph nodes, and in developing insulitis, although progression to overt diabetes has not been shown to be controlled by the microbiota
-
Lactobacillus johnsonii N6.2 protects BB-rats from T1D by mediating intestinal barrier function and inflammation [101,102] and a combination probiotic VSL#3 has been shown to attenuate insulitis and diabetes in NOD mice
-
breast fed infants have higher levels of Bifidobacteria spp. while formula fed infants have higher levels of Bacteroides spp., as well as increased Clostridium coccoides and Lactobacillus spp
-
In mice fed a diet high in fat, there are many key gut population changes, such as the absence of gut barrier-protecting Bifidobacteria spp
-
diet has a dominating role in shaping gut microbiota and changing key populations may transform healthy gut microbiota into a disease-inducing entity
-
“Western” diet, which is high in sugar and fat, causes dysbiosis which affects both host GI tract metabolism and immune homeostasis
1More
Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndr... - 0 views
63More
shared by Nathan Goodyear on 30 Mar 15
- No Cached
Testosterone level in men with type 2 diabetes mellitus and related metabolic... - 0 views
www.ncbi.nlm.nih.gov/...PMC4364844
low T low Testosterone Diabetes Testosterone men male hormones metabolic syndrome
![](/images/link.gif)
-
defined by consistent symptoms and signs of androgen deficiency, and an unequivocally low serum testosterone level
-
the threshold serum testosterone level below which adverse clinical outcomes occur in the general population is not known
-
most population-based studies use the serum testosterone level corresponding to the lower limit, quoted from 8.7 to 12.7 nmol/L, of the normal range for young Caucasian men as the threshold
- ...57 more annotations...
-
Researchers tried to examine whether serum total or free testosterone would be a better/more reliable choice when studying the effect of testosterone. The results were mixed. Some reported significant associations of both serum total and free testosterone level with clinical parameters25, whereas others reported that only serum free testosterone26 or only serum total testosterone6 showed significant associations.
-
−0.124 nmol/L/year in serum total testosterone
-
In experimental studies, androgen receptor knockout mice developed significant insulin resistance rapidly
-
In mouse models, testosterone promoted differentiation of pluripotent stem cells to the myogenic lineage
-
testosterone decreased insulin resistance by enhancing catecholamine induced lipolysis in vitro, and reducing lipoprotein lipase activity and triglyceride uptake in human abdominal tissue in vivo
-
testosterone regulated skeletal muscle genes involved in glucose metabolism that led to decreased systemic insulin resistance
-
In the liver, hepatic androgen receptor signaling inhibited development of insulin resistance in mice
-
independent and inverse association of testosterone with hepatic steatosis shown in a cross-sectional study carried out in humans
-
Although a low serum testosterone level could contribute to the development of obesity and type 2 diabetes through changes in body composition, obesity might also alter the metabolism of testosterone
-
In obese men, the peripheral conversion from testosterone to estrogen could attenuate the amplitude of luteinizing hormone pulses and centrally inhibit testosterone production
-
leptin, an adipokine, has been shown to be inversely correlated with serum testosterone level in men
-
Leydig cells expressed leptin receptors and leptin has been shown to inhibit testosterone secretion, suggesting a role of obesity and leptin in the pathogenesis of low testosterone
-
-
Baltimore Longitudinal Study of Aging (BLSA) cohort made up of 3,565 middle-class, mostly Caucasian men from the USA, the incidence of low serum total testosterone increased from approximately 20% of men aged over 60 years, 30% over 70 years, to 50% over 80 years-of-age
-
As the binding of testosterone to albumin is non-specific and therefore not tight, the sum of free and albumin-bound testosterone is named bioavailable testosterone, which reflects the hormone available at the cellular level
-
alterations in SHBG concentration might affect total serum testosterone level without altering free or bioavailable testosterone
-
A significant, independent and longitudinal effect of age on testosterone has been observed with an average change of −0.124 nmol/L/year in serum total testosterone28. The same trend has been shown in Europe and Australia
-
Asian men residing in HK and Japan, but not those living in the USA, had 20% higher serum total testosterone than in Caucasians living in the USA, as shown in a large multinational observational prospective cohort of the Osteoporotic Fractures in Men Study
-
subjects with chronic diseases consistently had a 10–15% lower level compared with age-matched healthy subjects
-
In Caucasians, the mean serum total testosterone level for men in large epidemiological studies has been reported to range from 15.1 to 16.6 nmol/L
-
Chinese middle-aged men reported a similar mean serum testosterone level of 17.1 nmol/L in 179 men who had a family history of type 2 diabetes and 17.8 nmol/L in 128 men who had no family history of type 2 diabetes
-
HK involving a cohort of 1,489 community-dwelling men with a mean age of 72 years, a mean serum total testosterone of 19.0 nmol/L was reported
-
pro-inflammatory factors, such as tumor necrosis factor-α in the testes, could locally inhibit testosterone biosynthesis in Leydig cells47, and testosterone treatment in men was shown to reduce the level of tumor necrosis factor-α
-
In Asians, a genetic deletion polymorphism of uridine diphosphate-glucuronosyltransferase UGT2B17 was associated with reduced androgen glucuronidation. This resulted in higher level of active androgen in Asians as compared to Caucasians, as Caucasians' androgen would be glucuronidated into inactive forms faster.
