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Nathan Goodyear

Effect of Lifestyle Intervention on the Hormonal Profile of Frail, Obese Older Men. - P... - 0 views

www.ncbi.nlm.nih.gov/...26892583

obesity men hormones low T low Testosterone Testosterone lifestyle intervention lifestyle

shared by Nathan Goodyear on 21 Apr 16 - No Cached
  • Nathan Goodyear on 21 Apr 16
     
    Nice study: 52 week study looked at lifestyle intervention to lose weight in men with low T and high estrogen levels.  The lifestyle intervention was successful in lower weight and estrogen levels, but not in raising Testosterone levels.
Nathan Goodyear

JAMA Network | JAMA Surgery | Three-Year Outcomes of Bariatric Surgery vs Lif... - 0 views

archsurg.jamanetwork.com/article.aspx

diabetes obesity obese bariatric surgery lifestyle

shared by Nathan Goodyear on 06 Jul 15 - No Cached
  • Nathan Goodyear on 06 Jul 15
     
    new study finds that bariatric surgery outperforms lifestyle interventions in improving glucose control in obese individuals.  On the surface this seems interesting, but the lifestyle interventions were based on the Diabetes Prevention program.  The diabetes prevention program doesn't do well in glucose control in any clients (see increasing diabetes rates), so it should be no surprise that bariatric surgery outperforms a program that doesn't work
Nathan Goodyear

Reduction in the incidence of type 2 diabetes w... [N Engl J Med. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11832527

Lifestyle interventions weight loss weight loss type II DM diabetes obesity overweight metformin

shared by Nathan Goodyear on 30 Mar 12 - No Cached
  • Nathan Goodyear on 30 Mar 12
     
    Lifestyle interventions significantly reduced weight and incidence of type II Diabetes compared to metformin.  Both significantly reduced the incidence, but lifestyle interventions were more beneficial than metformin.
Nathan Goodyear

Executive Summary - Lifestyle Interventions for Four Conditions - National Library of M... - 0 views

www.ncbi.nlm.nih.gov/...PMH0070536

lifestyle intervention metabolic syndrome diabetes breast cancer prostate cancer nutrition diet exercise lifestyle

shared by Nathan Goodyear on 13 Apr 16 - No Cached
  • Nathan Goodyear on 13 Apr 16
     
    analysis of Lifestyle interventions in metabolic syndrome, diabetes, breast cancer, and prostate cancer.
Nathan Goodyear

The Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome:... - 0 views

www.annals.org/...611.full

Lifestyle interventions metabolic syndrome MetS metformin diabetes prevention program

shared by Nathan Goodyear on 30 Mar 12 - No Cached
  • Nathan Goodyear on 30 Mar 12
     
    Lifestyle interventions reduced the incidence of metabolic syndrome by 41% versus only 17% in the metformin group.
Nathan Goodyear

Effect of Lifestyle Intervention on the Hormonal Profile of Frail, Obese Older Men. - P... - 0 views

www.ncbi.nlm.nih.gov/...26892583

lifestyle intervention low T low Testosterone Testosterone male hormones men hormones obesity estrogen

shared by Nathan Goodyear on 27 Sep 16 - No Cached
  • Nathan Goodyear on 27 Sep 16
     
    10% weight loss in older men, resulted in fat loss; this resulted in a decrease in estrogen production and an increase in Testosterone all via lifestyle interventions.
Nathan Goodyear

Intensive Lifestyle Intervention or Metformin on Inflammation and Coagulation in Partic... - 0 views

diabetes.diabetesjournals.org/...1566

CRP metformin type II diabetes DM IGT insulin resistance inflammation inflammatory markers lifestyle intervention glucose tolerance

shared by Nathan Goodyear on 20 Dec 11 - No Cached
  • Nathan Goodyear on 20 Dec 11
     
    Large study of over 3,000 adults shows lifestyle changes are more effective, than metformin, in reducing development of type II diabetes.  CRP, inflammatory marker, reduced at 1 year more in lifestyle (29%) versus metformin (14%).     And don't forget all the nutritional deficiencies that metformin creates.
Nathan Goodyear

JAMA Network | JAMA Oncology | Preventable Incidence and Mortality of Carcinoma Associa... - 0 views

oncology.jamanetwork.com/article.aspx

lifestyle intervention cancer health wellness

shared by Nathan Goodyear on 23 May 16 - No Cached
  • Nathan Goodyear on 23 May 16
     
    Health lifestyle interventions reduce the incidence and mortality from cancer.
Nathan Goodyear

Lifestyle changes in women with polycystic ovary syndrome. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21735412

PCOS polycystic ovarian syndrome lifestyle intervention insulin resistance body composition

shared by Nathan Goodyear on 26 Apr 17 - No Cached
  • Nathan Goodyear on 26 Apr 17
     
    Cochran review of 6 studies of only 164 women found lifestyle interventions improved body composition, mostly fat loss, decreased the hyperandrogen status and improved insulin resistance in women with PCOS.
Nathan Goodyear

