Skip to main content

Home/ Dr. Goodyear/ Group items tagged clostridium scindens

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Clostridium scindens: a human gut microbe with a high potential to convert glucocortico... - 0 views

www.jlr.org/...2437.full

gut microbiota gut microbiome gut bacteria androgens hormones clostridium scindens

shared by Nathan Goodyear on 29 Apr 15 - No Cached
  • During the enterohepatic circulation (EC), bile salts are synthesized in the liver, concentrated in the gallbladder, and function in the lumen of the small intestine to absorb dietary lipids and limit microbial growth at the site of nutrient uptake
  • Bile acid 7α/β-dehydroxylating bacteria are organisms capable of converting primary bile acids made by the host to harmful secondary bile acids, deoxycholic acid, and lithocholic acid
  • These bacteria normally comprise a small proportion of the gut microbiota (∼103–104/g wet weight) and consist of species within the genus Clostridium
  • ...3 more annotations...
  • C. scindens and a small number of species belonging to the genus Clostridium are responsible for significant alterations in the human bile acid pool composition through bile acid 7α/β dehydroxylation
  • bile acids play an important role in maintaining intestinal barrier function as antimicrobial agents in the small bowel (37, 38) and inducers of antimicrobial peptides
  • Perturbations in the biliary bile acid pool composition can be indicative of hepatogastrointestinal diseases such as fat malabsorption (40), gallstones (3), gastrointestinal cancers (41), and possibly type II diabetes
  • Nathan Goodyear on 29 Apr 15
     
    Gut microbiota appears to be source of androgen production that originates from the gut.  Who would have thought that the Gut as an androgen producing endocrine gland.
1 - 1 of 1
Showing 20▼ items per page