-
Compared with Caucasians, the frequency of this deletion polymorphism of UGT2B17 was 22-fold higher in Asian subjects
-
Other researchers have suggested that environmental, but not genetic, factors influenced serum total testosterone
-
The basal and ligand-induced activity of the AR is inversely associated with the length of the CAG repeat chain
-
In the European Male Aging Study, increased estrogen/androgen ratio in association with longer AR CAG repeat was observed
-
a smaller number of AR CAG repeat had been shown to be associated with benign prostate hypertrophy and faster prostate growth during testosterone treatment
-
the odds of having a short CAG repeat (≤17) were substantially higher in patients with lymph node-positive prostate cancer than in those with lymph node-negative disease or in the general population
-
assessing the polymorphism at the AR level could be a potential tool towards individualized assessment and treatment of hypogonadism.
-
In elderly men, there was reduced testicular response to gonadotropins with suppressed and altered pulsatility of the hypothalamic pulse generator
-
a significant, independent and longitudinal effect of age on serum total testosterone level had been observed
-
A significant graded inverse association between serum testosterone level and insulin levels independent of age has also been reported in Caucasian men
-
most studies showed that changes in serum testosterone level led to changes in body composition, insulin resistance and the presence of MES, the reverse might also be possible
-
MES predicted a 2.6-fold increased risk of development of low serum testosterone level independent of age, smoking and other potential confounders
-
Other prospective studies have shown that development of MES accelerated the age-related decline in serum testosterone level
-
In men with type 2 diabetes, changes in serum testosterone level over time correlated inversely with changes in insulin resistance
-
weight loss by either diet control or bariatric surgery led to a substantial increase in total testosterone, especially in morbidly obese men, and the rise in serum testosterone level was proportional to the amount of weight lost
-
To date, published clinical trials are small, of short duration and often used pharmacological, not physiological, doses of testosterone
-
In the population-based Osteoporotic Fractures in Men Study cohort from Sweden, men in the highest quartile of serum testosterone level had the lowest risk of cardiovascular events compared with men in the other three quartiles (hazard ratio [HR] 0.70
-
low serum total testosterone was associated with a significant fourfold higher risk of cardiovascular events when comparing men from the lowest testosterone tertile with those in the highest tertile
-
Shores et al. were the first to report that low serum testosterone level, including both serum total and free testosterone, was associated with increased mortality
-
low serum total testosterone increased all-cause (HR 1.35, 95% CI 1.13–1.62, P < 0.001) and cardiovascular mortality (HR 1.25
-
European Association for the Study of Diabetes 2013 suggested there was an inverse relationship between serum testosterone level and acute myocardial infarction
-
Diabetic men in the highest quartile of serum total testosterone had a significantly reduced risk of acute MI when compared with those in the lower quartiles
-
serum total testosterone level in the middle two quartiles at baseline predicted reduced incidence of death compared with having the highest and lowest levels
-
Nice review of Testosterone levels and some of the evidence linking Diabetes with low T. However, the conclusion by the authors regarding what is causing the low T in men with Diabetes is baffling. The literature does not point to one cause, it is clearly multifactorial--obesity, inflammation, high aromatase activity...I would suggest the authors continue their readings in the manner.