The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotl... - 0 views

www.nature.com/...s41416-018-0029-6

cancer lifestyle united kingdom england wales scotland ireland northern ireland

shared by Nathan Goodyear on 27 Mar 18 - No Cached
  • Nathan Goodyear on 27 Mar 18
     
    Amazing statistics out of UK.  The fraction of cancer attributable to lifestyle estimated to be as high as 41.2%.  The cure for cancer is prevention through lifestyle intervention.
Nathan Goodyear

Changes in arterial distensibility and flow-mediated dilation after acute resistance vs... - 0 views

www.ncbi.nlm.nih.gov/...20885204

resistance training exercise hypertension blood pressure lifestyle intervention

shared by Nathan Goodyear on 17 May 16 - No Cached
  • Nathan Goodyear on 17 May 16
     
    resistance exercise found to lower blood pressure.  Another feather in the cap of lifestyle intervention.  The blood pressure lowering effects with resistance training outperformed aerobic exercise.
Nathan Goodyear

JAMA Network | JAMA Oncology | The Preventability of Cancer:  Stacking the Deck - 0 views

oncology.jamanetwork.com/article.aspx

cancer lifestyle intervention health wellness

shared by Nathan Goodyear on 23 May 16 - No Cached
  • Nathan Goodyear on 23 May 16
     
    Lifestyle interventions to prevent cancer
Nathan Goodyear

A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holis... - 0 views

www.ncbi.nlm.nih.gov/...28359097

low T low Testosterone lifestyle intervention hypogonadism male hormones

shared by Nathan Goodyear on 27 Apr 17 - No Cached
  • Nathan Goodyear on 27 Apr 17
     
    literature review finds that lifestyle interventions can improve Testosterone levels in men.  For many men, low Testosterone, is the result not the cause.
  • Open TeleShop on 17 May 17
     
    Hey Dear Check Out Our Online Shopping store in all Over Pakistan.As Seen as On Tv Products Like as Health Beauty,Fitness,Homeware,Kitchenware,And Other Electronic Products in Pakistan Check Out Now| www.openTeleshop.Com
Nathan Goodyear

Reduction in the incidence of type 2 diabetes with... [N Engl J Med. 2002] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...11832527

diabetes lifestyle changes intervention treatment prevention metformin

shared by Nathan Goodyear on 11 Jun 11 - No Cached
  • The lifestyle intervention was more effective than metformin.
  • Nathan Goodyear on 11 Jun 11
     
    Lifestyle changes are more effective than metformin in Diabetes prevention in high risk individuals
Nathan Goodyear

https://www.jstage.jst.go.jp/article/jcbn/58/1/58_15-48/_pdf - 0 views

www.jstage.jst.go.jp/..._pdf

lifestyle Testosterone low T low Testosterone exercise nutrition hormones obesity overweight

shared by Nathan Goodyear on 25 Jan 16 - No Cached
  • Nathan Goodyear on 25 Jan 16
     
    study finds that lifestyle interventions, aerobic exercise and calorie restriction, increased Testosterone levels in men that were overweight or obese.  The men included in this study did not meet most definitions of "low Testosterone".
Nathan Goodyear

Effectiveness of altering serum cholesterol levels without drugs - 0 views

www.ncbi.nlm.nih.gov/...PMC1312230

cholesterol lifestyle nutrition mediterranean diet exercise plant sterols fiber omega 3 omega-3

shared by Nathan Goodyear on 06 Apr 16 - No Cached
  • Nathan Goodyear on 06 Apr 16
     
    nice review of the evidence of lifestyle interventions and/or alternative therapies with cholesterol
Nathan Goodyear

Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: The CE... - 0 views

circ.ahajournals.org/...CIRCULATIONAHA.117.030501

Mediterranean diet diet nutrition lifestyle obesity lifestyle intervention weight loss

shared by Nathan Goodyear on 19 Dec 17 - No Cached
  • Nathan Goodyear on 19 Dec 17
     
    low carb mediterranean nutrition out performs low fat diet; but both are not served by following weight number.  MRI shows that fat mobilization of the superior low carb mediterranean nutrition plan is not adequately reflected in weight measurement. 
Nathan Goodyear

An integrative analysis reveals coordinated reprogramming of the epigenome and the tran... - 0 views

www.ncbi.nlm.nih.gov/...PMC4622000

exercise epigenetics muscle

shared by Nathan Goodyear on 03 Oct 17 - No Cached
  • contribution to the training response of the epigenome as a mediator between genes and environment
  • Differential DNA methylation was predominantly observed in enhancers, gene bodies and intergenic regions and less in CpG islands or promoters
  • highly consistent and associated modifications in methylation and expression, concordant with observed health-enhancing phenotypic adaptations, are induced by a physiological stimulus
  • ...34 more annotations...
  • The health benefits following exercise training are elicited by gene expression changes in skeletal muscle, which are fundamental to the remodeling process
  • there is increasing evidence that more short-term environmental factors can influence DNA methylation
  • dietary factors have the potency to alter the degree of DNA methylation in different tissues, 9,10 including skeletal muscle
  • In one study, a single bout of endurance-type exercise was shown to affect methylation at a few promoter CpG sites
  • In the context of diabetes, exercise training has been shown to affect genome-wide methylation pattern in skeletal muscle,13 as well as in adipose tissue.
  • physiological stressors can indeed affect DNA methylation
  • training intervention reshapes the epigenome and induces significant changes in DNA methylation
  • the findings from this tightly controlled human study strongly suggest that the regulation and maintenance of exercise training adaptation is to a large degree associated to epigenetic changes, especially in regulatory enhancer regions
  • Endurance training [after training (T2) vs. before training (T1)] induced significant (false discovery rate, FDR< 0.05) methylation changes at 4919 sites across the genome in the trained leg
  • identified 4076 differentially expressed genes
  • a complementary approach revealed that over 600 CpG sites correlated to the increase in citrate synthase activity, an objective measure of training response (Figure S4 and Dataset S14). This might imply that some of these sites could influence the degree of training response.
  • As expected by a physiological environmental trigger on adult tissue, the observed effect size on DNA methylation was small in comparison to disease states such as cancer
  • a preferential localization outside of CpG Islands/Shelves/Shores
  • endurance training especially influences enhancers
  • negative correlation was more prominent for probes in promoter/5′UTR/1st exon regions, while gene bodies had a stronger peak of positive correlation
  • The significant changes in DNA methylation, that primarily occurred in enhancer regions, were to a large extent associated with relevant changes in gene expression
  • The main findings of this study were that 3 months of endurance training in healthy human volunteers induced significant methylation changes at almost 5000 sites across the genome and significant differential expression of approximately 4000 genes
  • DMPs that increased in methylation were mainly associated to structural remodeling of the muscle and glucose metabolism, while the DMPs with decreased methylation were associated to inflammatory/immunological processes and transcriptional regulation
  • This suggests that the changes in methylation seen with training were not a random effect across the genome but rather a controlled process that likely contributes to skeletal muscle adaptation to endurance training
  • Correlation of the changes in DNA methylation to the changes in gene expression showed that the majority of significant methylation/expression pairs were found in the groups representing either increases in expression with a concomitant decrease in methylation or vice versa
  • The fraction of genes showing both significant decrease in methylation and upregulation was 7.5% of the DEGs or 2.3% of all genes detected in muscle tissue with at least one measured DNA methylation position. Correspondingly, 7.0% of the DEGs or 2.1% of all genes showed both significant increase in methylation and downregulation
  • we show that DNA methylation changes are associated to gene expression changes in roughly 20% of unique genes that significantly changed with training
  • Examples of structural genes include COL4A1, COL4A2 and LAMA4. These genes have also been identified as important for differences in responsiveness to endurance training
  • methylation status could be part of the mechanism behind variable training response
  • Among the metabolic genes, MDH1 catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle and NDUFA8 plays an important role in transferring electrons from NADH to the respiratory chain
  • PPP1R12A,
  • In the present study, methylation predominantly changed in enhancer regions with enrichment for binding motifs for different transcription factors suggesting that enhancer methylation may be highly relevant also in exercise biology
  • Of special interest in the biology of endurance training may be that MRFs, through binding to the PGC-1α core promoter, can regulate this well-studied co-factor for mitochondrial biogenesis
  • That endurance training led to an increased methylation in enhancer regions containing motifs for the MRFs and MEFs is somewhat counterintuitive since it should lead to the repression of the action of the above discussed transcription factors
  • decrease with training in this study, including CDCH15, MYH3, TNNT2, RYR1 and SH3GLB1
  • expression of MEF2A itself decreased with training
  • this study demonstrates that the transcriptional alterations in skeletal muscle in response to a long-term endurance exercise intervention are coupled to DNA methylation changes
  • We suggest that the training-induced coordinated epigenetic reprogramming mainly targets enhancer regions, thus contributing to differences in individual response to lifestyle interventions
  • a physiological health-enhancing stimulus can induce highly consistent modifications in DNA methylation that are associated to gene expression changes concordant with observed phenotypic adaptations
  • Nathan Goodyear on 03 Oct 17
     
    Exercise alters gene expression via methylation--the power of epigenetics.  Interestingly, the majority of the methylation was outside the CPG island regions.  This 3 month study found methylation of 5,000 sites across the genome resulting in altered expression of apps 4,000 genes.  The altered muscle changes of the endurance training was linked to DNA methylation changes.
Nathan Goodyear

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin ... - 0 views

www.nejm.org/...NEJMoa012512

diabetes lifestyle changes metformin

shared by Nathan Goodyear on 07 Dec 10 - No Cached
  • Nathan Goodyear on 07 Dec 10
     
    lifestyle changes more effective than metformin in Type 2 diabetes
Nathan Goodyear

From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key... - 0 views

clinicalepigeneticsjournal.biomedcentral.com/...s13148-015-0068-2

epigenetics nutrition inflammation lifestyle intervention aging diet inflammaging

shared by Nathan Goodyear on 27 Oct 17 - No Cached
  • Nathan Goodyear on 27 Oct 17
     
    epigenetics is the key to customizing lifestyle choices to optimize health potential.  It all begins with matching nutrition with epigenetics to limit inflammation.
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