1More
shared by Nathan Goodyear on 18 Nov 15
- No Cached
International Journal of Obesity - Identification of skeletal muscle mass depletion acr... - 0 views
www.nature.com/...ijo2014161a.html
Muscle mass fat free mass lead dry mass fat obesity body composition muscle muscle loss sarcopenic obesity sarcopenia
![](/images/link.gif)
1More
shared by Nathan Goodyear on 26 Apr 17
- No Cached
Lifestyle changes in women with polycystic ovary syndrome. - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...21735412
PCOS polycystic ovarian syndrome lifestyle intervention insulin resistance body composition
![](/images/link.gif)
1More
shared by Nathan Goodyear on 09 Jan 17
- No Cached
Effects of testosterone on body composition, bone metabolism and serum lipid profile in... - 0 views
www.ncbi.nlm.nih.gov/...16117815
Testosterone low t low testosterone Testosterone therapy body composition fat muscle male hormones hormones
![](/images/link.gif)
1More
shared by arunaraayala on 28 Dec 16
- No Cached
Michael Jackson's Son Won't Follow In Dad's Paths - 0 views
www.localitynews.com/-son-wont-follow-in-dads-paths
HOLLYWOOD CELEBRITIE UPDATES STARS KING OF POP JACKSON NEWS LATEST MICHAEL SON PRINCE
![](/images/link.gif)
1More
shared by Nathan Goodyear on 27 Jun 12
- No Cached
JAMA Network | JAMA: The Journal of the American Medical Association | Effects of Dieta... - 0 views
jama.jamanetwork.com/article.aspx
low carb low carbohydrate diet calories overweight obesity weight-loss energy
![](/images/link.gif)
1More
Effects of short-term chromium supplementatio... [J Nutr Biochem. 2011] - PubMed - NCBI - 0 views
1More
Dehydroepiandrosterone Supplementation in Elderly Men: A Meta-Analysis Study of Placebo... - 0 views
4More
shared by Nathan Goodyear on 26 Sep 13
- No Cached
Testosterone Concentrations in Women Aged 25-50 Years: Associations with Lifestyle, Bod... - 0 views
aje.oxfordjournals.org/...256.full
women testosterone inflammation hormone hormones disease obesity overweight smoking
![](/images/link.gif)
-
Increasing weight was associated with increasing total testosterone concentration at every examination
-
Measures of body composition were consistently associated with testosterone concentrations in a dose-response relation
1More
shared by Nathan Goodyear on 08 Oct 14
- No Cached
Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherap... - 0 views
ict.sagepub.com/...183.abstract
chemotherapy lean body mass muscle muscle mass weight weight gain women breast cancer body composition
![](/images/link.gif)
7More
shared by Nathan Goodyear on 29 Apr 15
- No Cached
Clostridium scindens: a human gut microbe with a high potential to convert glucocortico... - 0 views
www.jlr.org/...2437.full
gut microbiota gut microbiome gut bacteria androgens hormones clostridium scindens
![](/images/link.gif)
-
During the enterohepatic circulation (EC), bile salts are synthesized in the liver, concentrated in the gallbladder, and function in the lumen of the small intestine to absorb dietary lipids and limit microbial growth at the site of nutrient uptake
-
Bile acid 7α/β-dehydroxylating bacteria are organisms capable of converting primary bile acids made by the host to harmful secondary bile acids, deoxycholic acid, and lithocholic acid
-
These bacteria normally comprise a small proportion of the gut microbiota (∼103–104/g wet weight) and consist of species within the genus Clostridium
- ...3 more annotations...
-
C. scindens and a small number of species belonging to the genus Clostridium are responsible for significant alterations in the human bile acid pool composition through bile acid 7α/β dehydroxylation
-
bile acids play an important role in maintaining intestinal barrier function as antimicrobial agents in the small bowel (37, 38) and inducers of antimicrobial peptides
-
Perturbations in the biliary bile acid pool composition can be indicative of hepatogastrointestinal diseases such as fat malabsorption (40), gallstones (3), gastrointestinal cancers (41), and possibly type II diabetes
1More
shared by wheelchairindia9 on 09 Sep 15
- No Cached
Karma 8020 Wheelchair - 0 views
www.disabilityproduct.in/...a-8020-X-Heavy-Duty-Wheelchair
Heavy Duty Wheelchairs The Most Important Form Of Patient fit in an average-sized chair fold like regular wheelchairs with a small motor assisting different types of wheelchairs adjusting to the hemi height centre of gravity adjustment
![](/images/link.gif)
-
Heavy duty wheelchair can either be manually-operated or motorized, each with its own pros and cons. A manual heavy-duty wheelchair gives full control of motion to the user, but the added weight from the reinforcements makes pushing or propelling the wheelchair much harder than normal. A motorized heavy duty wheelchair offers a solution to this dilemma, but is often more expensive and harder to maintain than a manual wheelchair. Some designs offer a combination of both, with a small motor assisting those pushing the wheelchair. The proper choice between types of Heavy Duty wheelchair depends largely on the user's expected level of activity. Heavy duty wheelchairs typically have larger seats than conventional wheelchairs. The frames of these wheelchairs can be made from several different reinforced metals, although a titanium wheelchair is often the most popular choice. The wheels themselves are made of thicker rubber than normal, preventing any possible failure due to the greater amount of weight supported. Most makes of heavy duty wheelchairs fold like regular wheelchairs, making storage relatively easy despite the wheelchair increased size. Heavy Duty Wheelchair specialy design for disabled and handicapped persons. They are two types of Heavy Duty Wheelchair for handicapped and disability product like- Karma 8020 X Heavy Duty Wheelchair Karma 8520 Heavy Duty Wheelchair Karma 8020 X Heavy Duty Wheelchair: It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Designed for maximum strength & weight capacity for people over 250 lbs. These end to be heavier and wider. This heavy duty bariatric wheelchair has seat dimensions of 24 inches wide by 18 inches deep to accommodate a weight capacity of up to 400 lbs. This wheelchair is dual axle, which means that the floor to seat heigh
2More
natural ingredients - 0 views
-
Spices are special kind of natural products that offer not only great food/ culinary value in terms of aroma, taste, colour and so on, but also tremendous nutritive and therapeutic value because of their chemical composition. http://www.internationalspiceconference.com/delegate-registration.html
12More
shared by Nathan Goodyear on 22 Dec 14
- No Cached
European Journal of Clinical Nutrition - Effect of maternal n-3 long-chain polyunsatura... - 0 views
www.nature.com/...ejcn2014158a.html
nutrition n-3 omega 3 omega-3 fish oil pregnancy childhood obesity
![](/images/link.gif)
-
It is estimated that approximately 30% of children and adolescents in the United States and about 15–30% of those in Europe can be classified as overweight or obese
-
An increasing body of evidence now suggests that the nutritional environment encountered in utero and the early postnatal life may elicit permanent alterations in adipose tissue structure or function and, thereby, programme the individual’s propensity to later obesity
-
The composition of fatty acids in the Western diets has shifted toward an increasing dominance of n-6 relative to n-3 LCPUFAs over the past decades.9,10 This shift is also reflected in the fatty acid composition of breast milk
- ...8 more annotations...
-
Evidence from animal studies suggests that the n-6 LCPUFA arachidonic acid promotes adipose tissue deposition, whereas the n-3 LCPUFAs eicosapentaenoic acid and docosahexaenoic acid seem to exert an opposite effect
-
Overall, no effect of supplementation was found on BMI in preschool (<5 years) and school-aged (6–12 years) children
-
Many studies have shown that even children <2 years with a high BMI are at increased risk of developing obesity later in life
-
Evidence from cell culture and animal studies suggests that early exposure to n-3 LCPUFAs has the potential to limit adipose tissue deposition mainly by attenuating the production of the arachidonic acid metabolite prostacyclin, which has been shown to enhance adipogenesis
-
In conclusion, there is currently no evidence to support that maternal n-3 LCPUFA supplementation during pregnancy and/or lactation exerts a favourable programming effect on adiposity status in childhood
-
our systematic review highlights that most of the trials reviewed were prone to methodological limitations
-
Literature review finds limited data (9 studies, only 6 RCTs) of omega-3 during pregnancy. No data was found that supported reduced obesity in children by mothers taking n-3 during pregnancy. No harm was found either. Data was sparse. Take home: not enough data, no harm to pregnancy, children, thus if indications are present for mother, then recommend n-3. At this point not studies have pointed to reduced obesity in children.